Marikki Laiho

Professor

1985 …2019

Research output per year

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Research Output

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2019

Effective targeting of RNA polymerase I in treatment-resistant prostate cancer

Low, J. Y., Sirajuddin, P., Moubarek, M., Agarwal, S., Rege, A., Guner, G., Liu, H., Yang, Z., De Marzo, A. M., Bieberich, C. & Laiho, M., Dec 1 2019, In : Prostate. 79, 16, p. 1837-1851 15 p.

Research output: Contribution to journalArticle

2018

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Wei, T., Najmi, S. M., Liu, H., Peltonen, K., Kucerova, A., Schneider, D. A. & Laiho, M., Apr 10 2018, In : Cell Reports. 23, 2, p. 404-414 11 p.

Research output: Contribution to journalArticle

2017

Novel assay to detect RNA polymerase I activity in vivo

Guner, G., Sirajuddin, P., Zheng, Q., Bai, B., Brodie, A., Liu, H., Af Hällström, T., Kulac, I., Laiho, M. & Demarzo, A. M., May 1 2017, In : Molecular Cancer Research. 15, 5, p. 577-584 8 p.

Research output: Contribution to journalArticle

Pharmacological inhibition of spinal cord injury-stimulated ribosomal biogenesis does not affect locomotor outcome

Kilanczyk, E., Andres, K. R., Hallgren, J., Ohri, S. S., Laiho, M., Whittemore, S. R. & Hetman, M., Mar 6 2017, In : Neuroscience Letters. 642, p. 153-157 5 p.

Research output: Contribution to journalArticle

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Köroǧlu, Ç., Peltonen, K., Steinberg, R. C., Maraş Genç, H., Hölttä-Vuori, M., Güven, A., Kanerva, K., Kotil, T., Solakoǧlu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 1 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticle

2016

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliäinen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS pathogens. 12, 2, e1005424.

Research output: Contribution to journalArticle

2015

Sequential recovery of macromolecular components of the nucleolus

Bai, B. & Laiho, M., Jan 1 2015, In : Methods in Molecular Biology. 1228, p. 43-51 9 p.

Research output: Contribution to journalArticle

2014

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity

Peltonen, K., Colis, L., Liu, H., Trivedi, R., Moubarek, M. S., Moore, H. M., Bai, B., Rudek, M. A., Bieberich, C. J. & Laiho, M., Jan 13 2014, In : Cancer cell. 25, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

A tissue graft model of DNA damage response in the normal and malignant human prostate

Af Hällström, T. M., Zhao, H., Tian, J., Rantanen, V., Reese, S. W., Nolley, R., Laiho, M. & Peehl, D. M., Mar 1 2014, In : Journal of Urology. 191, 3, p. 842-849 8 p.

Research output: Contribution to journalArticle

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase i inhibitors

Colis, L., Ernst, G., Sanders, S., Liu, H., Sirajuddin, P., Peltonen, K., Depasquale, M., Barrow, J. C. & Laiho, M., Jun 12 2014, In : Journal of medicinal chemistry. 57, 11, p. 4950-4961 12 p.

Research output: Contribution to journalArticle

DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells

Laos, M., Anttonen, T., Kirjavainen, A., Hällström, T. A., Laiho, M. & Pirvola, U., Jun 2014, In : Aging. 6, 6, p. 496-510 15 p.

Research output: Contribution to journalArticle

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

Colis, L., Peltonen, K., Sirajuddin, P., Liu, H., Sanders, S., Ernst, G., Barrow, J. C. & Laiho, M., 2014, In : Oncotarget. 5, 12, p. 4361-4369 9 p.

Research output: Contribution to journalArticle

Open Access

RNA-seq of the nucleolus reveals abundant SNORD44-derived small RNAs

Bai, B., Yegnasubramanian, S., Wheelan, S. J. & Laiho, M., Sep 2014, In : PloS one. 9, 9, e107519.

Research output: Contribution to journalArticle

Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress

Peltonen, K., Colis, L., Liu, H., Jäämaa, S., Zhang, Z., Hällström, T. A., Moore, H. M., Sirajuddin, P. & Laiho, M., Nov 1 2014, In : Molecular cancer therapeutics. 13, 11, p. 2537-2546 10 p.

Research output: Contribution to journalArticle

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

Bai, B., Liu, H. & Laiho, M., 2014, In : FEBS Open Bio. 4, p. 441-449 9 p.

Research output: Contribution to journalArticle

2013

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis

Bai, B., Moore, H. M. & Laiho, M., Jul 1 2013, In : Nucleus (United States). 4, 4

Research output: Contribution to journalArticle

Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM

Moore, H. M., Bai, B., Matilainen, O., Colis, L., Peltonen, K. & Laiho, M., Mar 12 2013, In : PloS one. 8, 3, e59096.

Research output: Contribution to journalArticle

PSA forms complexes with α1-antichymotrypsin in prostate

Zhu, L., Jäämaa, S., Af Hällström, T. M., Laiho, M., Sankila, A., Nordling, S., Stenman, U. H. & Koistinen, H., Jan 1 2013, In : Prostate. 73, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

2012

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate

Jäämaa, S., Sankila, A., Rantanen, V., Peltonen, K., Järvinen, P. M., Af Hällström, T. M., Ruutu, M., Taari, K., Andersson, L. C. & Laiho, M., Jul 1 2012, In : Prostate. 72, 10, p. 1060-1070 11 p.

Research output: Contribution to journalArticle

Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis

Järvinen, P. M., Myllärniemi, M., Liu, H., Moore, H. M., Leppäranta, O., Salmenkivi, K., Koli, K., Latonen, L., Band, A. M. & Laiho, M., Jun 1 2012, In : Journal of Cellular Physiology. 227, 6, p. 2605-2612 8 p.

Research output: Contribution to journalArticle

Efficient sequential recovery of nucleolar macromolecular components

Bai, B. & Laiho, M., Oct 1 2012, In : Proteomics. 12, 19-20, p. 3044-3048 5 p.

Research output: Contribution to journalArticle

SnoN oncoprotein enhances estrogen receptor-α transcriptional activity

Band, A. M. & Laiho, M., Apr 1 2012, In : Cellular Signalling. 24, 4, p. 922-930 9 p.

Research output: Contribution to journalArticle

2011

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture

Zhang, Z., Yang, Z., Jäämaa, S., Liu, H., Pellakuru, L. G., Iwata, T., Af Hällström, T. M., De Marzo, A. M. & Laiho, M., Oct 31 2011, In : Cell Cycle. 10, 20, p. 3545-3553 9 p.

Research output: Contribution to journalArticle

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., Laiho, M., DeWeese, T. L. & Lupold, S. E., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

Latonen, L., Moore, H. M., Bai, B., Jäämaa, S. & Laiho, M., Feb 17 2011, In : Oncogene. 30, 7, p. 790-805 16 p.

Research output: Contribution to journalArticle

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation

Moore, H. M., Bai, B., Boisvert, F. M., Latonen, L., Rantanen, V., Simpson, J. C., Pepperkok, R., Lamond, A. I. & Laiho, M., Oct 1 2011, In : Molecular and Cellular Proteomics. 10, 10

Research output: Contribution to journalArticle

2010

Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction

Sulg, M., Kirjavainen, A., Pajusola, K., Bueler, H., Ylikoski, J., Laiho, M. & Pirvola, U., Mar 1 2010, In : Journal of Neurochemistry. 112, 6, p. 1513-1526 14 p.

Research output: Contribution to journalArticle

DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue

Jäämaa, S., Af Hällström, T. M., Sankila, A., Rantanen, V., Koistinen, H., Stenman, U. H., Zhang, Z., Yang, Z., De Marzo, A. M., Taari, K., Ruutu, M., Andersson, L. C. & Laiho, M., Nov 1 2010, In : Cancer Research. 70, 21, p. 8630-8641 12 p.

Research output: Contribution to journalArticle

Identification of novel p53 Pathway activating Small-molecule compounds reveals unexpected similarities with known therapeutic agents

Peltonen, K., Colis, L., Liu, H., Jäämaa, S., Moore, H. M., Enbäck, J., Laakkonen, P., Vaahtokari, A., Jones, R. J., af Hällström, T. M. & Laiho, M., Nov 1 2010, In : PloS one. 5, 9, e12996.

Research output: Contribution to journalArticle

Non-CDK-bound p27 (p27NCDK) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

Björklund, M. A., Vaahtomeri, K., Peltonen, K., Viollet, B., Mäkelä, T. P., Band, A. M. & Laiho, M., Mar 10 2010, In : Experimental cell research. 316, 5, p. 762-774 13 p.

Research output: Contribution to journalArticle

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency

Sarek, G., Järviluoma, A., Moore, H. M., Tojkander, S., Vartia, S., Biberfeld, P., Laiho, M. & Ojala, P. M., Mar 1 2010, In : PLoS pathogens. 6, 3, e1000818.

Research output: Contribution to journalArticle

Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.

Latonen, L., Järvinen, P. M., Suomela, S., Moore, H. M., Saarialho-Kere, U. & Laiho, M., Apr 2010, In : Photodermatology, photoimmunology & photomedicine. 26, 2, p. 70-77 8 p.

Research output: Contribution to journalArticle

2009

The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-β signaling by destabilizing ski and inducing Smad7

Band, A. M., Björklund, M. & Laiho, M., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35441-35449 9 p.

Research output: Contribution to journalArticle

2008

Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death

Latonen, L., Järvinen, P. M. & Laiho, M., Feb 15 2008, In : Experimental cell research. 314, 4, p. 738-747 10 p.

Research output: Contribution to journalArticle

2007

Human prostate epithelium lacks Wee1A-media ted DNA damage-induced checkpoint enforcement

Kiviharju-af Hällström, T. M., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M. & Laiho, M., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7211-7216 6 p.

Research output: Contribution to journalArticle

p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., Feb 7 2007, In : Journal of Neuroscience. 27, 6, p. 1434-1444 11 p.

Research output: Contribution to journalArticle

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P., Laiho, M. & Ojala, P. M., Apr 2 2007, In : Journal of Clinical Investigation. 117, 4, p. 1019-1028 10 p.

Research output: Contribution to journalArticle

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis

Koopal, S., Furuhjelm, J. H., Järviluoma, A., Jäämaa, S., Pyakurel, P., Pussinen, C., Wirzenius, M., Biberfeld, P., Alitalo, K., Laiho, M. & Ojala, P. M., Sep 1 2007, In : PLoS pathogens. 3, 9, p. 1348-1360 13 p.

Research output: Contribution to journalArticle

2005

FGF-2 blocks TGF-β1-mediated suppression of Bcl-2 in normal melanocytes

von Willebrand, M., Köhler, K., Alanko, T., Laiho, M. & Saksela, O., Mar 1 2005, In : Experimental Dermatology. 14, 3, p. 202-208 7 p.

Research output: Contribution to journalArticle

Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis

Peltonen, K., Kiviharju, T. M., Järvinen, P. M., Ra, R. & Laiho, M., Jun 1 2005, In : Pigment Cell Research. 18, 3, p. 196-202 7 p.

Research output: Contribution to journalArticle

Myc antagonises Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway

Vaqué, J. P., Navascues, J., Shiio, Y., Laiho, M., Ajenjo, N., Mauleon, I., Matallanas, D., Crespo, P. & León, J., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1112-1122 11 p.

Research output: Contribution to journalArticle

2004

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

Kurki, S., Peltonen, K., Latonen, L., Kiviharju, T. M., Ojala, P. M., Meek, D. & Laiho, M., May 1 2004, In : Cancer cell. 5, 5, p. 465-475 11 p.

Research output: Contribution to journalArticle

2003

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses

Gentile, M., Latonen, L. & Laiho, M., Aug 15 2003, In : Nucleic acids research. 31, 16, p. 4779-4790 12 p.

Research output: Contribution to journalArticle

Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

Kurki, S., Latonen, L. & Laiho, M., Oct 1 2003, In : Journal of cell science. 116, 19, p. 3917-3925 9 p.

Research output: Contribution to journalArticle

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

Latonen, L., Kurki, S., Pitkänen, K. & Laiho, M., Jan 1 2003, In : Cellular Signalling. 15, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-β signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas

Zhang, F., Lundin, M., Ristimäki, A., Heikkilä, P., Lundin, J., Isola, J., Joensuu, H. & Laiho, M., Aug 15 2003, In : Cancer Research. 63, 16, p. 5005-5010 6 p.

Research output: Contribution to journalArticle

2002

Proteasomal activity modulates TGF-β signaling in a gene-specific manner

Zhang, F., Mönkkönen, M., Roth, S. & Laiho, M., Sep 11 2002, In : FEBS Letters. 527, 1-3, p. 58-62 5 p.

Research output: Contribution to journalArticle

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Buzek, J., Latonen, L., Kurki, S., Peltonen, K. & Laiho, M., Jun 1 2002, In : Nucleic acids research. 30, 11, p. 2340-2348 9 p.

Research output: Contribution to journalArticle

TGF-β induced G1 cell cycle arrest requires the activity of the proteasome pathway

Zhang, F., Mönkkönen, M., Roth, S. & Laiho, M., Jan 1 2002, In : Experimental cell research. 281, 2, p. 190-196 7 p.

Research output: Contribution to journalArticle