Mark Lazarev

Assistant Professor

20082018
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Research Output 2008 2018

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Article
2018

Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis

Adler, B., Pezhouh, M. K., Kim, A., Luan, L., Zhu, Q., Gani, F., Yarchoan, M., Chen, J., Voltaggio, L., Parian, A., Lazarev, M., Lauwers, G. Y., Pawlik, T. M., Montgomery, E. A., Jaffee, E., Le, D., Taube, J. M. & Anders, R. A., Jan 1 2018, (Accepted/In press) In : Journal of Internal Medicine.

Research output: Contribution to journalArticle

Colitis
Ulcerative Colitis
ipilimumab
Biopsy
Inflammatory Bowel Diseases

Low Incidence of Dysplasia and Colorectal Cancer Observed among Inflammatory Bowel Disease Patients with Prolonged Colonic Diversion

Bettner, W., Rizzo, A., Brant, S., Dudley-Brown, S., Efron, J., Fang, S. H., Gearhart, S. L., Marohn, M., Parian, A., Kherad Pezhouh, M., Melia, J., Safar, B., Truta, B., Wick, E. & Lazarev, M., Apr 23 2018, In : Inflammatory Bowel Diseases. 24, 5, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colorectal Neoplasms
Incidence
Ulcerative Colitis
Crohn Disease

Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus–encoded small RNA1 in situ hybridization

Pezhouh, M. K., Miller, J. A., Sharma, R., Borzik, D., Eze, O., Waters, K., Westerhoff, M. A., Parian, A., Lazarev, M. & Voltaggio, L., Dec 1 2018, In : Human Pathology. 82, p. 187-192 6 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Inflammatory Bowel Diseases
In Situ Hybridization
Epstein-Barr Virus Infections
Ulcerative Colitis

Serrated colorectal lesions in patients with inflammatory bowel disease

Parian, A. & Lazarev, M., Jan 1 2018, In : Gastroenterology and Hepatology. 14, 1, p. 19-25 7 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colorectal Neoplasms
Polyps
Adenoma
Colitis

Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

Wang, P., Hu, J., Ghadermarzi, S., Raza, A., O’Connell, D., Xiao, A., Ayyaz, F., Zhi, M., Zhang, Y., Parekh, N. K., Lazarev, M., Parian, A., Brant, S. R., Bedine, M. S., Truta, B., Hu, P., Banerjee, R. & Hutfless, S., Jun 4 2018, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
India
China
Smoking
Crohn Disease
2017

Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis

Jain, A., Lipson, E., Sharfman, W., Brant, S. R. & Lazarev, M., Mar 21 2017, In : World Journal of Gastroenterology. 23, 11, p. 2023-2028 6 p.

Research output: Contribution to journalArticle

Enterocolitis
Steroids
Diarrhea
Ulcer
Sigmoidoscopy

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease

Brant, S. R., Okou, D. T., Simpson, C. L., Cutler, D. J., Haritunians, T., Bradfield, J. P., Chopra, P., Prince, J., Begum, F., Kumar, A., Huang, C., Venkateswaran, S., Datta, L., Wei, Z., Thomas, K., Herrinton, L. J., Klapproth, J. M. A., Quiros, A. J., Seminerio, J., Liu, Z. & 41 others, Alexander, J. S., Baldassano, R. N., Dudley-Brown, S., Cross, R. K., Dassopoulos, T., Denson, L. A., Dhere, T. A., Dryden, G. W., Hanson, J. S., Hou, J. K., Hussain, S. Z., Hyams, J. S., Isaacs, K. L., Kader, H., Kappelman, M. D., Katz, J., Kellermayer, R., Kirschner, B. S., Kuemmerle, J. F., Kwon, J. H., Lazarev, M., Li, E., Mack, D., Mannon, P., Moulton, D. E., Newberry, R. D., Osuntokun, B. O., Patel, A. S., Saeed, S. A., Targan, S. R., Valentine, J. F., Wang, M. H., Zonca, M., Rioux, J. D., Duerr, R. H., Silverberg, M. S., Cho, J. H., Hakonarson, H., Zwick, M. E., McGovern, D. P. B. & Kugathasan, S., Jan 1 2017, In : Gastroenterology. 152, 1, p. 206-217.e2

Research output: Contribution to journalArticle

Genome-Wide Association Study
Inflammatory Bowel Diseases
African Americans
Ulcerative Colitis
Single Nucleotide Polymorphism
Inflammatory Bowel Diseases
Colorectal Neoplasms
Colectomy
Colonoscopy
Colitis

Routine Pouchoscopy Prior to Ileostomy Takedown May Not Be Necessary in Patients with Chronic Ulcerative Colitis

Cai, J. X., Barrow, J., Parian, A., Brant, S. R., Dudley-Brown, S., Efron, J., Fang, S. H., Gearhart, S. L., Marohn, M., Safar, B., Truta, B., Wick, E. & Lazarev, M., Jun 9 2017, (Accepted/In press) In : Digestive Diseases.

Research output: Contribution to journalArticle

Ileostomy
Ulcerative Colitis
Colonic Pouches
Pouchitis
Inflammatory Bowel Diseases

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

Liu, L., Dong, Y., Ye, M., Jin, S., Yang, J., Joosse, M. E., Sun, Y., Zhang, J., Lazarev, M., Brant, S. R., Safar, B., Marohn, M., Mezey, E. & Li, X., Jun 1 2017, In : Journal of Crohn's & colitis. 11, 6, p. 737-750 14 p.

Research output: Contribution to journalArticle

Inflammasomes
Inflammatory Bowel Diseases
Interleukin-10
Glyburide
Colitis
2016

Appendectomy does not decrease the risk of future colectomy in UC: Results from a large cohort and meta-analysis

Parian, A., Limketkai, B., Koh, J., Brant, S. R., Bitton, A., Cho, J. H., Duerr, R. H., McGovern, D. P., Proctor, D. D., Regueiro, M. D., Rioux, J. D., Schumm, P., Taylor, K. D., Silverberg, M. S., Steinhart, A. H., Hernaez, R. & Lazarev, M., Apr 13 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Appendectomy
Colectomy
Meta-Analysis
Cohort Studies
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

Compartment-specific immunity in the human gut: Properties and functions of dendritic cells in the colon versus the ileum

Mann, E. R., Bernardo, D., English, N. R., Landy, J., Al-Hassi, H. O., Peake, S. T. C., Man, R., Elliott, T. R., Spranger, H., Lee, G. H., Parian, A., Brant, S. R., Lazarev, M., Hart, A. L., Li, X. & Knight, S. C., Feb 1 2016, In : Gut. 65, 2, p. 256-270 15 p.

Research output: Contribution to journalArticle

Ileum
Dendritic Cells
Immunity
Colon
Bacterial Load

Development and reliability of the new endoscopic virtual chromoendoscopy score: The PICaSSO (Paddington International Virtual ChromoendoScopy ScOre) in ulcerative colitis

Iacucci, M., Daperno, M., Lazarev, M., Arsenascu, R., Tontini, G. E., Akinola, O., Gui, X. S., Villanacci, V., Goetz, M., Lowerison, M., Lethebe, B. C., Vecchi, M., Neumann, H., Ghosh, S., Bisschops, R. & Kiesslich, R., Oct 29 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Ulcerative Colitis
Blood Vessels
Inflammation
Logistic Models
Surgical Instruments

Inflammatory bowel disease associated neoplasia: A surgeon's perspective

Althumairi, A. A., Lazarev, M. & Gearhart, S. L., Jan 21 2016, In : World Journal of Gastroenterology. 22, 3, p. 961-973 13 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colorectal Neoplasms
Neoplasms
Sclerosing Cholangitis
Observer Variation
2015

Anti-tumor necrosis factor-α antibody therapy management before and after intestinal surgery for inflammatory bowel disease: A CCFA position paper

Holubar, S. D., Holder-Murray, J., Flasar, M. & Lazarev, M., Jul 25 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2658-2672 15 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Tumor Necrosis Factor-alpha
Perioperative Period
Antibodies
Ostomy

Association between serrated epithelial changes and colorectal dysplasia in inflammatory bowel disease

Parian, A., Koh, J., Limketkai, B. N., Eluri, S., Rubin, D. T., Brant, S. R., Ha, C. Y., Bayless, T. M., Giardiello, F. M., Hart, J., Montgomery, E. & Lazarev, M., Aug 8 2015, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colorectal Neoplasms
Pathology
Colitis
Information Systems

Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans

Huang, C., Haritunians, T., Okou, D. T., Cutler, D. J., Zwick, M. E., Taylor, K. D., Datta, L., Maranville, J. C., Liu, Z., Ellis, S., Chopra, P., Alexander, J. S., Baldassano, R. N., Cross, R. K., Dassopoulos, T., Dhere, T. A., Duerr, R. H., Hanson, J. S., Hou, J. K., Hussain, S. Z. & 34 others, Isaacs, K. L., Kachelries, K. E., Kader, H., Kappelman, M. D., Katz, J., Kellermayer, R., Kirschner, B. S., Kuemmerle, J. F., Kumar, A., Kwon, J. H., Lazarev, M., Mannon, P., Moulton, D. E., Osuntokun, B. O., Patel, A., Rioux, J. D., Rotter, J. I., Saeed, S., Scherl, E. J., Silverberg, M. S., Silverman, A., Targan, S. R., Valentine, J. F., Wang, M. H., Simpson, C. L., Bridges, S. L., Kimberly, R. P., Rich, S. S., Cho, J. H., Di Rienzo, A., Kao, L. W. H., McGovern, D. P. B., Brant, S. R. & Kugathasan, S., Nov 1 2015, In : Gastroenterology. 149, 6, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

Genetic Loci
Inflammatory Bowel Diseases
African Americans
Single Nucleotide Polymorphism
Ulcerative Colitis

Optimizing perioperative Crohn's disease management: Role of coordinated medical and surgical care

Bennett, J. L., Ha, C. Y., Efron, J., Gearhart, S. L., Lazarev, M. & Wick, E. C., Jan 28 2015, In : World Journal of Gastroenterology. 21, 4, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

Disease Management
Crohn Disease
Colonoscopy
Tertiary Care Centers
Gastroenterology

The bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E., Lazarev, M., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., Platz, E. A., Pardoll, A. M. & Sears, C. L., Jan 15 2015, In : Clinical Infectious Diseases. 60, 2, p. 208-215 8 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colorectal Neoplasms
Colon
Mucous Membrane
Genes
Inflammatory Bowel Diseases
Inflammation
Neoplasms
Intestinal Neoplasms
Sclerosing Cholangitis
2014

Best practices in the diagnosis and treatment of inflammatory bowel disease

Lazarev, M., 2014, In : Journal of Managed Care Medicine. 17, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Practice Guidelines
Intestinal Mucosa
Therapeutics
Quality of Life

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossettid, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., Stein, E., Vadivelu, J., Roslani, A. C., Malik, A. A., Wanyiri, J. W., Goh, K. L., Thevambiga, I., Fu, K., Wan, F., Llosa, N. & 9 others, Housseau, F., Romans, K., Wu, X., McAllister, F. M., Wu, S., Vogelstein, B., Kinzler, K. W., Pardoll, A. M. & Sears, C. L., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18321-18326 6 p.

Research output: Contribution to journalArticle

Microbiota
Colorectal Neoplasms
Biofilms
Neoplasms
Mucous Membrane
2013

Relationship between proximal Crohn's disease location and disease behavior and surgery: A cross-sectional study of the IBD genetics consortium

Lazarev, M., Huang, C., Bitton, A., Cho, J. H., Duerr, R. H., McGovern, D. P., Proctor, D. D., Regueiro, M., Rioux, J. D., Schumm, P. P., Taylor, K. D., Silverberg, M. S., Hillary Steinhart, A., Hutfless, S. & Brant, S. R., Jan 2013, In : American Journal of Gastroenterology. 108, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Crohn Disease
Cross-Sectional Studies
Jejunal Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
T-Cell Lymphoma
Crohn Disease
United States Food and Drug Administration
PubMed
Causality
2012

The effect of intravenous cyclosporine on rates of colonic surgery in hospitalized patients with severe Crohn's colitis

Lazarev, M., Present, D. H., Lichtiger, S., Kornbluth, A., Marion, J., Chapman, M. & Ullman, T. A., Oct 2012, In : Journal of Clinical Gastroenterology. 46, 9, p. 764-767 4 p.

Research output: Contribution to journalArticle

Colitis
Cyclosporine
Medical Records
Inpatients
Hospitalization

Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers

Olaru, A. V., Cheng, Y., Agarwal, R., Yang, J., David, S., Abraham, J. M., Yu, W., Kwon, J. H., Lazarev, M., Brant, S. R., Marohn, M., Hutcheon, D. F., Harpaz, N., Meltzer, S. & Mori, Y., Apr 2012, In : Inflammatory Bowel Diseases. 18, 4, p. 641-648 8 p.

Research output: Contribution to journalArticle

CpG Islands
Inflammatory Bowel Diseases
Methylation
Colorectal Neoplasms
Phenotype
2011

Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning

Mori, Y., Olaru, A. V., Cheng, Y., Agarwal, R., Yang, J., Luvsanjav, D., Yu, W., Selaru, F., Hutfless, S., Lazarev, M., Kwon, J. H., Brant, S. R., Marohn, M., Hutcheon, D. F., Duncan, M. D., Goel, A. & Meltzer, S., Aug 2011, In : Endocrine-Related Cancer. 18, 4, p. 465-478 14 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Methylation
Colorectal Neoplasms
Homeobox Genes
Adenoma
2010

Small bowel resection rates in Crohn's disease and the indication for surgery over time: Experience from a large tertiary care center

Lazarev, M., Uliman, T., Schraut, W. H., Kip, K. E., Saul, M. & Regueiro, M., 2010, In : Inflammatory Bowel Diseases. 16, 5, p. 830-835 6 p.

Research output: Contribution to journalArticle

Tertiary Care Centers
Crohn Disease
Tumor Necrosis Factor-alpha
Immunologic Factors
International Classification of Diseases
2009

Scope Early and Often in Ulcerative Colitis and Crohn's Colitis?

Ullman, T. & Lazarev, M., Feb 2009, In : Gastroenterology. 136, 2, p. 718-719 2 p.

Research output: Contribution to journalArticle

Colitis
Ulcerative Colitis
2008

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?

Lazarev, M., Lamb, J., Barmada, M. M., Dai, F., Anderson, M. A., Max, M. B. & Whitcomb, D. C., Nov 17 2008, In : Molecular Pain. 4, 58.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Chronic Pancreatitis
Haplotypes
Pain
Pancreatitis