Mehboob Hussain

Associate Professor

1993 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., O'Rourke, B. & He, L., Nov 5 2019, In : Cell Reports. 29, 6, p. 1511-1523.e5

Research output: Contribution to journalArticle

Open Access
2017

Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males

Qiu, S., Vazquez, J. T., Boulger, E., Liu, H., Xue, P., Hussain, M. & Wolfe, A., Dec 1 2017, In : Scientific Reports. 7, 1, 1661.

Research output: Contribution to journalArticle

Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis

Saloustros, E., Salpea, P., Starost, M., Liu, S., Faucz, F. R., London, E., Szarek, E., Song, W. J., Hussain, M. & Stratakis, C. A., Jan 1 2017, In : Endocrine-Related Cancer. 24, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S. M., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

Research output: Contribution to journalArticle

2016

The undoing and redoing of the diabetic β-cell

Wang, W., Liu, C., Jimenez-Gonzalez, M., Song, W. J. & Hussain, M., Nov 15 2016, (Accepted/In press) In : Journal of Diabetes and its Complications.

Research output: Contribution to journalArticle

2015

Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells

Salehi, S., Adeshina, I., Chen, H., Zirkin, B. R., Hussain, M. A., Wondisford, F., Wolfe, A. & Radovick, S., Apr 1 2015, In : Endocrinology. 156, 4, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

Human β-Cell proliferation and intracellular signaling: Part 3

Stewart, A. F., Hussain, M. A., García-Ocaña, A., Vasavada, R. C., Bhushan, A., Bernal-Mizrachi, E. & Kulkarni, R. N., Jun 2015, In : Diabetes. 64, 6, p. 1872-1885 14 p.

Research output: Contribution to journalArticle

Increasing β-cell mass requires additional stimulation for adaptation to secretory demand

Mondal, P., Song, W. J., Li, Y., Yang, K. S. & Hussain, M. A., Jan 1 2015, In : Molecular Endocrinology. 29, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes

Multhaup, M. L., Seldin, M. M., Jaffe, A. E., Lei, X., Kirchner, H., Mondal, P., Li, Y., Rodriguez, V., Drong, A., Hussain, M., Lindgren, C., McCarthy, M., Näslund, E., Zierath, J. R., Wong, G. W. & Feinberg, A. P., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 138-149 12 p.

Research output: Contribution to journalArticle

System for exposing cultured cells to intermittent hypoxia utilizing gas permeable cultureware

Polak, J., Studer-Rabeler, K., McHugh, H., Hussain, M. A. & Shimoda, L. A., Jan 1 2015, In : General physiology and biophysics. 34, 3, p. 235-247 13 p.

Research output: Contribution to journalArticle

2014

Glucagon regulates hepatic kisspeptin to impair insulin secretion

Song, W. J., Mondal, P., Wolfe, A., Alonso, L. C., Stamateris, R., Ong, B. W. T., Lim, O. C., Yang, K. S., Radovick, S., Novaira, H. J., Farber, E. A., Farber, C. R., Turner, S. D. & Hussain, M. A., Apr 1 2014, In : Cell Metabolism. 19, 4, p. 667-681 15 p.

Research output: Contribution to journalArticle

Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis

Riddle, R. C., Frey, J. L., Tomlinson, R. E., Ferron, M., Li, Y., DiGirolamo, D. J., Faugere, M. C., Hussain, M. A., Karsenty, G. & Clemens, T. L., May 2014, In : Molecular and cellular biology. 34, 10, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

2013

Pancreatic b-cell response to increased metabolic demand and to pharmacologic secretagogues requires epac2a

Song, W. J., Mondal, P., Li, Y., Lee, S. E. & Hussain, M. A., Aug 1 2013, In : Diabetes. 62, 8, p. 2796-2807 12 p.

Research output: Contribution to journalArticle

2011

Short telomeres compromise β-cell signaling and survival

Guo, N., Parry, E. M., Li, L. S., Kembou, F., Lauder, N., Hussain, M. A., Berggren, P. O. & Armanios, M., Mar 16 2011, In : PloS one. 6, 3, e17858.

Research output: Contribution to journalArticle

Snapin mediates incretin action and augments glucose-dependent insulin secretion

Song, W. J., Seshadri, M., Ashraf, U., Mdluli, T., Mondal, P., Keil, M., Azevedo, M., Kirschner, L. S., Stratakis, C. A. & Hussain, M. A., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 308-319 12 p.

Research output: Contribution to journalArticle

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H., Jul 1 2011, In : Molecular biology of the cell. 22, 13, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

2010

Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor

Barnett, B. P., Hwang, Y., Taylor, M. S., Kirchner, H., Pfluger, P. T., Bernard, V., Lin, Y. Y., Bowers, E. M., Mukherjee, C., Song, W. J., Longo, P. A., Leahy, D. J., Hussain, M. A., Tschöp, M. H., Boeke, J. D. & Cole, P. A., Dec 17 2010, In : Science. 330, 6011, p. 1689-1692 4 p.

Research output: Contribution to journalArticle

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L., Jul 1 2010, In : Cell. 142, 2, p. 309-319 11 p.

Research output: Contribution to journalArticle

Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection

Huang, Y., Chen, P., Zhang, C. B., Ko, G. J., Ruiz, M., Fiorina, P., Hussain, M. A., Wasowska, B. A., Rabb, H. & Womer, K. L., Dec 27 2010, In : Transplantation. 90, 12, p. 1307-1311 5 p.

Research output: Contribution to journalArticle

2009

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

He, L., Sabet, A., Djedjos, S., Miller, R., Sun, X., Hussain, M. A., Radovick, S. & Wondisford, F. E., May 15 2009, In : Cell. 137, 4, p. 635-646 12 p.

Research output: Contribution to journalArticle

2008

Exendin-4 stimulation of cyclin A2 in β-cell proliferation

Song, W. J., Schreiber, W. E., Zhong, E., Liu, F. F., Kornfeld, B. D., Wondisford, F. E. & Hussain, M. A., Sep 1 2008, In : Diabetes. 57, 9, p. 2371-2381 11 p.

Research output: Contribution to journalArticle

2006

Increased pancreatic β-cell proliferation mediated by CREB binding protein gene activation

Hussain, M. A., Porras, D. L., Rowe, M. H., West, J. R., Song, W. J., Schreiber, W. E. & Wondisford, F. E., Oct 1 2006, In : Molecular and cellular biology. 26, 20, p. 7747-7759 13 p.

Research output: Contribution to journalArticle

2005

Dose- and time-dependent oval cell reaction in acetaminophen-lnduced murine liver injury

Kofman, A. V., Morgan, G., Kirschenbaum, A., Osbeck, J., Hussain, M., Swenson, S. & Theise, N. D., Jun 1 2005, In : Hepatology. 41, 6, p. 1252-1261 10 p.

Research output: Contribution to journalArticle

2004

Paradigms of adult stem cell therapy for type 1 diabetes in mice

Kofman, A. V., Theise, N. D. & Hussain, M. A., Apr 1 2004, In : European Journal of Endocrinology. 150, 4, p. 415-419 5 p.

Research output: Contribution to journalArticle

Post-natal stem cells as participants in complex systems and the emergence of tissue integrity and function

Hussain, M. A. & Thiese, N. D., Dec 1 2004, In : Pediatric Diabetes, Supplement. 5, 2, p. 75-78 4 p.

Research output: Contribution to journalArticle

2003

Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus

Leonardi, O., Mints, G. & Hussain, M. A., Aug 1 2003, In : European Journal of Endocrinology. 149, 2, p. 99-102 4 p.

Research output: Contribution to journalArticle

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion

Ianus, A., Holz, G. G., Theise, N. D. & Hussain, M. A., Mar 1 2003, In : Journal of Clinical Investigation. 111, 6, p. 843-850 8 p.

Research output: Contribution to journalArticle

2002

Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220

Chepurny, O. G., Hussain, M. A. & Holz, G. G., Jan 1 2002, In : Endocrinology. 143, 6, p. 2303-2313 11 p.

Research output: Contribution to journalArticle

Open Access
2000

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element

Skoglund, G., Hussain, M. A. & Holz, G. G., Jul 2000, In : Diabetes. 49, 7, p. 1156-1164 9 p.

Research output: Contribution to journalArticle

Open Access

Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic β-cells

Hussain, M. A., Daniel, P. B. & Habener, J. F., Jan 1 2000, In : Diabetes. 49, 10, p. 1681-1690 10 p.

Research output: Contribution to journalArticle

Open Access

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

Stoffers, D. A., Kieffer, T. J., Hussain, M. A., Drucker, D. J., Bonner-Weir, S., Habener, J. F. & Egan, J. M., May 2000, In : Diabetes. 49, 5, p. 741-748 8 p.

Research output: Contribution to journalArticle

Open Access
1999

Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator

Hussain, M. A. & Habener, J. F., Oct 8 1999, In : Journal of Biological Chemistry. 274, 41, p. 28950-28957 8 p.

Research output: Contribution to journalArticle

The pharmacokinetics of free insulin-like growth factor-I in healthy subjects

Frystyk, J., Hussain, M., Skjærbæk, C., Pørksen, N., Froesch, E. R. & Ørskov, H., May 1999, In : Growth Hormone and IGF Research. 9, 2, p. 150-156 7 p.

Research output: Contribution to journalArticle

1998

Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum

Heller, R. S., Stoffers, D. A., Hussain, M. A., Miller, C. P., Habener, J. F. & Traber, P. G., Jan 1 1998, In : Gastroenterology. 115, 2, p. 381-387+487-488

Research output: Contribution to journalArticle

1997

Effects of low-dose L-arginine on insulin-mediated vasodilatation and insulin sensitivity

Wascher, T. C., Graier, W. F., Dittrich, P., Hussain, M. A., Bahadori, B., Wallner, S. & Toplak, H., Jan 1 1997, In : European Journal of Clinical Investigation. 27, 8, p. 690-695 6 p.

Research output: Contribution to journalArticle

Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man

Bianda, T., Hussain, M. A., Glatz, Y., Bouillon, R., Froesch, E. R. & Schmid, C., Jan 1 1997, In : Journal of Internal Medicine. 241, 2, p. 143-150 8 p.

Research output: Contribution to journalArticle

IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates

Pørksen, N., Hussain, M. A., Bianda, T. L., Nyholm, B., Christiansen, J. S., Butler, P. C., Veldhuis, J. D., Froesch, E. R. & Schmitz, O., Mar 1 1997, In : American Journal of Physiology - Endocrinology and Metabolism. 272, 3 35-3, p. E352-E358

Research output: Contribution to journalArticle

Polygenic models of non-insulin-dependent diabetes mellitus

Hussain, M. A., Jan 1 1997, In : European Journal of Endocrinology. 137, 5, p. 453-454 2 p.

Research output: Contribution to journalArticle

Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline

Frystyk, J., Hussain, M., Skjrbk, C., Schmitz, O., Christiansen, J. S., Froesch, E. R. & Orskov, H., Dec 1 1997, In : American Journal of Physiology. 273, 3 PART 1, p. E453-E461

Research output: Contribution to journalArticle

Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline

Frystyk, J., Hussain, M., Skjærbæk, C., Schmitz, O., Christiansen, J. S., Froesch, E. R. & Ørskov, H., Sep 1 1997, In : American Journal of Physiology - Endocrinology and Metabolism. 273, 3 36-3, p. E507-E513

Research output: Contribution to journalArticle

1996

IGF-I alters skeletal muscle substrate metabolism and blunts recovery from insulin-induced hypoglycemia

Hussain, M. A., Schmitz, O., Christiansen, J. S., Christensen, N. J., George, K., Alberti, M. M. & Rudolf Froesch, E., May 14 1996, In : American Journal of Physiology - Endocrinology and Metabolism. 270, 4 33-4, p. E545-E551

Research output: Contribution to journalArticle

Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: Comparison with growth hormone

Hussain, M. A., Schmitz, O., Jorgensen, J. O. L., Christiansen, J. S., Weeke, J., Schmid, C. & Froesch, E. R., May 1996, In : European Journal of Endocrinology. 134, 5, p. 563-567 5 p.

Research output: Contribution to journalArticle

Insulin-like growth factor-I in man enhances lipid mobilization and oxidation induced by a growth hormone pulse

Bianda, T. L., Hussain, M. A., Keller, A., Glatz, Y., Schmitz, O., Christiansen, J. S., Alberti, K. G. M. M. & Froesch, E. R., Jan 1 1996, In : Diabetologia. 39, 8, p. 961-969 9 p.

Research output: Contribution to journalArticle

1995

Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats

Zapf, J., Hauri, C., Futo, E., Hussain, M., Rutishauser, J., Maack, C. A. & Froesch, E. R., Jan 1 1995, In : Journal of Clinical Investigation. 95, 1, p. 179-186 8 p.

Research output: Contribution to journalArticle

Metabolic effects of insulin-like growth factor-I: A focus on insulin sensitivity

Hussain, M. A., Schmitz, O., Christiansen, J. S., Zapf, J. & Froesch, E. R., Oct 1995, In : Metabolism. 44, SUPPL. 4, p. 108-112 5 p.

Research output: Contribution to journalArticle

Treatment with insulin-like growth factor I alters capillary permeability in skin and retina

Hussain, M. A., Studer, K., Messmer, E. P. & Froesch, E. R., Jan 1 1995, In : Diabetes. 44, 10, p. 1209-1212 4 p.

Research output: Contribution to journalArticle