Research Output 1981 2017

2017

Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Zhang, F., Trent Magruder, J., Lin, Y. A., Crawford, T. C., Grimm, J. C., Sciortino, C. M., Wilson, M. A., Blue, M. E., Kannan, S., Johnston, M. V., Baumgartner, W. A. & Kannan, R. M. Mar 10 2017 In : Journal of Controlled Release. 249, p. 173-182 10 p.

Research output: Contribution to journalArticle

Dendrimers
Intravenous Administration
Hydroxyl Radical
Brain Injuries
Brain

Zoledronic acid improves bone histomorphometry in a murine model of Rett syndrome

Shapiro, J. R., Boskey, A. L., Doty, S. B., Lukashova, L. & Blue, M. E. Jun 1 2017 In : Bone. 99, p. 1-7 7 p.

Research output: Contribution to journalArticle

Rett Syndrome
Bone and Bones
Acids
Methyl-CpG-Binding Protein 2
Osteogenesis
2016

Enhancement of postsynaptic GABAA and extrasynaptic NMDA receptor-mediated responses in the barrel cortex of Mecp2-null mice

Lo, F. S., Blue, M. E. & Erzurumlu, R. S. Mar 1 2016 In : Journal of Neurophysiology. 115, 3, p. 1298-1306 9 p.

Research output: Contribution to journalArticle

Rett Syndrome
N-Methyl-D-Aspartate Receptors
gamma-Aminobutyric Acid
Synaptic Transmission
Methyl-CpG-Binding Protein 2
Dendrimers
Nanotechnology
Brain Injuries
Canidae
Inflammation
2015

Osteoblast function and bone histomorphometry in a murine model of Rett syndrome

Blue, M. E., Boskey, A. L., Doty, S. B., Fedarko, N. S., Hossain, M. A. & Shapiro, J. R. Jul 1 2015 In : Bone. 76, p. 23-30 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Osteoblasts
Bone and Bones
Heterozygote
Bone Development

Recent advances in understanding synaptic abnormalities in Rett syndrome

Johnston, M., Blue, M. E. & Naidu, S. 2015 In : F1000Research. 4, 1490

Research output: Contribution to journalReview article

Rett Syndrome
Neuronal Plasticity
Synapses
Cinanserin
Methyl-CpG-Binding Protein 2
2014

Brain injury in canine models of cardiac surgery

Blue, M. E., Wilson, M. A., Beaty, C. A., George, T. J., Arnaoutakis, G. J., Haggerty, K. A., Jones, M., Brawn, J., Manmohan, S., Lange, M. S., Johnston, M. V., Baumgartner, W. A. & Troncoso, J. C. Dec 8 2014 In : Journal of Neuropathology and Experimental Neurology. 73, 12, p. 1134-1143 10 p.

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Brain Injuries
Thoracic Surgery
Canidae
Hippocampus

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

Mishra, M. K., Beaty, C. A., Lesniak, W. G., Kambhampati, S. P., Zhang, F., Wilson, M. A., Blue, M. E., Troncoso, J. C., Kannan, S., Johnston, M. V., Baumgartner, W. A. & Kannan, R. M. Mar 25 2014 In : ACS Nano. 8, 3, p. 2134-2147 14 p.

Research output: Contribution to journalArticle

dendrimers
Dendrimers
Brain
Animals
Anthralin
2012

A role for serotonin in the modulation of cytokines in the CNS: Insights from a mouse model

Hohmann, C. F., Pardo, C. A., Ayorinde, M., Monu-Azinge, C., Braileanu, M., Smith-Connor, K. S. & Blue, M. E. Oct 2012 Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers, Inc., p. 127-148 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Serotonin
Cytokines
Pervasive Child Development Disorders
Brain
Neuroglia

Preclinical research in Rett syndrome: Setting the foundation for translational success

Katz, D. M., Berger-Sweeney, J. E., Eubanks, J. H., Justice, M. J., Neul, J. L., Pozzo-Miller, L., Blue, M. E., Christian, D., Crawley, J. N., Giustetto, M., Guy, J., Howell, C. J., Kron, M., Nelson, S. B., Samaco, R. C., Schaevitz, L. R., Hillaire-Clarke, C. S., Young, J. L., Zoghbi, H. Y. & Mamounas, L. A. Nov 2012 In : DMM Disease Models and Mechanisms. 5, 6, p. 733-745 13 p.

Research output: Contribution to journalArticle

Anthralin
Rett Syndrome
Atrophy
Caprylates
Porphobilinogen Synthase
2011

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest

Arnaoutakis, G. J., George, T. J., Wang, K. K., Wilson, M. A., Allen, J. G., Robinson, C. W., Haggerty, K. A., Weiss, E. S., Blue, M. E., Talbot, C. C., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. Oct 2011 In : Journal of Thoracic and Cardiovascular Surgery. 142, 4

Research output: Contribution to journalArticle

Esterases
Ubiquitin
Brain Injuries
Canidae
Neurons

Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice

Blue, M. E., Kaufmann, W. E., Bressler, J., Eyring, C., O'driscoll, C., Naidu, S. & Johnston, M. V. Oct 2011 In : Anatomical Record. 294, 10, p. 1624-1634 11 p.

Research output: Contribution to journalArticle

aspartic acid
N-Methyl-D-Aspartate Receptors
receptors
mice
N-Methylaspartate
2010

Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation

Jentarra, G. M., Olfers, S. L., Rice, S. G., Srivastava, N., Homanics, G. E., Blue, M., Naidu, S. & Narayanan, V. Feb 17 2010 In : BMC Neuroscience. 11, 19

Research output: Contribution to journalArticle

X-Linked Mental Retardation
Rett Syndrome
Cell Count
Mutation
Intellectual Disability

Bone mass in rett syndrome: Association with clinical parameters and MECP2 mutations

Shapiro, J. R., Bibat, G., Hiremath, G., Blue, M. E., Hundalani, S., Yablonski, T., Kantipuly, A., Rohde, C., Johnston, M. & Naidu, S. Nov 2010 In : Pediatric Research. 68, 5, p. 446-451 6 p.

Research output: Contribution to journalArticle

Rett Syndrome
Bone Density
Bone and Bones
Mutation
Scoliosis

Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest

Tseng, E. E., Brock, M. V., Lange, M. S., Troncoso, J. C., Blue, M. E., Lowenstein, C. J., Johnston, M. V. & Baumgartner, W. A. Feb 2010 In : Annals of Thoracic Surgery. 89, 2, p. 440-445 6 p.

Research output: Contribution to journalArticle

Glutamic Acid
Apoptosis
Dizocilpine Maleate
Glutamate Receptors
Nitric Oxide

Ocular MECP2 Protein Expression in Patients With and Without Rett Syndrome

Jain, D., Singh, K., Chirumamilla, S., Bibat, G. M., Blue, M. E., Naidu, S. R. & Eberhart, C. G. Jul 2010 In : Pediatric Neurology. 43, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
Gene Expression
Proteins
Genes
Pervasive Child Development Disorders
Serotonin
Homeostasis
Biological Markers
Brain

Transcriptional Profile of Brain Injury in Hypothermic Circulatory Arrest and Cardiopulmonary Bypass

Allen, J. G., Weiss, E. S., Wilson, M. A., Arnaoutakis, G. J., Blue, M. E., Talbot, C. C., Jie, C., Lange, M. S., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. Jun 2010 In : Annals of Thoracic Surgery. 89, 6, p. 1965-1971 7 p.

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Brain Injuries
Dogs
Genes
Nervous System
2009

Alpha II-Spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest

Weiss, E. S., Wang, K. K. W., Allen, J. G., Blue, M. E., Nwakanma, L. U., Liu, M. C., Lange, M. S., Berrong, J., Wilson, M. A., Gott, V. L., Troncoso, J. C., Hayes, R. L., Johnston, M. V. & Baumgartner, W. A. Aug 2009 In : Annals of Thoracic Surgery. 88, 2, p. 543-550 8 p.

Research output: Contribution to journalArticle

Spectrin
Calpain
Cardiopulmonary Bypass
Brain Injuries
Canidae
2008

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K. Dec 17 2008 In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Amyloid
Transgenic Mice
Alzheimer Disease
Pathology
Prosencephalon
2007

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

Russell, J. C., Blue, M. E., Johnston, M. V., Naidu, S. & Hossain, M. A. Dec 12 2007 In : Neuroscience. 150, 3, p. 563-574 12 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Anoxia
Cell Death
Neurons
Apoptosis Inducing Factor

Modeling early cortical serotonergic deficits in autism

Boylan, C. B., Blue, M. E. & Hohmann, C. F. Jan 10 2007 In : Behavioural Brain Research. 176, 1, p. 94-108 15 p.

Research output: Contribution to journalArticle

Autistic Disorder
Serotonin
5,7-Dihydroxytryptamine
Prosencephalon
Cerebral Cortex

Neonatal serotonin depletion alters behavioral responses to spatial change and novelty

Hohmann, C. F., Walker, E. M., Boylan, C. B. & Blue, M. E. Mar 30 2007 In : Brain Research. 1139, 1, p. 163-177 15 p.

Research output: Contribution to journalArticle

Serotonin
5,7-Dihydroxytryptamine
Medial Forebrain Bundle
Brain Diseases
Hippocampus
2006

Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy

Barreiro, C. J., Williams, J. A., Fitton, T. P., Lange, M. S., Blue, M. E., Kratz, L., Barker, P. B., Degaonkar, M., Gott, V. L., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. May 2006 In : Annals of Thoracic Surgery. 81, 5, p. 1593-1598 6 p.

Research output: Contribution to journalArticle

Diazoxide
Choline
Brain Injuries
Canidae
Magnetic Resonance Spectroscopy

Temporal shift in methyl-CpG binding protein 2 expression in a mouse model of Rett syndrome

Metcalf, B. M., Mullaney, B. C., Johnston, M. V. & Blue, M. E. 2006 In : Neuroscience. 139, 4, p. 1449-1460 12 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
X Chromosome Inactivation
Young Adult
Neurons

Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery

Williams, J. A., Barreiro, C. J., Nwakanma, L. U., Lange, M. S., Kratz, L. E., Blue, M. E., Berrong, J., Patel, N. D., Gott, V. L., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. Jun 2006 In : Annals of Thoracic Surgery. 81, 6, p. 2235-2242 8 p.

Research output: Contribution to journalArticle

Valproic Acid
Brain Injuries
Thoracic Surgery
Canidae
Dogs
2005
Rett Syndrome
Brain
Neurobiology
Genetic Association Studies
Molecular Structure

Rett syndrome and neuronal development

Johnston, M. V., Blue, M. E. & Naidu, S. Sep 2005 In : Journal of Child Neurology. 20, 9, p. 759-763 5 p.

Research output: Contribution to journalArticle

Rett Syndrome
Synapses
Glutamic Acid
Brain-Derived Neurotrophic Factor
gamma-Aminobutyric Acid
2004

Activity-dependent expression of Egr1 mRNA in somatosensory cortex of developing rats

Patra, R. C., Blue, M. E., Johnston, M. V., Bressler, J. & Wilson, M. A. Oct 15 2004 In : Journal of Neuroscience Research. 78, 2, p. 235-244 10 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Messenger RNA
Vibrissae
Transcription Factors
Magnetic Fields

Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain

Mullaney, B. C., Johnston, M. V. & Blue, M. E. 2004 In : Neuroscience. 123, 4, p. 939-949 11 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rodentia
Brain
Rett Syndrome
Synapses

Effects of somatosensory electrical stimulation on neuronal injury after global hypoxia-ischemia

Buitrago, M. M., Luft, A. R., Thakor, N. V., Blue, M. E. & Hanley, D. F. Oct 2004 In : Experimental Brain Research. 158, 3, p. 336-344 9 p.

Research output: Contribution to journalArticle

Electric Stimulation
Anoxia
Ischemia
Wounds and Injuries
Heart Arrest
2003

Clinical variability in Rett syndrome

Naidu, S., Bibat, G., Kratz, L., Kelley, R. I., Pevsner, J., Hoffman, E., Cuffari, C., Rohde, C., Blue, M. E. & Johnston, M. V. Oct 2003 In : Journal of Child Neurology. 18, 10, p. 662-668 7 p.

Research output: Contribution to journalArticle

Rett Syndrome
Mutation
Neurons
X Chromosome Inactivation
Missense Mutation

Neurobiology of Rett syndrome

Johnston, M. V., Mullaney, B. & Blue, M. E. Oct 2003 In : Journal of Child Neurology. 18, 10, p. 688-692 5 p.

Research output: Contribution to journalArticle

Rett Syndrome
Neurobiology
Synapses
Intellectual Disability
Rodentia
2002

GAP-43 Is Critical for Normal Development of the Serotonergic Innervation in Forebrain

Donovan, S. L., Mamounas, L. A., Andrews, A. M., Blue, M. E. & McCasland, J. S. May 1 2002 In : Journal of Neuroscience. 22, 9, p. 3543-3552 10 p.

Research output: Contribution to journalArticle

GAP-43 Protein
Prosencephalon
Serotonin
Axons
Hippocampus
Basal Forebrain
Cholinergic Agents
Vibrissae
Immunotoxins
Dilatation and Curettage

Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia

Caparrelli, D. J., Cattaneo, S. M., Bethea, B. T., Shake, J. G., Eberhart, C., Blue, M. E., Marbán, E., Johnston, M. V., Baumgartner, W. A. & Gott, V. L. Sep 2002 In : Annals of Thoracic Surgery. 74, 3, p. 838-845 8 p.

Research output: Contribution to journalArticle

Spinal Cord Ischemia
Diazoxide
Pharmacology
Wounds and Injuries
Nervous System Trauma
2001

Delayed increase in neuronal nitric oxide synthase immunoreactivity in thalamus and other brain regions after hypoxic-ischemic injury in neonatal rats

Ishida, A., Ishiwa, S., Trescher, W. H., Nakajima, W., Lange, M. S., Blue, M. E. & Johnston, M. V. 2001 In : Experimental Neurology. 168, 2, p. 323-333 11 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Thalamus
Wounds and Injuries
Brain
Cerebral Cortex

Neurobiology of Rett syndrome: a genetic disorder of synapse development

Johnston, M. V., Jeon, O. H., Pevsner, J., Blue, M. E. & Naidu, S. 2001 In : Brain and Development. 23, SUPPL. 1

Research output: Contribution to journalArticle

Rett Syndrome
Neurobiology
Frontal Lobe
Synapses
Transcription Factors

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism

Purcell, A. E., Jeon, O. H., Zimmerman, A. W., Blue, M. E. & Pevsner, J. Nov 13 2001 In : Neurology. 57, 9, p. 1618-1628 11 p.

Research output: Contribution to journalArticle

Autistic Disorder
Neurotransmitter Agents
Glutamic Acid
Brain
Cerebellum

Sculpting the developing brain.

Johnston, M. V., Nishimura, A., Harum, K., Pekar, J. & Blue, M. E. 2001 In : Advances in Pediatrics. 48, p. 1-38 38 p.

Research output: Contribution to journalArticle

Brain
Psychosocial Deprivation
Metabolic Brain Diseases
Lead Poisoning
Neuronal Plasticity
2000

Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat

Nakajima, W., Ishida, A., Lange, M. S., Gabrielson, K. L., Wilson, M. A., Martin, L. J., Blue, M. E. & Johnston, M. V. Nov 1 2000 In : Journal of Neuroscience. 20, 21, p. 7994-8004 11 p.

Research output: Contribution to journalArticle

Anoxia
Ischemia
Apoptosis
Caspase 3
Neurons

BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain

Mamounas, L. A., Altar, C. A., Blue, M. E., Kaplan, D. R., Tessarollo, L. & Lyons, W. E. Jan 15 2000 In : Journal of Neuroscience. 20, 2, p. 771-782 12 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Axons
Brain
Serotonin
p-Chloroamphetamine
Rodentia
Lead
Neocortex
Vibrissae
Sensory Receptor Cells
1999
Rett Syndrome
GABA Receptors
Glutamate Receptors
Basal Ganglia
Putamen

Apoptosis detection in brain using low-magnification dark-field microscopy

Lange, M. S., Johnston, M. V., Tseng, E. E., Baumgartner, W. A. & Blue, M. E. Jul 1999 In : Experimental Neurology. 158, 1, p. 254-260 7 p.

Research output: Contribution to journalArticle

Microscopy
Apoptosis
Brain
Wounds and Injuries
Brain Injuries

Assessing the impact of cerebral injury after cardiac surgery: Will determining the mechanism reduce this injury?

Baumgartner, W. A., Walinsky, P. L., Salazar, J. D., Tseng, E. E., Brock, M. V., Doty, J. R., Redmond, J. M., Blue, M. E., Goldsborough, M. A., Troncoso, J. C. & Johnston, M. V. Jun 1999 In : Annals of Thoracic Surgery. 67, 6, p. 1871-1873 3 p.

Research output: Contribution to journalArticle

Thoracic Surgery
Nitric Oxide
Wounds and Injuries
Citrulline
Excitatory Amino Acid Antagonists
Amino Acid Receptors
Rett Syndrome
Frontal Lobe
Metabotropic Glutamate Receptors
N-Methylaspartate

Nitric oxide mediates neurologic injury after hypothermic circulatory arrest

Tseng, E. E., Brock, M. V., Lange, M. S., Troncoso, J. C., Lowenstein, C. J., Blue, M. E., Johnston, M. V. & Baumgartner, W. A. Jan 1999 In : Annals of Thoracic Surgery. 67, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

Nervous System Trauma
Nitric Oxide
Necrosis
Nitric Oxide Synthase Type I
Dogs
1998
Neocortex
Glutamate Receptors
Cholinergic Agents
Basal Forebrain
AMPA Receptors

Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest

Tseng, E. E., Brock, M. V., Lange, M. S., Troncoso, J. C., Blue, M. E., Lowenstein, C. J., Johnston, M. V., Baumgartner, W. A., Billiar, T. R. & Selke, F. W. 1998 In : Surgery. 124, 2, p. 298-306 9 p.

Research output: Contribution to journalArticle

Nitric Oxide
Apoptosis
Glutamic Acid
Aspartic Acid
Citrulline