Mark J Levis

Professor

1992 …2018
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  • 4 Similar Profiles
Acute Myeloid Leukemia Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
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Leukemia Medicine & Life Sciences
fms-Like Tyrosine Kinase 3 Medicine & Life Sciences
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Chemotherapy Chemical Compounds

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Research Output 1992 2018

A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations

Levis, M. J., Perl, A. E., Altman, J. K., Gocke, C. D., Bahceci, E., Hill, J., Liu, C., Xie, Z., Carson, A. R., McClain, V., Stenzel, T. T. & Miller, J. E., Apr 24 2018, In : Blood advances. 2, 8, p. 825-831 7 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Acute Myeloid Leukemia
Mutation
DNA
fms-Like Tyrosine Kinase 3

Cabozantinib is well tolerated in acute myeloid leukemia and effectively inhibits the resistance-conferring FLT3/tyrosine kinase domain/F691 mutation

Fathi, A. T., Blonquist, T. M., Hernandez, D., Amrein, P. C., Ballen, K. K., McMasters, M., Avigan, D. E., Joyce, R., Logan, E. K., Hobbs, G., Brunner, A. M., Joseph, C., Perry, A. M., Burke, M., Behnan, T., Foster, J., Bergeron, M. K., Moran, J. A., Ramos, A. Y., Som, T. T. & 6 othersRae, J., Fishman, K. M., McGregor, K. L., Connolly, C., Neuberg, D. S. & Levis, M. J., Jan 15 2018, In : Cancer. 124, 2, p. 306-314 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
Maximum Tolerated Dose
3-tyrosine

Clinical implications of molecular markers in acute myeloid leukemia

Kayser, S. & Levis, M. J., Jan 1 2018, (Accepted/In press) In : European Journal of Haematology.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Myeloid Leukemia
Neoplasms
Decision Making

Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3

Nagai, K., Hou, L., Li, L., Nguyen, B., Seale, T., Shirley, C., Ma, H., Levis, M. J., Ghiaur, G., Duffield, A. S. & Small, D., Aug 31 2018, In : Oncotarget. 9, 68, p. 32885-32899 15 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Leukemia
Acute Myeloid Leukemia
Acute Promyelocytic Leukemia
Ubiquitination

Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Lau, B., Huh, K., Madero-Marroquin, R., De Marchi, F., Lim, Y., Wang, Q., Lobo, F., Marchionni, L., Smith, B. D., Dezern, A., Levis, M. J., Aplan, P. D., Matsui, W. & Gondek, L., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Granulocyte-Macrophage Progenitor Cells
Gene Expression Profiling
Acute Myeloid Leukemia
Disease Progression