Mark Ranek

2023

Growth hormone–releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice

Condor Capcha, J. M., Kamiar, A., Robleto, E., Saad, A. G., Cui, T., Wong, A., Villano, J., Zhong, W., Pekosz, A., Medina, E., Cai, R., Sha, W., Ranek, M. J., Webster, K. A., Schally, A. V., Jackson, R. M. & Shehadeh, L. A., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 48, e2308342120.

Research output: Contribution to journal › Article › peer-review

Open Access

Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation

Mishra, S., Ma, J., McKoy, D., Sasaki, M., Farinelli, F., Page, R. C., Ranek, M. J., Zachara, N. & Kass, D. A., Mar 17 2023, In: iScience. 26, 3, 106294.

Research output: Contribution to journal › Article › peer-review

Open Access

TSC2 S1365A mutation potently regulates CD8⁺ T cell function and differentiation and improves adoptive cellular cancer therapy

Patel, C. H., Dong, Y., Koleini, N., Wang, X., Dunkerly-Eyring, B. L., Wen, J., Ranek, M. J., Bartle, L. M., Henderson, D. B., Sagert, J., Kass, D. A. & Powell, J. D., 2023, In: JCI Insight. 8, 21, e167829.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8

Tarasov, K. V., Chakir, K., Riordon, D. R., Lyashkov, A. E., Ahmet, I., Perino, M. G., Silvester, A. J., Zhang, J., Wang, M., Lukyanenko, Y. O., Qu, J. H., Barrera, M. C. R., Juhaszova, M., Tarasova, Y. S., Ziman, B., Telljohann, R., Kumar, V., Ranek, M., Lammons, J., Bychkov, R., & 18 othersde Cabo, R., Jun, S., Keceli, G., Gupta, A., Yang, D., Aon, M. A., Adamo, L., Morrell, C. H., Otu, W., Carroll, C., Chambers, S., Paolocci, N., Huynh, T., Pacak, K., Weiss, R., Field, L., Sollott, S. J. & Lakatta, E. G., 2022, In: eLife. 11, e80949.

Research output: Contribution to journal › Article › peer-review

Open Access

Pathophysiology of heart failure and an overview of therapies

Ranek, M. J., Berthiaume, J. M., Kirk, J. A., Lyon, R. C., Sheikh, F., Jensen, B. C., Hoit, B. D., Butany, J., Tolend, M., Rao, V. & Willis, M. S., Jan 1 2022, Cardiovascular Pathology. Elsevier, p. 149-221 73 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt

Dunkerly-Eyring, B. L., Pan, S., Pinilla-Vera, M., McKoy, D., Mishra, S., Grajeda Martinez, M. I., Oeing, C. U., Ranek, M. J. & Kass, D. A., Jun 2022, In: Life science alliance. 5, 6, e202101169.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Editorial: Targeting Cardiac Proteotoxicity

Ranek, M. J., Bhuiyan, M. S. & Wang, X., Mar 25 2021, In: Frontiers in Physiology. 12, 669356.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Editorial: Post-translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease

Ranek, M. J., Gomes, A. V. & Su, H., Aug 30 2021, In: Frontiers in Physiology. 12, 745887.

Research output: Contribution to journal › Editorial › peer-review

Open Access

MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury

Oeing, C. U., Jun, S., Mishra, S., Dunkerly-Eyring, B. L., Chen, A., Grajeda, M. I., Tahir, U. A., Gerszten, R. E., Paolocci, N., Ranek, M. J. & Kass, D. A., Mar 5 2021, In: Circulation research. 128, 5, p. 639-651 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Pulmonary artery pulsatility index predicts right ventricular myofilament dysfunction in advanced human heart failure

Aslam, M. I., Jani, V., Lin, B. L., Dunkerly-Eyring, B., Livingston, C. E., Ramachandran, A., Ranek, M. J., Bedi, K. C., Margulies, K. B., Kass, D. A. & Hsu, S., Feb 2021, In: European Journal of Heart Failure. 23, 2, p. 339-341 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

2020

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Ranek, M. J., Oeing, C., Sanchez-Hodge, R., Kokkonen-Simon, K. M., Dillard, D., Aslam, M. I., Rainer, P. P., Mishra, S., Dunkerly-Eyring, B., Holewinski, R. J., Virus, C., Zhang, H., Mannion, M. M., Agrawal, V., Hahn, V., Lee, D. I., Sasaki, M., Van Eyk, J. E., Willis, M. S., Page, R. C., & 2 othersSchisler, J. C. & Kass, D. A., Dec 1 2020, In: Nature communications. 11, 1, 5237.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Phosphorylation Modifications Regulating Cardiac Protein Quality Control Mechanisms

Mishra, S., Dunkerly-Eyring, B. L., Keceli, G. & Ranek, M. J., Nov 12 2020, In: Frontiers in Physiology. 11, 593585.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

PKG1a Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy

Oeing, C. U., Nakamura, T., Pan, S., Mishra, S., Dunkerly-Eyring, B. L., Kokkonen-Simon, K. M., Lin, B. L., Chen, A., Zhu, G., Bedja, D., Lee, D. I., Kass, D. A. & Ranek, M. J., Jul 31 2020, In: Circulation research. 127, 4, p. 522-533 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Targeting Protein Kinase G to Treat Cardiac Proteotoxicity

Oeing, C. U., Mishra, S., Dunkerly-Eyring, B. L. & Ranek, M. J., Jul 28 2020, In: Frontiers in Physiology. 11, 858.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

2019

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M. J., Pantages, L., McFarland, M., Netherton, M. R., Berry, A., & 10 othersWong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Ranek, M. J., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In: Nature. 566, 7743, p. 264-269 6 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

2018

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M. J., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In: Nature communications. 9, 1, 5230.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M. J., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. I. & Kass, D. A., Aug 9 2018, In: JCI Insight. 3, 15, e121739.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In: Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S. B., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In: Circulation research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

The role of heat shock proteins and co-chaperones in heart failure

Ranek, M. J., Stachowski, M. J., Kirk, J. A. & Willis, M. S., Jan 19 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1738, 20160530.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

2017

Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart

Ranek, M. J., Vu, A., Willis, M. S. & Lymperopoulos, A., 2017, Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart. Elsevier Inc., p. 207-227 21 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2016

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M. J., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P., & 7 othersHeymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., Jun 27 2016, In: Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Pathophysiology of Heart Failure and an Overview of Therapies

Berthiaume, J. M., Kirk, J. A., Ranek, M. J., Lyon, R. C., Sheikh, F., Jensen, B. C., Hoit, B. D., Butany, J., Tolend, M., Rao, V. & Willis, M. S., Jan 1 2016, Cardiovascular Pathology: Fourth Edition. Elsevier Inc., p. 271-339 69 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2015

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure

Parry, T. L., Melehani, J. H., Ranek, M. J. & Willis, M. S., May 19 2015, In: Frontiers in Cardiovascular Medicine. 2, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M. J., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In: Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D. I., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M. J., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In: Nature. 519, 7544, p. 472-476 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Scopus citations

Prevention of PKG1a oxidation augments cardioprotection in the stressed heart

Nakamura, T., Ranek, M. J., Lee, D. I., Hahn, V. S., Kim, C., Eaton, P. & Kass, D. A., Jun 1 2015, In: Journal of Clinical Investigation. 125, 6, p. 2468-2472 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse

Zhu, G., Groneberg, D., Sikka, G., Hori, D., Ranek, M. J., Nakamura, T., Takimoto, E., Paolocci, N., Berkowitz, D. E., Friebe, A. & Kass, D. A., Feb 21 2015, In: Hypertension. 65, 2, p. 385-392 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2014

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M. J., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Apr 2014, In: Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

The Pathophysiology of Cardiac Hypertrophy and Heart Failure

Stansfield, W. E., Ranek, M., Pendse, A., Schisler, J. C., Wang, S., Pulinilkunnil, T. & Willis, M. S., Jan 2014, Cellular and Molecular Pathobiology of Cardiovascular Disease. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter