Mark J Levis

Professor

1992 …2018
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Acute Myeloid Leukemia Medicine & Life Sciences
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Research Output 1992 2018

Cabozantinib is well tolerated in acute myeloid leukemia and effectively inhibits the resistance-conferring FLT3/tyrosine kinase domain/F691 mutation

Fathi, A. T. , Blonquist, T. M. , Hernandez, D. , Amrein, P. C. , Ballen, K. K. , McMasters, M. , Avigan, D. E. , Joyce, R. , Logan, E. K. , Hobbs, G. , Brunner, A. M. , Joseph, C. , Perry, A. M. , Burke, M. , Behnan, T. , Foster, J. , Bergeron, M. K. , Moran, J. A. , Ramos, A. Y. , Som, T. T. & 6 others Rae, J., Fishman, K. M., McGregor, K. L., Connolly, C., Neuberg, D. S. & Levis, M. J. Jan 15 2018 In : Cancer. 124, 2, p. 306-314 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
Maximum Tolerated Dose
3-tyrosine

Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial

Cortes, J. , Perl, A. E. , Döhner, H. , Kantarjian, H. , Martinelli, G. , Kovacsovics, T. , Rousselot, P. , Steffen, B. , Dombret, H. , Estey, E. , Strickland, S. , Altman, J. K. , Baldus, C. D. , Burnett, A. , Krämer, A. , Russell, N. , Shah, N. P. , Smith, C. C. , Wang, E. S. , Ifrah, N. & 4 others Gammon, G., Trone, D., Lazzaretto, D. & Levis, M. Jan 1 2018 (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
quizartinib
Therapeutics
Febrile Neutropenia

Adaptation to TKI treatment reactivates ERK signaling in tyrosine kinase–driven leukemias and other malignancies

Bruner, J. K., Ma, H. S., Li, L., Qin, A. C. R., Rudek, M. A., Jones, R. J., Levis, M. J., Pratz, K. W., Pratilas, C. A. & Small, D. Oct 15 2017 In : Cancer Research. 77, 20, p. 5554-5563 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Leukemia
Neoplasms
Acute Myeloid Leukemia
Mitogen-Activated Protein Kinase Kinases

Advances in targeted therapy for acute myeloid leukaemia

Kayser, S. & Levis, M. J. Jan 1 2017 (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Drug Therapy
Therapeutics
Chromosome Aberrations
Protein-Tyrosine Kinases

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I. , Beumer, J. H. , Pratz, K. W. , McDevitt, M. A. , Baer, M. R. , Blackford, A. L. , Smith, B. D. , Gore, S. D. , Carraway, H. E. , Showel, M. M. , Levis, M. J. , Dezern, A. E. , Gladstone, D. E. , Ji, J. J. , Wang, L. , Kinders, R. J. , Pouquet, M. , Ali-Walbi, I. , Rudek, M. A. , Poh, W. & 5 others Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E. Feb 1 2017 In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

temozolomide
Acute Myeloid Leukemia
Methylation
Phosphorylation
Polymers