Michelle Vaz

Research output

Research output per year 2008 2008 2012 2017 2020 2020

• 11 Article
• 1 Review article

Research output per year

Research output per year

Search results

• 2020

  Epigenetic therapy inhibits metastases by disrupting premetastatic niches

  Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., Li, H., Cai, Y., Xia, L., Huang, P., Rodgers, K., Lee, B., Riemer, J. B., Day, C. P., Yen, R. W. C., Cui, Y., & 28 othersWang, Y., Wang, Y., Zhang, W., Easwaran, H., Hulbert, A., Kim, K. B., Juergens, R. A., Yang, S. C., Battafarano, R. J., Bush, E. L., Broderick, S. R., Cattaneo, S. M., Brahmer, J. R., Rudin, C. M., Wrangle, J., Mei, Y., Kim, Y. J., Zhang, B., Wang, K. K. H., Forde, P. M., Margolick, J. B., Nelkin, B. D., Zahnow, C. A., Pardoll, D. M., Housseau, F., Baylin, S. B., Shen, L. & Brock, M. V., Mar 12 2020, In: Nature. 579, 7798, p. 284-290 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid-Derived Suppressor Cells 100%
  • Epigenomics 65%
  • Neoplasm Metastasis 46%
  • entinostat 20%
  • Neoplasms 20%
  48 Scopus citations

• The emerging role of epigenetic therapeutics in immuno-oncology

  Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R. & Baylin, S. B., Feb 1 2020, In: Nature Reviews Clinical Oncology. 17, 2, p. 75-90 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunotherapy 100%
  • Epigenomics 99%
  • Genetic Epigenesis 32%
  • Neoplasms 21%
  • Therapeutics 18%
  58 Scopus citations
• 2018

  FOSL1 promotes Kras-induced lung cancer through amphiregulin and cell survival gene regulation

  Elangovan, I. M., Vaz, M., Tamatam, C. R., Potteti, H. R., Reddy, N. M. & Reddy, S. P., May 1 2018, In: American journal of respiratory cell and molecular biology. 58, 5, p. 625-635 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Amphiregulin 100%
  • Effector 72%
  • Cell Viability 65%
  • Adenocarcinoma of Lung 62%
  • Mutation 56%
  8 Scopus citations
• 2017

  Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

  Vaz, M., Hwang, S. Y., Kagiampakis, I., Phallen, J., Patil, A., O'Hagan, H. M., Murphy, L., Zahnow, C. A., Gabrielson, E., Velculescu, V. E., Easwaran, H. P. & Baylin, S. B., Sep 11 2017, In: Cancer cell. 32, 3, p. 360-376.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Smoke 100%
  • Oncogenes 99%
  • Tobacco Products 98%
  • Epigenomics 91%
  • Epithelial Cells 74%
  87 Scopus citations

• Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

  Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R. W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., Tran, P. T., Zahnow, C. A., Hellmann, M. D., Anagnostou, V., Strissel, P. L., Strick, R., Velculescu, V. E. & Baylin, S. B., Nov 30 2017, In: Cell. 171, 6, p. 1284-1300.e21

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methyltransferase Inhibitor 100%
  • Immune Evasion 69%
  • Histone 59%
  • Epigenomics 48%
  • Lung Neoplasms 43%
  153 Scopus citations
• 2015

  Myeloid-specific Fos-related antigen-1 regulates cigarette smoke - Induced lung inflammation, not emphysema, in mice

  Vaz, M., Rajasekaran, S., Potteti, H. R. & Reddy, S. P., Jul 1 2015, In: American journal of respiratory cell and molecular biology. 53, 1, p. 125-134 10 p.

  Research output: Contribution to journal › Article › peer-review

  • fos-related antigen 1 100%
  • Smoke 62%
  • Emphysema 61%
  • Tobacco Products 51%
  • Pneumonia 44%
  4 Scopus citations
• 2012

  Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo

  Rajasekaran, S., Vaz, M. & Reddy, S. P., Jul 24 2012, In: PloS one. 7, 7, e41611.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bleomycin 100%
  • fibrosis 89%
  • Pulmonary Fibrosis 84%
  • Transcription Factor AP-1 81%
  • Collagen 69%
  22 Scopus citations

• Genetic disruption of fra-1 decreases susceptibility to endotoxin-induced acute lung injury and mortality in mice

  Vaz, M., Reddy, N. M., Rajasekaran, S., Reddy, S. P. & Subbiah, R., Jan 1 2012, In: American journal of respiratory cell and molecular biology. 46, 1, p. 55-62 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lung Injury 87%
  • Endotoxins 76%
  • Antigen 64%
  • Resistance 48%
  • Mortality 38%
  11 Scopus citations

• Oxidant-induced cell death and Nrf2-dependent antioxidative response are controlled by Fra-1/AP-1

  Vaz, M., Machireddy, N., Irving, A., Potteti, H. R., Chevalier, K., Kalvakolanu, D. & Reddy, S. P., May 2012, In: Molecular and cellular biology. 32, 9, p. 1694-1709 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Factor AP-1 100%
  • Oxidants 94%
  • Cell Death 68%
  • Antioxidants 53%
  • Diquat 31%
  15 Scopus citations

• The transcription factor encyclopedia.

  Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y. C., Dickman, C. T. D., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H. P., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W. F., Kist, R., Wilson, M. S. C., Marco-Ferreres, R., & 79 othersBrosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D. C., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M. M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperrière, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W. Z., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P. S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, G. N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., LeBrun, D. P., Biswal, S., Harvey, C. J., DeBruyne, J. P., Hogenesch, J. B. & Hevner, R. F., 2012, In: Genome biology. 13, 3, p. R24

  Research output: Contribution to journal › Article › peer-review

  • encyclopedia 100%
  • Encyclopedias 85%
  • transcription factors 51%
  • Transcription Factors 49%
  • Information Storage and Retrieval 8%
  70 Scopus citations
• 2008

  A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion

  Adiseshaiah, P., Vaz, M., Machireddy, N., Kalvakolanu, D. V. & Reddy, S. P., Aug 2008, In: Journal of Cellular Physiology. 216, 2, p. 405-412 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Matrix Metalloproteinase 1 100%
  • Matrix Metalloproteinase 2 71%
  • Matrix Metalloproteinase 9 69%
  • Cell Movement 66%
  • Matrix Metalloproteinases 62%
  38 Scopus citations

• ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter

  Adiseshaiah, P., Li, J., Vaz, M., Kalvakolanu, D. V. & Reddy, S. P., Jun 27 2008, In: Biochemical and Biophysical Research Communications. 371, 2, p. 304-308 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Serum Response Element 100%
  • Tumor Promoter 95%
  • Phorbol Ester 89%
  • Carcinogens 61%
  • Phorbol Esters 35%
  22 Scopus citations