Mark A Marzinke

Associate Professor

20082019

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2008

The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation

Muley, P. D., McNeill, E. M., Marzinke, M. A., Knobel, K. M., Barr, M. M. & Clagett-Dame, M., Nov 2008, In : Developmental Neurobiology. 68, 13, p. 1441-1453 13 p.

Research output: Contribution to journalArticle

2010

Calmin expression in embryos and the adult brain, and its regulation by all-trans retinoic acid

Marzinke, M. A., Henderson, E. M., Yang, K. S., See, A. W. M., Knutson, D. C. & Clagett-Dame, M., Feb 1 2010, In : Developmental Dynamics. 239, 2, p. 620-629 10 p.

Research output: Contribution to journalArticle

Calmin expression in embryos and the adult brain, and its regulation by all-trans retinoic acid.

Marzinke, M. A., Henderson, E. M., Yang, K. S., See, A. W. M., Knutson, D. C. & Clagett-Dame, M., Feb 2010, In : Developmental dynamics : an official publication of the American Association of Anatomists. 239, 2, p. 610-619 10 p.

Research output: Contribution to journalArticle

2011

Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy.

Salgado, M., Rabi, S. A., O'Connell, K. A., Buckheit, R. W., Bailey, J. R., Chaudhry, A. A., Breaud, A. R., Marzinke, M. A., Clarke, W., Margolick, J. B., Siliciano, R. F. & Blankson, J. N., Dec 1 2011, In : Retrovirology. 8, 1 p.

Research output: Contribution to journalArticle

2012

Origin of a false positive urine pregnancy test in a patient with membranoproliferative glomerulonephritis type I

Marzinke, M. A., Jarrar, P., Atkinson, M., Humphrey, R. L., Detrick, B. & Sokoll, L. J., Jan 18 2012, In : Clinica Chimica Acta. 413, 1-2, p. 361-363 3 p.

Research output: Contribution to journalArticle

2013

14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation

Marzinke, M. A., Mavencamp, T., Duratinsky, J. & Clagett-Dame, M., Nov 13 2013, In : Archives of Biochemistry and Biophysics. 540, 1-2, p. 94-100 7 p.

Research output: Contribution to journalArticle

Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)

Laeyendecker, O., Piwowar-Manning, E., Fiamma, A., Kulich, M., Donnell, D., Bassuk, D., Mullis, C. E., Chin, C., Swanson, P., Hackett, J., Clarke, W., Marzinke, M., Szekeres, G., Gray, G., Richter, L., Alexandre, M. W., Chariyalertsak, S., Chingono, A., Celentano, D. D., Morin, S. F. & 3 others, Sweat, M., Coates, T. & Eshleman, S. H., Jul 11 2013, In : PloS one. 8, 7, e68349.

Research output: Contribution to journalArticle

Proteomic analysis of temporally stimulated ovarian cancer cells for biomarker discovery

Marzinke, M. A., Choi, C. H., Chen, L., Shih, I. M., Chan, D. W. & Zhang, H., Feb 1 2013, In : Molecular and Cellular Proteomics. 12, 2, p. 356-368 13 p.

Research output: Contribution to journalArticle

The development and validation of an UHPLC-MS/MS method for the rapid quantification of the antiretroviral agent dapivirine in human plasma

Seserko, L. A., Emory, J. F., Hendrix, C. & Marzinke, M. A., Nov 2013, In : Bioanalysis. 5, 22, p. 2771-2783 13 p.

Research output: Contribution to journalArticle

2014

Antiviral activity of genital tract secretions after oral or topical tenofovir pre-exposure prophylaxis for HIV-1

Herold, B. C., Dezzutti, C. S., Richardson, B. A., Marrazzo, J., Mesquita, P. M. M., Carpenter, C., Huber, A., Louissaint, N., Marzinke, M. A., Hillier, S. L. & Hendrix, C. W., May 1 2014, In : Journal of Acquired Immune Deficiency Syndromes. 66, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

Failure to identify HIV-infected individuals in a clinical trial using a single HIV rapid test for screening

Piwowar-Manning, E., Fogel, J., Laeyendecker, O., Wolf, S., Cummings, V., Marzinke, M., Clarke, W., Breaud, A., Wendel, S., Wang, L., Swanson, P., Hackett, J., Mannheimer, S., Del Rio, C., Kuo, I., Harawa, N., Koblin, B., Moore, R., Blankson, J. & Eshleman, S., Jan 1 2014, In : HIV clinical trials. 15, 2, p. 62-68 7 p.

Research output: Contribution to journalArticle

Low-level viremia early in HIV infection

Chen, I., Cummings, V., Fogel, J. M., Marzinke, M. A., Clarke, W., Connor, M. B., Griffith, S., Buchbinder, S., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Wheeler, D. P., Mayer, K. H., Koblin, B. A. & Eshleman, S. H., Jan 1 2014, In : Journal of Acquired Immune Deficiency Syndromes. 67, 4, p. 405-408 4 p.

Research output: Contribution to journalArticle

Nondisclosure of HIV status in a clinical trial setting: Antiretroviral drug screening can help distinguish between newly diagnosed and previously diagnosed HIV infection

Marzinke, M. A., Clarke, W., Wang, L., Cummings, V., Liu, T. Y., Piwowar-Manning, E., Breaud, A., Griffith, S., Buchbinder, S., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Fields, S. D., Mayer, K. H., Wheeler, D. P., Koblin, B. A., Eshleman, S. H. & Fogel, J. M., Jan 1 2014, In : Clinical Infectious Diseases. 58, 1, p. 117-120 4 p.

Research output: Contribution to journalArticle

Quantification of rifapentine, a potent antituberculosis drug, from dried blood spot samples using liquid chromatographic-tandem mass spectrometric analysis

Parsons, T. L., Marzinke, M. A., Hoang, T., Bliven-Sizemore, E., Weiner, M., Mac Kenzie, W. R., Dorman, S. E. & Dooley, K. E., Nov 1 2014, In : Antimicrobial agents and chemotherapy. 58, 11, p. 6747-6757 11 p.

Research output: Contribution to journalArticle

Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: An update of data from a randomised, double-blind, phase 3 trial

Baeten, J. M., Donnell, D., Mugo, N. R., Ndase, P., Thomas, K. K., Campbell, J. D., Wangisi, J., Tappero, J. W., Bukusi, E. A., Cohen, C. R., Katabira, E., Ronald, A., Tumwesigye, E., Were, E., Fife, K. H., Kiarie, J., Farquhar, C., John-Stewart, G., Kidoguchi, L., Coombs, R. W. & 6 others, Hendrix, C., Marzinke, M. A., Frenkel, L., Haberer, J. E., Bangsberg, D. & Celum, C., Nov 1 2014, In : The Lancet Infectious Diseases. 14, 11, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

The development and validation of a method using high-resolution mass spectrometry (HRMS) for the qualitative detection of antiretroviral agents in human blood

Marzinke, M. A., Breaud, A., Parsons, T. L., Cohen, M. S., Piwowar-Manning, E., Eshleman, S. H. & Clarke, W., Jun 10 2014, In : Clinica Chimica Acta. 433, p. 157-168 12 p.

Research output: Contribution to journalArticle

The development and validation of a turbulent flow-liquid chromatography-tandem mass spectrometric method for the simultaneous quantification of citalopram, sertraline, bupropion and hydroxybupropion in serum

Petrides, A. K., Moskowitz, J., Johnson-Davis, K. L., Jannetto, P. J., Langman, L. J., Clarke, W. & Marzinke, M. A., Dec 1 2014, In : Clinical Biochemistry. 47, 15, p. 73-79 7 p.

Research output: Contribution to journalArticle

2015

Antiretroviral drug use and HIV drug resistance among HIV-infected black men who have sex with men: HIV prevention trials network 061

Chen, I., Connor, M. B., Clarke, W., Marzinke, M. A., Cummings, V., Breaud, A., Fogel, J. M. L., Laeyendecker, O. B., Fields, S. D., Donnell, D., Griffith, S., Scott, H. M., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Wheeler, D. P., Mayer, K. H., Koblin, B. A. & Eshleman, S., 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 4, p. 446-452 7 p.

Research output: Contribution to journalArticle

Antiretroviral drug use in a cohort of HIV-uninfected women in the United States: HIV Prevention Trials Network 064

Chen, I., Clarke, W., Ou, S. S., Marzinke, M. A., Breaud, A., Emel, L. M., Wang, J., Hughes, J. P., Richardson, P., Haley, D. F., Lucas, J., Rompalo, A., Justman, J. E., Hodder, S. L. & Eshleman, S. H., Oct 7 2015, In : PloS one. 10, 10, e0140074.

Research output: Contribution to journalArticle

Antiretroviral pre-exposure prophylaxis does not enhance immune responses to HIV in exposed but uninfected persons

Partners PrEP Study Team, Jun 15 2015, In : Journal of Infectious Diseases. 211, 12, p. 1943-1952 10 p.

Research output: Contribution to journalArticle

A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)

Hiruy, H., Fuchs, E., Marzinke, M. A., Bakshi, R., Breakey, J. C., Aung, W. S., Manohar, M., Yue, C., Caffo, B. S., Du, Y., Abebe, K. Z., Spiegel, H. M. L., Rohan, L. C., McGowan, I. & Hendrix, C., Nov 1 2015, In : AIDS Research and Human Retroviruses. 31, 11, p. 1098-1108 11 p.

Research output: Contribution to journalArticle

A phase 1 randomized, open label, rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of three formulations of tenofovir 1% Gel (the CHARM-01 study)

Mcgowan, I., Cranston, R. D., Duffill, K., Siegel, A., Engstrom, J. C., Nikiforov, A., Jacobson, C., Rehman, K. K., Elliott, J., Khanukhova, E., Abebe, K., Mauck, C., Spiegel, H. M. L., Dezzutti, C. S., Rohan, L. C., Marzinke, M. A., Hiruy, H., Hendrix, C., Richardson-Harman, N. & Anton, P. A., May 5 2015, In : PLoS One. 10, 5, e0125363.

Research output: Contribution to journalArticle

A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film

Bunge, K. E., Dezzutti, C. S., Rohan, L. C., Hendrix, C., Marzinke, M. A., Richardson-Harman, N., Moncla, B. J., Devlin, B., Meyn, L. A., Spiegel, H. M. L. & Hillier, S. L., Nov 11 2015, (Accepted/In press) In : Journal of Acquired Immune Deficiency Syndromes.

Research output: Contribution to journalArticle

A scoring tool to identify East African HIV-1 serodiscordant partnerships with a high likelihood of pregnancy

Heffron, R., Cohen, C. R., Ngure, K., Bukusi, E., Were, E., Kiarie, J., Mugo, N., Celum, C., Baeten, J. M., Donnell, D., Coombs, R. W., Frenkel, L., Hendrix, C., Lingappa, J., McElrath, M. J., Fife, K., Tumwesigye, E., Ndase, P., Katabira, E., Ronald, A. & 46 others, Wangisi, J., Campbell, J., Tappero, J., Farquhar, C., John-Stewart, G., Wald, A., Campbell, M., Corey, L., Hughes, J. P., Magaret, A., Morrow, R., Mullins, J. I., Coetzee, D., Essex, M., Makhema, J., Allen, S., Kayitenkore, K., Karita, E., Kanweka, W., Vwalika, B., Kapiga, S., Manongi, R., Inambao, M., Delany-Moretlwe, S., Rees, H., De Bruyn, G., Gray, G., McIntyre, J., Barnabas, R., Haugen, H., Kidoguchi, L., Morrison, S., Morton, J., Mujugira, A., Scoville, C., Shell-Duncan, B., Thomas, K., Asiimwe, S., Tindimwebwa, E., Bulya, N., Odoyo, J., Bangsberg, D., Haberer, J., Ware, N., Wyatt, M. & Marzinke, M. A., Dec 1 2015, In : PLoS One. 10, 12, e0145515.

Research output: Contribution to journalArticle

Determination of HIV status in african adults with discordant HIV rapid tests

Fogel, J. M. L., Piwowar-Manning, E., Donohue, K., Cummings, V., Marzinke, M. A., Clarke, W., Breaud, A., Fiamma, A., Donnell, D., Kulich, M., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S., 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 4, p. 430-438 9 p.

Research output: Contribution to journalArticle

Fluctuating creatinine in the cardiac unit

Petrides, A. K., Ness, M. A., Judge, D. P., Sokoll, L. J. & Marzinke, M. A., Jul 1 2015, In : Clinica Chimica Acta. 447, p. 52-54 3 p.

Research output: Contribution to journalArticle

Laboratory developed tests in the clinical laboratory: Challenges for implementation

Marzinke, M. A. & Clarke, W., Aug 1 2015, In : Bioanalysis. 7, 15, p. 1817-1820 4 p.

Research output: Contribution to journalArticle

Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers

ACTG A5311 Study Team & Dorman, S. E., Jun 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 6, p. 3399-3405 7 p.

Research output: Contribution to journalArticle

Performance of the fourth-generation Bio-Rad GS HIV Combo Ag/Ab enzyme immunoassay for diagnosis of HIV infection in Southern Africa

Piwowar-Manning, E., Fogel, J. M., Richardson, P., Wolf, S., Clarke, W., Marzinke, M. A., Fiamma, A., Donnell, D., Kulich, M., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S. H., Jan 1 2015, In : Journal of Clinical Virology. 62, p. 75-79 5 p.

Research output: Contribution to journalArticle

Pharmacokinetics of long-acting tenofovir alafenamide (GS-7340) subdermal implant for HIV prophylaxis

Gunawardana, M., Remedios-Chan, M., Miller, C. S., Fanter, R., Yang, F., Marzinke, M. A., Hendrix, C., Beliveau, M., Moss, J. A., Smith, T. J. & Baum, M. M., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3913-3919 7 p.

Research output: Contribution to journalArticle

Phase 1 safety, pharmacokinetics, and pharmacodynamics of dapivirine and maraviroc vaginal rings: A double-blind randomized trial

behalf of the MTN-013/IPM 026 Protocol Team for the Microbicide Trials Network, Jan 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 70, 3, p. 242-249 8 p.

Research output: Contribution to journalArticle

Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single-or dual-agent preexposure prophylaxis

Lehman, D. A., Baeten, J. M., McCoy, C. O., Weis, J. F., Peterson, D., Mbara, G., Donnell, D., Thomas, K. K., Hendrix, C. W., Marzinke, M. A., Frenkel, L., Ndase, P., Mugo, N. R., Celum, C., Overbaugh, J. & Matsen, F. A., Apr 15 2015, In : Journal of Infectious Diseases. 211, 8, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Tenofovir-based preexposure prophylaxis for HIV infection among African women

VOICE Study Team, Feb 5 2015, In : New England Journal of Medicine. 372, 6, p. 509-518 10 p.

Research output: Contribution to journalArticle

2016

Analysis of HIV diversity in HIV-infected Black men who have sex with men (HPTN 061)

Chen, I., Chau, G., Wang, J., Clarke, W., Marzinke, M. A., Cummings, V., Breaud, A., Laeyendecker, O. B., Fields, S. D., Griffith, S., Scott, H. M., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Tieu, H. V., Wheeler, D. P., Mayer, K. H., Koblin, B. A. & Eshleman, S., Dec 1 2016, In : PLoS One. 11, 12, e0167629.

Research output: Contribution to journalArticle

Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043)

Fogel, J. M. L., Clarke, W., Kulich, M., Piwowar-Manning, E., Breaud, A., Olson, M. T., Marzinke, M. A., Laeyendecker, O. B., Fiamma, A., Donnell, D., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S., Nov 3 2016, (Accepted/In press) In : Journal of Acquired Immune Deficiency Syndromes.

Research output: Contribution to journalArticle

A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring

Keller, M. J., Mesquita, P. M., Marzinke, M. A., Teller, R., Espinoza, L., Atrio, J. M., Lo, Y., Frank, B., Srinivasan, S., Fredricks, D. N., Rabe, L., Anderson, P. L., Hendrix, C. W., Kiser, P. F. & Herold, B. C., Mar 13 2016, In : AIDS. 30, 5, p. 743-751 9 p.

Research output: Contribution to journalArticle

A phase 2 randomized trial of a rifapentine plus moxifloxacin-based regimen for treatment of pulmonary tuberculosis

Conde, M. B., Mello, F. C. Q., Duarte, R. S., Cavalcante, S. C., Rolla, V., Dalcolmo, M., Loredo, C., Durovni, B., Armstrong, D. T., Efron, A., Link Barnes, G., Marzinke, M. A., Savic, R. M., Dooley, K. E., Cohn, S., Moulton, L. H., Chaisson, R. E. & Dorman, S. E., May 1 2016, In : PLoS One. 11, 5, e0154778.

Research output: Contribution to journalArticle

A randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy

Beigi, R. H., Noguchi, L. M., Montgomery, E., Biggio, J., Hendrix, C., Marzinke, M. A., Dai, J. Y., Pan, J., Kunjara Na Ayudhya, R., Schwartz, J. L., Isaacs, K., Piper, J. M. & Watts, D. H., 2016, In : Journal of the International AIDS Society. 19, 1, 20990.

Research output: Contribution to journalArticle

Combination pod-intravaginal ring delivers antiretroviral agents for HIV prophylaxis: Pharmacokinetic evaluation in an ovine model

Moss, J. A., Butkyavichene, I., Churchman, S. A., Gunawardana, M., Fanter, R., Miller, C. S., Yang, F., Easley, J. T., Marzinke, M. A., Hendrix, C., Smith, T. J. & Baum, M. M., Jun 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 6, p. 3759-3766 8 p.

Research output: Contribution to journalArticle

Comparison of subjective and objective adherence measures for preexposure prophylaxis against HIV infection among serodiscordant couples in East Africa

Musinguzi, N., Muganzi, C. D., Boum, Y., Ronald, A., Marzinke, M. A., Hendrix, C. W., Celum, C., Baeten, J. M., Bangsberg, D. R. & Haberer, J. E., Apr 24 2016, In : AIDS. 30, 7, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Noguchi, L. M., Montgomery, E. T., Biggio, J. R., Hendrix, C., Bogen, D. L., Hillier, S. L., Dai, J. Y., Piper, J. M., Marzinke, M. A., Dezzutti, C. S., Isaacs, S. K., Schwartz, J. L., Watts, D. H. & Beigi, R. H., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5616-5619 4 p.

Research output: Contribution to journalArticle

Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study

Van Der Straten, A., Brown, E. R., Marrazzo, J. M., Chirenje, M. Z., Liu, K., Gomez, K., Marzinke, M. A., Piper, J. M. & Hendrix, C. W., Feb 4 2016, In : Journal of the International AIDS Society. 19, 1, 20642.

Research output: Contribution to journalArticle

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V. & 2 others, Mayer, K. H. & Patterson, K. B., Jan 1 2016, In : AIDS Research and Human Retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle