Mario L Amzel

Professor

1969 …2019
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Research Output 1969 2019

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2019

Ca 2+ -dependent regulation of sodium channels Na V 1.4 and Na V 1.5 is controlled by the post-IQ motif

Yoder, J. B., Ben-Johny, M., Farinelli, F., Srinivasan, L., Shoemaker, S. R., Tomaselli, G. F., Gabelli, S. B. & Amzel, M. L., Dec 1 2019, In : Nature communications. 10, 1, 1514.

Research output: Contribution to journalArticle

Open Access
Sodium Channels
Cams
Calmodulin
lobes
Cardiac Arrhythmias

Getting the most out of your crystals: Data collection at the new high-flux, Microfocus MX beamlines at NSLS-II

Miller, M. S., Maheshwari, S., Shi, W., Gao, Y., Chu, N., Soares, A. S., Cole, P. A., Amzel, M. L., Fuchs, M. R., Jakoncic, J. & Gabelli, S. B., Jan 30 2019, In : Molecules. 496.

Research output: Contribution to journalArticle

Fluxes
Crystals
Cytidine Diphosphate
crystals
Crystallography

Lacking catalase, a protistan parasite draws on its photosynthetic ancestry to complete an antioxidant repertoire with ascorbate peroxidase

Schott, E. J., Di Lella, S., Bachvaroff, T. R., Amzel, M. L. & Vasta, G. R., Jul 19 2019, In : BMC Evolutionary Biology. 19, 1, 146.

Research output: Contribution to journalArticle

Open Access
Perkinsus marinus
ascorbate peroxidase
ancestry
antioxidant
catalase

Structure of the zebrafish galectin-1-L2 and model of its interaction with the infectious hematopoietic necrosis virus (IHNV) envelope glycoprotein

Ghosh, A., Banerjee, A., Amzel, M. L., Vasta, G. R. & Bianchet, M. A., May 1 2019, In : Glycobiology. 29, 5, p. 419-430 12 p.

Research output: Contribution to journalArticle

Infectious hematopoietic necrosis virus
Galectin 1
Galectins
Zebrafish
Viruses
2018

A hyaluronic acid binding peptide-polymer system for treating osteoarthritis

Faust, H. J., Sommerfeld, S. D., Rathod, S., Rittenbach, A., Ray, S., Tsui, B., Pomper, M. G., Amzel, M. L., Singh, A. & Elisseeff, J. H., Nov 1 2018, In : Biomaterials. 183, p. 93-101 9 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Hyaluronic Acid
Osteoarthritis
Peptides
Polymers

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

Chu, N., Salguero, A. L., Liu, A. Z., Chen, Z., Dempsey, D. R., Ficarro, S. B., Alexander, W. M., Marto, J. A., Li, Y., Amzel, M. L., Gabelli, S. B. & Cole, P. A., Aug 9 2018, In : Cell. 174, 4, p. 897-907.e14

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Chemical activation
Proteins
Structural Models

Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels

Banerjee, R., Yoder, J. B., Yue, D. T., Amzel, M. L., Tomaselli, G. F., Gabelli, S. B. & Ben-Johny, M., Mar 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 13, p. E3026-E3035

Research output: Contribution to journalArticle

Calmodulin
Calcium Channels
Proteins

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Majumdar, S., Wang, X., Sommerfeld, S. D., Chae, J. J., Athanasopoulou, E. N., Shores, L. S., Duan, X., Amzel, M. L., Stellacci, F., Schein, O. D., Guo, Q., Singh, A. & Elisseeff, J. H., Jan 1 2018, (Accepted/In press) In : Advanced Functional Materials.

Research output: Contribution to journalArticle

cornea
Cyclodextrins
biomimetics
Biomimetics
collagens

Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

Maheshwari, S., Shimokawa, C., Rudzka, K., Kline, C. D., Eipper, B. A., Mains, R. E., Gabelli, S. B., Blackburn, N. & Amzel, M. L., Dec 1 2018, In : Communications Biology. 1, 1, 74.

Research output: Contribution to journalArticle

Open Access
Mixed Function Oxygenases
Copper
copper
Metals
metals

Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis

McCarthy, E. K., Vakos, A., Cottagiri, M., Mantila, J. J., Santhanam, L., Thomas, D. L., Amzel, M. L., Rose, N. R. & Njoku, D. B., Oct 10 2018, In : mSphere. 3, 5

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Cytochromes
Hepatitis
Anesthetics
Epitopes
2017

A Tunable Brake for HECT Ubiquitin Ligases

Chen, Z., Jiang, H., Xu, W., Li, X., Dempsey, D. R., Zhang, X., Devreotes, P. N., Wolberger, C., Amzel, M. L., Gabelli, S. B. & Cole, P. A., May 4 2017, In : Molecular Cell. 66, 3, p. 345-357.e6

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Ubiquitin-Protein Ligases
Immune System Diseases
Post Translational Protein Processing

Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

Yang, J-M., Schiapparelli, P., Nguyen, H. N., Igarashi, A., Zhang, Q., Abbadi, S., Amzel, M. L., Sesaki, H., Quiñones-Hinojosa, A. & Iijima, M., Mar 6 2017, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Protein Stability
Ubiquitination
Phosphoric Monoester Hydrolases
Brain Neoplasms
PTEN Phosphohydrolase

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

Miller, M. S., Maheshwari, S., McRobb, F. M., Kinzler, K. W., Amzel, M. L., Vogelstein, B. & Gabelli, S. B., Feb 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 4, p. 1481-1486 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Allosteric Site
Binding Sites
X ray crystallography
X Ray Crystallography

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

Maheshwari, S., Miller, M. S., O’Meally, R., Cole, R. N., Amzel, M. L. & Gabelli, S. B., 2017, In : Journal of Biological Chemistry. 292, 33, p. 13541-13550 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Catalysis
Phosphotransferases
Kinetics
2016

Calmodulin and Ca2+ control of voltage gated Na+ channels

Gabelli, S. B., Yoder, J. B., Tomaselli, G. F. & Amzel, M. L., Jan 1 2016, In : Channels. 10, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Calmodulin
Calcium
Mutation
Electric potential

Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis

O’Handley, S. F., Thirawatananond, P., Kang, L. W., Cunningham, J. E., Leyva, J. A., Amzel, M. L. & Gabelli, S. B., Sep 28 2016, (Accepted/In press) In : Journal of Bioenergetics and Biomembranes. p. 1-11 11 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Hydrolases
Mycobacterium tuberculosis
Catalysis
Enzymes

Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights

Alqassim, S. S., Urquiza, M., Borgnia, E., Nagib, M., Amzel, M. L. & Bianchet, M. A., Mar 3 2016, In : Scientific Reports. 6, 22176.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Actins
Actin Depolymerizing Factors
Small Angle Scattering
X Ray Crystallography

Na+ coordination at the Na2 site of the Na+ /I- symporter

Ferrandino, G., Nicola, J. P., Sánchez, Y. E., Echeverria, I., Liu, Y., Amzel, M. L. & Carrasco, N., Sep 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5379-E5388

Research output: Contribution to journalArticle

Symporters
Binding Sites
Active Biological Transport
Thyroid Hormones
Thyroid Gland
2015

A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development

Wolff, K. A., de la Peña, A. H., Nguyen, H. T., Pham, T. H., Amzel, M. L., Gabelli, S. B. & Nguyen, L., Apr 1 2015, In : PLoS Pathogens. 11, 4, e1004839.

Research output: Contribution to journalArticle

Biofilms
NAD
Oxidation-Reduction
Macrophages
Flavin-Adenine Dinucleotide

Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters

Ravera, S., Quick, M., Nicola, J. P., Carrasco, N. & Amzel, M. L., 2015, In : Journal of General Physiology. 145, 6, p. 555-563 9 p.

Research output: Contribution to journalArticle

Symporters
Active Biological Transport
Ions
Thyroid Hormones
Iodine

Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α

Echeverria, I., Liu, Y., Gabelli, S. B. & Amzel, M. L., Sep 1 2015, In : FEBS Journal. 282, 18, p. 3528-3542 15 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Mutation
Cell signaling
Macromolecular Substances
Cell growth

Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations

Munns, C. H., Chung, M. K., Sanchez, Y. E., Amzel, M. L. & Caterina, M., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5707-5724 18 p.

Research output: Contribution to journalArticle

Cations
Permeability
Capsaicin
Phenotype
Substitution reactions

Sodium/iodide symporter mutant V270E causes stunted growth but no cognitive deficiency

Nicola, J. P., Reyna-Neyra, A., Saenger, P., Rodriguez-Buritica, D. F., Godoy, J. D. G., Muzumdar, R., Amzel, M. L. & Carrasco, N., Oct 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 10, p. E1353-E1361

Research output: Contribution to journalArticle

Growth Disorders
Symporters
Cell membranes
Genes
Cell Membrane

Structural and enzymatic characterization of a nucleoside diphosphate sugar hydrolase from Bdellovibrio bacteriovorus

De La Peña, A. H., Suarez, A., Duong-Ly, K. C., Schoeffield, A. J., Pizarro-Dupuy, M. A., Zarr, M., Pineiro, S. A., Amzel, M. L. & Gabelli, S. B., Nov 2 2015, In : PLoS One. 10, 11, e141716.

Research output: Contribution to journalArticle

Nucleoside Diphosphate Sugars
Bdellovibrio bacteriovorus
nucleosides
Hydrolases
hydrolases
2014

Activation of PI3Kα by physiological effectors and by oncogenic mutations: Structural and dynamic effects

Gabelli, S. B., Echeverria, I., Alexander, M., Duong-Ly, K. C., Chaves-Moreira, D., Brower, E. T., Vogelstein, B. & Amzel, M. L., Mar 2014, In : Biophysical Reviews. 6, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Mutation
Phosphotransferases
Phosphatidylinositols
Enzymes

Physiological sodium concentrations enhance the iodide affinity of the Na+ /I- symporter

Nicola, J. P., Carrasco, N. & Amzel, M. L., Jun 3 2014, In : Nature Communications. 5, 3948.

Research output: Contribution to journalArticle

Symporters
Iodides
iodides
affinity
Sodium

Regulation of the NaV 1.5 cytoplasmic domain by calmodulin

Gabelli, S. B., Boto, A., Kuhns, V. H., Bianchet, M. A., Farinelli, F., Aripirala, S., Yoder, J., Jakoncic, J., Tomaselli, G. F. & Amzel, M. L., 2014, In : Nature Communications. 5, 5126.

Research output: Contribution to journalArticle

calmodulin
Calmodulin
Chemical activation
activation
Voltage-Gated Sodium Channels

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Aripirala, S., Gonzalez-Pacanowska, D., Oldfield, E., Kaiser, M., Amzel, M. L. & Gabelli, S. B., Mar 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 3, p. 802-810 9 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Leishmania major
Diphosphonates
Thermodynamics
Nitrogen

Structural basis of nSH2 regulation and lipid binding in PI3Kα

Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I. G., Thompson, P. E., Cole, P. A., Amzel, M. L., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198-5208 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
src Homology Domains
Lipids
Phosphotransferases
Binding Sites
2013

Asn441 plays a key role in folding and function of the Na +/I- symporter (NIS)

Li, W., Nicola, J. P., Amzel, M. L. & Carrasco, N., Aug 2013, In : FASEB Journal. 27, 8, p. 3229-3238 10 p.

Research output: Contribution to journalArticle

Symporters
Cell membranes
Cell Membrane
Defects
Active Biological Transport

A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis

Duong-Ly, K. C., Woo, H. N., Dunn, C. A., Xu, W. L., Babič, A., Bessman, M. J., Amzel, M. L. & Gabelli, S. B., May 15 2013, In : PLoS One. 8, 5, e64241.

Research output: Contribution to journalArticle

Streptococcus pneumoniae
Peptidoglycan
peptidoglycans
Biosynthesis
biosynthesis

Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): Structural and computational study

Rudzka, K., Moreno, D. M., Eipper, B., Mains, R., Estrin, D. A. & Amzel, M. L., Feb 2013, In : Journal of Biological Inorganic Chemistry. 18, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Peroxides
Mixed Function Oxygenases
Copper
Hydroxylation
Hydrogen Peroxide

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

Bolduc, D., Rahdar, M., Tu-Sekine, B., Sivakumaren, S. C., Raben, D. M., Amzel, M. L., Devreotes, P. N., Gabelli, S. B. & Cole, P., Jul 9 2013, In : eLife. 2013, 2, e00691.

Research output: Contribution to journalArticle

Phosphorylation
PTEN Phosphohydrolase
Membranes
Proteins
Cell membranes

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Zhang, P., Yang, X., Zhang, F., Gabelli, S. B., Wang, R., Zhang, Y., Bhat, S., Chen, X., Furlani, M., Amzel, M. L., Liu, J. & Ma, D., May 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2600-2617 18 p.

Research output: Contribution to journalArticle

Aminopeptidases
Methionine
Structure-Activity Relationship
Mammals
Pharmaceutical Chemistry

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells

Zhang, F., Bhat, S., Gabelli, S. B., Chen, X., Miller, M. S., Nacev, B. A., Cheng, Y. L., Meyers, D. J., Tenney, K., Shim, J. S., Crews, P., Amzel, M. L., Ma, D. & Liu, J., May 23 2013, In : Journal of Medicinal Chemistry. 56, 10, p. 3996-4016 21 p.

Research output: Contribution to journalArticle

Aminopeptidases
Methionine
Quinazolines
Mammals
Metals

Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies

Armstrong, A., Hildreth, J. E. K. & Amzel, M. L., Jun 12 2013, In : Journal of Molecular Biology. 425, 11, p. 2027-2038 12 p.

Research output: Contribution to journalArticle

Thermodynamics
Anti-Idiotypic Antibodies
Peptides
Micrococcal Nuclease
Proteins
2012

Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase

Aripirala, S., Szajnman, S. H., Jakoncic, J., Rodriguez, J. B., Docampo, R., Gabelli, S. B. & Amzel, M. L., Jul 26 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6445-6454 10 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Calorimetry
Trypanosoma cruzi
Diphosphonates
Chagas Disease

Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects.

Vasta, G. R., Ahmed, H., Bianchet, M. A., Fernández-Robledo, J. A. & Amzel, M. L., Apr 2012, In : Annals of the New York Academy of Sciences. 1253

Research output: Contribution to journalArticle

Galectins
Lectins
Polysaccharides
Carbohydrates
Ligands

Estimation of free-energy differences from computed work distributions: An application of Jarzynski's equality

Echeverria, I. & Amzel, M. L., Sep 13 2012, In : Journal of Physical Chemistry B. 116, 36, p. 10986-10995 10 p.

Research output: Contribution to journalArticle

Free energy
free energy
Trajectories
trajectories
estimates

Targeting the cell wall of mycobacterium tuberculosis: Structure and mechanism of L,D-transpeptidase 2

Erdemli, S. B., Gupta, R., Bishai, W. R., Lamichhane, G., Amzel, M. L. & Bianchet, M. A., Dec 5 2012, In : Structure. 20, 12, p. 2103-2115 13 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Mycobacterium tuberculosis
Cell Wall
Peptidoglycan
Mycobacterium

Unfolding ubiquitin by force: Water mediated H-bond destabilization

Pabón, G. & Amzel, M. L., 2012, In : Universitas Scientiarum. 17, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

destabilization
water
molecules
simulation
pulling
2011

A compact β model of huntingtin toxicity

Zhang, Q. C., Yeh, T. L., Leyva, A., Frank, L. G., Miller, J., Kim, Y. E., Langen, R., Finkbeiner, S., Amzel, M. L., Ross, C. A. & Poirier, M. A., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8188-8196 9 p.

Research output: Contribution to journalArticle

Toxicity
Aptitude
Poisons
Huntington Disease
Pathology

Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase

Gabelli, S. B., Duong-Ly, K. C., Brower, E. T. & Amzel, M. L., 2011, In : Advances in Enzyme Regulation. 51, 1, p. 273-279 7 p.

Research output: Contribution to journalArticle

Protein Conformation
Molecular Models
Protein Subunits
Protein Kinase Inhibitors
Phosphatidylinositol 3-Kinases

Direct activation of Epac by sulfonylurea is isoform selective

Herbst, K. J., Coltharp, C., Amzel, M. L. & Zhang, J., Feb 25 2011, In : Chemistry and Biology. 18, 2, p. 243-251 9 p.

Research output: Contribution to journalArticle

Protein Isoforms
Chemical activation
Proteins
Sulfonylurea Receptors
Enzyme Activators

Disaccharide binding to galectin-1: Free energy calculations and molecular recognition mechanism

Echeverria, I. & Amzel, M. L., May 4 2011, In : Biophysical Journal. 100, 9, p. 2283-2292 10 p.

Research output: Contribution to journalArticle

Galectin 1
Disaccharides
Binding Sites
Galectins
Ligands

Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels

Mustafa, A. K., Sikka, G., Gazi, S. K., Steppan, J., Jung, S. M., Bhunia, A. K., Barodka, V., Gazi, F. K., Barrow, R. K., Wang, R., Amzel, M. L., Berkowitz, D. E. & Snyder, S. H., Nov 11 2011, In : Circulation Research. 109, 11, p. 1259-1268 10 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Potassium Channels
Endothelium
Endothelium-Dependent Relaxing Factors
Cystathionine

Mechanism of anion selectivity and stoichiometry of the Na +/I - symporter (NIS)

Paroder-Belenitsky, M., Maestas, M. J., Dohán, O., Nicola, J. P., Reyna-Neyra, A., Follenzi, A., Dadachova, E., Eskandari, S., Amzel, M. L. & Carrasco, N., Nov 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17933-17938 6 p.

Research output: Contribution to journalArticle

Symporters
Anions
Bacterial Structures
Environmental Pollutants
Ion Transport

Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity

Vasta, G. R., Nita-Lazar, M., Giomarelli, B., Ahmed, H., Du, S., Cammarata, M., Parrinello, N., Bianchet, M. A. & Amzel, M. L., Dec 2011, In : Developmental and Comparative Immunology. 35, 12, p. 1388-1399 12 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Lectins
Innate Immunity
Fishes
Ligands

Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition

Boto, A. N., Xu, W., Jakoncic, J., Pannuri, A., Romeo, T., Bessman, M. J., Gabelli, S. B. & Amzel, M. L., Aug 2011, In : Proteins. 79, 8, p. 2455-2466 12 p.

Research output: Contribution to journalArticle

Guanosine Diphosphate Mannose
Adenosine Diphosphate Ribose
Pyrophosphatases
Hydrolases
Mannose

The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor

Yeh, T. L., Lee, C-Y., Amzel, M. L., Espenshade, P. & Bianchet, M. A., Apr 13 2011, In : Structure. 19, 4, p. 503-514 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Sterols
Oxygen
Transcription Factors
Schizosaccharomyces pombe Proteins