Marshall Shuler

Associate Professor

19992019
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Research Output 1999 2019

2019

Are You There, Cortex? It's Me, Acetylcholine

Monk, K. J. & Shuler, M., Jan 1 2019, (Accepted/In press) In : Neuron.

Research output: Contribution to journalShort survey

Cholinergic Neurons
Acetylcholine
Cues
Neurons
Basal Forebrain

Validating a dimension of doubt in decisionmaking: A proposed endophenotype for obsessive-compulsive disorder

Marton, T., Samuels, J., Nestadt, P., Krasnow, J., Wang, Y., Shuler, M., Kamath, V., Chib, V. S., Bakker, A. & Nestadt, G., Jun 1 2019, In : PloS one. 14, 6, e0218182.

Research output: Contribution to journalArticle

Open Access
obsessive-compulsive disorder
Endophenotypes
Obsessive-Compulsive Disorder
Decision making
decision making
2018

Time's weird in the brain-that's a good thing, and here's why

Shuler, M. & Namboodiri, V. M. K., Apr 24 2018, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience. Yale University Press, p. 135-144 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
2017

The timing of reward-seeking action tracks visually cued theta oscillations in primary visual cortex

Levy, J. M., Zold, C. L., Namboodiri, V. M. K. & Shuler, M., Oct 25 2017, In : Journal of Neuroscience. 37, 43, p. 10408-10420 13 p.

Research output: Contribution to journalArticle

Visual Cortex
Reward
Power (Psychology)
2016

Analytical calculation of errors in time and value perception due to a subjective time accumulator: A mechanistic model and the generation of Weber's law

Namboodiri, V. M. K., Mihalas, S. & Shuler, M., Jan 1 2016, In : Neural Computation. 28, 1, p. 89-117 29 p.

Research output: Contribution to journalArticle

Time Perception
Decision Making
Reward
Synapses
Depression

Rationalizing spatial exploration patterns of wild animals and humans through a temporal discounting framework

Namboodiri, V. M. K., Levy, J. M., Mihalas, S., Sims, D. W. & Shuler, M., Aug 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. 8747-8752 6 p.

Research output: Contribution to journalArticle

animals
costs
vertebrates
random walk

Rationalizing spatial exploration patterns of wild animals and humans through a temporal discounting framework

Namboodiri, V. M. K., Levy, J. M., Mihalas, S., Sims, D. W. & Shuler, M., Aug 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. 8747-8752 6 p.

Research output: Contribution to journalArticle

Wild Animals
Reward
Costs and Cost Analysis
Animal Behavior
Vertebrates

The hunt for the perfect discounting function and a reckoning of time perception

Namboodiri, V. MK. & Shuler, M., Oct 1 2016, In : Current Opinion in Neurobiology. 40, p. 135-141 7 p.

Research output: Contribution to journalReview article

Time Perception
Decision Making
Decision Theory
Observation
Costs and Cost Analysis

Timing in the visual cortex and its investigation

Shuler, M., Apr 1 2016, In : Current Opinion in Behavioral Sciences. 8, p. 73-77 5 p.

Research output: Contribution to journalArticle

Visual Cortex
Learning
Reinforcement (Psychology)
2015

A simple network architecture accounts for diverse reward time responses in primary visual cortex

Huertas, M. A., Shuler, M. & Shouval, H. Z., Sep 16 2015, In : Journal of Neuroscience. 35, 37, p. 12659-12672 14 p.

Research output: Contribution to journalArticle

Visual Cortex
Reward
Aptitude
Cues
Rodentia
Metabotropic Glutamate 5 Receptor
Neuronal Plasticity
Reward
Phosphorylation
Synapses

Memory bias in the temporal bisection point

Levy, J. M., Namboodiri, V. M. K. & Shuler, M., Jul 7 2015, In : Frontiers in Integrative Neuroscience. 9, JULY, 44.

Research output: Contribution to journalArticle

Aptitude
Population

Optogenetic dissection of the basal forebrain neuromodulatory control of cortical activation, plasticity, and cognition

Lin, S. C., Brown, R. E., Shuler, M., Petersen, C. C. H. & Kepecs, A., Oct 14 2015, In : Journal of Neuroscience. 35, 41, p. 13896-13903 8 p.

Research output: Contribution to journalArticle

Optogenetics
Cognition
Dissection
Arousal
Nervous System Diseases

Selective Activation of a Putative Reinforcement Signal Conditions Cued Interval Timing in Primary Visual Cortex

Liu, C. H., Coleman, J. E., Davoudi, H., Zhang, K. & Shuler, M., Jun 15 2015, In : Current Biology. 25, 12, p. 1551-1561 11 p., 11971.

Research output: Contribution to journalArticle

cholinergic agents
conditioned behavior
Visual Cortex
Reward
Cholinergic Agents

Theta oscillations in visual cortex emerge with experience to convey expected reward time and experienced reward rate

Zold, C. L. & Shuler, M., Jul 1 2015, In : Journal of Neuroscience. 35, 26, p. 9603-9614 12 p.

Research output: Contribution to journalArticle

Visual Cortex
Reward
Cues
Visual Perception
Learning

Visually cued action timing in the primary visual cortex

Namboodiri, V. M. K., Huertas, M. A., Monk, K. J., Shouval, H. Z. & Shuler, M., Apr 8 2015, In : Neuron. 86, 1, p. 319-330 12 p.

Research output: Contribution to journalArticle

Visual Cortex
Optogenetics
Automatic Data Processing
Decision Making
Drive
2014

A general theory of intertemporal decision-making and the perception of time

Namboodiri, V. M. K., Mihalas, S., Marton, T. M. & Shuler, M., Feb 28 2014, In : Frontiers in Behavioral Neuroscience. 8, FEB, 61.

Research output: Contribution to journalArticle

Time Perception
Reward
Animal Behavior
Delay Discounting

A temporal basis for weber’s law in value perception

Namboodiri, V. M. K., Mihalas, S. & Shuler, M., Oct 14 2014, In : Frontiers in Integrative Neuroscience. 8, OCT, 79.

Research output: Contribution to journalArticle

Reward
Noise
Decision Making
Time Perception
Aptitude

Report of interval timing or action?

Namboodiri, V. M. K. & Shuler, M., Jun 3 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 22

Research output: Contribution to journalArticle

Time Perception
Prefrontal Cortex
Action Potentials
Neurons

What does scalar timing tell us about neural dynamics?

Shouval, H. Z., Shuler, M., Agarwal, A. & Gavornik, J. P., Jun 19 2014, In : Frontiers in Human Neuroscience. 8, JUNE, 438.

Research output: Contribution to journalArticle

Animal Models
2013

A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex

Chubykin, A. A., Roach, E. B., Bear, M. F. & Shuler, M., Feb 20 2013, In : Neuron. 77, 4, p. 723-735 13 p.

Research output: Contribution to journalArticle

Visual Cortex
Reward
Cholinergic Agents
Muscarinic Receptors
Rodentia
2009

Learning reward timing in cortex through reward dependent expression of synaptic plasticity

Gavornik, J. P., Shuler, M., Loewenstein, Y., Bear, M. F. & Shouval, H. Z., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6826-6831 6 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Reward
Learning
Aptitude
Visual Cortex
2008

Cannabinoid Receptor Blockade Reveals Parallel Plasticity Mechanisms in Different Layers of Mouse Visual Cortex

Liu, C. H., Heynen, A. J., Shuler, M. & Bear, M. F., May 8 2008, In : Neuron. 58, 3, p. 340-345 6 p.

Research output: Contribution to journalArticle

ocular Dominance
Cannabinoid Receptors
Visual Cortex
Cannabinoid Receptor Antagonists
Therapeutic Uses
2006

Learning induces long-term potentiation in the hippocampus

Whitlock, J. R., Heynen, A. J., Shuler, M. & Bear, M. F., Aug 25 2006, In : Science. 313, 5790, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Hippocampus
Learning
Avoidance Learning
Glutamate Receptors

Reward timing in the primary visual cortex

Shuler, M. & Bear, M. F., Mar 17 2006, In : Science. 311, 5767, p. 1606-1609 4 p.

Research output: Contribution to journalArticle

Visual Cortex
Reward
Neurons
Brain
2004

Layer-specific somatosensory cortical activation during active tactile discrimination

Krupa, D. J., Wiest, M. C., Shuler, M., Laubach, M. & Nicolelis, M. A. L., Jun 25 2004, In : Science. 304, 5679, p. 1989-1992 4 p.

Research output: Contribution to journalArticle

Vibrissae
Touch
Somatosensory Cortex

Neuron/Target Plasticity in the Peripheral Gustatory System

Shuler, M., Krimm, R. F. & Hill, D. L., Apr 26 2004, In : Journal of Comparative Neurology. 472, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

Taste Buds
Neurons
Geniculate Ganglion
Tongue
Sodium-Restricted Diet
2002

Integration of bilateral whisker stimuli in rats: Role of the whisker barrel cortices

Shuler, M., Krupa, D. J. & Nicoleis, M. A. L., 2002, In : Cerebral Cortex. 12, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

Vibrissae
Aptitude
Somatosensory Cortex
Touch
Task Performance and Analysis
2001

Bilateral integration of whisker information in the primary somatosensory cortex of rats

Shuler, M., Krupa, D. J. & Nicolelis, M. A. L., Jul 15 2001, In : Journal of Neuroscience. 21, 14, p. 5251-5261 11 p.

Research output: Contribution to journalArticle

Vibrissae
Somatosensory Cortex
Touch
Neurons
Aptitude

Thalamocortical and corticocortical interactions in the somatosensory system

Nicolelis, M. A. L. & Shuler, M., 2001, In : Progress in Brain Research. 130, p. 89-110 22 p.

Research output: Contribution to journalArticle

Vibrissae
Somatosensory Cortex
Touch
Thalamus
Synaptic Transmission
1999

Independent component analyses for quantifying neuronal ensemble interactions

Laubach, M., Shuler, M. & Nicolelis, M. A. L., Dec 15 1999, In : Journal of Neuroscience Methods. 94, 1, p. 141-154 14 p.

Research output: Contribution to journalArticle

Principal Component Analysis
Neurons
Motor Cortex
Population
Analysis of Variance