Michael V Johnston

Act Staff Full Time

1972 …2018
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Research Output 1972 2018

2018

Are dopamine receptor and transporter changes in Rett syndrome reflected in Mecp2-deficient mice?

Wong, D. F., Blue, M. E., Brašić, J. R., Nandi, A., Valentine, H., Stansfield, K. H., Rousset, O., Bibat, G., Yablonski, M. E., Johnston, M. V., Gjedde, A. & Naidu, S. B. Sep 1 2018 In : Experimental Neurology. 307, p. 74-81 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Dopamine Plasma Membrane Transport Proteins
Dopamine Receptors
Positron-Emission Tomography
Autoradiography

Cognitive Development One Year after Infantile Critical Pertussis∗

Johnston, M. V. Feb 1 2018 In : Pediatric Critical Care Medicine. 19, 2, p. 161-162 2 p.

Research output: Contribution to journalEditorial

Whooping Cough
Rett Syndrome
Dendrimers
Microglia
Names
Cysteine

Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1)

Magruder, J. T., Fraser, C. D., Grimm, J. C., Crawford, T. C., Beaty, C. A., Suarez-Pierre, A., Hayes, R. L., Johnston, M. V. & Baumgartner, W. A. Jan 1 2018 (Accepted/In press) In : Journal of Cardiothoracic and Vascular Anesthesia.

Research output: Contribution to journalArticle

Ubiquitin Thiolesterase
Nervous System Trauma
Cardiopulmonary Bypass
Biomarkers
Oxygen

Early detection of hypothermic neuroprotection using T2-weighted magnetic resonance imaging in a mouse model of hypoxic ischemic encephalopathy

Doman, S. E., Girish, A., Nemeth, C. L., Drummond, G. T., Carr, P., Garcia, M. S., Johnston, M. V., Kannan, S., Fatemi, A., Zhang, J. & Wilson, M. A. May 8 2018 In : Frontiers in Neurology. 9, MAY, 304

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Ischemia
Magnetic Resonance Imaging
Hypothermia
Wounds and Injuries

Sleep dysfunction following neonatal ischemic seizures are differential by neonatal age of insult as determined by qEEG in a mouse model

Kang, S. K., Ammanuel, S., Thodupunuri, S., Adler, D. A., Johnston, M. V. & Kadam, S. D. Aug 1 2018 In : Neurobiology of Disease. 116, p. 1-12 12 p.

Research output: Contribution to journalArticle

Sleep
Seizures
Age Groups
Brain Hypoxia-Ischemia
Phenobarbital
2017

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

Nance, E., Kambhampati, S. P., Smith, E. S., Zhang, Z., Zhang, F., Singh, S., Johnston, M. V., Rangaramanujam, K., Blue, M. E. & Kannan, S. Dec 19 2017 In : Journal of Neuroinflammation. 14, 1, 252

Research output: Contribution to journalArticle

Rett Syndrome
Dendrimers
Microglia
Cysteine
Neuroglia

Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Zhang, F., Trent Magruder, J., Lin, Y. A., Crawford, T. C., Grimm, J. C., Sciortino, C. M., Wilson, M. A., Blue, M. E., Kannan, S., Johnston, M. V., Baumgartner, W. A. & Kannan, R. M. Mar 10 2017 In : Journal of Controlled Release. 249, p. 173-182 10 p.

Research output: Contribution to journalArticle

Dendrimers
Intravenous Administration
Hydroxyl Radical
Brain Injuries
Brain
Tuberous Sclerosis
Sirolimus
Infantile Spasms
Brain
Seizures

Randomized open-label trial of dextromethorphan in Rett syndrome

Smith-Hicks, C. L., Gupta, S., Ewen, J. B., Hong, M., Kratz, L., Kelley, R., Tierney, E., Vaurio, R., Bibat, G., Sanyal, A., Yenokyan, G., Brereton, N., Johnston, M. V. & Naidu, S. Oct 17 2017 In : Neurology. 89, 16, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Dextromethorphan
Rett Syndrome
Seizures
Checklist
Electroencephalography

Umbilical cord blood NOS1 as a potential biomarker of neonatal encephalopathy

Lei, J., Paules, C., Nigrini, E., Rosenzweig, J. M., Bahabry, R., Farzin, A., Yang, S., Northington, F. J., Oros, D., McKenney, S., Johnston, M. V., Graham, E. M. & Burd, I. May 22 2017 In : Frontiers in Pediatrics. 5, 112

Research output: Contribution to journalArticle

Umbilical Cord
Brain Diseases
Fetal Blood
Biomarkers
Endothelial Cells

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

Nemeth, C. L., Drummond, G. T., Mishra, M. K., Zhang, F., Carr, P., Garcia, M. S., Doman, S., Fatemi, A., Johnston, M. V., Kannan, R. M., Kannan, S. & Wilson, M. A. Oct 1 2017 In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 7, p. 2359-2369 11 p.

Research output: Contribution to journalArticle

Hypothermia
Dendrimers
Microglia
Brain Hypoxia-Ischemia
Hippocampus
2016

Cerebral plasticity: Windows of opportunity in the developing brain

Ismail, F. Y., Fatemi, A. & Johnston, M. V. 2016 (Accepted/In press) In : European Journal of Paediatric Neurology.

Research output: Contribution to journalArticle

Neuronal Plasticity
Brain
Brain Diseases
Pediatrics
Central Nervous System

Cerebral reorganization after hemispherectomy: A DTI study

Meoded, A., Faria, A. V., Hartman, A. L., Jallo, G. I., Mori, S., Johnston, M. V., Huisman, T. A. G. M. & Andrea, P. May 1 2016 In : American Journal of Neuroradiology. 37, 5, p. 924-931 8 p.

Research output: Contribution to journalArticle

Hemispherectomy
Anisotropy
Pathology
Linear Models
Neurosurgical Procedures

Diffusion Tensor Imaging Abnormalities in the Cerebral White Matter Correlate with Sex-Dependent Neurobehavioral Deficits in Adult Mice with Neonatal Ischemia

Breu, M., Zhang, J., Porambo, M., Pletnikov, M. V., Goeral, K., Kakara, M., Johnston, M. V. & Fatemi, A. Mar 16 2016 (Accepted/In press) In : Developmental Neuroscience.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Anisotropy
Ischemia
Wounds and Injuries
Cerebral Palsy
Asphyxia Neonatorum
Fetal Hypoxia
Brain Hypoxia-Ischemia
Asphyxia
Aspartate Aminotransferases

Excitotoxicity as a Common Mechanism for Fetal Neuronal Injury with Hypoxia and Intrauterine Inflammation

Burd, I., Welling, J., Kannan, G. & Johnston, M. V. 2016 (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Inflammation
AMPA Receptors
Wounds and Injuries
Brain Injuries

Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact

Sweda, R., Phillips, A. W., Marx, J., Johnston, M. V., Wilson, M. A. & Fatemi, A. Jul 1 2016 In : Stem Cells and Development. 25, 13, p. 975-985 11 p.

Research output: Contribution to journalArticle

Neuroglia
Cell Death
Brain
Stem Cells
Ischemia
Dendrimers
Nanotechnology
Brain Injuries
Canidae
Inflammation
Brain Hypoxia-Ischemia
Induced Hypothermia
Ultrasonography
Brain
Anterior Cerebral Artery
2015

Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia

Kang, S. K., Johnston, M. V. & Kadam, S. D. Nov 1 2015 In : European Journal of Neuroscience. 42, 10, p. 2792-2804 13 p.

Research output: Contribution to journalArticle

Phenobarbital
Seizures
Ischemia
Symporters
Brain Hypoxia-Ischemia

Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: Role of chloride co-transporters

Kang, S. K., Markowitz, G. J., Kim, S. T., Johnston, M. V. & Kadam, S. D. May 12 2015 In : Frontiers in Cellular Neuroscience. 9, MAY

Research output: Contribution to journalArticle

Symporters
Phenobarbital
Chlorides
Seizures
Bumetanide
Brain Hypoxia-Ischemia
Induced Hypothermia
Homeostasis
Cohort Studies
Newborn Infant

Autism Phenotypes in Tuberous Sclerosis Complex: Diagnostic and Treatment Considerations

Gipson, T. T., Poretti, A., Thomas, E. A., Jenkins, K. T., Desai, S. & Johnston, M. V. Dec 1 2015 In : Journal of Child Neurology. 30, 14, p. 1871-1876 6 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Autistic Disorder
Phenotype
Therapeutics
Intellectual Disability

Cell-based therapies in neonatal stroke

Tsuji, M. & Johnston, M. V. Jan 1 2015 Cell Therapy for Brain Injury. Springer International Publishing, p. 321-349 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell- and Tissue-Based Therapy
Stem cells
Stroke
Brain
Blood

Correction: Systemic Injection of CD34+ -Enriched Human Cord Blood Cells Modulates Poststroke Neural and Glial Response in a Sex-Dependent Manner in CD1 Mice (Stem Cells and Development (2015) 24, 1 (51-66))

Kadam, S., Chen, H., Markowitz, G. J., Raja, S., George, S., Verina, T., Shotwell, E., Loechelt, B., Johnston, M. V., Kamani, N., Fatemi, A. & Comi, A. M. Apr 1 2015 In : Stem Cells and Development. 24, 7, p. 916 1 p.

Research output: Contribution to journalArticle

Fetal Blood
Neuroglia
Blood Cells
Stem Cells
Injections

Heightened delta power during slow-wave- sleep in patients with rett syndrome associated with poor sleep efficiency

Ammanuel, S., Chan, W. C., Adler, D. A., Lakshamanan, B. M., Gupta, S. S., Ewen, J. B., Johnston, M. V., Marcus, C. L., Naidu, S. & Kadam, S. D. Oct 7 2015 In : PLoS One. 10, 10, e0138113

Research output: Contribution to journalArticle

Rett Syndrome
sleep
Sleep
Electroencephalography
Wave power

Murine model: maternal administration of stem cells for prevention of prematurity

Lei, J., Firdaus, W., Rosenzweig, J. M., Alrebh, S., Bakhshwin, A., Borbiev, T., Fatemi, A., Blakemore, K., Johnston, M. V. & Burd, I. May 1 2015 In : American Journal of Obstetrics and Gynecology. 212, 5

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Premature Birth
Stem Cells
Mothers
Inflammation
Extracorporeal Membrane Oxygenation
Observational Studies
Electroencephalography
Medical Subject Headings
Nervous System Trauma

Ongoing Cerebral Vasculitis During Treatment of Rocky Mountain Spotted Fever

Sun, L. R., Huisman, T. A. G. M., Yeshokumar, A. K. & Johnston, M. V. Nov 1 2015 In : Pediatric Neurology. 53, 5, p. 434-438 5 p.

Research output: Contribution to journalArticle

Rocky Mountain Spotted Fever
Central Nervous System Vasculitis
Vasculitis
Infection
Therapeutics

Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes

Mainigi, M., Rosenzweig, J. M., Lei, J., Mensah, V., Thomaier, L., Talbot, C. C., Olalere, D., Ord, T., Rozzah, R., Johnston, M. V. & Burd, I. 2015 In : Reproductive Sciences. 23, 6, p. 785-794 10 p.

Research output: Contribution to journalArticle

Assisted Reproductive Techniques
Superovulation
Live Birth
DNA Methylation
Fetal Development

Recent advances in understanding synaptic abnormalities in Rett syndrome

Johnston, M., Blue, M. E. & Naidu, S. 2015 In : F1000Research. 4, 1490

Research output: Contribution to journalReview article

Rett Syndrome
Neuronal Plasticity
Synapses
Plasticity
Methyl-CpG-Binding Protein 2

Risk factors for attention and behavioral issues in pediatric sickle cell disease

Lance, E. I., Comi, A. M., Johnston, M. V., Casella, J. F. & Shapiro, B. K. Oct 11 2015 In : Clinical Pediatrics. 54, 11, p. 1087-1093 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pediatrics
Sickle Hemoglobin
Learning Disorders
Attention Deficit Disorder with Hyperactivity

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

Nance, E., Porambo, M., Zhang, F., Mishra, M. K., Buelow, M., Getzenberg, R., Johnston, M., Kannan, R. M., Fatemi, A. & Kannan, S. Jul 31 2015 In : Journal of Controlled Release. 214, p. 112-120 9 p.

Research output: Contribution to journalArticle

Dendrimers
Ischemia
Wounds and Injuries
Pharmaceutical Preparations
Oligodendroglia

Systemic injection of CD34+-enriched human cord Blood cells modulates poststroke neural and glial response in a sex-dependent manner in CD1 mice

Kadam, S. D., Chen, H., Markowitz, G. J., Raja, S., George, S., Shotwell, E., Loechelt, B., Johnston, M. V., Kamani, N., Fatemi, A. & Comi, A. M. Jan 1 2015 In : Stem Cells and Development. 24, 1, p. 51-66 16 p.

Research output: Contribution to journalArticle

Fetal Blood
Neuroglia
Blood Cells
Stroke
Glial Fibrillary Acidic Protein

Transplanted glial restricted precursor cells improve neurobehavioral and neuropathological outcomes in a mouse model of neonatal white matter injury despite limited cell survival

Porambo, M., Phillips, A. W., Marx, J., Ternes, K., Arauz, E., Pletnikov, M., Wilson, M. A., Rothstein, J. D., Johnston, M. V. & Fatemi, A. Mar 1 2015 In : GLIA. 63, 3, p. 452-465 14 p.

Research output: Contribution to journalArticle

Neuroglia
Cell Survival
Wounds and Injuries
Cell Transplantation
Oligodendroglia
2014

Acute onset rhythmic hiccup-like respirations secondary to oral baclofen toxicity

Srivastava, S., Hoon, A., Ogborn, J. & Johnston, M. 2014 In : Pediatric Neurology. 51, 2, p. 252-254 3 p.

Research output: Contribution to journalArticle

Hiccup
Baclofen
Respiration
GABA Receptors
Tetralogy of Fallot

A Diagnostic Approach for Cerebral Palsy in the Genomic Era

Lee, R. W., Poretti, A., Cohen, J. S., Levey, E., Gwynn, H., Johnston, M. V., Hoon, A. H. & Fatemi, A. 2014 In : NeuroMolecular Medicine. 16, 4, p. 821-844 24 p.

Research output: Contribution to journalArticle

Cerebral Palsy
Molecular Biology
Phenotype
Family Therapy
Muscle Spasticity

A novel variant in GABRB2 associated with intellectual disability and epilepsy

Srivastava, S., Cohen, J., Pevsner, J., Aradhya, S., Mcknight, D., Butler, E., Johnston, M. & Fatemi, A. Nov 1 2014 In : American Journal of Medical Genetics, Part A. 164, 11, p. 2914-2921 8 p.

Research output: Contribution to journalArticle

Intellectual Disability
gamma-Aminobutyric Acid
Epilepsy
Mutation
Exome

Brain injury in canine models of cardiac surgery

Blue, M. E., Wilson, M. A., Beaty, C. A., George, T. J., Arnaoutakis, G. J., Haggerty, K. A., Jones, M., Brawn, J., Manmohan, S., Lange, M. S., Johnston, M. V., Baumgartner, W. A. & Troncoso, J. C. Dec 8 2014 In : Journal of Neuropathology and Experimental Neurology. 73, 12, p. 1134-1143 10 p.

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Brain Injuries
Thoracic Surgery
Canidae
Hippocampus

Circadian cycle-dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation

Adler, D. A., Ammanuel, S., Lei, J., Dada, T., Borbiev, T., Johnston, M. V., Kadam, S. D. & Burd, I. Sep 5 2014 In : Neuroscience. 275, p. 305-313 9 p.

Research output: Contribution to journalArticle

Virulence
Lipopolysaccharides
Electroencephalography
Biomarkers
Inflammation

Cognitive and functional impairment associated with care in the PICU

Johnston, M. V. 2014 In : Pediatric Critical Care Medicine. 15, 7, p. 676-677 2 p.

Research output: Contribution to journalArticle

Cognition Disorders
Pediatric Intensive Care Units
Brain Diseases
Hospitalization
Cognitive Dysfunction
brain damage
Dendrimers
animal models
dendrimers
brain

Early neurodevelopmental screening in tuberous sclerosis complex: A potential window of opportunity

Gipson, T. T., Gerner, G., Srivastava, S., Poretti, A., Vaurio, R., Hartman, A. & Johnston, M. V. 2014 In : Pediatric Neurology. 51, 3, p. 398-402 5 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Infantile Spasms
Language Therapy
Vigabatrin
Speech Therapy

Early Predictive Value of Susceptibility Weighted Imaging (SWI) in Pediatric Hypoxic-Ischemic Injury

Messina, S. A., Poretti, A., Tekes, A., Robertson, C., Johnston, M. V. & Huisman, T. A. G. M. 2014 In : Journal of Neuroimaging. 24, 5, p. 528-530 3 p.

Research output: Contribution to journalArticle

Pediatrics
Wounds and Injuries
Heart Arrest
Drainage
Veins
Interleukin-1 Receptors
Premature Birth
Brain Injuries
Inflammation
Interleukin-1

Mouse model of intrauterine inflammation: Sex-specific differences in long-term neurologic and immune sequelae

Dada, T., Rosenzweig, J. M., Al Shammary, M., Firdaus, W., Al Rebh, S., Borbiev, T., Tekes, A., Zhang, J., Alqahtani, E., Mori, S., Pletnikov, M. V., Johnston, M. V. & Burd, I. 2014 In : Brain, Behavior, and Immunity. 38, p. 142-150 9 p.

Research output: Contribution to journalArticle

Sex Characteristics
Nervous System
Inflammation
Brain
Encephalitis
Myotonic Dystrophy
Neuroimaging
Muscle Hypotonia
Respiratory Insufficiency
Gestational Age

Perinatal biomarkers in prematurity: Early identification of neurologic injury

Andrikopoulou, M., Almalki, A., Farzin, A., Cordeiro, C. N., Johnston, M. V. & Burd, I. 2014 In : International Journal of Developmental Neuroscience. 36, p. 25-31 7 p.

Research output: Contribution to journalArticle

Nervous System Trauma
Biomarkers
Brain Injuries
Nervous System
Extremely Premature Infants
Organelle Biogenesis
Sex Characteristics
Oxygen
Neurons
Glucose