Mark Chang Hwa Liu

Associate Professor

1982 …2020

Research output per year

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Research Output

2020

Update: Mepolizumab treatment in patients with severe eosinophilic asthma and prior omalizumab use

Albers, F. C., Hozawa, S., Bratton, D. J., Yancey, S. W., Prazma, C. M., Humbert, M. & Liu, M. C., Apr 1 2020, In : Allergy: European Journal of Allergy and Clinical Immunology. 75, 4, p. 942-946 5 p.

Research output: Contribution to journalLetter

Open Access
2019

Effect of mepolizumab in severe eosinophilic asthma according to omalizumab eligibility

Humbert, M., Albers, F. C., Bratton, D. J., Yancey, S. W., Liu, M. C. H., Hozawa, S., Llanos, J. P. & Kwon, N., Jul 1 2019, In : Respiratory Medicine. 154, p. 69-75 7 p.

Research output: Contribution to journalArticle

The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma

Chapman, K. R., Albers, F. C., Chipps, B., Muñoz, X., Devouassoux, G., Bergna, M., Galkin, D., Azmi, J., Mouneimne, D., Price, R. G. & Liu, M. C., Sep 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 9, p. 1716-1726 11 p.

Research output: Contribution to journalArticle

Open Access
2018

Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung

Liu, M. C. H., Xiao, H., Breslin, L. M., Bochner, B. S. & Schroeder, J. T., Mar 1 2018, In : Clinical and Experimental Allergy. 48, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

2016

Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease

Pothoven, K. L., Norton, J. E., Suh, L. A., Carter, R. G., Harris, K. E., Biyasheva, A., Welch, K., Shintani-Smith, S., Conley, D. B., Liu, M. C. H., Kato, A., Avila, P. C., Hamid, Q., Grammer, L. C., Peters, A. T., Kern, R. C., Tan, B. K. & Schleimer, R. P., Jun 27 2016, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

2015

Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease

Pothoven, K. L., Norton, J. E., Hulse, K. E., Suh, L. A., Carter, R. G., Rocci, E., Harris, K. E., Shintani-Smith, S., Conley, D. B., Chandra, R. K., Liu, M. C., Kato, A., Gonsalves, N., Grammer, L. C., Peters, A. T., Kern, R. C., Bryce, P. J., Tan, B. K. & Schleimer, R. P., Sep 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 3, p. 737-746.e4

Research output: Contribution to journalArticle

2014

Mepolizumab treatment in patients with severe eosinophilic asthma

Ortega, H. G., Liu, M. C., Pavord, I. D., Brusselle, G. G., FitzGerald, J. M., Chetta, A., Humbert, M., Katz, L. E., Keene, O. N., Yancey, S. W. & Chanez, P., Sep 25 2014, In : New England Journal of Medicine. 371, 13, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

2013

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

Busse, W. W., Wenzel, S. E., Meltzer, E. O., Kerwin, E. M., Liu, M. C., Zhang, N., Chon, Y., Budelsky, A. L., Lin, J. & Lin, S. L., Feb 1 2013, In : Journal of Allergy and Clinical Immunology. 131, 2, p. 339-345 7 p.

Research output: Contribution to journalArticle

2012

Association of vitamin D and antimicrobial peptide production during late-phase allergic responses in the lung

Liu, M. C., Xiao, H. Q., Brown, A. J., Ritter, C. S. & Schroeder, J., Mar 1 2012, In : Clinical and Experimental Allergy. 42, 3, p. 383-391 9 p.

Research output: Contribution to journalArticle

Asthma outcomes: Pulmonary physiology

Tepper, R. S., Wise, R. S., Covar, R., Irvin, C. G., Kercsmar, C. M., Kraft, M., Liu, M. C., O'Connor, G. T., Peters, S. P., Sorkness, R. & Togias, A., Mar 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 3 SUPPL., p. S65-S87

Research output: Contribution to journalArticle

Obstructive airway diseases: Asthma and chronic obstructive pulmonary disease

Wise, R. A. & Liu, M. C. H., Mar 27 2012, Principles of Ambulatory Medicine: Seventh Edition. Wolters Kluwer Health, p. 891-925 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: A randomized trial

Horton, M. R., Santopietro, V., Mathew, L., Horton, K. M., Polito, A. J., Liu, M. C., Danoff, S. K. & Lechtzin, N., Sep 18 2012, In : Annals of internal medicine. 157, 6, p. 398-406 9 p.

Research output: Contribution to journalArticle

2010

A genome-wide association study on African-ancestry populations for asthma

Mathias, R. A., Grant, A. V., Rafaels, N., Hand, T., Gao, L., Vergara, C., Tsai, Y. J., Yang, M., Campbell, M., Foster, C., Gao, P., Togias, A., Hansel, N. N., Diette, G., Adkinson, N. F., Liu, M. C., Faruque, M., Dunston, G. M., Watson, H. R., Bracken, M. B. & 29 others, Hoh, J., Maul, P., Maul, T., Jedlicka, A. E., Murray, T., Hetmanski, J. B., Ashworth, R., Ongaco, C. M., Hetrick, K. N., Doheny, K. F., Pugh, E. W., Rotimi, C. N., Ford, J., Eng, C., Burchard, E. G., Sleiman, P. M. A., Hakonarson, H., Forno, E., Raby, B. A., Weiss, S. T., Scott, A. F., Kabesch, M., Liang, L., Abecasis, G., Moffatt, M. F., Cookson, W. O. C., Ruczinski, I., Beaty, T. H. & Barnes, K. C., Feb 2010, In : Journal of Allergy and Clinical Immunology. 125, 2, p. 336-346.e4

Research output: Contribution to journalArticle

Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge

Eckman, J. A., Sterba, P. M., Kelly, D., Alexander, V., Liu, M. C., Bochner, B. S., MacGlashan, D. W. & Saini, S. S., Apr 2010, In : Journal of Allergy and Clinical Immunology. 125, 4, p. 889-895.e7

Research output: Contribution to journalArticle

Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon-α from plasmacytoid dendritic cells

Schroeder, J. T., Bieneman, A. P., Chichester, K. L., Breslin, L., Xiao, H. & Liu, M. C., May 1 2010, In : Clinical and Experimental Allergy. 40, 5, p. 745-754 10 p.

Research output: Contribution to journalArticle

Serum amyloid a regulates granulomatous inflammation in sarcoidosis through toll-like receptor-2

Chen, E. S., Song, Z., Willett, M. H., Heine, S., Yung, R. C., Liu, M. C., Groshong, S. D., Zhang, Y., Tuder, R. M. & Moller, D. R., Feb 15 2010, In : American journal of respiratory and critical care medicine. 181, 4, p. 360-373 14 p.

Research output: Contribution to journalArticle

2009

Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004

Ginde, A. A., Liu, M. C. & Camargo, C. A., Mar 23 2009, In : Archives of internal medicine. 169, 6, p. 626-632 7 p.

Research output: Contribution to journalArticle

Epithelium, inflammation, and immunity in the upper airways of humans: Studies in chronic rhinosinusitis

Schleimer, R. P., Kato, A., Peters, A., Conley, D., Kim, J., Liu, M. C., Harris, K. E., Kuperman, D. A., Chandra, R., Favoreto, S., Avila, P. C., Grammer, L. C. & Kern, R. C., May 1 2009, In : Proceedings of the American Thoracic Society. 6, 3, p. 288-294 7 p.

Research output: Contribution to journalArticle

Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects

Kato, A., Xiao, H. Q., Chustz, R. T., Liu, M. C. & Schleimer, R. P., Feb 2009, In : Journal of Allergy and Clinical Immunology. 123, 2, p. 369-375.e2

Research output: Contribution to journalArticle

2008

Effects of inhaled human insulin on airway lining fluid composition in adults with diabetes

Liu, M. C., Riese, R. J., Van Gundy, K., Norwood, P., Sullivan, B. E., Schwartz, P. F. & Teeter, J. G., Jul 1 2008, In : European Respiratory Journal. 32, 1, p. 180-188 9 p.

Research output: Contribution to journalArticle

The effects of nebulized albuterol on esophageal function in asthmatic patients

Lacy, B. E., Mathis, C., Desbiens, J. & Liu, M. C., Oct 1 2008, In : Digestive diseases and sciences. 53, 10, p. 2627-2633 7 p.

Research output: Contribution to journalArticle

2007

Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge

Georas, S. N., Berdyshev, E., Hubbard, W., Gorshkova, I. A., Usatyuk, P. V., Saatian, B., Myers, A. C., Williams, M. A., Xiao, H. Q., Liu, M. & Natarajan, V., Mar 1 2007, In : Clinical and Experimental Allergy. 37, 3, p. 311-322 12 p.

Research output: Contribution to journalArticle

2006

Reply from Drs. Brown, Pearse, Pyrgos, Liu, Togias, and Permutt [6]

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C., Togias, A. & Permutt, S., Dec 1 2006, In : Journal of applied physiology. 101, 6, 1 p.

Research output: Contribution to journalLetter

The structural basis of airways hyperresponsiveness in asthma

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C., Togias, A. & Permutt, S., Jul 17 2006, In : Journal of applied physiology. 101, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

2005

Nasal nitric oxide in experimental rhinovirus infection [7] (multiple letters)

Maniscalco, M., Sofia, M., Sanders, S., Liu, M., Proud, D. & Permutt, S., Jan 1 2005, In : Journal of Allergy and Clinical Immunology. 115, 1, p. 207-208 2 p.

Research output: Contribution to journalLetter

TLR9- and FcεRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression

Schroeder, J. T., Bieneman, A. P., Xiao, H. Q., Chichester, K. L., Vasagar, K., Saini, S. & Liu, M. C., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5724-5731 8 p.

Research output: Contribution to journalArticle

2004

Role of nasal nitric oxide in the resolution of experimental rhinovirus infection

Sanders, S. P., Proud, D., Permutt, S., Siekierski, E. S., Yachechko, R. & Liu, M. C., Apr 2004, In : Journal of Allergy and Clinical Immunology. 113, 4, p. 697-702 6 p.

Research output: Contribution to journalArticle

2003

Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation

Peters-Golden, M., Sampson, A. P., Henderson, W., Holgate, S., Liu, M., Moqbel, R., Bisgaard, H., Peters, S., Panettieri, R. & Hamid, Q., Jan 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 1 SUPPL., p. S37-S48

Research output: Contribution to journalArticle

Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation

Sampson, A. P., Pizzichini, E., Bisgaard, H., Moqbel, R., Peters-Golden, M., Peters, S., Liu, M., Hamid, Q. & Edelman, J., Jan 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 1 SUPPL., p. S49-S61

Research output: Contribution to journalArticle

Inflammatory cells in asthma: Mechanisms and implications for therapy

Hamid, Q., Tulic', M. K., Liu, M. C., Moqbel, R., Peters-Golden, M., Holgate, S. & Pizzichini, E., Jan 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 1 SUPPL., p. S5-S17

Research output: Contribution to journalArticle

Leukotriene receptor antagonists in asthma therapy

Peters, S. P., Hamid, Q., Moqbel, R., Sampson, A., Peters-Golden, M., Leff, J., Pizzichini, E., Edelman, J., Liu, M., Bisgaard, H. & Henderson, B., Jan 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 1 SUPPL., p. S62-S70

Research output: Contribution to journalArticle

Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions

Bochner, B. S., Hudson, S. A., Xiao, H. Q. & Liu, M. C., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 930-934 5 p.

Research output: Contribution to journalArticle

Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling

Holgate, S. T., Peters-Golden, M., Panettieri, R. A., Henderson, W. R., Bisgaard, H., Sampson, A., Hamid, Q., Liu, M., Peters, S. & Henderson, B., Jan 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 1 SUPPL., p. S18-S36

Research output: Contribution to journalArticle

Tracheobronchial stenosis from acid aspiration presenting as asthma

Rubin, A. E., Wang, K. P. & Liu, M. C., Feb 1 2003, In : CHEST. 123, 2, p. 643-646 4 p.

Research output: Contribution to journalArticle

2002

Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge

Viksman, M. Y., Bochner, B. S., Peebles, R. S., Schleimer, R. P. & Liu, M. C., Jan 1 2002, In : Clinical Immunology. 104, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

2001

Allergen-induced changes in airway responsiveness are not related to indices of airway edema

Peebles, R. S., Wagner, E. M., Liu, M. C., Proud, D., Hamilton, R. G. & Togias, A., May 2001, In : Journal of Allergy and Clinical Immunology. 107, 5 SUPPL., p. 805-811 7 p.

Research output: Contribution to journalArticle

Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactions

Stokes Peebles, R., Hamilton, R. G., Lichtenstein, L. M., Schlosberg, M., Liu, M. C., Proud, D. & Togias, A., Apr 2 2001, In : Clinical and Experimental Allergy. 31, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

Cutting edge: Expression of the C-C chemokine receptor CCR3 in human airway epithelial cells

Stellato, C., Brummet, M. E., Plitt, J. R., Shahabuddin, S., Baroody, F. M., Liu, M. C., Ponath, P. D. & Beck, L. A., Feb 1 2001, In : Journal of Immunology. 166, 3, p. 1457-1461 5 p.

Research output: Contribution to journalArticle

Open Access

Effects of prednisone on the cellular responses and release of cytokines and mediators after segmental allergen challenge of asthmatic subjects

Liu, M. C., Proud, D., Lichtenstein, L. M., Hubbard, W. C., Bochner, B. S., Stealey, B. A., Breslin, L., Xiao, H. Q., Freidhoff, L. R., Schroeder, J. T. & Schleimer, R. P., Jan 1 2001, In : Journal of Allergy and Clinical Immunology. 108, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

Identification of a novel cytokine, ML-1, and its expression in subjects with asthma

Kawaguchi, M., Onuchic, L. F., Li, X. D., Essayan, D. M., Schroeder, J., Xiao, H. Q., Liu, M. C., Krishnaswamy, G., Germino, G. & Huang, S. K., Oct 15 2001, In : Journal of Immunology. 167, 8, p. 4430-4435 6 p.

Research output: Contribution to journalArticle

Open Access

IL-4 production by human basophils found in the lung following segmental allergen challenge

Schroeder, J. T., Lichtenstein, L. M., Roche, E. M., Xiao, H. Q. & Liu, M. C., Jan 1 2001, In : Journal of Allergy and Clinical Immunology. 107, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

Measurement of low picomolar levels of triamcinolone acetonide in human bronchoalveolar lavage fluid by gas chromatography-electron-capture negative-ion mass spectrometry

Hubbard, W. C., Liu, M. C., Bickel, C., Argenti, D., Heald, D. & Schleimer, R. P., Mar 1 2001, In : Analytical biochemistry. 290, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

Profiling of differential gene expression in activated, allergen-specific human Th2 cells

Li, X. D., Essayan, D. M., Liu, M. C., Beaty, T. H. & Huang, S. K., Apr 2001, In : Genes and immunity. 2, 2, p. 88-98 11 p.

Research output: Contribution to journalArticle

Open Access

Repetitive ozone exposure of young adults: Evidence of persistent small airway dysfunction

Frank, R., Liu, M. C., Spannhake, E. W., Mlynarek, S., Macri, K. & Weinmann, G. G., Oct 1 2001, In : American journal of respiratory and critical care medicine. 164, 7, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

The effects of an inhaled β2-adrenergic agonist on lower esophageal function: A dose-response study

Crowell, M. D., Zayat, E. N., Lacy, B. E., Schettler-Duncan, A. & Liu, M. C., Jan 1 2001, In : CHEST. 120, 4, p. 1184-1189 6 p.

Research output: Contribution to journalArticle

2000

Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses

Henig, N. R., Aitken, M. L., Liu, M. C., Yu, A. S. & Henderson, W. R., Jan 1 2000, In : American journal of respiratory and critical care medicine. 162, 2 I, p. 523-527 5 p.

Research output: Contribution to journalArticle

Extensive surface phenotyping of alveolar macrophages in interstitial lung disease

Taylor, M. L., Noble, P. W., White, B., Wise, R., Liu, M. C. & Bochner, B. S., Jan 2000, In : Clinical Immunology. 94, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions

Wenzel, S. E., Fahy, J. V., Irvin, C., Peters, S. P., Spector, S., Szefler, S. J., Casale, T. B., Cloutier, M. M., Elias, J. A., Liu, M. C. & Taggert, V., Jan 1 2000, In : American journal of respiratory and critical care medicine. 162, 6, p. 2341-2351 11 p.

Research output: Contribution to journalArticle

1999

Allergen-induced sensory neuroplasticity in airways

Undem, B. J., Hunter, D. D., Liu, M., Haak-Frendscho, M., Oakragly, A. & Fischer, A., Jan 1 1999, In : International archives of allergy and immunology. 118, 2-4, p. 150-153 4 p.

Research output: Contribution to journalArticle