Mark Ranek

Assistant Professor

20082019
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Fingerprint Dive into the research topics where Mark Ranek is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Cyclic GMP-Dependent Protein Kinases Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Proteasome Endopeptidase Complex Medicine & Life Sciences
Heart Diseases Medicine & Life Sciences
Heart Failure Medicine & Life Sciences
Cardiomegaly Medicine & Life Sciences
Cyclic GMP Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences

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Research Output 2008 2019

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Heart Diseases
Fibrosis
Kidney
NFATC Transcription Factors
Gene Expression

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Ranek, M., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J. E., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In : Nature. 566, 7743, p. 264-269 6 p.

Research output: Contribution to journalLetter

Protein Kinases
Phosphorylation
Autophagy
Serine
Heart Diseases

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Histone Demethylases
fibrosis
lysine
Cardiomegaly
Left Ventricular Hypertrophy

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. & Kass, D. A., Aug 9 2018, In : JCI insight. 3, 15

Research output: Contribution to journalArticle

Cyclic GMP
MicroRNAs
Heart Diseases
Pressure
Nitric Oxide

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access
Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Constriction
Cardiomegaly
Muscle Cells