Mark A Marzinke

Associate Professor

20082019

Research output per year

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Research Output

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2017
Open Access

Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice

Gallay, P. A., Chatterji, U., Kirchhoff, A., Gandarilla, A., Gunawardana, M., Pyles, R. B., Marzinke, M. A., Moss, J. A. & Baum, M. M., Sep 1 2017, In : PLoS One. 12, 9, e0184303.

Research output: Contribution to journalArticle

Rapid screening for targeted genetic variants via high-resolution melting curve analysis

Chambliss, A. B., Resnick, M., Petrides, A. K., Clarke, W. & Marzinke, M. A., Mar 1 2017, In : Clinical Chemistry and Laboratory Medicine. 55, 4, p. 507-516 10 p.

Research output: Contribution to journalArticle

Safety and tolerability of maraviroc-containing regimens to prevent HIV infection in women

Gulick, R. M., Wilkin, T. J., Chen, Y. Q., Landovitz, R. J., Amico, K. R., Young, A. M., Richardson, P., Marzinke, M. A., Hendrix, C., Eshleman, S., McGowan, I., Cottle, L. M., Andrade, A., Marcus, C., Klingman, K. L., Chege, W., Rinehart, A. R., Rooney, J. F., Andrew, P., Salata, R. A. & 10 others, Siegel, M., Manabe, Y. C., Frank, I., Ho, K., Santana, J., Stekler, J. D., Swaminathan, S., McCauley, M., Hodder, S. & Mayer, K. H., Sep 19 2017, In : Annals of Internal Medicine. 167, 6, p. 384-393 10 p.

Research output: Contribution to journalArticle

2016

Analysis of HIV diversity in HIV-infected Black men who have sex with men (HPTN 061)

Chen, I., Chau, G., Wang, J., Clarke, W., Marzinke, M. A., Cummings, V., Breaud, A., Laeyendecker, O. B., Fields, S. D., Griffith, S., Scott, H. M., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Tieu, H. V., Wheeler, D. P., Mayer, K. H., Koblin, B. A. & Eshleman, S., Dec 1 2016, In : PLoS One. 11, 12, e0167629.

Research output: Contribution to journalArticle

Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043)

Fogel, J. M. L., Clarke, W., Kulich, M., Piwowar-Manning, E., Breaud, A., Olson, M. T., Marzinke, M. A., Laeyendecker, O. B., Fiamma, A., Donnell, D., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S., Nov 3 2016, (Accepted/In press) In : Journal of Acquired Immune Deficiency Syndromes.

Research output: Contribution to journalArticle

A phase 2 randomized trial of a rifapentine plus moxifloxacin-based regimen for treatment of pulmonary tuberculosis

Conde, M. B., Mello, F. C. Q., Duarte, R. S., Cavalcante, S. C., Rolla, V., Dalcolmo, M., Loredo, C., Durovni, B., Armstrong, D. T., Efron, A., Link Barnes, G., Marzinke, M. A., Savic, R. M., Dooley, K. E., Cohn, S., Moulton, L. H., Chaisson, R. E. & Dorman, S. E., May 1 2016, In : PLoS One. 11, 5, e0154778.

Research output: Contribution to journalArticle

A randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy

Beigi, R. H., Noguchi, L. M., Montgomery, E., Biggio, J., Hendrix, C., Marzinke, M. A., Dai, J. Y., Pan, J., Kunjara Na Ayudhya, R., Schwartz, J. L., Isaacs, K., Piper, J. M. & Watts, D. H., 2016, In : Journal of the International AIDS Society. 19, 1, 20990.

Research output: Contribution to journalArticle

Combination pod-intravaginal ring delivers antiretroviral agents for HIV prophylaxis: Pharmacokinetic evaluation in an ovine model

Moss, J. A., Butkyavichene, I., Churchman, S. A., Gunawardana, M., Fanter, R., Miller, C. S., Yang, F., Easley, J. T., Marzinke, M. A., Hendrix, C., Smith, T. J. & Baum, M. M., Jun 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 6, p. 3759-3766 8 p.

Research output: Contribution to journalArticle

Comparison of subjective and objective adherence measures for pre-exposure prophylaxis against HIV infection among serodiscordant couples in East Africa

Musinguzi, N., Muganzi, C. D., Boum, Y., Ronald, A., Marzinke, M. A., Hendrix, C., Celum, C., Baeten, J., Bangsberg, D. R. & Haberer, J. E., Jan 16 2016, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Noguchi, L. M., Montgomery, E. T., Biggio, J. R., Hendrix, C., Bogen, D. L., Hillier, S. L., Dai, J. Y., Piper, J. M., Marzinke, M. A., Dezzutti, C. S., Isaacs, S. K., Schwartz, J. L., Watts, D. H. & Beigi, R. H., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5616-5619 4 p.

Research output: Contribution to journalArticle

Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study

Van Der Straten, A., Brown, E. R., Marrazzo, J. M., Chirenje, M. Z., Liu, K., Gomez, K., Marzinke, M. A., Piper, J. M. & Hendrix, C., Feb 4 2016, In : Journal of the International AIDS Society. 19, 1, 20642.

Research output: Contribution to journalArticle

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V. & 2 others, Mayer, K. H. & Patterson, K. B., Jan 1 2016, In : AIDS Research and Human Retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

HIV-1-neutralizing IgA detected in genital secretions of highly HIV-1-exposed seronegative women on oral preexposure prophylaxis

for the Partners PrEP Study, 2016, In : Journal of Virology. 90, 21, p. 9855-9861 7 p.

Research output: Contribution to journalArticle

Impact of sex on the pharmacokinetics and pharmacodynamics of 1% tenofovir gel

Herold, B. C., Chen, B. A., Salata, R. A., Marzinke, M. A., Kelly, C. W., Dezzutti, C. S., Mcgowan, I., Galaska, B., Levy, L., Piper, J. M., Hillier, S. & Hendrix, C., Feb 1 2016, In : Clinical Infectious Diseases. 62, 3, p. 375-382 8 p.

Research output: Contribution to journalArticle

Improvements in the continuum of HIV care in an inner-city emergency department

Kelen, G. D., Hsieh, Y-H., Rothman, R., Patel, E. U., Laeyendecker, O. B., Marzinke, M. A., Clarke, W., Parsons, T., Manucci, J. L. & Quinn, T. C., Jan 2 2016, In : AIDS. 30, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

Integrated Delivery of Antiretroviral Treatment and Pre-exposure Prophylaxis to HIV-1–Serodiscordant Couples: A Prospective Implementation Study in Kenya and Uganda

Baeten, J. M., Heffron, R., Kidoguchi, L., Mugo, N. R., Katabira, E., Bukusi, E. A., Asiimwe, S., Haberer, J. E., Morton, J., Ngure, K., Bulya, N., Odoyo, J., Tindimwebwa, E., Hendrix, C., Marzinke, M. A., Ware, N. C., Wyatt, M. A., Morrison, S., Haugen, H., Mujugira, A. & 2 others, Donnell, D. & Celum, C., Aug 1 2016, In : PLoS Medicine. 13, 8, e1002099.

Research output: Contribution to journalArticle

Non-linearity within the primary measurement range of a lipase assay as the cause of a gap in the interpatient lipase results distribution

Vogel, A. N., Goldsmith, B. M., Marzinke, M. A., Sokoll, L. J. & Stickle, D. F., Jan 1 2016, In : Clinical Biochemistry. 49, 1, p. 176-179 4 p.

Research output: Contribution to journalArticle

Optimizing Pre-Exposure Antiretroviral Prophylaxis Adherence in Men Who Have Sex with Men: Results of a Pilot Randomized Controlled Trial of “Life-Steps for PrEP”

Mayer, K. H., Safren, S. A., Elsesser, S. A., Psaros, C., Tinsley, J. P., Marzinke, M. A., Clarke, W., Hendrix, C., Wade Taylor, S., Haberer, J. & Mimiaga, M. J., Nov 15 2016, (Accepted/In press) In : AIDS and Behavior. p. 1-11 11 p.

Research output: Contribution to journalArticle

Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial

On behalf of the Microbicide Trials Network, MTN-013/IPM 026 Protocol Team, Jul 1 2016, In : Medicine. 95, 28, e4174.

Research output: Contribution to journalArticle

Pharmacological measures of treatment adherence and risk of HIV infection in the VOICE study

Dai, J. Y., Hendrix, C., Richardson, B. A., Kelly, C., Marzinke, M. A., Chirenje, Z. M., Marrazzo, J. M. & Brown, E. R., Feb 1 2016, In : Journal of Infectious Diseases. 213, 3, p. 335-342 8 p.

Research output: Contribution to journalArticle

Preexposure prophylaxis-selected drug resistance decays rapidly after drug cessation

Weis, J. F., Baeten, J. M., McCoy, C. O., Warth, C., Donnell, D., Thomas, K. K., Hendrix, C., Marzinke, M. A., Mugo, N., Iv, F. A. M., Celum, C. & Lehman, D. A., Jan 2 2016, In : AIDS. 30, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

Pre-exposure Prophylaxis Use by Breastfeeding HIV-Uninfected Women: A Prospective Short-Term Study of Antiretroviral Excretion in Breast Milk and Infant Absorption

Mugwanya, K. K., Hendrix, C., Mugo, N. R., Marzinke, M. A., Katabira, E. T., Ngure, K., Semiyaga, N. B., John-Stewart, G., Muwonge, T. R., Muthuri, G., Stergachis, A., Celum, C. L. & Baeten, J. M., Sep 1 2016, In : PLoS Medicine. 13, 9, e1002132.

Research output: Contribution to journalArticle

Use of a risk scoring tool to identify higher-risk HIV-1 serodiscordant couples for an antiretroviral-based HIV-1 prevention intervention

for the Partners Demonstration Project Team, Oct 17 2016, In : BMC Infectious Diseases. 16, 1, 571.

Research output: Contribution to journalArticle

Use of a vaginal ring containing dapivirine for HIV-1 prevention in women

MTN-020-ASPIRE Study Team, Dec 1 2016, In : New England Journal of Medicine. 375, 22, p. 2121-2132 12 p.

Research output: Contribution to journalArticle

2015

Antiretroviral drug use and HIV drug resistance among HIV-infected black men who have sex with men: HIV prevention trials network 061

Chen, I., Connor, M. B., Clarke, W., Marzinke, M. A., Cummings, V., Breaud, A., Fogel, J. M. L., Laeyendecker, O. B., Fields, S. D., Donnell, D., Griffith, S., Scott, H. M., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Wheeler, D. P., Mayer, K. H., Koblin, B. A. & Eshleman, S., 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 4, p. 446-452 7 p.

Research output: Contribution to journalArticle

Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064

Chen, I., Clarke, W., Ou, S. S., Marzinke, M. A., Breaud, A., Emel, L. M., Wang, J., Hughes, J. P., Richardson, P., Haley, D. F., Lucas, J., Rompalo, A. M., Justman, J. E., Hodder, S. L. & Eshleman, S., Oct 7 2015, In : PLoS One. 10, 10, e0140074.

Research output: Contribution to journalArticle

Antiretroviral pre-exposure prophylaxis does not enhance immune responses to HIV in exposed but uninfected persons

Partners PrEP Study Team, Jun 15 2015, In : Journal of Infectious Diseases. 211, 12, p. 1943-1952 10 p.

Research output: Contribution to journalArticle

A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)

Hiruy, H., Fuchs, E., Marzinke, M. A., Bakshi, R., Breakey, J. C., Aung, W. S., Manohar, M., Yue, C., Caffo, B. S., Du, Y., Abebe, K. Z., Spiegel, H. M. L., Rohan, L. C., McGowan, I. & Hendrix, C., Nov 1 2015, In : AIDS Research and Human Retroviruses. 31, 11, p. 1098-1108 11 p.

Research output: Contribution to journalArticle

A phase 1 randomized, open label, rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of three formulations of tenofovir 1% Gel (the CHARM-01 study)

Mcgowan, I., Cranston, R. D., Duffill, K., Siegel, A., Engstrom, J. C., Nikiforov, A., Jacobson, C., Rehman, K. K., Elliott, J., Khanukhova, E., Abebe, K., Mauck, C., Spiegel, H. M. L., Dezzutti, C. S., Rohan, L. C., Marzinke, M. A., Hiruy, H., Hendrix, C., Richardson-Harman, N. & Anton, P. A., May 5 2015, In : PLoS One. 10, 5, e0125363.

Research output: Contribution to journalArticle

A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring

Keller, M. J., Mesquita, P. M., Marzinke, M. A., Teller, R., Espinoza, L., Atrio, J. M., Lo, Y., Frank, B., Srinivasan, S., Fredricks, D. N., Rabe, L., Anderson, P. L., Hendrix, C., Kiser, P. F. & Herold, B. C., Nov 24 2015, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film

Bunge, K. E., Dezzutti, C. S., Rohan, L. C., Hendrix, C., Marzinke, M. A., Richardson-Harman, N., Moncla, B. J., Devlin, B., Meyn, L. A., Spiegel, H. M. L. & Hillier, S. L., Nov 11 2015, (Accepted/In press) In : Journal of Acquired Immune Deficiency Syndromes.

Research output: Contribution to journalArticle

A scoring tool to identify East African HIV-1 serodiscordant partnerships with a high likelihood of pregnancy

Heffron, R., Cohen, C. R., Ngure, K., Bukusi, E., Were, E., Kiarie, J., Mugo, N., Celum, C., Baeten, J. M., Donnell, D., Coombs, R. W., Frenkel, L., Hendrix, C., Lingappa, J., McElrath, M. J., Fife, K., Tumwesigye, E., Ndase, P., Katabira, E., Ronald, A. & 46 others, Wangisi, J., Campbell, J., Tappero, J., Farquhar, C., John-Stewart, G., Wald, A., Campbell, M., Corey, L., Hughes, J. P., Magaret, A., Morrow, R., Mullins, J. I., Coetzee, D., Essex, M., Makhema, J., Allen, S., Kayitenkore, K., Karita, E., Kanweka, W., Vwalika, B., Kapiga, S., Manongi, R., Inambao, M., Delany-Moretlwe, S., Rees, H., De Bruyn, G., Gray, G., McIntyre, J., Barnabas, R., Haugen, H., Kidoguchi, L., Morrison, S., Morton, J., Mujugira, A., Scoville, C., Shell-Duncan, B., Thomas, K., Asiimwe, S., Tindimwebwa, E., Bulya, N., Odoyo, J., Bangsberg, D., Haberer, J., Ware, N., Wyatt, M. & Marzinke, M. A., Dec 1 2015, In : PLoS One. 10, 12, e0145515.

Research output: Contribution to journalArticle

Determination of HIV status in african adults with discordant HIV rapid tests

Fogel, J. M. L., Piwowar-Manning, E., Donohue, K., Cummings, V., Marzinke, M. A., Clarke, W., Breaud, A., Fiamma, A., Donnell, D., Kulich, M., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S., 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 4, p. 430-438 9 p.

Research output: Contribution to journalArticle

Fluctuating creatinine in the cardiac unit

Petrides, A. K., Ness, M. A., Judge, D. P., Sokoll, L. J. & Marzinke, M. A., Jul 1 2015, In : Clinica Chimica Acta. 447, p. 52-54 3 p.

Research output: Contribution to journalArticle

Laboratory developed tests in the clinical laboratory: Challenges for implementation

Marzinke, M. A. & Clarke, W., Aug 1 2015, In : Bioanalysis. 7, 15, p. 1817-1820 4 p.

Research output: Contribution to journalArticle

Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers

ACTG A5311 Study Team & Dorman, S. E., Jun 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 6, p. 3399-3405 7 p.

Research output: Contribution to journalArticle

Performance of the fourth-generation Bio-Rad GS HIV Combo Ag/Ab enzyme immunoassay for diagnosis of HIV infection in Southern Africa

Piwowar-Manning, E., Fogel, J. M. L., Richardson, P., Wolf, S., Clarke, W., Marzinke, M. A., Fiamma, A., Donnell, D., Kulich, M., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S., Jan 1 2015, In : Journal of Clinical Virology. 62, p. 75-79 5 p.

Research output: Contribution to journalArticle

Pharmacokinetics of long-acting tenofovir alafenamide (GS-7340) subdermal implant for HIV prophylaxis

Gunawardana, M., Remedios-Chan, M., Miller, C. S., Fanter, R., Yang, F., Marzinke, M. A., Hendrix, C., Beliveau, M., Moss, J. A., Smith, T. J. & Baum, M. M., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3913-3919 7 p.

Research output: Contribution to journalArticle

Phase 1 safety, pharmacokinetics, and pharmacodynamics of dapivirine and maraviroc vaginal rings: A double-blind randomized trial

behalf of the MTN-013/IPM 026 Protocol Team for the Microbicide Trials Network, 2015, In : Journal of Acquired Immune Deficiency Syndromes. 70, 3, p. 242-249 8 p.

Research output: Contribution to journalArticle

Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single-or dual-agent preexposure prophylaxis

Lehman, D. A., Baeten, J. M., McCoy, C. O., Weis, J. F., Peterson, D., Mbara, G., Donnell, D., Thomas, K. K., Hendrix, C., Marzinke, M. A., Frenkel, L., Ndase, P., Mugo, N. R., Celum, C., Overbaugh, J. & Matsen, F. A., Apr 15 2015, In : Journal of Infectious Diseases. 211, 8, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Tenofovir-based preexposure prophylaxis for HIV infection among African women

Marrazzo, J. M., Ramjee, G., Richardson, B. A., Gomez, K., Mgodi, N., Nair, G., Palanee, T., Nakabiito, C., Van Der Straten, A., Noguchi, L., Hendrix, C., Dai, J. Y., Ganesh, S., Mkhize, B., Taljaard, M., Parikh, U. M., Piper, J., Mâsse, B., Grossman, C., Rooney, J. & 6 others, Schwartz, J. L., Watts, H., Marzinke, M. A., Hillier, S. L., Mcgowan, I. M. & Chirenje, Z. M., Jul 13 2015, In : Obstetrical and Gynecological Survey. 70, 7, p. 444-446 3 p.

Research output: Contribution to journalArticle

Tenofovir-based preexposure prophylaxis for HIV infection among African women

VOICE Study Team, Feb 5 2015, In : New England Journal of Medicine. 372, 6, p. 509-518 10 p.

Research output: Contribution to journalArticle

2014

Antiviral activity of genital tract secretions after oral or topical tenofovir pre-exposure prophylaxis for HIV-1

Herold, B. C., Dezzutti, C. S., Richardson, B. A., Marrazzo, J., Mesquita, P. M. M., Carpenter, C., Huber, A., Louissaint, N., Marzinke, M. A., Hillier, S. L. & Hendrix, C., May 1 2014, In : Journal of Acquired Immune Deficiency Syndromes. 66, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle