Ming Zhang

Research output

Research output per year 2004 2007 2015 2017 2019 2023

• 23 Article
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules

  Wang, Y., Douville, C., Cohen, J. D., Mattox, A., Curtis, S., Silliman, N., Popoli, M., Ptak, J., Dobbyn, L., Nehme, N., Dudley, J. C., Summers, M., Zhang, M., Ho-Pham, L. T., Tran, B. N. H., Tran, T. S., Nguyen, T. V., Bettegowda, C., Papadopoulos, N., Kinzler, K. W., & 1 othersVogelstein, B., Apr 11 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 15, e2220704120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-Methylcytosine 100%
  • Methylation 95%
  • Epigenomics 61%
  • Mutation 59%
  • DNA 58%
• 2021

  Mutation and methylation profiles of ectopic and eutopic endometrial tissues

  Li, L., Antero, M. F., Zhang, M., Chu, T., Seckin, T., Ayhan, A., Pisanic, T., Wang, T. L., Cope, L., Segars, J. & Shih, I. M., Dec 2021, In: Journal of Pathology. 255, 4, p. 387-398 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Endometrium 100%
  • Methylation 87%
  • Adenomyosis 76%
  • Epithelium 62%
  • Mutation 53%
• 2019

  Direct detection and quantification of neoantigens

  Wang, Q., Douglass, J., Hwang, M. S., Hsiue, E. H. C., Mog, B. J., Zhang, M., Papadopoulos, N., Kinzler, K. W., Zhou, S. & Vogelstein, B., 2019, In: Cancer Immunology Research. 7, 11, p. 1748-1754 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peptides 100%
  • Cancer Vaccines 94%
  • Allergy and Immunology 83%
  • HLA Antigens 80%
  • Chromatography 77%
  9 Scopus citations

• Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions

  Wu, R. C., Wang, P., Lin, S. F., Zhang, M., Song, Q., Chu, T., Wang, B. G., Kurman, R. J., Vang, R., Kinzler, K., Tomasetti, C., Jiao, Y., Shih, I. M. & Wang, T. L., May 2019, In: Journal of Pathology. 248, 1, p. 41-50 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Neoplasms 100%
  • Carcinoma in Situ 93%
  • Carcinoma 72%
  • Mutation 23%
  • History 20%
  23 Scopus citations

• Genomic Landscape of Intramedullary Spinal Cord Gliomas

  Zhang, M., Iyer, R. R., Azad, T. D., Wang, Q., Garzon-Muvdi, T., Wang, J., Liu, A., Burger, P., Eberhart, C., Rodriguez, F. J., Sciubba, D. M., Wolinsky, J. P., Gokaslan, Z., Groves, M. L., Jallo, G. I. & Bettegowda, C., Dec 1 2019, In: Scientific reports. 9, 1, 18722.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ependymoma 100%
  • Glioma 95%
  • Spinal Cord 84%
  • Spinal Cord Neoplasms 74%
  • Mutation 43%
  5 Scopus citations

• Prognostic significance of human telomerase reverse transcriptase promoter region mutations C228T and C250T for overall survival in spinal chordomas

  Bettegowda, C., Yip, S., Jiang, B., Wang, W. L., Clarke, M. J., Lazary, A., Gambarotti, M., Zhang, M., Sciubba, D. M., Wolinsky, J. P., Goodwin, C. R., McCarthy, E., Germscheid, N. M., Sahgal, A., Gokaslan, Z. L., Boriani, S., Varga, P. P., Fisher, C. G. & Rhines, L. D., Aug 1 2019, In: Neuro-oncology. 21, 8, p. 1005-1015 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • human TERT protein 100%
  • Chordoma 96%
  • Genetic Promoter Regions 68%
  • Mutation 39%
  • Survival 39%
  6 Scopus citations
• 2018

  Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

  Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C. L., Hruban, R. H., Ishii, M., Klein, A. P., Reh, D. D., Rooper, L. M., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K., & 5 othersAgrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In: Nature communications. 9, 1, 5410.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • deletion 92%
  • Dystrophin 82%
  • Nucleotide 54%
  • genes 51%
  • tumors 42%
  7 Scopus citations

• Precancerous neoplastic cells can move through the pancreatic ductal system

  Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., Hruban, R. H., Klimstra, D. S., Papadopoulos, N., Nowak, M. A., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Sep 13 2018, In: Nature. 561, 7722, p. 201-205 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms 100%
  • Pancreas 60%
  • Carcinoma 23%
  • Mutation 19%
  • Genes 14%
  42 Scopus citations
• 2017

  Cancer-associated mutations in endometriosis without cancer

  Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F., & 20 othersHasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, K. W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T. L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In: New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endometriosis 100%
  • Mutation 53%
  • Neoplasms 30%
  • Epithelium 19%
  • Exome 10%
  225 Scopus citations

• Genetic landscape of extreme responders with anaplastic oligodendroglioma

  Holdhoff, M., Cairncross, G. J., Kollmeyer, T. M., Zhang, M., Zhang, P., Mehta, M. P., Werner-Wasik, M., Souhami, L., Bahary, J. P., Kwok, Y., Hartford, A. C., Chakravarti, A., Yegnasubramanian, S., Vogelstein, B., Papadopoulos, N., Kinzler, K., Jenkins, R. B. & Bettegowda, C., May 30 2017, In: Oncotarget. 8, 22, p. 35523-35531 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oligodendroglioma 100%
  • Survivors 65%
  • Radiation 24%
  • Survival 23%
  • PCV regimen 23%

• Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

  Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Mar 1 2017, In: Nature genetics. 49, 3, p. 358-366 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Neoplasm Metastasis 65%
  • Mutation 59%
  • Genes 42%
  • Whole Genome Sequencing 24%
  179 Scopus citations

• Selected reaction monitoring approach for validating peptide biomarkers

  Wang, Q., Zhang, M., Tomita, T., Vogelstein, J. T., Zhou, S., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B., Dec 19 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13519-13524 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biomarkers 100%
  • Peptides 97%
  • Ovarian Neoplasms 46%
  • Cyclophilin A 25%
  • Chromatography 16%
  13 Scopus citations

• Spinal column chordoma: Prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival

  Bettegowda, C., Yip, S., Lo, S. F. L., Fisher, C. G., Boriani, S., Rhines, L. D., Wang, J. Y., Lazary, A., Gambarotti, M., Wang, W. L., Luzzati, A., Dekutoski, M. B., Bilsky, M. H., Chou, D., Fehlings, M. G., McCarthy, E. F., Quraishi, N. A., Reynolds, J. J., Sciubba, D. M., Williams, R. P., & 7 othersWolinsky, J. P., Zadnik, P. L., Zhang, M., Germscheid, N. M., Kalampoki, V., Varga, P. P. & Gokaslan, Z. L., Mar 1 2017, In: Neuro-oncology. 19, 3, p. 405-413 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brachyury protein 100%
  • Chordoma 87%
  • Single Nucleotide Polymorphism 54%
  • Spine 49%
  • Recurrence 37%
  22 Scopus citations
• 2016

  Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers

  Robles, A. I., Traverso, G., Zhang, M., Roberts, N. J., Khan, M. A., Joseph, C., Lauwers, G. Y., Selaru, F. M., Popoli, M., Pittman, M. E., Ke, X., Hruban, R. H., Meltzer, S. J., Kinzler, K. W., Vogelstein, B., Harris, C. C. & Papadopoulos, N., Apr 1 2016, In: Gastroenterology. 150, 4, p. 931-943 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Exome Sequencing 100%
  • Inflammatory Bowel Diseases 79%
  • Colorectal Neoplasms 66%
  • Mutation 21%
  • Neoplasms 17%
  125 Scopus citations
• 2015

  Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

  Wang, Y., Springer, S., Zhang, M., McMahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, A., Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D., Weingart, J. D., & 11 othersWolinsky, J. P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Bettegowda, C., Aug 4 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 31, p. 9704-9709 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Cerebrospinal Fluid 93%
  • Spinal Cord 87%
  • DNA 59%
  • Cell-Free Nucleic Acids 38%
  163 Scopus citations

• The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

  Llosa, N. J., Cruise, M., Tam, A., Wicks, E. C., Hechenbleikner, E. M., Taube, J. M., Blosser, R. L., Fan, H., Wang, H., Luber, B. S., Zhang, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Sears, C. L., Anders, R. A., Pardoll, D. M. & Housseau, F., 2015, In: Cancer discovery. 5, 1, p. 43-51 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microsatellite Repeats 100%
  • Colonic Neoplasms 86%
  • Microsatellite Instability 77%
  • Cytotoxic T-Lymphocytes 68%
  • Colorectal Neoplasms 50%
  756 Scopus citations

• Very long-term survival following resection for pancreatic cancer is not explained by commonly mutated genes: Results of whole-exome sequencing analysis

  Dal Molin, M., Zhang, M., De Wilde, R. F., Ottenhof, N. A., Rezaee, N., Wolfgang, C. L., Blackford, A., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Hruban, R. H., Maitra, A. & Wood, L. D., Apr 15 2015, In: Clinical Cancer Research. 21, 8, p. 1944-1950 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Exome Sequencing 100%
  • Pancreatic Neoplasms 79%
  • Survival 46%
  • Mutation 39%
  • Genes 33%
  54 Scopus citations
• 2014

  Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

  Zhang, M., Wang, Y., Jones, S., Sausen, M., McMahon, K. W., Sharma, R., Wang, Q., Belzberg, A. J., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Riggins, G. J., Wolinksy, J. P., Wood, L. D., Montgomery, E. A., Hruban, R. H., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Bettegowda, C., Nov 5 2014, In: Nature genetics. 46, 11, p. 1170-1172 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurofibrosarcoma 100%
  • Neurofibroma 64%
  • Mutation 41%
  • Neurofibromatosis 1 30%
  • Genome 16%
  147 Scopus citations
• 2013

  TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

  Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., Grollman, A. P., He, T. C., He, Y., Hruban, R. H., Jallo, G. I., Mandahl, N., Meeker, A. K., Mertens, F., Netto, G. J., Ahmed Rasheed, B., & 17 othersRiggins, G. J., Rosenquist, T. A., Schiffman, M., Shih, I. M., Theodorescu, D., Torbenson, M. S., Velculescu, V. E., Wang, T. L., Wentzensen, N., Wood, L. D., Zhang, M., McLendon, R. E., Bigner, D. D., Kinzler, K. W., Vogelstein, B., Papadopoulos, N. & Yan, H., Apr 9 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 6021-6026 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomerase 100%
  • Glioma 81%
  • Telomere 55%
  • Mutation 49%
  • ATR-X syndrome 44%
  840 Scopus citations
• 2011

  Loss of a single Hic1 allele accelerates polyp formation in Apc Δ716 mice

  Mohammad, H. P., Zhang, W., Prevas, H. S., Leadem, B. R., Zhang, M., Herman, J. G., Hooker, C. M., Watkins, D. N., Karim, B., Huso, D. L. & Baylin, S. B., Jun 9 2011, In: Oncogene. 30, 23, p. 2659-2669 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyps 100%
  • Heterozygote 78%
  • Alleles 71%
  • APC Genes 68%
  • Gastrointestinal Tract 63%
  21 Scopus citations
• 2007

  Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and γ-secretase-dependent E-cadherin cleavage

  Wu, S., Rhee, K. J., Zhang, M., Franco-Mora, A. A. & Sears, C. L., Jun 1 2007, In: Journal of cell science. 120, 11, p. 1944-1952 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteroides fragilis toxin 100%
  • Amyloid Precursor Protein Secretases 62%
  • Cadherins 51%
  • Catenins 45%
  • Epithelial Cells 36%
  113 Scopus citations

• Enterotoxigenic Bacteroides fragilis: A potential instigator of colitis

  Rabizadeh, S., Rhee, K. J., Wu, S., Huso, D. L., Gan, C. M., Golub, J. E., Wu, X., Zhang, M. & Sears, C. L., Dec 2007, In: Inflammatory bowel diseases. 13, 12, p. 1475-1483 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacteroides fragilis 100%
  • Colitis 77%
  • Dextran Sulfate 53%
  • Inflammation 14%
  • Inflammatory Bowel Diseases 11%
  70 Scopus citations

• Erratum: Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and γ-secretase-dependent E-cadherin cleavage (Journal of Cell Science vol. 120 (1944-1952))

  Wu, S., Rhee, K. J., Zhang, M., Franco-Mora, A. A. & Sears, C. L., Oct 15 2007, In: Journal of cell science. 120, 20, p. 3713 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
• 2004

  Glutamate Receptor Antagonists Protect from Virus-induced Neural Degeneration

  Nargi-Aizenman, J. L., Havert, M. B., Zhang, M., Irani, D. N., Rothstein, J. D. & Griffin, D. E., Apr 2004, In: Annals of neurology. 55, 4, p. 541-549 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sindbis Virus 100%
  • Encephalomyelitis 94%
  • Excitatory Amino Acid Antagonists 89%
  • AMPA Receptors 82%
  • Alphavirus 63%
  57 Scopus citations