Mark A Marzinke

Associate Professor

20082020

Research output per year

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Research Output

2020

A subcutaneous implant of tenofovir alafenamide fumarate causes local inflammation and tissue necrosis in rabbits and macaques

Su, J. T., Simpson, S. M., Sung, S., Tfaily, E. B., Veazey, R., Marzinke, M., Qiu, J., Watrous, D., Widanapathirana, L., Pearson, E., Peet, M. M., Karunakaran, D., Grasperge, B., Dobek, G., Cain, C. M., Hope, T. & Kiser, P. F., Jan 1 2020, In : Antimicrobial agents and chemotherapy. 64, 3, e01893.

Research output: Contribution to journalArticle

Open Access

Brief Report: Phase IIa Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Young Women

MTN-023/IPM 030 Study Team, Feb 1 2020, In : Journal of acquired immune deficiency syndromes (1999). 83, 2, p. 135-139 5 p.

Research output: Contribution to journalArticle

Comparison of adherence measurement tools used in a pre-exposure prophylaxis demonstration study among female sex workers in Benin

Mboup, A., Béhanzin, L., Guédou, F., Giguère, K., Geraldo, N., Zannou, D. M., Kêkê, R. K., Bachabi, M., Gangbo, F., Affolabi, D., Marzinke, M. A., Hendrix, C., Diabaté, S. & Alary, M., May 22 2020, In : Medicine. 99, 21, p. e20063

Research output: Contribution to journalArticle

Open Access

Hypoglycemic risk exposures in relation to low serum glucose values in ambulatory patients

Abusamaan, M. S., Marzinke, M. A., Ashok, A., Carroll, K., Lane, K., Jeun, R., Moseley, K. F., Carson, K. A. & Mathioudakis, N. N., Jan 1 2020, In : Medicine (United States). 99, 2, e18679.

Research output: Contribution to journalArticle

Open Access

Once-weekly rifapentine and isoniazid for tuberculosis prevention in patients with HIV taking dolutegravir-based antiretroviral therapy: a phase 1/2 trial

Dooley, K. E., Savic, R., Gupte, A., Marzinke, M. A., Zhang, N., Edward, V. A., Wolf, L., Sebe, M., Likoti, M., Fyvie, M. J., Shibambo, I., Beattie, T., Chaisson, R. E. & Churchyard, G. J., Jun 2020, In : The Lancet HIV. 7, 6, p. e401-e409

Research output: Contribution to journalArticle

Safety and tolerability of injectable Rilpivirine LA in HPTN 076: A phase 2 HIV pre-exposure prophylaxis study in women

HPTN 076 Study Team, Apr 2020, In : EClinicalMedicine. 21, 100303.

Research output: Contribution to journalArticle

Open Access

Sexual Behavior and Perceived HIV Risk Among HIV-Negative Members of Serodiscordant Couples in East Africa

the Partners Demonstration Project Team, Jan 1 2020, (Accepted/In press) In : AIDS and behavior.

Research output: Contribution to journalArticle

2019

2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis

Pons-Faudoa, F. P., Sizovs, A., Di Trani, N., Paez-Mayorga, J., Bruno, G., Rhudy, J., Manohar, M., Gwenden, K., Martini, C., Chua, C. Y. X., Varchi, G., Marzinke, M. A. & Grattoni, A., Jul 28 2019, In : Journal of Controlled Release. 306, p. 89-96 8 p.

Research output: Contribution to journalArticle

Fecal Coliform Bacterial Detection to Assess Enema Adherence in HIV Prevention Clinical Studies

Aung, W. S., Bakshi, R. P., Breakey, J., Johnson, J. E., Hendrix, C. W., Weld, E., Fuchs, E. J. & Marzinke, M. A., Jan 15 2019, In : AIDS and behavior. 23, 1, p. 252-258 7 p.

Research output: Contribution to journalArticle

Incentives for Viral Suppression in People Living with HIV: A Randomized Clinical Trial

Silverman, K., Holtyn, A. F., Rodewald, A. M., Siliciano, R. F., Jarvis, B. P., Subramaniam, S., Leoutsakos, J. M., Getty, C. A., Ruhs, S., Marzinke, M. A. & Fingerhood, M., Sep 1 2019, In : AIDS and behavior. 23, 9, p. 2337-2346 10 p.

Research output: Contribution to journalArticle

Low Disclosure of PrEP Nonadherence and HIV-Risk Behaviors Associated with Poor HIV PrEP Adherence in the HPTN 067/ADAPT Study

Ojeda, V. D., Amico, K. R., Hughes, J. P., Wilson, E., Li, M., Holtz, T. H., Chitwarakorn, A., Grant, R. M., Dye, B. J., Bekker, L. G., Mannheimer, S., Marzinke, M. & Hendrix, C. W., Sep 1 2019, In : Journal of acquired immune deficiency syndromes. 82, 1, p. 34-40 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics of dapivirine transfer into blood plasma, breast milk, and cervicovaginal fluid of lactating women using the dapivirine vaginal ring

Noguchi, L. M., Hoesley, C., Kelly, C., Scheckter, R., Bunge, K., Nel, A., Marzinke, M. A., Hendrix, C. W., Dezzutti, C. S., Hillier, S. L., Bogen, D. L., Piper, J. M. & Beigi, R. H., Mar 2019, In : Antimicrobial agents and chemotherapy. 63, 3, e01930-18.

Research output: Contribution to journalArticle

Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

Chen, B. A., Zhang, J., Gundacker, H. M., Hendrix, C. W., Hoesley, C. J., Salata, R. A., Dezzutti, C. S., Van Der Straten, A., Hall, W. B., Jacobson, C. E., Johnson, S., Mcgowan, I., Nel, A. M., Soto-Torres, L. & Marzinke, M. A., Mar 19 2019, In : Clinical Infectious Diseases. 68, 7, p. 1144-1151 8 p.

Research output: Contribution to journalArticle

Predictors of Daily Adherence to HIV Pre-exposure Prophylaxis in Gay/Bisexual Men in the PRELUDE Demonstration Project

the NSW HIV Prevention Partnership Project & the PRELUDE Study Team, May 15 2019, In : AIDS and behavior. 23, 5, p. 1287-1296 10 p.

Research output: Contribution to journalArticle

Rifampicin effect on intracellular and plasma pharmacokinetics of tenofovir alafenamide

Cerrone, M., Alfarisi, O., Neary, M., Marzinke, M. A., Parsons, T. L., Owen, A., Maartens, G., Pozniak, A., Flexner, C. & Boffito, M., Jan 1 2019, In : Journal of Antimicrobial Chemotherapy. 74, 6, p. 1670-1678 9 p., dkz068.

Research output: Contribution to journalArticle

Short- and Long-Term Pharmacologic Measures of HIV Pre-exposure Prophylaxis Use among High-Risk Men Who Have Sex with Men in HPTN 067/ADAPT

Velloza, J., Bacchetti, P., Hendrix, C. W., Murnane, P., Hughes, J. P., Li, M., Curlin, M. E., Holtz, T. H., Mannheimer, S., Marzinke, M. A., Amico, K. R., Liu, A., Piwowar-Manning, E., Eshleman, S. H., Dye, B. J., Gandhi, M. & Grant, R. M., Oct 1 2019, In : Journal of acquired immune deficiency syndromes. 82, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

Tenofovir-diphosphate as a marker of HIV pre-exposure prophylaxis use among east african men and women

Partners Demonstration Project Study Team, Jan 1 2019, In : Frontiers in Pharmacology. 10, APR, 401.

Research output: Contribution to journalArticle

Open Access

Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial

Keller, M. J., Wood, L., Billingsley, J. M., Ray, L. L., Goymer, J., Sinclair, S., McGinn, A. P., Marzinke, M. A., Frank, B., Srinivasan, S., Liu, C., Atrio, J. M., Espinoza, L., Mugo, N., Spiegel, H. M. L., Anderson, P. L., Fredricks, D. N., Hendrix, C. W., Marrazzo, J., Bosinger, S. E. & 1 others, Herold, B. C., Aug 2019, In : The Lancet HIV. 6, 8, p. e498-e508

Research output: Contribution to journalArticle

Tenofovir Gel for Prevention of Herpes Simplex Virus Type 2 Acquisition: Findings From the VOICE Trial

VOICE Study Team, May 24 2019, In : The Journal of infectious diseases. 219, 12, p. 1940-1947 8 p.

Research output: Contribution to journalArticle

The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing pre-exposure prophylaxis regimens in MSM

Mcgowan, I., Wilkin, T., Landovitz, R. J., Wu, C., Chen, Y., Marzinke, M. A., Hendrix, C. W., Richardson, P., Eshleman, S. H., Andrade, A., Chege, W., Anderson, P. L., McCauley, M., Farley, J., Mayer, K. H., Anton, P., Brand, R. M., Cranston, R. D. & Gulick, R., Feb 1 2019, In : AIDS. 33, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

Open Access

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/ levonorgestrel vaginal rings

Thurman, A. R., Schwartz, J. L., Ravel, J., Gajer, P., Marzinke, M. A., Yousefieh, N., Anderson, S. M. & Doncel, G. F., May 1 2019, In : PloS one. 14, 5, e0217229.

Research output: Contribution to journalArticle

Open Access
2018

Daily and Nondaily Oral Preexposure Prophylaxis in Men and Transgender Women Who Have Sex with Men: The Human Immunodeficiency Virus Prevention Trials Network 067/ADAPT Study

Grant, R. M., Mannheimer, S., Hughes, J. P., Hirsch-Moverman, Y., Loquere, A., Chitwarakorn, A., Curlin, M. E., Li, M., Amico, K. R., Hendrix, C. W., Anderson, P. L., Dye, B. J., Marzinke, M. A., Piwowar-Manning, E., McKinstry, L., Elharrar, V., Stirratt, M., Rooney, J. F., Eshleman, S. H., McNicholl, J. M. & 2 others, Van Griensven, F. & Holtz, T. H., May 17 2018, In : Clinical Infectious Diseases. 66, 11, p. 1712-1721 10 p.

Research output: Contribution to journalArticle

Daily and non-daily pre-exposure prophylaxis in African women (HPTN 067/ADAPT Cape Town Trial): a randomised, open-label, phase 2 trial

HPTN 067 (ADAPT) study team, Feb 2018, In : The Lancet HIV. 5, 2, p. e68-e78

Research output: Contribution to journalArticle

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema

Hoang, T., Date, A. A., Ortiz, J. O., Young, T. W., Bensouda, S., Xiao, P., Marzinke, M. A., Rohan, L., Fuchs, E., Hendrix, C., Gumber, S., Villinger, F., Cone, R. A., Hanes, J. S. & Ensign-Hodges, L., Jan 1 2018, (Accepted/In press) In : European Journal of Pharmaceutics and Biopharmaceutics.

Research output: Contribution to journalArticle

Elevated creatinine in a patient on IVIG-therapy

Knezevic, C. E., Ness, M. A., Kratz, L. E. & Marzinke, M. A., Nov 1 2018, In : Clinica Chimica Acta. 486, p. 94-97 4 p.

Research output: Contribution to journalArticle

FAME-04: A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of film and gel formulations of tenofovir

Bunge, K. E., Dezzutti, C. S., Hendrix, C., Marzinke, M. A., Spiegel, H. M. L., Moncla, B. J., Schwartz, J. L., Meyn, L. A., Richardson-Harman, N., Rohan, L. C. & Hillier, S. L., Aug 1 2018, In : Journal of the International AIDS Society. 21, 8, e25156.

Research output: Contribution to journalArticle

Fertility Intentions, Pregnancy, and Use of PrEP and ART for Safer Conception Among East African HIV Serodiscordant Couples

Partners Demonstration Project Team, Jun 1 2018, In : AIDS and Behavior. 22, 6, p. 1758-1765 8 p.

Research output: Contribution to journalArticle

Hypo-osmolar formulation of tenofovir (TFV) enema promotes uptake and metabolism of TFV in tissues, leading to prevention of SHIV/SIV infection

Xiao, P., Gumber, S., Marzinke, M. A., Date, A. A., Hoang, T., Hanes, J. S., Ensign-Hodges, L., Wang, L., Rohan, L., Fuchs, E., Hendrix, C. & Villinger, F., Jan 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01644-17.

Research output: Contribution to journalArticle

Patterns of Oral PrEP Adherence and HIV Risk Among Eastern African Women in HIV Serodiscordant Partnerships

for the Partners Demonstration Project Team, Nov 1 2018, In : AIDS and behavior. 22, 11, p. 3718-3725 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Rifat, D., Prideaux, B., Savic, R. M., Urbanowski, M. E., Parsons, T. L., Luna, B., Marzinke, M. A., Ordonez Suarez, A., DeMarco, V. P., Jain, S., Dartois, V., Bishai, W. R. & Dooley, K. E., Apr 4 2018, In : Science Translational Medicine. 10, 435, eaai7786.

Research output: Contribution to journalArticle

Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc

Vincent, K. L., Moss, J. A., Marzinke, M. A., Hendrix, C. W., Anton, P. A., Gunawardana, M., Dawson, L. N., Olive, T. J., Pyles, R. B. & Baum, M. M., Aug 2018, In : PloS one. 13, 8, e0201952.

Research output: Contribution to journalArticle

Pregnancy outcomes and infant growth among babies with in-utero exposure to tenofovir-based preexposure prophylaxis for HIV prevention

Partners Demonstration Project & Partners PrEP Study Teams M, Jan 1 2018, In : AIDS. 32, 12, p. 1707-1713 7 p.

Research output: Contribution to journalArticle

Quality control practices for chemistry and immunochemistry in a cohort of 21 large academic medical centers

Rosenbaum, M. W., Flood, J. G., Melanson, S. E. F., Baumann, N. A., Marzinke, M. A., Rai, A. J., Hayden, J., Wu, A. H. B., Ladror, M., Lifshitz, M. S., Scott, M. G., Peck-Palmer, O. M., Bowen, R., Babic, N., Sobhani, K., Giacherio, D., Bocsi, G. T., Herman, D. S., Wang, P., Toffaletti, J. & 9 others, Handel, E., Kelly, K. A., Albeiroti, S., Wang, S., Zimmer, M., Driver, B., Yi, X., Wilburn, C. & Lewandrowski, K. B., Jul 3 2018, In : American journal of clinical pathology. 150, 2, p. 96-104 9 p.

Research output: Contribution to journalArticle

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

Thurman, A. R., Schwartz, J. L., Brache, V., Clark, M. R., McCormick, T., Chandra, N., Marzinke, M. A., Stanczyk, F. Z., Dezzutti, C. S., Hillier, S. L., Herold, B. C., Fichorova, R., Asin, S. N., Rollenhagen, C., Weiner, D., Kiser, P. & Doncel, G. F., Jun 2018, In : PloS one. 13, 6, e0199778.

Research output: Contribution to journalArticle

Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial

Landovitz, R. J., Li, S., Grinsztejn, B., Dawood, H., Liu, A. Y., Magnus, M., Hosseinipour, M. C., Panchia, R., Cottle, L., Chau, G., Richardson, P., Marzinke, M. A., Hendrix, C. W., Eshleman, S. H., Zhang, Y., Tolley, E., Sugarman, J., Kofron, R., Adeyeye, A., Burns, D. & 6 others, Rinehart, A. R., Margolis, D., Spreen, W. R., Cohen, M. S., McCauley, M. & Eron, J. J., Nov 2018, In : PLoS medicine. 15, 11, e1002690.

Research output: Contribution to journalArticle

Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

Vincent, K. L., Moss, J. A., Marzinke, M. A., Hendrix, C. W., Anton, P. A., Pyles, R. B., Guthrie, K. M., Dawson, L., Olive, T. J., Butkyavichene, I., Churchman, S. A., Cortez, J. M., Fanter, R., Gunawardana, M., Miller, C. S., Yang, F., Rosen, R. K., Vargas, S. E. & Baum, M. M., Sep 2018, In : PLoS medicine. 15, 9, e1002655.

Research output: Contribution to journalArticle

Short Communication: Specimen Processing Impacts Tissue Tenofovir Pharmacokinetic Measurements

Bakshi, R., Breakey, J., Manohar, M., Jois, B., Fuchs, E. & Marzinke, M. A., Apr 1 2018, In : AIDS Research and Human Retroviruses. 34, 4, p. 354-356 3 p.

Research output: Contribution to journalArticle

Tenofovir 1% vaginal gel for prevention of HIV-1 infection in women in South Africa (FACTS-001): a phase 3, randomised, double-blind, placebo-controlled trial

Delany-Moretlwe, S., Lombard, C., Baron, D., Bekker, L. G., Nkala, B., Ahmed, K., Sebe, M., Brumskine, W., Nchabeleng, M., Palanee-Philips, T., Ntshangase, J., Sibiya, S., Smith, E., Panchia, R., Myer, L., Schwartz, J. L., Marzinke, M., Morris, L., Brown, E. R., Doncel, G. F. & 2 others, Gray, G. & Rees, H., Nov 2018, In : The Lancet Infectious Diseases. 18, 11, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Tenofovir and tenofovir-diphosphate concentrations during pregnancy among HIV-uninfected women using oral preexposure prophylaxis

Pyra, M., Anderson, P. L., Hendrix, C. W., Heffron, R., Mugwanya, K., Haberer, J. E., Thomas, K. K., Celum, C., Donnell, D., Marzinke, M. A., Bukusi, E. A., Mugo, N. R., Asiimwe, S., Katabira, E. & Baeten, J. M., Jan 1 2018, In : AIDS. 32, 13, p. 1891-1898 8 p.

Research output: Contribution to journalArticle

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis

Chua, C. Y. X., Jain, P., Ballerini, A., Bruno, G., Hood, R. L., Gupte, M., Gao, S., Di Trani, N., Susnjar, A., Shelton, K., Bushman, L. R., Folci, M., Filgueira, C. S., Marzinke, M. A., Anderson, P. L., Hu, M., Nehete, P., Arduino, R. C., Sastry, J. K. & Grattoni, A., Sep 28 2018, In : Journal of Controlled Release. 286, p. 315-325 11 p.

Research output: Contribution to journalArticle

2017

Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH project accept (HPTN 043)

Fogel, J. M., Clarke, W., Kulich, M., Piwowar-Manning, E., Breaud, A., Olson, M. T., Marzinke, M. A., Laeyendecker, O., Fiamma, A., Donnell, D., Mbwambo, J. K. K., Richter, L., Gray, G., Sweat, M., Coates, T. J. & Eshleman, S. H., Feb 1 2017, In : Journal of acquired immune deficiency syndromes. 74, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle

Brief Participant-Centered Convergence Interviews Integrate Self-Reports, Product Returns, and Pharmacokinetic Results to Improve Adherence Measurement in MTN-017

on behalf of the MTN-017 Protocol Team, Oct 26 2017, (Accepted/In press) In : AIDS and Behavior. p. 1-10 10 p.

Research output: Contribution to journalArticle

Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception

on behalf of the MTN-020/ASPIRE Study Team, Oct 1 2017, In : Journal of acquired immune deficiency syndromes. 76, 2, p. e47-e51

Research output: Contribution to journalArticle

Brief Report: Medication Sharing is Rare among African HIV-1 Serodiscordant Couples Enrolled in an Efficacy Trial of Oral Pre-exposure Prophylaxis (PrEP) for HIV-1 Prevention

Thomson, K. A., Haberer, J. E., Marzinke, M. A., Mujugira, A., Hendrix, C. W., Celum, C., Ndase, P., Ronald, A., Bangsberg, D. R. & Baeten, J. M., Jun 1 2017, In : Journal of acquired immune deficiency syndromes. 75, 2, p. 184-189 6 p.

Research output: Contribution to journalArticle