Marikki Laiho

Professor

1985 …2019
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Fingerprint Dive into the research topics where Marikki Laiho is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Transforming Growth Factors Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
RNA Polymerase I Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Cell Cycle Medicine & Life Sciences
Proteins Medicine & Life Sciences
Growth Medicine & Life Sciences
Prostate Medicine & Life Sciences

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Research Output 1985 2019

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Hämäläinen, R. H., Landoni, J. C., Ahlqvist, K. J., Goffart, S., Ryytty, S., Rahman, M. O., Brilhante, V., Icay, K., Hautaniemi, S., Wang, L., Laiho, M. & Suomalainen, A., Oct 1 2019, In : Nature Metabolism. 1, 10, p. 958-965 8 p.

Research output: Contribution to journalLetter

Genomic Instability
DNA Replication
Mitochondrial DNA
Nucleotides
Genome

Effective targeting of RNA polymerase I in treatment-resistant prostate cancer

Low, J. Y., Sirajuddin, P., Moubarek, M., Agarwal, S., Rege, A., Guner, G., Liu, H., Yang, Z., De Marzo, A. M., Bieberich, C. & Laiho, M., Dec 1 2019, In : Prostate. 79, 16, p. 1837-1851 15 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Castration
Growth
Heterografts
Neoplasms

Equity and diversity in academic medicine: A perspective from the JCI editors

Smith Resar, L. M., Jaffee, E., Armanios, M., Jackson, S., Azad, N., Horton, M., Kaplan, M. J., Laiho, M., Maus, M. V., Sumner, C., Wheelan, S. & Wills-Karp, M., Oct 1 2019, In : Journal of Clinical Investigation. 129, 10

Research output: Contribution to journalComment/debate

Open Access
Medicine
RNA Polymerase I
RNA Polymerase III
Antibodies
Neoplasms
Anti-Idiotypic Antibodies

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Wei, T., Najmi, S. M., Liu, H., Peltonen, K., Kucerova, A., Schneider, D. A. & Laiho, M., Apr 10 2018, In : Cell Reports. 23, 2, p. 404-414 11 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Transcription
Elongation
Molecules
Response Elements