Mi-Kyung Shin

Research Associate

20112019
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Research Output 2011 2019

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Article
2019

Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet

Younas, H., Vieira, M., Gu, C., Lee, R., Shin, M-K., Berger, S., Loube, J., Nelson, A., Bevans-Fonti, S., Zhong, Q., D'Alessio, F., McCormack, M., Hansel, N., Mitzner, W. A. & Polotsky, V., Dec 1 2019, In : Scientific Reports. 9, 1, 279.

Research output: Contribution to journalArticle

Caloric Restriction
High Fat Diet
Interleukin-1
Diet
Interleukin 1 Receptor Antagonist Protein
Carotid Body
Hormones
Leptin
Respiration
Denervation

Intranasal leptin relieves sleep-disordered breathing in mice with diet-induced obesity

Berger, S., Pho, H., Fleury Curado, T., Bevans-Fonti, S., Younas, H., Shin, M-K., Jun, J., Anokye-Danso, F., Ahima, R. S., Enquist, L. W., Mendelowitz, D., Schwartz, A. R. & Polotsky, V., Mar 15 2019, In : American journal of respiratory and critical care medicine. 199, 6, p. 773-783 11 p.

Research output: Contribution to journalArticle

Sleep Apnea Syndromes
Leptin
Obesity
Diet
Hypoventilation

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body

Shin, M. K., Eraso, C. C., Mu, Y. P., Gu, C., Yeung, B. H. Y., Kim, L. J., Liu, X. R., Wu, Z. J., Paudel, O., Pichard, L. E., Shirahata, M., Tang, W. Y., Sham, J. S. K. & Polotsky, V. Y., Nov 8 2019, In : Circulation research. 125, 11, p. 989-1002 14 p.

Research output: Contribution to journalArticle

Carotid Body
Leptin
Hypertension
Inbred C57BL Mouse
Transient Receptor Potential Channels
2018

High fat diet induces airway hyperresponsiveness in mice

Fricke, K., Vieira, M., Younas, H., Shin, M-K., Bevans-Fonti, S., Berger, S., Lee, R., D'Alessio, F., Zhong, Q., Nelson, A., Loube, J., Sanchez, I., Hansel, N., Mitzner, W. A. & Polotsky, V., Dec 1 2018, In : Scientific Reports. 8, 1, 6404.

Research output: Contribution to journalArticle

High Fat Diet
Interleukin-1
Methacholine Chloride
Lung
Bronchoalveolar Lavage

Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response

Caballero-Eraso, C., Shin, M-K., Pho, H., Kim, L. J., Pichard, L. E., Wu, Z. J., Gu, C., Berger, S., Pham, L., Yeung, H. Y. B., Shirahata, M., Schwartz, A. R., Tang, W-Y., Sham, J. & Polotsky, V., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Carotid Body
Wakefulness
Leptin
Ventilation
Sleep

Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity

Fleury Curado, T., Pho, H., Berger, S., Caballero-Eraso, C., Shin, M-K., Sennes, L. U., Pham, L., Schwartz, A. R. & Polotsky, V., Aug 1 2018, In : Sleep. 41, 8

Research output: Contribution to journalArticle

Sleep Apnea Syndromes
Inbred C57BL Mouse
Obese Mice
Obesity
Diet
2017

Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test

Shin, M-K., Han, W., Joo, H., Bevans-Fonti, S., Shiota, M., Stefanovski, D. & Polotsky, V., 2017, In : Journal of Applied Physiology. 122, 4, p. 767-774 8 p.

Research output: Contribution to journalArticle

Glucose Tolerance Test
Glucose
Insulin
Fasting
Insulin Resistance
2016

Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis

Jun, J., Devera, R., Unnikrishnan, D., Shin, M-K., Bevans-Fonti, S., Yao, Q., Rathore, A., Younas, H., Halberg, N., Scherer, P. E. & Polotsky, V., Oct 14 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-11 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Brown Adipose Tissue
Thermogenesis
Obesity
Oxygen Consumption

Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease

Mesarwi, O. A., Shin, M-K., Bevans-Fonti, S., Schlesinger, C., Shaw, J. & Polotsky, V., Dec 1 2016, In : PLoS One. 11, 12, e0168572.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
liver cirrhosis
fatty liver
Liver Cirrhosis
Liver
2015

Is the Carotid Body a Metabolic Monitor?

Shirahata, M., Tang, W-Y., Shin, M-K. & Polotsky, V., 2015, In : Advances in Experimental Medicine and Biology. 860, p. 153-159 7 p.

Research output: Contribution to journalArticle

Carotid Body
Carotid Sinus
Glucose
Leptin
Transient Receptor Potential Channels

Lysyl oxidase as a serum biomarker of liver fibrosis in patients with severe obesity and obstructive sleep Apnea

Mesarwi, O. A., Shin, M-K., Drager, L. F., Bevans-Fonti, S., Jun, J., Putcha, N., Torbenson, M. S., Pedrosa, R. P., Lorenzi-Filho, G., Steele, K., Schweitzer, M. A., Magnuson, T., Lidor, A. O., Schwartz, A. R. & Polotsky, V., Oct 1 2015, In : Sleep. 38, 10, p. 1583-1591B

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Morbid Obesity
Obstructive Sleep Apnea
Liver Cirrhosis
Biomarkers
2014

Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia

Shin, M-K., Yao, Q., Jun, J., Bevans-Fonti, S., Yoo, D. Y., Han, W., Mesarwi, O., Richardson, R., Fu, Y. Y., Pasricha, P. J., Schwartz, A. R., Shirahata, M. & Polotsky, V., Oct 1 2014, In : Journal of Applied Physiology. 117, 7, p. 765-776 12 p.

Research output: Contribution to journalArticle

Carotid Body
Denervation
Hyperglycemia
Fasting
Carotid Sinus

Intermittent hypoxia-induced glucose intolerance is abolished by a-adrenergic blockade or adrenal medullectomy

Jun, J., Shin, M-K., Devera, R., Yao, Q., Mesarwi, O., Bevans-Fonti, S. & Polotsky, V., Dec 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 11, p. E1073-E1083

Research output: Contribution to journalArticle

Glucose Intolerance
Adrenergic Agents
Hyperglycemia
Insulin Resistance
Phentolamine

The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia

Shin, M-K., Han, W., Bevans-Fonti, S., Jun, J., Punjabi, N. M. & Polotsky, V., Nov 1 2014, In : Respiratory Physiology and Neurobiology. 203, p. 60-67 8 p.

Research output: Contribution to journalArticle

Epinephrine
Insulin
Insulin Resistance
Glucose
Hyperglycemia
2013

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M-K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J., Myers, A. C., Olivecrona, G., Schwartz, A. R., Halberg, N., Scherer, P. E., Semenza, G. L., Powell, D. R. & Polotsky, V., Jul 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 188, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

Atherosclerosis
Lipoprotein Lipase
Dyslipidemias
Hypoxia-Inducible Factor 1
Sleep Apnea Syndromes

Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues

Yao, Q., Shin, M-K., Jun, J., Hernandez, K. L., Aggarwal, N. R., Mock, J. R., Gay, J., Drager, L. F. & Polotsky, V., Apr 2013, In : Journal of Lipid Research. 54, 4, p. 1058-1065 8 p.

Research output: Contribution to journalArticle

Angiopoietins
Lipoprotein Lipase
Triglycerides
Tissue
Lung

Thermoneutrality modifies the impact of hypoxia on lipid metabolism

Jun, J., Shin, M-K., Yao, Q., Devera, R., Fonti-Bevans, S. & Polotsky, V., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4

Research output: Contribution to journalArticle

Lipid Metabolism
Lipids
Temperature
Triglycerides
Glucose
2012

Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice.

Jun, J., Shin, M-K., Yao, Q., Bevans-Fonti, S., Poole, J., Drager, L. F. & Polotsky, V., Aug 1 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 303, 3

Research output: Contribution to journalArticle

Hypertriglyceridemia
Triglycerides
White Adipose Tissue
Nonesterified Fatty Acids
Liver

Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea

Drager, L. F., Li, J., Shin, M-K., Reinke, C., Aggarwal, N. R., Jun, J., Bevans-Fonti, S., Sztalryd, C., Obyrne, S. M., Kroupa, O., Olivecrona, G., Blaner, W. S. & Polotsky, V., Mar 2012, In : European Heart Journal. 33, 6, p. 783-790 8 p.

Research output: Contribution to journalArticle

Lipoprotein Lipase
Sleep Apnea Syndromes
Lipoproteins
Triglycerides
Angiopoietins

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Shin, M-K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J., Aja, S. M., Bhanot, S. & Polotsky, V., Oct 1 2012, In : PLoS One. 7, 10, e46562.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Antisense Oligonucleotides
High Fat Diet
high fat diet
Nutrition
2011

Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes

Reinke, C., Bevans-Fonti, S., Drager, L. F., Shin, M-K. & Polotsky, V., Sep 2011, In : Journal of Applied Physiology. 111, 3, p. 881-890 10 p.

Research output: Contribution to journalArticle

Metabolome
Oxygen
Obese Mice
Fats
Leptin