Ming-Tseh Lin

Associate Professor

1989 …2020

Research output per year

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Research Output

2020

Multiclonal colorectal cancers with divergent histomorphological features and RAS mutations: one cancer or separate cancers?

Lin, M. T., Zheng, G., Tseng, L. H., Zhang, P., Ling, H., Azad, N., Gocke, C. D., Montgomery, E. & Eshleman, J. R., Apr 2020, In : Human pathology. 98, p. 120-128 9 p.

Research output: Contribution to journalArticle

2019

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Open Access

Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways in lung cancers

De Marchi, F., Haley, L., Fryer, H., Ibrahim, J., Beierl, K., Zheng, G., Gocke, C., Eshleman, J., Belchis, D. A., Illei, P. B. & Lin, M-T., Feb 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Clinical validation of coexisting driver mutations in colorectal cancers

Zheng, G., Tseng, L. H., Haley, L., Ibrahim, J., Bynum, J., Xian, R., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Apr 2019, In : Human pathology. 86, p. 12-20 9 p.

Research output: Contribution to journalArticle

Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status

Wobker, S. E., Matoso, A., Pratilas, C. A., Mangray, S., Zheng, G., Lin, M. T., Debeljak, M., Epstein, J. I. & Argani, P., Sep 1 2019, In : American Journal of Surgical Pathology. 43, 9, p. 1157-1169 13 p.

Research output: Contribution to journalArticle

The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Zheng, G., Chen, P., Pallavajjalla, A., Haley, L., Gondek, L., Dezern, A., Ling, H., De Marchi, F., Lin, M. T. & Gocke, C., Oct 1 2019, In : American journal of hematology. 94, 10, p. 1141-1148 8 p.

Research output: Contribution to journalArticle

2018

Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association

Palsgrove, D. N., Brosnan-Cashman, J. A., Giannini, C., Raghunathan, A., Jentoft, M., Bettegowda, C., Gokden, M., Lin, D., Yuan, M., Lin, M. T., Heaphy, C. M. & Rodriguez, F. J., Jul 4 2018, (Accepted/In press) In : Modern Pathology. p. 1-14 14 p.

Research output: Contribution to journalArticle

Validation Strategy for Ultrasensitive Mutation Detection

Debeljak, M., Noë, M., Riel, S. L., Haley, L. M., Norris, A. L., Anderson, D. A., Adams, E. M., Suenaga, M., Beierl, K. F., Lin, M-T., Goggins, M. S., Gocke, C. & Eshleman, J., Jul 5 2018, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-9 9 p.

Research output: Contribution to journalArticle

2017

Clinical mutational profiling of 1006 lung cancers by next generation sequencing

Illei, P. B., Belchis, D., Tseng, L. H., Nguyen, D., De Marchi, F., Haley, L., Riel, S., Beierl, K., Zheng, G., Brahmer, J. R., Askin, F. B., Gocke, C. D., Eshleman, J. R., Forde, P. M. & Lin, M. T., Jan 1 2017, In : Oncotarget. 8, 57, p. 96684-96696 13 p.

Research output: Contribution to journalArticle

Detection of chromosomal translocation in hematologic malignancies by a novel DNA-based Looped Ligation Assay (LOLA)

Harada, S., Sizzle, E., Lin, M-T. & Gocke, C., Jul 1 2017, In : Clinical Chemistry. 63, 7, p. 1278-1287 10 p.

Research output: Contribution to journalArticle

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

2016

A rapidly progressive dementia case with pathological diagnosis of FTLD-UPS

Tabbarah, A. Z., Robert Bell, W., Sun, M., Gelwan, E., Pletnikova, O., Hillis-Trupe, A., Troncoso, J. C., Lin, M-T. & Chen, L. L., Aug 1 2016, In : Acta Neuropathologica. 132, 2, p. 309-311 3 p.

Research output: Contribution to journalLetter

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Frequent BRAF V600E mutations in metanephric stromal tumor

Argani, P., Lee, J., Netto, G. J., Zheng, G., Tseh-Lin, M. & Park, B. H., Jan 1 2016, In : American Journal of Surgical Pathology. 40, 5, p. 719-722 4 p.

Research output: Contribution to journalLetter

Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma

Belchis, D. A., Tseng, L. H., Gniadek, T., Haley, L., Lokhandwala, P., Illei, P., Gocke, C. D., Forde, P., Brahmer, J., Askin, F. B., Eshleman, J. R. & Lin, M. T., Jan 1 2016, In : Oncotarget. 7, 29, p. 45237-45248 12 p.

Research output: Contribution to journalArticle

Impact of genomic heterogeneity associated with acquired anti- EGFR resistance in colorectal cancers

Chen, G. & Lin, M. T., Jan 1 2016, In : Translational Cancer Research. 5, p. S95-S98

Research output: Contribution to journalComment/debate

Microsatellite instability as a biomarker for PD-1 blockade

Dudley, J. C., Lin, M-T., Le, D. & Eshleman, J., Feb 15 2016, In : Clinical Cancer Research. 22, 4, p. 813-820 8 p.

Research output: Contribution to journalArticle

Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas

Nauen, D., Haley, L., Lin, M. T., Perry, A., Giannini, C., Burger, P. C. & Rodriguez, F. J., Mar 1 2016, In : Brain Pathology. 26, 2, p. 206-214 9 p.

Research output: Contribution to journalArticle

Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective

Chen, G., Yang, Z., Eshleman, J. R., Netto, G. J. & Lin, M. T., Jan 1 2016, In : BioMed research international. 2016, 9850690.

Research output: Contribution to journalReview article

Recent Advances on the Molecular Pathology of Glial Neoplasms in Children and Adults

Rodriguez, F. J., Vizcaino, M. A. & Lin, M-T., Sep 1 2016, In : Journal of Molecular Diagnostics. 18, 5, p. 620-634 15 p.

Research output: Contribution to journalReview article

Test feasibility of next-generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens

Zheng, G., Tsai, H., Tseng, L. H., Illei, P. B., Gocke, C., Eshleman, J., Netto, G. & Lin, M-T., May 1 2016, In : American Journal of Clinical Pathology. 145, 5, p. 696-702 7 p.

Research output: Contribution to journalArticle

2015

A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML

Lin, M. T., Tseng, L. H., Dudley, J. C., Riel, S., Tsai, H., Zheng, G., Pratz, K. W., Levis, M. J. & Gocke, C. D., Dec 1 2015, In : Molecular Diagnosis and Therapy. 19, 6, p. 409-417 9 p.

Research output: Contribution to journalArticle

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers

Dudley, J., Tseng, L. H., Rooper, L., Harris, M., Haley, L., Chen, G., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

Zheng, G., Tseng, L. H., Chen, G., Haley, L., Illei, P., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Oct 24 2015, In : BMC cancer. 15, 1, 779.

Research output: Contribution to journalArticle

Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin

Wang, Y., Wu, R. C., Shwartz, L. E., Haley, L., Lin, M. T., Shih, I. M. & Kurman, R. J., Oct 1 2015, In : Journal of Pathology. 237, 2, p. 146-151 6 p.

Research output: Contribution to journalArticle

Lymph node metastases of melanoma: Challenges for BRAF mutation detection

Chen, G., Dudley, J., Tseng, L. H., Smith, K., Gurda, G. T., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Jan 1 2015, In : Human pathology. 46, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins

Wang, Y., Shwartz, L. E., Anderson, D., Lin, M. T., Haley, L., Wu, R. C., Vang, R., Shih, I. M. & Kurman, R. J., Jan 1 2015, In : Oncotarget. 6, 26, p. 22949-22958 10 p.

Research output: Contribution to journalArticle

Open Access

Non-p.V600E BRAF mutations are common using a more sensitive and broad detection tool

Carter, J., Tseng, L. H., Zheng, G., Dudley, J., Illei, P., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Oct 2015, In : American journal of clinical pathology. 144, 4, p. 620-628 9 p.

Research output: Contribution to journalArticle

PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation

Rodic, N., Anders, R. A., Eshleman, J. R., Lin, M. T., Xu, H., Kim, J. H., Beierl, K., Chen, S., Luber, B. S., Wang, H., LTopalian, S., Pardoll, D. M. & Taube, J. M., Feb 2015, In : Cancer Immunology Research. 3, 2, p. 110-115 6 p.

Research output: Contribution to journalArticle

Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers

Haley, L., Tseng, L. H., Zheng, G., Dudley, J., Anderson, D. A., Azad, N. S., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Oct 3 2015, In : Modern Pathology. 28, 10, p. 1390-1399 10 p.

Research output: Contribution to journalArticle

Transflip mutations produce deletions in pancreatic cancer

Norris, A. L., Kamiyama, H., Makohon-Moore, A., Pallavajjala, A., Morsberger, L. A., Lee, K., Batista, D., Iacobuzio-Donahue, C. A., Lin, M. T., Klein, A. P., Hruban, R. H., Wheelan, S. J. & Eshleman, J. R., Aug 1 2015, In : Genes Chromosomes and Cancer. 54, 8, p. 472-481 10 p.

Research output: Contribution to journalArticle

2014

BRAF pyrosequencing analysis aided by a lookup table

Olson, M. T., Harrington, C., Beierl, K., Chen, G., Thiess, M., O'Neill, A., Taube, J. M., Zeiger, M. A., Lin, M. T. & Eshleman, J. R., May 1 2014, In : American journal of clinical pathology. 141, 5, p. 639-647 9 p.

Research output: Contribution to journalArticle

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M. T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S. J., Gocke, C. D. & Eshleman, J. R., Jun 2014, In : American journal of clinical pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle

Cytosine Deamination Is a Major Cause of Baseline Noise in Next-Generation Sequencing

Chen, G., Mosier, S., Gocke, C. D., Lin, M. T. & Eshleman, J. R., Oct 1 2014, In : Molecular Diagnosis and Therapy. 18, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

False positives in multiplex PCR-based next-generation sequencing have unique signatures

McCall, C. M., Mosier, S., Thiess, M., Debeljak, M., Pallavajjala, A., Beierl, K., Deak, K. L., Datto, M. B., Gocke, C. D., Lin, M. T. & Eshleman, J. R., Sep 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 541-549 9 p.

Research output: Contribution to journalArticle

Fatal myocardial microabscesses caused by methicillin-resistant Staphylococcus aureus in a burn patient

Huanga, H. W., Cowan, M., Matthews, J., Lin, M. T., Milner, S. & Halushka, M., Jan 1 2014, In : Human Pathology: Case Reports. 1, 1, p. 10-12 3 p.

Research output: Contribution to journalArticle

Genetic and pathologic evolution of early secondary gliosarcoma

Codispoti, K. E. T., Mosier, S., Ramsey, R., Lin, M. T. & Rodriguez, F. J., Jan 2014, In : Brain tumor pathology. 31, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection

Debeljak, M., Freed, D. N., Welch, J. A., Haley, L., Beierl, K., Iglehart, B. S., Pallavajjala, A., Gocke, C. D., Leffell, M. S., Lin, M. T., Pevsner, J., Wheelan, S. J. & Eshleman, J. R., Sep 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 495-503 9 p.

Research output: Contribution to journalArticle

Improved FLT3 Internal Tandem Duplication PCR Assay Predicts Outcome after Allogeneic Transplant for Acute Myeloid Leukemia

Grunwald, M. R., Tseng, L. H., Lin, M. T., Pratz, K. W., Eshleman, J. R., Levis, M. J. & Gocke, C. D., Dec 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 12, p. 1989-1995 7 p.

Research output: Contribution to journalArticle

Microsatellite instability confounds engraftment analysis of hematopoietic stem-cell transplantation

Tseng, L. H., Tang, J. L., Haley, L., Beierl, K., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Jul 2014, In : Applied Immunohistochemistry and Molecular Morphology. 22, 6, p. 416-420 5 p.

Research output: Contribution to journalReview article

Molecular alterations in non-small cell lung carcinomas of the young

Vandenbussche, C. J., Illei, P. B., Lin, M. T., Ettinger, D. S. & Maleki, Z., Dec 1 2014, In : Human pathology. 45, 12, p. 2379-2387 9 p.

Research output: Contribution to journalArticle

Tumor cellularity as a quality assurance measure for accurate clinical detection of braf mutations in melanoma

Dudley, J. C., Gurda, G. T., Tseng, L. H., Anderson, D. A., Chen, G., Taube, J. M., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Aug 2014, In : Molecular Diagnosis and Therapy. 18, 4, p. 409-418 10 p.

Research output: Contribution to journalArticle

2013

Detection of minor clones with internal tandem duplication mutations of FLT3 gene in acute myeloid leukemia using delta-PCR

Beierl, K., Tseng, L. H., Beierl, R., Haley, L., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Mar 1 2013, In : Diagnostic Molecular Pathology. 22, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Donor-transmitted malignancy in a liver transplant recipient: A case report and review of literature

Kim, B., Woreta, T., Chen, P. H., Limketkai, B., Singer, A., Dagher, N., Cameron, A., Lin, M. T., Kamel, I. & Gurakar, A., May 1 2013, In : Digestive Diseases and Sciences. 58, 5, p. 1185-1190 6 p.

Research output: Contribution to journalReview article