Mark Ranek

Assistant Professor

20082019

Research output per year

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Research Output

2019

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Ranek, M., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J. E., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In : Nature. 566, 7743, p. 264-269 6 p.

Research output: Contribution to journalLetter

2018

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. & Kass, D. A., Aug 9 2018, In : JCI insight. 3, 15

Research output: Contribution to journalArticle

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

The role of heat shock proteins and co-chaperones in heart failure

Ranek, M., Stachowski, M. J., Kirk, J. A. & Willis, M. S., Jan 19 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1738, 20160530.

Research output: Contribution to journalReview article

2016

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P. & 7 others, Heymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journalArticle

Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart

Ranek, M., Vu, A., Willis, M. S. & Lymperopoulos, A., Nov 4 2016, Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart. Elsevier Inc., p. 207-227 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journalArticle

Pathophysiology of Heart Failure and an Overview of Therapies

Berthiaume, J. M., Kirk, J. A., Ranek, M., Lyon, R. C., Sheikh, F., Jensen, B. C., Hoit, B. D., Butany, J., Tolend, M., Rao, V. & Willis, M. S., Jan 1 2015, Cardiovascular Pathology: Fourth Edition. Elsevier Inc., p. 271-339 69 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In : Nature. 519, 7544, p. 472-476 5 p.

Research output: Contribution to journalArticle

Prevention of PKG1a oxidation augments cardioprotection in the stressed heart

Nakamura, T., Ranek, M., Lee, D., Hahn, V. S., Kim, C., Eaton, P. & Kass, D. A., Jun 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2468-2472 5 p.

Research output: Contribution to journalArticle

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse

Zhu, G., Groneberg, D., Sikka, G., Hori, D., Ranek, M., Nakamura, T., Takimoto, E., Paolocci, N., Berkowitz, D. E., Friebe, A. & Kass, D. A., Feb 21 2015, In : Hypertension. 65, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

2014

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

The Pathophysiology of Cardiac Hypertrophy and Heart Failure

Stansfield, W. E., Ranek, M., Pendse, A., Schisler, J. C., Wang, S., Pulinilkunnil, T. & Willis, M. S., Jan 1 2014, Cellular and Molecular Pathobiology of Cardiovascular Disease. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

2011

Albert szent-györgyi, MD, PhD: Discoverer of vitamin C and a pioneer of cellular respiration, muscle physiology, and cancer development

Ranek, M., Cotten, S. W. & Willis, M. S., Nov 1 2011, In : Laboratory Medicine. 42, 11, p. 694-698 5 p.

Research output: Contribution to journalArticle

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

2009

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy

Wang, X. & Ranek, M., Dec 1 2009, In : Current Hypertension Reports. 11, 6, p. 389-395 7 p.

Research output: Contribution to journalReview article

2008

Protein quality control and degradation in cardiomyocytes

Wang, X., Su, H. & Ranek, M., Jul 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 1, p. 11-27 17 p.

Research output: Contribution to journalReview article