Mark Ranek

Assistant Professor


Research output per year

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Research Output

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M. J., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

  • PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

    Ranek, M., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J. E., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In : Nature. 566, 7743, p. 264-269 6 p.

    Research output: Contribution to journalLetter

  • Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

    Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

    Research output: Contribution to journalArticle

  • Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

    Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M. J., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. I. & Kass, D. A., Aug 9 2018, In : JCI Insight. 3, 15, e121739.

    Research output: Contribution to journalArticle

  • Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

    Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

    Research output: Contribution to journalArticle

    Open Access