Mario L Amzel

Director & Professor

1969 …2018
If you made any changes in Pure these will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Enzymes Medicine & Life Sciences
Binding Sites Medicine & Life Sciences
Peptides Medicine & Life Sciences
Protein Conformation Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Entropy Medicine & Life Sciences
X-Ray Diffraction Medicine & Life Sciences
NAD(P)H Dehydrogenase (Quinone) Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1969 2018

Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels

Banerjee, R., Yoder, J. B., Yue, D. T., Amzel, L. M., Tomaselli, G. F., Gabelli, S. B. & Ben-Johny, M. Mar 27 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 13, p. E3026-E3035

Research output: Contribution to journalArticle

Calmodulin
Calcium Channels
Proteins

A Tunable Brake for HECT Ubiquitin Ligases

Chen, Z., Jiang, H., Xu, W., Li, X., Dempsey, D. R., Zhang, X., Devreotes, P., Wolberger, C., Amzel, L. M., Gabelli, S. B. & Cole, P. A. May 4 2017 In : Molecular Cell. 66, 3, p. 345-357.e6

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Ubiquitin-Protein Ligases
Immune System Diseases
Post Translational Protein Processing

F-Type Lectins: A highly diversified family of fucose-binding proteins with a unique sequence motif and structural fold, involved in self/non-self-recognition

Vasta, G. R., Mario Amzel, L., Bianchet, M. A., Cammarata, M., Feng, C. & Saito, K. Nov 29 2017 In : Frontiers in Immunology. 8, NOV, 1648

Research output: Contribution to journalReview article

Lectins
fucose-binding lectin
Frontotemporal Lobar Degeneration
Gene Duplication
Fucose

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

Miller, M. S., Maheshwari, S., McRobb, F. M., Kinzler, K. W., Amzel, L. M., Vogelstein, B. & Gabelli, S. B. Feb 15 2017 In : Bioorganic and Medicinal Chemistry. 25, 4, p. 1481-1486 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Allosteric Site
Binding Sites
X ray crystallography
X Ray Crystallography

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

Maheshwari, S., Miller, M. S., O’Meally, R., Cole, R. N., Amzel, L. M. & Gabelli, S. B. 2017 In : Journal of Biological Chemistry. 292, 33, p. 13541-13550 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Catalysis
Phosphotransferases
Kinetics