Mark Ranek

Assistant Professor

20082019
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Research Output 2008 2019

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Article
2019

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Heart Diseases
Fibrosis
Kidney
NFATC Transcription Factors
Gene Expression
2018

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Histone Demethylases
fibrosis
lysine
Cardiomegaly
Left Ventricular Hypertrophy

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. & Kass, D. A., Aug 9 2018, In : JCI insight. 3, 15

Research output: Contribution to journalArticle

Cyclic GMP
MicroRNAs
Heart Diseases
Pressure
Nitric Oxide

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access
Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Constriction
Cardiomegaly
Muscle Cells

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Phosphotransferases
Heart Failure
Sudden Cardiac Death
2016

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P. & 7 others, Heymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journalArticle

Myofibrils
Mast Cells
Myocardial Infarction
Calcium
Cardiac Myocytes
2015

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cardiac Myocytes
Heart Failure
Ubiquitin
Constriction

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In : Nature. 519, 7544, p. 472-476 5 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Type 5 Cyclic Nucleotide Phosphodiesterases
Heart Diseases
Nitric Oxide

Prevention of PKG1a oxidation augments cardioprotection in the stressed heart

Nakamura, T., Ranek, M., Lee, D., Hahn, V. S., Kim, C., Eaton, P. & Kass, D. A., Jun 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2468-2472 5 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Heart Diseases
Rodent Diseases
Transient Receptor Potential Channels
Cyclic GMP-Dependent Protein Kinases

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse

Zhu, G., Groneberg, D., Sikka, G., Hori, D., Ranek, M., Nakamura, T., Takimoto, E., Paolocci, N., Berkowitz, D. E., Friebe, A. & Kass, D. A., Feb 21 2015, In : Hypertension. 65, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

Vasodilation
Cyclic GMP-Dependent Protein Kinases
Oxidation-Reduction
Vasodilator Agents
Cysteine
2014

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Muscarinic Receptors
Proteasome Endopeptidase Complex
Proteolysis
Peptide Hydrolases
2013

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Proteasome Endopeptidase Complex
Proteolysis
Ubiquitin
Ubiquitinated Proteins
2011

Albert szent-györgyi, MD, PhD: Discoverer of vitamin C and a pioneer of cellular respiration, muscle physiology, and cancer development

Ranek, M., Cotten, S. W. & Willis, M. S., Nov 1 2011, In : Laboratory Medicine. 42, 11, p. 694-698 5 p.

Research output: Contribution to journalArticle

Muscle Neoplasms
Cell Respiration
Ascorbic Acid

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

Desmin
Autophagy
Cardiac Myocytes
Cardiomyopathies
Muscle Cells

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Autophagy
Proteasome Endopeptidase Complex
Necrosis
Ubiquitin