Michael Topper

2024

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

Narayanan, S. A., Jamison, D. A., Guarnieri, J. W., Zaksas, V., Topper, M., Koutnik, A. P., Park, J., Clark, K. B., Enguita, F. J., Leitão, A. L., Das, S., Moraes-Vieira, P. M., Galeano, D., Mason, C. E., Trovão, N. S., Schwartz, R. E., Schisler, J. C., Coelho-dos-Reis, J. G. A., Wurtele, E. S. & Beheshti, A., Jan 2024, In: European Journal of Human Genetics. 32, 1, p. 10-20 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2023

A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy

Jang, H. J., Hostetter, G., Macfarlane, A. W., Madaj, Z., Ross, E. A., Hinoue, T., Kulchycki, J. R., Burgos, R. S., Tafseer, M., Alpaugh, R. K., Schwebel, C. L., Kokate, R., Geynisman, D. M., Zibelman, M. R., Ghatalia, P., Nichols, P. W., Chung, W., Madzo, J., Hahn, N. M., Quinn, D. I., & 7 othersIssa, J. P. J., Topper, M. J., Baylin, S. B., Shen, H., Campbell, K. S., Jones, P. A. & Plimack, E. R., Jun 1 2023, In: Clinical Cancer Research. 29, 11, p. 2052-2065 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Derivation of CD8⁺ T cell infiltration potentiators in non-small-cell lung cancer through tumor microenvironment analysis

Topper, M. J., Anagnostou, V., Marrone, K. A., Velculescu, V. E., Jones, P. A., Brahmer, J. R., Baylin, S. B. & Hostetter, G. H., Jul 21 2023, In: iScience. 26, 7, 107095.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

Jamison, D. A., Anand Narayanan, S., Trovão, N. S., Guarnieri, J. W., Topper, M. J., Moraes-Vieira, P. M., Zaksas, V., Singh, K. K., Wurtele, E. S. & Beheshti, A., Aug 2022, In: European Journal of Human Genetics. 30, 8, p. 889-898 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia

Kogan, A. A., Topper, M. J., Dellomo, A. J., Stojanovic, L., McLaughlin, L. J., Creed, T. M., Eberly, C. L., Kingsbury, T. J., Baer, M. R., Kessler, M. D., Baylin, S. B. & Rassool, F. V., Jul 5 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 27, e2123227119.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Epigenetic therapies in ovarian cancer alter repetitive element expression in a TP53-dependent manner

McDonald, J. I., Diab, N., Arthofer, E., Hadley, M., Kanholm, T., Rentia, U., Gomez, S., Yu, A., Grundy, E. E., Cox, O., Topper, M. J., Xing, X., Strissel, P. L., Strick, R., Wang, T., Baylin, S. B. & Chiappinelli, K. B., Oct 15 2021, In: Cancer Research. 81, 20

Research output: Contribution to journal › Article › peer-review

Open Access

Erratum: Evaluating the impact of age on immune checkpoint therapy biomarkers (Cell Reports (2021) 36(8), (S2211124721010378), (10.1016/j.celrep.2021.109599))

Erbe, R., Wang, Z., Wu, S., Xiu, J., Zaidi, N., La, J., Tuck, D., Fillmore, N., Giraldo, N. A., Topper, M., Baylin, S., Lippman, M., Isaacs, C., Basho, R., Serebriiskii, I., Lenz, H. J., Astsaturov, I., Marshall, J., Taverna, J., Lee, J., & 5 othersJaffee, E. M., Roussos Torres, E. T., Weeraratna, A., Easwaran, H. & Fertig, E. J., Nov 16 2021, In: Cell Reports. 37, 7, 110033.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Evaluating the impact of age on immune checkpoint therapy biomarkers

Erbe, R., Wang, Z., Wu, S., Xiu, J., Zaidi, N., La, J., Tuck, D., Fillmore, N., Giraldo, N. A., Topper, M., Baylin, S., Lippman, M., Isaacs, C., Basho, R., Serebriiskii, I., Lenz, H. J., Astsaturov, I., Marshall, J., Taverna, J., Lee, J., & 5 othersJaffee, E. M., Roussos Torres, E. T., Weeraratna, A., Easwaran, H. & Fertig, E. J., Aug 24 2021, In: Cell Reports. 36, 8, 109599.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., Li, H., Cai, Y., Xia, L., Huang, P., Rodgers, K., Lee, B., Riemer, J. B., Day, C. P., Yen, R. W. C., Cui, Y., & 28 othersWang, Y., Wang, Y., Zhang, W., Easwaran, H., Hulbert, A., Kim, K. B., Juergens, R. A., Yang, S. C., Battafarano, R. J., Bush, E. L., Broderick, S. R., Cattaneo, S. M., Brahmer, J. R., Rudin, C. M., Wrangle, J., Mei, Y., Kim, Y. J., Zhang, B., Wang, K. K. H., Forde, P. M., Margolick, J. B., Nelkin, B. D., Zahnow, C. A., Pardoll, D. M., Housseau, F., Baylin, S. B., Shen, L. & Brock, M. V., Mar 12 2020, In: Nature. 579, 7798, p. 284-290 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

McLaughlin, L. J., Stojanovic, L., Kogan, A. A., Rutherford, J. L., Choi, E. Y., Yen, R. W. C., Xia, L., Zou, Y., Lapidus, R. G., Baylin, S. B., Topper, M. J. & Rassool, F. V., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17785-17795 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The emerging role of epigenetic therapeutics in immuno-oncology

Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R. & Baylin, S. B., Feb 1 2020, In: Nature Reviews Clinical Oncology. 17, 2, p. 75-90 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Scopus citations

2019

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Chiu Yen, R. W., Topper, M. J., Zahnow, C. A., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In: Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation

Abbotts, R., Topper, M. J., Biondi, C., Fontaine, D., Goswami, R., Stojanovic, L., Choi, E. Y., McLaughlin, L., Kogan, A. A., Xia, L., Lapidus, R., Mahmood, J., Baylin, S. B. & Rassool, F. V., Nov 5 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22609-22618 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2018

Reply to Haffner et al. DNA hypomethylation renders tumors more immunogenic

Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., Mathios, D., Lim, M., Shih, I. M., Wang, T. L., Hung, C. F., Bhargava, V., Wiehagen, K. R., Cowley, G. S., Bachman, K. E., Strick, R., Strissel, P. L., Baylin, S. B. & Zahnow, C. A., Sep 11 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8583-E8584

Research output: Contribution to journal › Letter › peer-review

Open Access

2 Scopus citations

2017

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., Mathios, D., Lim, M., Shih, I. M., Wang, T. L., Hung, C. F., Bhargava, V., Wiehagen, K. R., Cowley, G. S., Bachman, K. E., Strick, R., Strissel, P. L., Baylin, S. B. & Zahnow, C. A., Dec 19 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. E10981-E10990

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R. W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., Tran, P. T., Zahnow, C. A., Hellmann, M. D., Anagnostou, V., Strissel, P. L., Strick, R., Velculescu, V. E. & Baylin, S. B., Nov 30 2017, In: Cell. 171, 6, p. 1284-1300.e21

Research output: Contribution to journal › Article › peer-review

Open Access

153 Scopus citations

2016

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation. A Perfect Combination for Cancer Therapy.

Zahnow, C. A., Topper, M., Stone, M., Murray-Stewart, T., Li, H., Baylin, S. B. & Casero, R. A., 2016, Advances in Cancer Research, 2016. Fisher, P. B. & Tew, K. D. (eds.). Academic Press Inc., p. 55-111 57 p. (Advances in Cancer Research; vol. 130).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

53 Scopus citations

2015

Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer

Vendetti, F. P., Topper, M., Huang, P., Dobromilskaya, I., Easwaran, H., Wrangle, J., Baylin, S. B., Poirier, J. T. & Rudin, C. M., 2015, In: Oncotarget. 6, 1, p. 56-70 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2014

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Li, H., Chiappinelli, K. B., Guzzetta, A. A., Easwaran, H., Yen, R. W. C., Vatapalli, R., Topper, M. J., Luo, J., Connolly, R. M., Azad, N. S., Stearns, V., Pardoll, D. M., Davidson, N., Jones, P. A., Slamon, D. J., Baylin, S. B., Zahnow, C. A. & Ahuja, N., 2014, In: Oncotarget. 5, 3, p. 587-598 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

250 Scopus citations

Michael Topper

Research output

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