Research output per year
Research output per year
- 43 results
Search results
-
2023
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Datta, S., Cano, M., Satyanarayana, G., Liu, T., Wang, L., Wang, J., Cheng, J., Itoh, K., Sharma, A., Bhutto, I., Kannan, R., Qian, J., Sinha, D. & Handa, J. T., 2023, In: Autophagy. 19, 3, p. 966-983 18 p.Research output: Contribution to journal › Article › peer-review
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2022
Bactericidal Efficacy of High Irradiance Ultraviolet A Photoactivation of Riboflavin Versus Standard Corneal Cross-Linking Protocol in Vitro
Tarff, A., Drew-Bear, L. E., Yee, R., Cano, M., Zhang, Y. & Behrens, A., Sep 1 2022, In: Cornea. 41, 9, p. 1166-1170 5 p.Research output: Contribution to journal › Article › peer-review
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Cell Death in AMD: The Rationale for Targeting Fas
Zacks, D. N., Kocab, A. J., Choi, J. J., Gregory-Ksander, M. S., Cano, M. & Handa, J. T., Feb 1 2022, In: Journal of Clinical Medicine. 11, 3, 592.Research output: Contribution to journal › Review article › peer-review
Open Access -
Effect of topical bovine colostrum in wound healing of corneal surface after acute ocular alkali burn in mice
Tarff, A., Drew-Bear, L. E., Di Meglio, L., Yee, R., Vizcaino, M. A., Gupta, P., Annadanam, A., Cano, M. & Behrens, A., Jul 2022, In: Experimental eye research. 220, 109093.Research output: Contribution to journal › Article › peer-review
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2021
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction
Cano, M., Datta, S., Wang, L., Liu, T., Flores-Bellver, M., Sachdeva, M., Sinha, D. & Handa, J. T., Aug 2021, In: Aging Cell. 20, 8, e13444.Research output: Contribution to journal › Article › peer-review
Open Access -
Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria
Ahn, J. Y., Datta, S., Bandeira, E., Cano, M., Mallick, E., Rai, U., Powell, B., Tian, J., Witwer, K. W., Handa, J. T. & Paulaitis, M. E., Apr 2021, In: Biochimica et Biophysica Acta - General Subjects. 1865, 4, 129598.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2019
The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE
Jun, S., Datta, S., Wang, L., Pegany, R., Cano, M. & Handa, J. T., Apr 2019, In: Experimental eye research. 181, p. 346-355 10 p.Research output: Contribution to journal › Review article › peer-review
16 Scopus citations -
2018
ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H., Merbs, S. L., Zack, D. J., Handa, J. T., Sinha, D., Blackshaw, S. & Qian, J., Dec 1 2018, In: Nature communications. 9, 1, 1364.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Oxidative stress induces an interactive decline in Wnt and Nrf2 signaling in degenerating retinal pigment epithelium
Ebrahimi, K. B., Cano, M., Rhee, J., Datta, S., Wang, L. & Handa, J. T., Aug 1 2018, In: Antioxidants and Redox Signaling. 29, 4, p. 389-407 19 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2017
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
Handa, J. T., Cano, M., Wang, L., Datta, S. & Liu, T., Apr 1 2017, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 4, p. 430-440 11 p.Research output: Contribution to journal › Review article › peer-review
57 Scopus citations -
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K., Wang, L. & Handa, J. T., Sep 2017, In: Progress in Retinal and Eye Research. 60, p. 201-218 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access216 Scopus citations -
2016
Biology of p62/sequestosome-1 in age-related macular degeneration (AMD)
Wang, L., Ebrahimi, K. B., Chyn, M., Cano, M. & Handa, J. T., Oct 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 17-22 6 p. (Advances in Experimental Medicine and Biology; vol. 854).Research output: Chapter in Book/Report/Conference proceeding › Chapter
16 Scopus citations -
Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation
Wang, L., Cano, M., Datta, S., Wei, H., Ebrahimi, K. B., Gorashi, Y., Garlanda, C. & Handa, J. T., Dec 1 2016, In: Journal of Pathology. 240, 4, p. 495-506 12 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2014
Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J. T., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In: Aging Cell. 13, 6, p. 1091-1094 4 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J. T., Campochiaro, P., Wawrousek, E., Zigler, J. S. & Sinha, D., Mar 2014, In: Autophagy. 10, 3, p. 480-496 17 p.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Mice that produce ApoB100 lipoproteins in the RPE do not develop drusen yet are still a valuable experimental system
Fujihara, M., Cano, M. & Handa, J. T., 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7285-7295 11 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Nrf2 signaling is impaired in the aging RPE given an oxidative insult
Sachdeva, M. M., Cano, M. & Handa, J. T., Feb 2014, In: Experimental eye research. 119, p. 111-114 4 p.Research output: Contribution to journal › Article › peer-review
Open Access101 Scopus citations -
Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J. T., May 2014, In: Free Radical Biology and Medicine. 70, p. 155-166 12 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells
Cano, M., Wang, L., Wan, J., Barnett, B. P., Ebrahimi, K., Qian, J. & Handa, J. T., Apr 2014, In: Free Radical Biology and Medicine. 69, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release
Ebrahimi, K. B., Fijalkowski, N., Cano, M. & Handa, J. T., 2014, In: Advances in experimental medicine and biology. 801, p. 259-265 7 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
P62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium
Wang, L., Cano, M. & Handa, J. T., Jul 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 7, p. 1248-1258 11 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells
Chen, C., Cano, M., Wang, J. J., Li, J., Huang, C., Yu, Q., Herbert, T. P., Handa, J. T. & Zhang, S. X., May 10 2014, In: Antioxidants and Redox Signaling. 20, 14, p. 2091-2106 16 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration
Cruz-Guilloty, F., Saeed, A. M., Duffort, S., Cano, M., Ebrahimi, K. B., Ballmick, A., Tan, Y., Wang, H., Laird, J. M., Salomon, R. G., Handa, J. T. & Perez, V. L., Feb 19 2014, In: PloS one. 9, 2, e88201.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2013
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration
Ebrahimi, K. B., Fijalkowski, N., Cano, M. & Handa, J. T., Apr 2013, In: Journal of Pathology. 229, 5, p. 729-742 14 p.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
2012
βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
Sinha, D., Valapala, M., Bhutto, I., Patek, B., Zhang, C., Hose, S., Yang, F., Cano, M., Stark, W. J., Lutty, G. A., Zigler, J. S. & Wawrousek, E. F., Sep 2012, In: Transgenic Research. 21, 5, p. 1033-1042 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2011
Advanced glycation endproduct changes to Bruch's membrane promotes lipoprotein retention by lipoprotein lipase
Cano, M., Fijalkowski, N., Kondo, N., Dike, S. & Handa, J., Aug 2011, In: American Journal of Pathology. 179, 2, p. 850-859 10 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Weismann, D., Hartvigsen, K., Lauer, N., Bennett, K. L., Scholl, H. P. N., Issa, P. C., Cano, M., Brandstätter, H., Tsimikas, S., Skerka, C., Superti-Furga, G., Handa, J. T., Zipfel, P. F., Witztum, J. L. & Binder, C. J., Oct 6 2011, In: Nature. 478, 7367, p. 76-81 6 p.Research output: Contribution to journal › Article › peer-review
Open Access358 Scopus citations -
2010
Apolipoprotein B100 secretion by cultured ARPE-19 cells is modulated by alteration of cholesterol levels
Wu, T., Fujihara, M., Tian, J., Jovanovic, M., Grayson, C., Cano, M., Gehlbach, P., Margaron, P. & Handa, J. T., Sep 2010, In: Journal of Neurochemistry. 114, 6, p. 1734-1744 11 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration
Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M., Wang, A. L., Neufeld, A. H., Biswal, S. & Handa, J. T., Mar 2010, In: Vision Research. 50, 7, p. 652-664 13 p.Research output: Contribution to journal › Article › peer-review
Open Access140 Scopus citations -
Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy
Nishi, Y., Engler, C., Na, D. R., Kashiwabuchi, R. T., Shin, Y. J., Cano, M., Jun, A. S. & Chuck, R. S., Dec 2010, In: Acta Ophthalmologica. 88, 8, p. e323-e327Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
High expression of macrophage migration inhibitory factor in the murine lacrimal gland
Yong Park, C., Shin, Y. J., Lekhanont, K., Zhang, C., Lee, W. S., Cano, M., Bucala, R. & Chuck, R. S., Feb 2010, In: Cornea. 29, 2, p. 187-191 5 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2009
A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization
Cano, M. D. V., Karagiannis, E. D., Soliman, M., Bakir, B., Zhuang, W., Popel, A. S. & Gehlbach, P. L., 2009, In: Investigative Ophthalmology and Visual Science. 50, 8, p. 3840-3845 6 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Nrf2 is a critical modulator of the innate immune response in a model of uveitis
Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In: Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
2008
Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: A potential new treatment for infectious keratitis
Martins, S. A. R., Combs, J. C., Noguera, G., Camacho, W., Wittmann, P., Walther, R., Cano, M., Dick, J. & Behrens, A., Aug 2008, In: Investigative Ophthalmology and Visual Science. 49, 8, p. 3402-3408 7 p.Research output: Contribution to journal › Article › peer-review
183 Scopus citations -
Corneal wound healing is modulated by topical application of amniotic fluid in an ex vivo organ culture model
Castro-Combs, J., Noguera, G., Cano, M., Yew, M., Gehlbach, P. L., Palmer, J. & Behrens, A., Jul 17 2008, In: Experimental eye research. 87, 1, p. 56-63 8 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress
Cano, M. D. V., Reyes, J. M., Park, C. Y., Gao, X., Mori, K., Chuck, R. S. & Gehlbach, P. L., Jun 2008, In: Investigative Ophthalmology and Visual Science. 49, 6, p. 2606-2612 7 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Periocular triamcinolone enhances intraocular gene expression after delivery by adenovirus
Park, C. Y., Chuck, R. S., Cano, M., Yew, M., Nguyen, V., Parker, J., Mori, K. & Gehlbach, P. L., Jan 2008, In: Investigative Ophthalmology and Visual Science. 49, 1, p. 399-406 8 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
PPAR-α ligands as potential therapeutic agents for wet age-related macular degeneration
Gehlbach, P. L. & Del V Cano, M., 2008, In: PPAR Research. 821592.Research output: Contribution to journal › Review article › peer-review
Open Access15 Scopus citations -
2007
Lacrimal gland inflammatory cytokine gene expression in the botulinum toxin B-induced murine dry eye model
Park, C. Y., Zhuang, W., Lekhanont, K., Zhang, C., Cano, M., Lee, W. S., Gehlbach, P. L. & Chuck, R. S., Nov 29 2007, In: Molecular vision. 13, p. 2222-2232 11 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2006
Age as a determinant factor for endotoxin induced uveitis
Brito, B. E., Marcano, J. C., Salazar, E., Cano, M., Baute, L., Bernal, G. & Gonzalez, L. R., Mar 1 2006, In: Ocular Immunology and Inflammation. 14, 2, p. 117-124 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Developmental abnormalities in the Nuc1 rat retina: A spontaneous mutation that affects neuronal and vascular remodeling and retinal function
Gehlbach, P., Hose, S., Lei, B., Zhang, C., Cano, M., Arora, M., Neal, R., Barnstable, C., Goldberg, M. F., Zigler, J. S. & Sinha, D., 2006, In: Neuroscience. 137, 2, p. 447-461 15 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Use of Topical Human Amniotic Fluid in the Treatment of Acute Ocular Alkali Injuries in Mice
Herretes, S., Suwan-Apichon, O., Pirouzmanesh, A., Reyes, J. M. G., Broman, A. T., Cano, M., Gehlbach, P. L., Gurewitsch, E. D., Duh, E. J. & Behrens, A., Aug 2006, In: American journal of ophthalmology. 142, 2, p. 271-278.e1Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2005
A potential role for β- and γ-crystallins in the vascular remodeling of the eye
Zhang, C., Gehlbach, P., Gongora, C., Cano, M., Fariss, R., Hose, S., Nath, A., Green, W. R., Goldberg, M. F., Zigler, J. S. & Sinha, D., Sep 2005, In: Developmental Dynamics. 234, 1, p. 36-47 12 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations