Michael S Goggins

Professor

1992 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1992 2019

Filter
Article
2019

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh, N., Zhang, H., Hyland, P. L., Yang, Q., Mocci, E., Zhang, M., Childs, E. J., Collins, I., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Brennan, P., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M., Goodman, G. E., Goodman, P. J. & 78 others, Hung, R. J., Kooperberg, C., Kurtz, R. C., Malats, N., Lemarchand, L., Neale, R. E., Olson, S. H., Scelo, G., Shu, X. O., Van Den Eeden, S. K., Visvanathan, K., White, E., Zheng, W., Albanes, D., Andreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Borgida, A., Boutron-Ruault, M. C., Brais, L., Bueno-De-Mesquita, B., Buring, J., Chaffee, K. G., Chanock, S., Cleary, S., Cotterchio, M., Foretova, L., Fuchs, C., M Gaziano, J. M., Giovannucci, E., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Janout, V., Klein, E. A., Laheru, D., Lee, I. M., Lu, L., Mannisto, S., Milne, R. L., Oberg, A. L., Orlow, I., Patel, A. V., Peters, U., Porta, M., Real, F. X., Rothman, N., Sesso, H. D., Severi, G., Silverman, D., Strobel, O., Sund, M., Thornquist, M. D., Tobias, G. S., Wactawski-Wende, J., Wareham, N., Weiderpass, E., Wentzensen, N., Wheeler, W., Yu, H., Zeleniuch-Jacquotte, A., Kraft, P., Li, D., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Amundadottir, L. T., Yu, K., Klein, A. P. & Stolzenberg-Solomon, R. Z., Jun 1 2019, In : Journal of the National Cancer Institute. 111, 6, p. 557-567 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pancreatic Neoplasms
Genes
Single Nucleotide Polymorphism
Adenocarcinoma

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

Analysis of heritability and genetic architecture of pancreatic cancer: A PANC4 study

Chen, F., Childs, E. J., Mocci, E., Bracci, P., Gallinger, S., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Bamlet, W. R., Blackford, A. L., Borges, M., Brennan, P., Chaffee, K. G., Duggal, P., Hassan, M. J., Holly, E. A., Hung, R. J., Goggins, M. G., Kurtz, R. C. & 6 others, Oberg, A. L., Orlow, I., Yu, H., Petersen, G. M., Risch, H. A. & Klein, A. P., Jan 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 7, p. 1238-1245 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genome-Wide Association Study
Genome
Neoplasm Genes
Linkage Disequilibrium

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA
Neoplasms
Adenocarcinoma
Recurrence

Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., O'Broin-Lennon, A. M., Shin, E., Klein, A., Hruban, R. H., Canto, M. & Goggins, M. S., May 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 13, p. 1070-1080 11 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
Neoplasm Genes
Mutation
Incidence

Direct Interactions with Cancer-Associated Fibroblasts Lead to Enhanced Pancreatic Cancer Stem Cell Function

Begum, A., McMillan, R. H., Chang, Y. T., Penchev, V. R., Rajeshkumar, N. V., Maitra, A., Goggins, M. S., Eshelman, J. R., Wolfgang, C., Rasheed, Z. A. & Matsui, W., Mar 1 2019, In : Pancreas. 48, 3, p. 329-334 6 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Pancreatic Neoplasms
Adenocarcinoma
Focal Adhesion Protein-Tyrosine Kinases
Integrins

Evaluating susceptibility to pancreatic cancer: ASCO provisional clinical opinion

Stoffel, E. M., McKernin, S. E., Brand, R., Canto, M., Goggins, M. S., Moravek, C., Nagarajan, A., Petersen, G. M., Simeone, D. M., Yurgelun, M. & Khorana, A. A., Jan 10 2019, In : Journal of Clinical Oncology. 37, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Genetic Testing
Neoplasms
Bibliography

Follow-up of incidentally detected pancreatic cystic neoplasms: Do baseline MRI and CT features predict cyst growth?

Pandey, P., Pandey, A., Luo, Y., Ghasabeh, M. A., Khoshpouri, P., Ameli, S., O'Broin-Lennon, A. M., Canto, M., Hruban, R. H., Goggins, M. S., Wolfgang, C. & Kamel, I. R., Jan 1 2019, In : Radiology. 292, 3, p. 647-654 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cysts
Growth
Radiology

Genetics of Familial and Sporadic Pancreatic Cancer

Wood, L. D., Yurgelun, M. B. & Goggins, M. S., May 1 2019, In : Gastroenterology. 156, 7, p. 2041-2055 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Carcinogenesis
Adenocarcinoma
Exome

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Hutchings, D., Jiang, Z., Skaro, M., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Zheng, L., Klimstra, D. S., Brand, R. E., Singhi, A. D., Goggins, M. S., Klein, A., Roberts, N. & Hruban, R. H., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Pancreatic Neoplasms
Colloids
Adenocarcinoma
Carcinoma

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma

Kudo, Y., Kohi, S., Hirata, K., Goggins, M. S. & Sato, N., Sep 1 2019, In : Oncotarget. 10, 54, p. 5592-5604 13 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Adenocarcinoma
Phenotype
Hymecromone
Cell Migration Assays

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
Fibroblasts
Pancreatic Neoplasms
Epigenomics
Lactic Acid
Stem cells

Management of patients with increased risk for familial pancreatic cancer: Updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E., Fockens, P., Gress, T. M., Van Hooft, J. E., Hruban, R. H., Kastrinos, F., Klein, A., Lennon, A. M., Lucas, A., Park, W., Rustgi, A. & 6 others, Simeone, D., Stoffel, E., Vasen, H. F. A., Cahen, D. L., Canto, M. I. & Bruno, M., Jan 1 2019, (Accepted/In press) In : Gut. 319352.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Consensus
Germ-Line Mutation
Cost-Benefit Analysis

Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements

He, H. J., Stein, E. V., Konigshofer, Y., Forbes, T., Tomson, F. L., Garlick, R., Yamada, E., Godfrey, T., Abe, T., Tamura, K., Borges, M., Goggins, M., Elmore, S., Gulley, M. L., Larson, J. L., Ringel, L., Haynes, B. C., Karlovich, C., Williams, P. M., Garnett, A. & 6 others, Ståhlberg, A., Filges, S., Sorbara, L., Young, M. R., Srivastava, S. & Cole, K. D., Jul 2019, In : Journal of Molecular Diagnostics. 21, 4, p. 658-676 19 p.

Research output: Contribution to journalArticle

Open Access
DNA
Gene Frequency
Neoplasms
Nucleotides
Polymerase Chain Reaction

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

Nakamura, S., Sadakari, Y., Ohtsuka, T., Okayama, T., Nakashima, Y., Gotoh, Y., Saeki, K., Mori, Y., Nakata, K., Miyasaka, Y., Onishi, H., Oda, Y., Goggins, M. S. & Nakamura, M., Jan 1 2019, In : Annals of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreatic Juice
MicroRNAs
Adenocarcinoma
Biomarkers
Exosomes

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes
Pancreatic Neoplasms
Pancreatectomy
Length of Stay
Adenocarcinoma
Mortality

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Silva, B. D., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, D., Gimotty, P. A. & 8 others, Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. & Tuveson, D. A., Jan 1 2019, In : Science. 364, 6446, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreatitis
Polysaccharides
Carbohydrates
Antigens
2018
Blood Group Antigens
Neoplasms
Adenocarcinoma
Logistic Models
Pancreatic Neoplasms

BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma

Blair, A. B., Groot, V. P., Gemenetzis, G., Wei, J., Cameron, J. L., Weiss, M. J., Goggins, M. S., Wolfgang, C., Yu, J. & He, J., Apr 1 2018, In : Journal of the American College of Surgeons. 226, 4, p. 630-637.e1

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Survival
Mutation
Platinum

Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome

Robinson, C., Estrada, A., Zaheer, A., Singh, V., Wolfgang, C., Goggins, M. S., Hruban, R. H., Wood, L. D., Noë, M., Montgomery, E. A., Guthrie, L. C., O'Broin-Lennon, A. M., Boyce, A. M. & Collins, M. T., Nov 1 2018, In : The Journal of clinical endocrinology and metabolism. 103, 11, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Pathology
Magnetic resonance
Medical problems
Magnetic Resonance Cholangiopancreatography

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Klein, A., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E. J., Hoskins, J. W., Jermusyk, A., Zhong, J., Chen, F., Albanes, D., Andreotti, G., Arslan, A. A., Babic, A., Bamlet, W. R., Beane-Freeman, L., Berndt, S. I., Blackford, A. & 103 others, Borges, M., Borgida, A., Bracci, P. M., Brais, L., Brennan, P., Brenner, H., Bueno-De-Mesquita, B., Buring, J., Campa, D., Capurso, G., Cavestro, G. M., Chaffee, K. G., Chung, C. C., Cleary, S., Cotterchio, M., Dijk, F., Duell, E. J., Foretova, L., Fuchs, C., Funel, N., Gallinger, S., Gaziano, J. M. M., Gazouli, M., Giles, G. G., Giovannucci, E., Goggins, M. S., Goodman, G. E., Goodman, P. J., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Hegyi, P., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Hung, R. J., Jacobs, E. J., Jamroziak, K., Janout, V., Kaaks, R., Khaw, K. T., Klein, E. A., Kogevinas, M., Kooperberg, C., Kulke, M. H., Kupcinskas, J., Kurtz, R. J., Laheru, D., Landi, S., Lawlor, R. T., Lee, I. M., Lemarchand, L., Lu, L., Malats, N., Mambrini, A., Mannisto, S., Milne, R. L., Mohelníková-Duchoňová, B., Neale, R. E., Neoptolemos, J. P., Oberg, A. L., Olson, S. H., Orlow, I., Pasquali, C., Patel, A. V., Peters, U., Pezzilli, R., Porta, M., Real, F. X., Rothman, N., Scelo, G., Sesso, H. D., Severi, G., Shu, X. O., Silverman, D., Smith, J. P., Soucek, P., Sund, M., Talar-Wojnarowska, R., Tavano, F., Thornquist, M. D., Tobias, G. S., Van Den Eeden, S. K., Vashist, Y., Visvanathan, K., Vodicka, P., Wactawski-Wende, J., Wang, Z., Wentzensen, N., White, E., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Zheng, W., Kraft, P., Li, D., Chanock, S., Obazee, O., Petersen, G. M. & Amundadottir, L. T., Dec 1 2018, In : Nature Communications. 9, 1, 556.

Research output: Contribution to journalArticle

genome
loci
Pancreatic Neoplasms
Meta-Analysis
Genes

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

Hata, T., Suenaga, M., Marchionni, L., Macgregor-Das, A., Yu, J., Shindo, K., Tamura, K., Hruban, R. H. & Goggins, M. S., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1723-1733 11 p.

Research output: Contribution to journalArticle

Genome
Mutation
Neoplasms
Adenocarcinoma
Single Nucleotide Polymorphism

IPMNs with co-occurring invasive cancers: Neighbours but not always relatives

Felsenstein, M., Noë, M., Masica, D. L., Hosoda, W., Chianchiano, P., Fischer, C. G., Lionheart, G., Brosens, L. A. A., Pea, A., Yu, J., Gemenetzis, G., Groot, V. P., Makary, M. A., He, J., Weiss, M. J., Cameron, J. L., Wolfgang, C., Hruban, R. H., Roberts, N., Karchin, R. & 2 others, Goggins, M. S. & Wood, L. D., Mar 2 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Neoplasms
Adenocarcinoma
Mucinous Adenocarcinoma
Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., MacGregor-Das, A., Borges, M., Wolfgang, C., Weiss, M. J., He, J., Canto, M., Petersen, G. M., Gallinger, S., Syngal, S., Brand, R. E., Rustgi, A., Olson, S. H., Stoffel, E., Cote, M. L. & 13 others, Zogopoulos, G., Potash, J. B., Goes, F. S., McCombie, R. W., Zandi, P. P., Pirooznia, M., Kramer, M., Parla, J., Eshleman, J., Roberts, N., Hruban, R. H., Klein, A. & Goggins, M. S., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4767-4772 6 p.

Research output: Contribution to journalArticle

Carboxypeptidases A
Pancreatic Neoplasms
Endoplasmic Reticulum Stress
Mutation
Enzymes

Pancreatic cancer arising in the remnant pancreas is not always a relapse of the preceding primary

Luchini, C., Pea, A., Yu, J., He, J., Salvia, R., Riva, G., Weiss, M. J., Bassi, C., Cameron, J. L., Hruban, R. H., Goggins, M. S., Wolfgang, C., Scarpa, A., Wood, L. D. & Lawlor, R. T., Jan 1 2018, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Recurrence
Neoplasms

Pancreatic cancer incidence trends: Evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data

Gordon-Dseagu, V. L., Devesa, S. S., Goggins, M. S. & Stolzenberg-Solomon, R., Apr 1 2018, In : International Journal of Epidemiology. 47, 2, p. 427-439 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epidemiology
Incidence
Population
Adenocarcinoma

Pancreatic juice mutation concentrations can help predict the grade of dysplasia in patients undergoing pancreatic surveillance

Suenaga, M., Yu, J., Shindo, K., Tamura, K., Almario, J. A., Zaykoski, C., Witmer, P. D., Fesharakizadeh, S., Borges, M., O'Broin-Lennon, A. M., Shin, E., Canto, M. & Goggins, M. S., Jun 15 2018, In : Clinical Cancer Research. 24, 12, p. 2963-2974 12 p.

Research output: Contribution to journalArticle

Pancreatic Juice
Mutation
Pancreatic Neoplasms
Area Under Curve
Sensitivity and Specificity

Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors

Elias, K. M., Tsantoulis, P., Tille, J. C., Vitonis, A., Doyle, L. A., Hornick, J. L., Kaya, G., Barnes, L., Cramer, D. W., Puppa, G., Stuckelberger, S., Hooda, J., Dietrich, P. Y., Goggins, M. S., Kerr, C. L., Birrer, M., Hirsch, M. S., Drapkin, R. & Labidi-Galy, S. I., Jan 1 2018, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Germ Cells
Neoplasms
Mucinous Adenocarcinoma
Epithelium

Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance

Canto, M., Almario, J. A., Schulick, R. D., Yeo, C. J., Klein, A., Blackford, A., Shin, E., Sanyal, A., Yenokyan, G., O'Broin-Lennon, A. M., Kamel, I. R., Fishman, E. K., Wolfgang, C., Weiss, M. J., Hruban, R. H. & Goggins, M. S., Sep 1 2018, In : Gastroenterology. 155, 3, p. 740-751.e2

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Cysts
Endosonography
Pancreatic Ducts

Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid

Hata, T., Dal Molin, M., McGregor-Das, A., Song, T. J., Wolfgang, C., Eshleman, J., Hruban, R. H. & Goggins, M. S., Jan 1 2018, In : Journal of Molecular Diagnostics. 20, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
Telomere
Pancreatic Neoplasms
Neoplasms

The Effect of Pancreatic Juice Collection Time on the Detection of KRAS Mutations

Suenaga, M., Dudley, B., Karloski, E., Borges, M., Irene Canto, M., Brand, R. E. & Goggins, M., Jan 1 2018, In : Pancreas. 47, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

Pancreatic Juice
Mutation
Secretin
Duodenum
Biomarkers

Validation of Biomarkers for Early Detection of Pancreatic Cancer: Summary of the Alliance of Pancreatic Cancer Consortia for Biomarkers for Early Detection Workshop

Young, M. R., Wagner, P. D., Ghosh, S., Rinaudo, J. A., Baker, S. G., Zaret, K. S., Goggins, M. S. & Srivastava, S., Feb 1 2018, In : Pancreas. 47, 2, p. 135-141 7 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Education

Validation Strategy for Ultrasensitive Mutation Detection

Debeljak, M., Noë, M., Riel, S. L., Haley, L. M., Norris, A. L., Anderson, D. A., Adams, E. M., Suenaga, M., Beierl, K. F., Lin, M-T., Goggins, M. S., Gocke, C. & Eshleman, J., Jul 5 2018, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-9 9 p.

Research output: Contribution to journalArticle

Point Mutation
Gene Frequency
Haplotypes
Cell Line
Polymerase Chain Reaction
2017

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L., Molin, M. D., Wolfgang, C., Tomita, T., Ostovaneh, M. R., Blackford, A., Moran, R. A., Law, J. K., Barkley, T., Goggins, M. S., Canto, M., Pittman, M., Eshleman, J., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Ahuja, N., Makary, M. A. & 16 others, Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & O'Broin-Lennon, A. M., 2017, In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Clinical Pathology
Biomarkers
Sensitivity and Specificity
Serous Cystadenoma

Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions

Poruk, K. E., Valero, V., He, J., Ahuja, N., Cameron, J. L., Weiss, M. J., O'Broin-Lennon, A. M., Goggins, M. S., Wood, L. D. & Wolfgang, C., Aug 1 2017, In : Pancreas. 46, 7, p. 943-947 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epithelial Cells
Keratins
Neoplasms
Pancreas

Circulating tumor cells expressing markers of tumor-initiating cells predict poor survival and cancer recurrence in patients with pancreatic ductal adenocarcinoma

Poruk, K. E., Blackford, A. L., Weiss, M. J., Cameron, J. L., He, J., Goggins, M. S., Rasheed, Z. A., Wolfgang, C. & Wood, L. D., Jun 1 2017, In : Clinical Cancer Research. 23, 11, p. 2681-2690 10 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Neoplastic Stem Cells
Adenocarcinoma
Recurrence
Survival

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Biopsy
DNA

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Cho, C., Macgregor-Das, A., Siddiqui, A., Witmer, P. D., Tamura, K., Song, T. J., Almario, J. A. N., Brant, A., Borges, M., Ford, M., Barkley, T., He, J., Weiss, M. J., Wolfgang, C., Roberts, N., Hruban, R. H. & 2 others, Klein, A. & Goggins, M. S., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Duodenal Involvement is an Independent Prognostic Factor for Patients with Surgically Resected Pancreatic Ductal Adenocarcinoma

Dal Molin, M., Blackford, A. L., Siddiqui, A., Brant, A., Cho, C., Rezaee, N., Yu, J., He, J., Weiss, M. J., Hruban, R. H., Wolfgang, C. & Goggins, M. S., Apr 24 2017, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Confidence Intervals
Common Bile Duct
Pancreas

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Fang, J., Jia, J., Makowski, M., Xu, M., Wang, Z., Zhang, T., Hoskins, J. W., Choi, J., Han, Y., Zhang, M., Thomas, J., Kovacs, M., Collins, I., Dzyadyk, M., Thompson, A., O'Neill, M., Das, S., Lan, Q., Koster, R., Stolzenberg-Solomon, R. S. & 215 others, Kraft, P., Wolpin, B. M., Jansen, P. W. T. C., Olson, S., McGlynn, K. A., Kanetsky, P. A., Chatterjee, N., Barrett, J. H., Dunning, A. M., Taylor, J. C., Newton-Bishop, J. A., Timothy Bishop, D., Andresson, T., Petersen, G. M., Amos, C. I., Iles, M. M., Nathanson, K. L., Landi, M. T., Vermeulen, M., Brown, K. M., Amundadottir, L. T., Canzian, F., Kooperberg, C., Arslan, A. A., Bracci, P. M., Buring, J., Duell, E. J., Gallinger, S., Jacobs, E. J., Kamineni, A., Van Den Eeden, S., Klein, A., Kolonel, L. N., Li, D., Olson, S. H., Risch, H. A., Sesso, H. D., Visvanathan, K., Zheng, W., Albanes, D., Austin, M. A., Boutron-Ruault, M. C., Bueno-De-Mesquita, H. B., Cotterchio, M., Gaziano, J. M., Giovannucci, E. L., Goggins, M. S., Gross, M., Hassan, M., Helzlsouer, K. J., Holly, E. A., Hunter, D. J., Jenab, M., Kaaks, R., Key, T. J., Khaw, K. T., Krogh, V., Kurtz, R. C., LaCroix, A., Le Marchand, L., Mannisto, S., Patel, A. V., Peeters, P. H. M., Riboli, E., Shu, X. O., Sund, M., Thornquist, M., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Wactawski-Wende, J., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Hoover, R., Hartge, P., Fuchs, C., Chanock, S. J., Stevens, V., Albanes, D., Caporaso, N. E., Brennan, P., McKay, J., Wu, X., Hung, R. J., McLaughlin, J. R., Bickeboller, H., Risch, A., Wichmann, E., Houlston, R. S., Mann, G., Hopper, J., Aitken, J., Armstrong, B., Giles, G., Holland, E., Kefford, R., Cust, A., Jenkins, M., Schmid, H., Puig, S., Aguilera, P., Badenas, C., Barreiro, A., Carrera, C., Gabriel, D., Xavier, P. G., Iglesias-Garcia, P., Malvehy, J., Mila, M., Pigem, R., Potrony, M., Puig Butille, J. A., Tell-Marti, G., Hayward, N. K., Martin, N. G., Montgomery, G., Duffy, D. L., Whiteman, D. C., MacGregor, S., Calista, D., Landi, G., Minghetti, P., Arcangeli, F., Bertazzi, P. A., Ghiorzo, P., Bianchi-Scarra, G., Pastorino, L., Bruno, W., Andreotti, V., Queirolo, P., Spagnolo, F., MacKie, R., Lang, J., Gruis, N., Van Nieuwpoort, F. A., Out, C., Bergman, W., Kukutsch, N., Bavinck, J. N. B., Bakker, B., Van Der Stoep, N., Ter Huurne, J., Van Der Rhee, H., Bekkenk, M., Snels, D., Van Praag, M., Brochez, L., Gerritsen, R., Crijns, M., Vasen, H., Janssen, B., Ingvar, C., Olsson, H., Jönsson, G., Borg, Å., Harbst, K., Nielsen, K., Zander, A. S., Molven, A., Helsing, P., Andresen, P. A., Rootwelt, H., Akslen, L. A., Paillerets, B. B. D., Demenais, F., Avril, M. F., Chaudru, V., Jeannin, P., Lesueur, F., Maubec, E., Mohamdi, H., Bossard, M., Vaysse, A., Boitier, F., Caron, O., Caux, F., Dalle, S., Dereure, O., Leroux, D., Martin, L., Mateus, C., Robert, C., Stoppa-Lyonnet, D., Thomas, L., Wierzbicka, E., Elder, D. E., Ming, M., Mitra, N., Debniak, T., Lubinski, J., Hocevar, M., Novakovic, S., Peric, B., Skerl, P., Hansson, J., Höiom, V., Friedman, E., Azizi, E., Baron-Epel, O., Scope, A., Pavlotsky, F., Cohen-Manheim, I., Laitman, Y., Harland, M., Randerson-Moor, J., Laye, J., Davies, J., Nsengimana, J., O'Shea, S., Chan, M., Gascoyne, J., Tucker, M. A., Goldstein, A. M. & Yang, X. R., Jan 1 2017, In : Nature Communications. 8, 15034.

Research output: Contribution to journalArticle

Zinc Fingers
loci
Zinc
zinc
cancer

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W., Chianchiano, P., Griffin, J. F., Pittman, M. E., Brosens, L. A. A., Noë, M., Yu, J., Shindo, K., Suenaga, M., Rezaee, N., Yonescu, R., Ning, Y., Albores-Saavedra, J., Yoshizawa, N., Harada, K., Yoshizawa, A., Hanada, K., Yonehara, S., Shimizu, M., Uehara, T. & 6 others, Samra, J. S., Gill, A. J., Wolfgang, C., Goggins, M. S., Hruban, R. H. & Wood, L. D., May 1 2017, In : Journal of Pathology. 242, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma
Exome
Genes

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth

Ayars, M., O'Sullivan, E., Macgregor-Das, A., Shindo, K., Kim, H., Borges, M., Yu, J., Hruban, R. H. & Goggins, M. S., 2017, In : Oncotarget. 8, 48, p. 83370-83383 14 p.

Research output: Contribution to journalArticle

Interleukin Receptor Common gamma Subunit
Pancreatic Neoplasms
RNA
Pancreatic Ducts
Growth

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Tamura, K., Almario, J. A. N., Brant, A., Borges, M., Siddiqui, A., Datta, L., Wolfgang, C., Hruban, R. H., Klein, A. & Goggins, M. S., Feb 7 2017, In : Oncotarget. 8, 31, p. 50824-50831 8 p.

Research output: Contribution to journalArticle

Lipase
Pancreatic Neoplasms
Pancreatitis
Esters
Alleles

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A., Le, D., Jaffee, E., Azad, N., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. & Goggins, M. S., 2017, In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas

Wood, L. D., Noë, M., Hackeng, W., Brosens, L. A. A., Bhaijee, F., Debeljak, M., Yu, J., Suenaga, M., Singhi, A. D., Zaheer, A., Boyce, A., Robinson, C., Eshleman, J., Goggins, M. S., Hruban, R. H., Collins, M. T., O'Broin-Lennon, A. M. & Montgomery, E. A., Feb 10 2017, (Accepted/In press) In : Virchows Archiv. p. 1-10 10 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Gastrointestinal Tract
Pancreas
Polyps
Esophagogastric Junction

Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers

Hata, T., Dal Molin, M., Hong, S. M., Tamura, K., Suenaga, M., Yu, J., Sedogawa, H., Weiss, M. J., Wolfgang, C., O'Broin-Lennon, A. M., Hruban, R. H. & Goggins, M. S., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3935-3944 10 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
DNA Methylation
Pancreatic Neoplasms
Genetic Markers

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Todoric, J., Antonucci, L., Di Caro, G., Li, N., Wu, X., Lytle, N. K., Dhar, D., Banerjee, S., Fagman, J. B., Browne, C. D., Umemura, A., Valasek, M. A., Kessler, H., Tarin, D., Goggins, M. S., Reya, T., Diaz-Meco, M., Moscat, J. & Karin, M., Dec 11 2017, In : Cancer Cell. 32, 6, p. 824-839.e8

Research output: Contribution to journalArticle

Pancreas
Adenocarcinoma
Acinar Cells
Autophagy
Chronic Pancreatitis