Masanobu Komatsu

Associate Professor

19962019
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Research Output 1996 2019

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2019

Mitochondria Penetrating Peptide-Conjugated TAMRA for Live-Cell Long-Term Tracking

Zhao, T., Liu, X., Singh, S., Liu, X., Zhang, Y., Sawada, J., Komatsu, M. & Belfield, K. D., Jan 1 2019, (Accepted/In press) In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

Mitochondria
Phenylalanine
Peptides
Neurodegenerative diseases
Mitochondrial Diseases
2018

Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS

Perrot, C. Y., Sawada, J. & Komatsu, M., Nov 1 2018, In : FASEB Journal. 32, 11, p. 5793-5812 20 p.

Research output: Contribution to journalArticle

Endothelial cells
Permeability
Chemical activation
Gene expression
Endothelial Cells
2017
lumens
Microtubules
Chemical activation
activation
Tissue
2016

Lack of R-Ras leads to increased vascular permeability in ischemic retinopathy

Vähätupa, M., Prince, S., Vataja, S., Mertimo, T., Kataja, M., Kinnunen, K., Marjomäki, V., Uusitalo, H., Komatsu, M., Järvinen, T. A. H. & Uusitalo-Järvinen, H., Sep 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 11, p. 4898-4909 12 p.

Research output: Contribution to journalArticle

Retinal Vessels
Capillary Permeability
Diabetic Retinopathy
Oxygen
Blood Vessels

R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells

Sawada, J., Li, F. & Komatsu, M., Apr 1 2016, In : Journal of Vascular Research. 52, 5, p. 347-359 13 p.

Research output: Contribution to journalArticle

HSP27 Heat-Shock Proteins
Vascular Endothelial Growth Factor A
Endothelial Cells
Phosphorylation
Vascular Endothelial Growth Factor Receptor

The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes

Zhao, W., Mazar, J., Lee, B., Sawada, J., Li, J. L., Shelley, J., Govindarajan, S., Towler, D., Mattick, J. S., Komatsu, M., Dinger, M. E. & Perera, R. J., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 819-828 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Melanocytes
Cell proliferation
Genes
Cell Proliferation
2015

Developmental origin of age-related coronary artery disease

Wei, K., Díaz-Trelles, R., Liu, Q., Diez-Cuñado, M., Scimia, M. C., Cai, W., Sawada, J., Komatsu, M., Boyle, J. J., Zhou, B., Ruiz-Lozano, P. & Mercola, M., Jul 15 2015, In : Cardiovascular Research. 107, 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Coronary Vessels
Smooth Muscle Myocytes
Pericardium
Paracrine Communication

Near-Infrared Fluorescent 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene Probes for One- and Two-Photon Fluorescence Bioimaging

Kim, B., Yue, X., Sui, B., Zhang, X., Xiao, Y., Bondar, M. V., Sawada, J., Komatsu, M. & Belfield, K. D., Sep 1 2015, In : European Journal of Organic Chemistry. 2015, 25, p. 5563-5571 9 p.

Research output: Contribution to journalArticle

Photons
Fluorescence
Infrared radiation
fluorescence
probes

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

Yue, X., Morales, A. R., Githaiga, G. W., Woodward, A. W., Tang, S., Sawada, J., Komatsu, M., Liu, X. & Belfield, K. D., Jan 1 2015, In : Organic and Biomolecular Chemistry. 13, 43, p. 10716-10725 10 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Photons
Tumors
tumors
Tissue
ras Proteins
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Vascular Endothelial Growth Factor A
Tumors
2014

A novel vascular homing peptide strategy to selectively enhance pulmonary drug efficacy in pulmonary arterial hypertension

Toba, M., Alzoubi, A., O'Neill, K., Abe, K., Urakami, T., Komatsu, M., Alvarez, D., Järvinen, T. A. H., Mann, D., Ruoslahti, E., McMurtry, I. F. & Oka, M., Feb 1 2014, In : American Journal of Pathology. 184, 2, p. 369-375 7 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Blood Vessels
Lung
Peptides
Pharmaceutical Preparations

Peptide-coated liposomal fasudil enhances site specific vasodilation in pulmonary arterial hypertension

Nahar, K., Absar, S., Gupta, N., Kotamraju, V. R., McMurtry, I. F., Oka, M., Komatsu, M., Nozik-Grayck, E. & Ahsan, F., Dec 1 2014, In : Molecular Pharmaceutics. 11, 12, p. 4374-4384 11 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Vasodilation
Liposomes
Peptides
Lung
2013

Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury

Tigges, U., Komatsu, M. & Stallcup, W. B., Feb 1 2013, In : Journal of Vascular Research. 50, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

Adventitia
Pericytes
Mesenchymal Stromal Cells
Wounds and Injuries
Femoral Artery

Deep Vascular Imaging in Wounds by Two-Photon Fluorescence Microscopy

Yanez, C. O., Morales, A. R., Yue, X., Urakami, T., Komatsu, M., Järvinen, T. A. H. & Belfield, K. D., Jul 2 2013, In : PLoS One. 8, 7, e67559.

Research output: Contribution to journalArticle

Fluorescence microscopy
fluorescence microscopy
Photons
Fluorescence Microscopy
blood vessels

Inhaled PLGA particles of prostaglandin E1 ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency

Gupta, V., Gupta, N., Shaik, I. H., Mehvar, R., Nozik-Grayck, E., McMurtry, I. F., Oka, M., Komatsu, M. & Ahsan, F., May 6 2013, In : Molecular Pharmaceutics. 10, 5, p. 1655-1667 13 p.

Research output: Contribution to journalArticle

Alprostadil
Pulmonary Hypertension
Right Ventricular Hypertrophy
Lung
Proliferating Cell Nuclear Antigen

Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension

Gupta, V., Gupta, N., Shaik, I. H., Mehvar, R., McMurtry, I. F., Oka, M., Nozik-Grayck, E., Komatsu, M. & Ahsan, F., Apr 28 2013, In : Journal of Controlled Release. 167, 2, p. 189-199 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Pulmonary Hypertension
Vasodilation
Lung
Liposomes
2012

Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels

Sawada, J., Urakami, T., Li, F., Urakami, A., Zhu, W., Fukuda, M., Li, D. Y., Ruoslahti, E. & Komatsu, M., Aug 14 2012, In : Cancer Cell. 22, 2, p. 235-249 15 p.

Research output: Contribution to journalArticle

Vascular Tissue Neoplasms
Monomeric GTP-Binding Proteins
Blood Vessels
Neoplasms
Pericytes

Small molecule fluorophore and copolymer RGD peptide conjugates for ex vivo two-photon fluorescence tumor vasculature imaging

Morales, A. R., Yanez, C. O., Zhang, Y., Wang, X., Biswas, S., Urakami, T., Komatsu, M. & Belfield, K. D., Nov 1 2012, In : Biomaterials. 33, 33, p. 8477-8485 9 p.

Research output: Contribution to journalArticle

Fluorophores
Photons
Peptides
Tumors
Copolymers
2011

Control of mammary tumor differentiation by SKI-606 (bosutinib)

Hebbard, L., Cecena, G., Golas, J., Sawada, J., Ellies, L. G., Charbono, A., Williams, R., Jimenez, R. E., Wankell, M., Arndt, K. T., Dejoy, S. Q., Rollins, R. A., Diesl, V., Follettie, M., Chen, L., Rosfjord, E., Cardiff, R. D., Komatsu, M., Boschelli, F. & Oshima, R. G., Jan 20 2011, In : Oncogene. 30, 3, p. 301-312 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Vascular Tissue Neoplasms
bosutinib
Growth Factor Receptors

Folate receptor-targeted aggregation-enhanced near-IR emitting silica nanoprobe for one-photon in vivo and two-photon ex vivo fluorescence bioimaging

Wang, X., Morales, A. R., Urakami, T., Zhang, L., Bondar, M. V., Komatsu, M. & Belfield, K. D., Jul 20 2011, In : Bioconjugate Chemistry. 22, 7, p. 1438-1450 13 p.

Research output: Contribution to journalArticle

Receptor Aggregation
Nanoprobes
Photons
Folic Acid
Silicon Dioxide

Peptide-directed highly selective targeting of pulmonary arterial hypertension

Urakami, T., Järvinen, T. A. H., Toba, M., Sawada, J., Ambalavanan, N., Mann, D., McMurtry, I., Oka, M., Ruoslahti, E. & Komatsu, M., Jan 1 2011, In : American Journal of Pathology. 178, 6, p. 2489-2495 7 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Lung
Peptides
Therapeutics
Monocrotaline

Two-photon fluorescence vascular bioimaging with new bioconjugate probes selective toward the vascular endothelial growth factor receptor 2

Andrade, C. D., Yanez, C. O., Ahn, H. Y., Urakami, T., Bondar, M. V., Komatsu, M. & Belfield, K. D., Oct 19 2011, In : Bioconjugate Chemistry. 22, 10, p. 2060-2071 12 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Photons
Blood Vessels
Dyes
Fluorescence
2009
vpr Genes
ras Genes
Cloning
GA-Binding Protein Transcription Factor
Blood Vessels
2006

Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds

Pilch, J., Brown, D. M., Komatsu, M., Järvinen, T. A. H., Yang, M., Peters, D., Hoffman, R. M. & Ruoslahti, E., Feb 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 8, p. 2800-2804 5 p.

Research output: Contribution to journalArticle

Peptides
Wounds and Injuries
Neoplasms
Fibrin
Fibronectins
2005

R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis

Komatsu, M. & Ruoslahti, E., Dec 1 2005, In : Nature Medicine. 11, 12, p. 1346-1350 5 p.

Research output: Contribution to journalArticle

Tunica Intima
Blood vessels
Hyperplasia
Blood Vessels
Tumors
2004

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

Jan, Y., Matter, M., Pai, J. T., Chen, Y. L., Pilch, J., Komatsu, M., Ong, E., Fukuda, M. & Ruoslahti, E., Mar 5 2004, In : Cell. 116, 5, p. 751-762 12 p.

Research output: Contribution to journalArticle

Anoikis
Transducin
Co-Repressor Proteins
Mitochondrial Proteins
Integrins
2003

Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95l-, TNFR1-, and TRAIL-dependent killing

Komatsu, M., Mammolenti, M., Jones, M., Jurecic, R., Sayers, T. J. & Levy, R. B., May 15 2003, In : Blood. 101, 10, p. 3991-3999 9 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
CD8 Antigens
Perforin
T-cells
Stem Cells
2002

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinase B/Akt pathways

Jepson, S., Komatsu, M., Haq, B., Arango, M. E., Huang, D., Carothers Carraway, C. A. & Carraway, K. L., Jan 1 2002, In : Oncogene. 21, 49, p. 7524-7532 9 p.

Research output: Contribution to journalArticle

Sialomucins
Proto-Oncogene Proteins c-akt
Mitogens
Phosphotransferases
Neuregulins

Synthesis and secretion of Muc4/sialomucin complex: Implication of intracellular proteolysis

Komatsu, M., Arango, M. E. & Carraway, K. L., Nov 15 2002, In : Biochemical Journal. 368, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Sialomucins
Proteolysis
Tumors
Cells
Mucins
2001

Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor

Komatsu, M., Jepson, S., Arango, M. E., Carothers Carraway, C. A. & Carraway, K. L., Jan 25 2001, In : Oncogene. 20, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Sialomucins
Apoptosis
Growth
Neoplasms
Up-Regulation

Production and localization of Muc4/Sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland

Arango, M. E., Li, P., Komatsu, M., Montes, C., Carraway, C. A. C. & Carraway, K. L., Nov 17 2001, In : Investigative Ophthalmology and Visual Science. 42, 12, p. 2749-2756 8 p.

Research output: Contribution to journalArticle

Sialomucins
Lacrimal Apparatus
Receptor Protein-Tyrosine Kinases
Mucin-4
Membranes
2000
Major Histocompatibility Complex
Allografts
Bone Marrow
Stem Cells
Fas Ligand Protein

Potentiation of metastasis by cell surface sialomucin complex (Rat MUC4), a multifunctional anti-adhesive glycoprotein

Komatsu, M., Tatum, L., Altman, N. H., Carothers Carraway, C. A. & Carraway, K. L., Sep 2 2000, In : International Journal of Cancer. 87, 4, p. 480-486 7 p.

Research output: Contribution to journalArticle

Sialomucins
Adhesives
Glycoproteins
Neoplasm Metastasis
Neoplasms
1999

An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling

Carraway, K. L., Rossi, E. A., Komatsu, M., Price-Schiavi, S. A., Huang, D., Guy, P. M., Carvajal, M. E., Fregien, N., Carothers Carraway, C. A. & Carraway, K. L., Feb 26 1999, In : Journal of Biological Chemistry. 274, 9, p. 5263-5266 4 p.

Research output: Contribution to journalArticle

Neuregulins
Receptor Protein-Tyrosine Kinases
Modulators
Rats
Tumors

Membrane mucins and breast cancer

Carraway, K. L., Price-Schiavi, S. A., Zhu, X. & Komatsu, M., Jan 1 1999, In : Cancer Control. 6, 6, p. 613-614 2 p.

Research output: Contribution to journalArticle

Mucins
Breast Neoplasms
Membranes

Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells

Komatsu, M., Yee, L. & Carraway, K. L., May 1 1999, In : Cancer Research. 59, 9, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

Sialomucins
Lymphokine-Activated Killer Cells
Mucins
Neoplasms
Mucin-4
1997

Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex

Komatsu, M., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 26 1997, In : Journal of Biological Chemistry. 272, 52, p. 33245-33254 10 p.

Research output: Contribution to journalArticle

Sialomucins
Cell Communication
Mucin-4
Mucins
Cell adhesion

Sialomucin complex is secreted by proteolytic cleavage of membrane precursor

Komatsu, M., Rossi, E. A., McNeer, R. R., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

Sialomucins
Membranes
1996

Sialomucin complex, a heterodimeric glycoprotein complex: Expression as a soluble, secretable form in lactating mammary gland and colon

Rossi, E. A., McNeer, R. R., Price-Schiavi, S. A., Van den Brande, J. M. H., Komatsu, M., Thompson, J. F., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 1 1996, In : Journal of Biological Chemistry. 271, 52, p. 33476-33485 10 p.

Research output: Contribution to journalArticle

Mucin-4
Sialomucins
Human Mammary Glands
Glycoproteins
Colon