Mark Kohr

Assistant Professor

20052019
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Research Output 2005 2019

2019

A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release

Fillmore, N., Casin, K. M., Sinha, P., Sun, J., Ma, H., Boylston, J., Noguchi, A., Liu, C., Wang, N., Zhou, G., Kohr, M. & Murphy, E., Nov 1 2019, In : Journal of Molecular and Cellular Cardiology. 136, p. 95-101 7 p.

Research output: Contribution to journalArticle

Cysteine
Reperfusion Injury
Mutation
Insulin Resistance
Ischemia

Inorganic arsenic exposure induces sex-disparate effects and exacerbates ischemia-reperfusion injury in the female heart

Veenema, R., Casin, K. M., Sinha, P., Kabir, R., Mackowski, N., Taube, N., Bedja, D., Chen, R., Rule, A. M. & Kohr, M., May 1 2019, In : American journal of physiology. Heart and circulatory physiology. 316, 5, p. H1053-H1064

Research output: Contribution to journalArticle

Arsenic
Reperfusion Injury
Heart Injuries
Myocardial Ischemia
Myocardial Reperfusion Injury

miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Banavath, H. N., Roman, B., Mackowski, N., Biswas, D., Afzal, J., Nomura, Y., Solhjoo, S., O'Rourke, B., Kohr, M., Murphy, E., Steenbergen, C. & Das, S., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e012919

Research output: Contribution to journalArticle

Open Access
Calcium
Reperfusion Injury
Mitochondria
Muscle Cells
Small Interfering RNA

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

Bian, Z., Wang, Q., Zhou, X., Tan, T., Park, K. H., Kramer, H. F., McDougal, A., Laping, N. J., Kumar, S., Adesanya, T. M. A., Sermersheim, M., Yi, F., Wang, X., Wu, J., Gumpper, K., Jiang, Q., He, D., Lin, P. H., Li, H., Guan, F. & 5 others, Zhou, J., Kohr, M., Zeng, C., Zhu, H. & Ma, J., Dec 1 2019, In : Nature communications. 10, 1, 4659.

Research output: Contribution to journalArticle

Open Access
mice
Muscle
Tissue
Repair
muscles

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian, R., Colucci, W. S., Arany, Z., Bachschmid, M. M., Ballinger, S. W., Boudina, S., Bruce, J. E., Busija, D. W., Dikalov, S., Dorn, G. W., Galis, Z. S., Gottlieb, R. A., Kelly, D. P., Kitsis, R. N., Kohr, M. J., Levy, D., Lewandowski, E. D., McClung, J. M., Mochly-Rosen, D., O'Brien, K. D. & 12 others, O'Rourke, B., Park, J. Y., Ping, P., Sack, M. N., Sheu, S. S., Shi, Y., Shiva, S., Wallace, D. C., Weiss, R. G., Vernon, H. J., Wong, R. & Schwartz Longacre, L., Oct 1 2019, In : Circulation. 140, 14, p. 1205-1216 12 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Cardiovascular System
Mitochondria
Heart Failure
Education
2018

S-Nitrosoglutathione Reductase Is Essential for Protecting the Female Heart From Ischemia-Reperfusion Injury

Casin, K. M., Fallica, J., Mackowski, N., Veenema, R. J., Chan, A., St Paul, A., Zhu, G., Bedja, D., Biswal, S. & Kohr, M., Nov 9 2018, In : Circulation Research. 123, 11, p. 1232-1243 12 p.

Research output: Contribution to journalArticle

glutathione-independent formaldehyde dehydrogenase
Reperfusion Injury
NADH Dehydrogenase
Formaldehyde
Myocardial Ischemia
2017

Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts

Shao, Q., Casin, K. M., Mackowski, N., Murphy, E., Steenbergen, C. J. & Kohr, M., May 1 2017, In : PLoS One. 12, 5, e0177315.

Research output: Contribution to journalArticle

S-Nitrosothiols
Adenosine A1 Receptors
Protein S
adenosine
ischemia

Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets

Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C. J., 2017, In : Journal of the American Heart Association. 6, 3, e004694.

Research output: Contribution to journalArticle

MicroRNAs
Phosphoric Monoester Hydrolases
Porifera
Oxidative Stress
Gene Expression

Kcnj11 Ablation Is Associated with Increased Nitro-Oxidative Stress during Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy

Zhang, B., Novitskaya, T., Wheeler, D. G., Xu, Z., Chepurko, E., Huttinger, R., He, H., Varadharaj, S., Zweier, J. L., Song, Y., Xu, M., Harrell, F. E., Su, Y. R., Absi, T., Kohr, M., Ziolo, M. T., Roden, D. M., Shaffer, C. M., Galindo, C. L., Wells, Q. S. & 1 others, Gumina, R. J., Feb 1 2017, In : Circulation: Heart Failure. 10, 2, e003523.

Research output: Contribution to journalArticle

Reperfusion Injury
Cardiomyopathies
Reticulum
Oxidative Stress
Calcium-Transporting ATPases
2016

Characterization of the sex-dependent myocardial S-nitrosothiol proteome

Shao, Q., Fallica, J., Casin, K. M., Murphy, E., Steenbergen, C. J. & Kohr, M., Feb 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 4, p. H505-H515

Research output: Contribution to journalArticle

S-Nitrosothiols
Proteome
Protein S
Ischemic Preconditioning
Calcium-Transporting ATPases
2015

Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: Is protein S-nitrosylation involved?

Kovács, M., Kiss, A., Gönczi, M., Miskolczi, G., Seprényi, G., Kaszaki, J., Kohr, M., Murphy, E. & Végh, Á., Apr 24 2015, In : PLoS One. 10, 4, e0122243.

Research output: Contribution to journalArticle

Sodium Nitrite
sodium nitrite
Protein S
arrhythmia
Nitrites

Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria

Sun, J., Nguyen, T., Aponte, A. M., Menazza, S., Kohr, M., Roth, D. M., Patel, H. H., Murphy, E. & Steenbergen, C. J., May 1 2015, In : Cardiovascular Research. 106, 2, p. 227-236 10 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein S
Mitochondria
Caveolin 3
Caveolae
Cardiotonic Agents
Myocardial Reperfusion Injury
Recombinant Proteins
Carrier Proteins
Biomarkers
2014

Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart

Kohr, M., Murphy, E. & Steenbergen, C. J., Oct 27 2014, In : PLoS One. 9, 10, e111448.

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
glyceraldehyde-3-phosphate dehydrogenase
heart
Mitochondrial Proteins
Mitochondria

Postconditioning leads to an increase in protein S-nitrosylation

Tong, G., Aponte, A. M., Kohr, M., Steenbergen, C. J., Murphy, E. & Sun, J., Mar 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 6

Research output: Contribution to journalArticle

Protein S
Reperfusion
NG-Nitroarginine Methyl Ester
Ischemia
Cyclic GMP-Dependent Protein Kinases

Signaling by S-nitrosylation in the heart

Murphy, E., Kohr, M., Menazza, S., Nguyen, T., Evangelista, A., Sun, J. & Steenbergen, C. J., 2014, In : Journal of Molecular and Cellular Cardiology. 73, p. 18-25 8 p.

Research output: Contribution to journalArticle

Nitric Oxide
Cardiovascular System
Oxidation-Reduction
Cysteine
Nobel Prize
Proteolysis
Cysteine
Cell Death
Cell Survival
Cardiac Myocytes
2013

Essential role of nitric oxide in acute ischemic preconditioning: S-Nitros(yl)ation versus sGC/cGMP/PKG signaling?

Sun, J., Aponte, A. M., Kohr, M., Tong, G., Steenbergen, C. J. & Murphy, E., Jan 2013, In : Free Radical Biology and Medicine. 54, p. 105-112 8 p.

Research output: Contribution to journalArticle

Guanylate Kinases
Cyclic GMP-Dependent Protein Kinases
Ischemic Preconditioning
Guanylate Cyclase
Cyclic GMP

S-Nitrosylation: Specificity, occupancy, and interaction with other post-translational modifications

Evangelista, A. M., Kohr, M. & Murphy, E., Oct 10 2013, In : Antioxidants and Redox Signaling. 19, 11, p. 1209-1219 11 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Oxidation-Reduction
Cysteine
Physiology
Research
2012

Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore (Journal of Biological Chemistry (2011) 286 (40184-40192))

Nguyen, T. T., Stevens, M. V., Kohr, M., Steenbergen, C. J., Sack, M. N. & Murphy, E., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34496-34498 3 p.

Research output: Contribution to journalArticle

Cysteine
Chemical activation
cyclophilin D
mitochondrial permeability transition pore

Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteins

Sun, J., Kohr, M., Nguyen, T., Aponte, A. M., Connelly, P. S., Esfahani, S. G., Gucek, M., Daniels, M. P., Steenbergen, C. J. & Murphy, E., Jan 1 2012, In : Antioxidants and Redox Signaling. 16, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

Caveolae
Ischemic Preconditioning
Mitochondrial Proteins
Mitochondria
Nitric Oxide

Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags: Short communication

Kohr, M., Aponte, A., Sun, J., Gucek, M., Steenbergen, C. J. & Murphy, E., Oct 26 2012, In : Circulation Research. 111, 10, p. 1308-1312 5 p.

Research output: Contribution to journalArticle

Cysteine
Myocardium
S-Nitrosoglutathione
Ischemic Preconditioning
Proteins

Modulation of myocardial contraction by peroxynitrite

Kohr, M., Roof, S. R., Zweier, J. L. & Ziolo, M. T., 2012, In : Frontiers in Physiology. 3 DEC, Article 468.

Research output: Contribution to journalArticle

Myocardial Contraction
Peroxynitrous Acid
Cardiac Myocytes
Cardiovascular System
Oxidants

S-nitrosylation: A radical way to protect the heart

Murphy, E., Kohr, M., Sun, J., Nguyen, T. & Steenbergen, C. J., Mar 2012, In : Journal of Molecular and Cellular Cardiology. 52, 3, p. 568-577 10 p.

Research output: Contribution to journalArticle

Protein S
Post Translational Protein Processing
Nitric Oxide Synthase
Proteins
2011

Characterization of potential S-nitrosylation sites in the myocardium

Kohr, M., Aponte, A. M., Sun, J., Wang, G., Murphy, E., Gucek, M. & Steenbergen, C. J., Apr 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 4

Research output: Contribution to journalArticle

Myocardium
Protein S
Proteome
Proteins
Cardiovascular Physiological Phenomena

Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore

Nguyen, T. T., Stevens, M. V., Kohr, M., Steenbergen, C. J., Sack, M. N. & Murphy, E., Nov 18 2011, In : Journal of Biological Chemistry. 286, 46, p. 40184-40192 9 p.

Research output: Contribution to journalArticle

Cysteine
Chemical activation
Fibroblasts
mitochondrial permeability transition pore
cyclophilin D

Mechanism of cardioprotection: What can we learn from females?

Murphy, E., Lagranha, C., Deschamps, A., Kohr, M., Nguyen, T., Wong, R., Sun, J. & Steenbergen, C. J., Mar 2011, In : Pediatric Cardiology. 32, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Estrogens
Estrogen Receptor beta
Estrogen Receptor alpha
G-Protein-Coupled Receptors
Phosphatidylinositol 3-Kinases

Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia/reperfusion injury with resin-assisted capture

Kohr, M., Sun, J., Aponte, A., Wang, G., Gucek, M., Murphy, E. & Steenbergen, C. J., Feb 18 2011, In : Circulation Research. 108, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein S
Reperfusion Injury
Reperfusion
Ischemia
2010

cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes

Kohr, M., Traynham, C. J., Roof, S. R., Davis, J. P. & Ziolo, M. T., Apr 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 645-648 4 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cyclic AMP-Dependent Protein Kinases
Cardiac Myocytes
Muscle Cells
Phosphoric Monoester Hydrolases

Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling

Kohr, M., Kaludercic, N., Tocchetti, C. G., Gao, W. D., Kass, D. A., Janssen, P. M. L., Paolocci, N. & Ziolo, M. T., Jan 1 2010, In : Frontiers in Bioscience - Elite. 2 E, 2, p. 614-626 13 p.

Research output: Contribution to journalArticle

Muscle Cells
Action Potentials
Cardiac Myocytes
Myocardial Contraction
Nitrites

Regulation of myocyte contraction via neuronal nitric oxide synthase: Role of ryanodine receptor S-nitrosylation

Wang, H., Viatchenko-Karpinski, S., Sun, J., Györke, I., Benkusky, N. A., Kohr, M., Valdivia, H. H., Murphy, E., Györke, S. & Ziolo, M. T., Aug 2010, In : Journal of Physiology. 588, 15, p. 2905-2917 13 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Ryanodine Receptor Calcium Release Channel
Muscle Cells
Sarcoplasmic Reticulum
Ryanodine
2009
Protein Phosphatase 2
Peroxynitrous Acid
Phosphoprotein Phosphatases
Myocardium
Protein Phosphatase 1

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes

Wang, H., Kohr, M., Traynham, C. J. & Ziolo, M. T., Aug 2009, In : Journal of Molecular and Cellular Cardiology. 47, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Cardiac Myocytes
Isoproterenol
Muscle Cells
Phosphodiesterase 5 Inhibitors
2008

Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state

Kohr, M., Wang, H., Wheeler, D. G., Velayutham, M., Zweier, J. L. & Ziolo, M. T., Jul 1 2008, In : Free Radical Biology and Medicine. 45, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cardiac Myocytes
Isoproterenol
Adrenergic Agents
Adrenergic Agonists
Nitric Oxide Synthase Type III
Adrenergic Agents
Muscle Cells
Isoproterenol
Cardiac Arrhythmias

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban

Wang, H., Kohr, M., Traynham, C. J., Wheeler, D. G., Janssen, P. M. L. & Ziolo, M. T., Jun 2008, In : American Journal of Physiology - Cell Physiology. 294, 6

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Cardiac Myocytes
Muscle Cells
Phosphorylation
Peroxynitrous Acid

Nitric oxide signaling and the regulation of myocardial function

Ziolo, M. T., Kohr, M. & Wang, H., Nov 2008, In : Journal of Molecular and Cellular Cardiology. 45, 5, p. 625-632 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Cardiac Myocytes
Health

Targeting of phospholamban by peroxynitrite decreases β-adrenergic stimulation in cardiomyocytes

Kohr, M., Wang, H., Wheeler, D. G., Velayutham, M., Zweier, J. L. & Ziolo, M. T., Jan 2008, In : Cardiovascular Research. 77, 2, p. 353-361 9 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cardiac Myocytes
Adrenergic Agents
Muscle Cells
Phosphorylation
2005

Synthesis and biological testing of aminoxyls designed for long-term retention by living cells

Rosen, G. M., Burks, S. R., Kohr, M. & Kao, J. P. Y., Feb 21 2005, In : Organic and Biomolecular Chemistry. 3, 4, p. 645-648 4 p.

Research output: Contribution to journalArticle

Paramagnetic resonance
Cells
Imaging techniques
Testing
synthesis