Mark J Levis


1992 …2018
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Research Output 1992 2018

Cabozantinib is well tolerated in acute myeloid leukemia and effectively inhibits the resistance-conferring FLT3/tyrosine kinase domain/F691 mutation

Fathi, A. T. , Blonquist, T. M. , Hernandez, D. , Amrein, P. C. , Ballen, K. K. , McMasters, M. , Avigan, D. E. , Joyce, R. , Logan, E. K. , Hobbs, G. , Brunner, A. M. , Joseph, C. , Perry, A. M. , Burke, M. , Behnan, T. , Foster, J. , Bergeron, M. K. , Moran, J. A. , Ramos, A. Y. , Som, T. T. & 6 others Rae, J., Fishman, K. M., McGregor, K. L., Connolly, C., Neuberg, D. S. & Levis, M. J., Jan 15 2018, In : Cancer. 124, 2, p. 306-314 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Maximum Tolerated Dose

Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3

Nagai, K., Hou, L., Li, L., Nguyen, B., Seale, T., Shirley, C., Ma, H., Levis, M., Ghiaur, G., Duffield, A. & Small, D., Aug 31 2018, In : Oncotarget. 9, 68, p. 32885-32899 15 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Acute Myeloid Leukemia
Acute Promyelocytic Leukemia

Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Lau, B. W., Huh, K., Madero-Marroquin, R., De Marchi, F., Lim, Y., Wang, Q., Lobo, F., Marchionni, L., Smith, D. B., DeZern, A., Levis, M. J., Aplan, P. D., Matsui, W. & Gondek, L. P., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Granulocyte-Macrophage Progenitor Cells
Gene Expression Profiling
Acute Myeloid Leukemia
Disease Progression

Phase 2b study of 2 dosing regimens of quizartinib monotherapy in FLT3-ITD–mutated, relapsed or refractory AML

Cortes, J. E., Tallman, M. S., Schiller, G. J., Trone, D., Gammon, G., Goldberg, S. L., Perl, A. E., Marie, J. P., Martinelli, G., Kantarjian, H. M. & Levis, M. J., Aug 9 2018, In : Blood. 132, 6, p. 598-607 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Salvage Therapy

Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial

Cortes, J. , Perl, A. E. , Döhner, H. , Kantarjian, H. , Martinelli, G. , Kovacsovics, T. , Rousselot, P. , Steffen, B. , Dombret, H. , Estey, E. , Strickland, S. , Altman, J. K. , Baldus, C. D. , Burnett, A. , Krämer, A. , Russell, N. , Shah, N. P. , Smith, C. C. , Wang, E. S. , Ifrah, N. & 4 others Gammon, G., Trone, D., Lazzaretto, D. & Levis, M., Jan 1 2018, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Febrile Neutropenia