Marie-France Penet

Assistant Professor

20042018
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Research Output 2004 2018

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Article
2018
Cyclooxygenase 2
Dextrans
Small Interfering RNA
Down-Regulation
Acids

A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma

Han, C. , Bellone, S. , Siegel, E. R. , Altwerger, G. , Menderes, G. , Bonazzoli, E. , Egawa-Takata, T. , Pettinella, F. , Bianchi, A. , Riccio, F. , Zammataro, L. , Yadav, G. , Marto, J. A. , Penet, M. F. , Levine, D. A. , Drapkin, R. , Patel, A. , Litkouhi, B. , Ratner, E. , Silasi, D. A. & 4 others Huang, G. S., Azodi, M., Schwartz, P. E. & Santin, A. D. Jan 1 2018 (Accepted/In press) In : Gynecologic oncology.

Research output: Contribution to journalArticle

Area Under Curve
ROC Curve
Biomarkers
Carcinoma
Ovarian Neoplasms

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft

Bharti, S. K., Mironchik, Y., Wildes, F., Penet, M. F., Goggins, E., Krishnamachary, B. & Bhujwalla, Z. M. Jan 1 2018 In : Oncotarget. 9, 20, p. 15326-15339 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Heterografts
Magnetic Resonance Spectroscopy
Neoplasms
Hypoxia
Disease control
Molecular imaging
Precision Medicine
Molecular Imaging
Oncology
2017
Cyclooxygenase 2
Extracellular Matrix
Breast Neoplasms
Collagen
Down-Regulation

Metabolomic characterization of experimental ovarian cancer ascitic fluid

Bharti, S. K., Wildes, F., Hung, C. F., Wu, T. C., Bhujwalla, Z. M. & Penet, M. F. Oct 1 2017 In : Metabolomics. 13, 10, 113

Research output: Contribution to journalArticle

Metabolomics
Ascitic Fluid
Ascites
Ovarian Neoplasms
Cells
Extracellular Matrix
Prostatic Neoplasms
Neoplasms
Collagen
Albumins
2016

Detection of pancreatic cancer-induced cachexia using a fluorescent myoblast reporter system and analysis of metabolite abundance

Winnard, P. T., Bharti, S. K., Penet, M. F., Marik, R., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Mar 15 2016 In : Cancer Research. 76, 6, p. 1441-1450 10 p.

Research output: Contribution to journalArticle

Cachexia
Myoblasts
Systems Analysis
Pancreatic Neoplasms
Weight Loss

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, M. F., Krishnamachary, B., Wildes, F., Mironchik, Y., Mezzanzanica, D., Podo, F., De Reggi, M., Gharib, B. & Bhujwalla, Z. M. Nov 16 2016 In : Frontiers in Oncology. 6, NOV, 244

Research output: Contribution to journalArticle

Choline
Neoplasms
Ovarian Neoplasms
Ascites
pantethine
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Neoplasms
Precision Medicine
Therapeutics

Microglia activation in a pediatric rabbit model of tuberculous meningitis

Tucker, E. W., Pokkali, S., Zhang, Z., DeMarco, V. P., Klunk, M., Smith, E. S., Ordonez, A. A., Penet, M. F., Bhujwalla, Z., Jain, S. K. & Kannan, S. Dec 1 2016 In : DMM Disease Models and Mechanisms. 9, 12, p. 1497-1502 6 p.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Pediatrics
Microglia
Macrophages
Chemical activation
Cytosine Deaminase
Flucytosine
Prodrugs
Cell death
Antigens
2015

Cancer cachexia, recent advances, and future directions

Penet, M. F. & Bhujwalla, Z. M. Mar 9 2015 In : Cancer Journal (United States). 21, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Cachexia
Neoplasms
Molecular Imaging
Nutritional Support
Skeletal Muscle
Choline
Neoplasms
Choline Kinase
Magnetic Resonance Spectroscopy
Phospholipase D

Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism

Penet, M. F., Shah, T., Bharti, S., Krishnamachary, B., Artemov, D., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Jan 15 2015 In : Clinical Cancer Research. 21, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Choline
Adenocarcinoma
Choline Kinase
Biomarkers
Tumor Cell Line
2014

A biomimetic collagen derived peptide exhibits anti- Angiogenic activity in triple negative breast cancer

Rosca, E. V., Penet, M. F., Mori, N., Koskimaki, J. E., Lee, E., Pandey, N. B., Bhujwalla, Z. M. & Popel, A. S. Nov 10 2014 In : PLoS One. 9, 11, e111901

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
biomimetics
Biomimetics
breast neoplasms
collagen
Precision Medicine
Molecular Imaging
Tumor Microenvironment
Neoplasms
Stromal Cells
2013

COX-2 in cancer: Gordian knot or achilles heel?

Stasinopoulos, I., Shah, T., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M. 2013 In : Frontiers in Pharmacology. 4 MAR, Article 34

Research output: Contribution to journalArticle

Cyclooxygenase 2
Neoplasms
Neoplasm Metastasis
Lymphatic Vessels
Tumor Microenvironment
collagen
Tumors
Collagen
neoplasms
Fibers

MR - Eyes For Cancer: Looking Within An Impenetrable Disease

Penet, M. F., Artemov, D., Farahani, K. & Bhujwalla, Z. M. Jul 2013 In : NMR in Biomedicine. 26, 7, p. 745-755 11 p.

Research output: Contribution to journalArticle

Eye Neoplasms
Imaging techniques
Molecular Probes
Neoplasms
Molecular Imaging
2012
Triple Negative Breast Neoplasms
breast neoplasms
hypoxia
Protein Isoforms
Cells
Prodrugs
Enzymes
Neoplasms
Therapeutics
Cytotoxins
antigens
Antigens
therapy
cancer
membranes

The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway

Jin, K., Kong, X., Shah, T., Penet, M. F., Wildes, F., Sgroi, D. C., Ma, X. J., Huang, Y., Kallioniemi, A., Landberg, G., Bieche, I., Wu, X., Lobie, P. E., Davidson, N. E., Bhujwalla, Z. M., Zhu, T. & Sukumar, S. Feb 21 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2736-2741 6 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
MCF-7 Cells
Proteins
Receptor Cross-Talk

Theranostic imaging of cancer

Penet, M. F., Chen, Z., Kakkad, S., Pomper, M. G. & Bhujwalla, Z. M. Sep 2012 In : European Journal of Radiology. 81, SUPPL1

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Tumor Microenvironment
Molecular Pathology
Diagnostic Imaging
Antineoplastic Agents
2011

Exploiting the tumor microenvironment for theranostic imaging

Stasinopoulos, I., Penet, M. F., Chen, Z., Kakkad, S., Glunde, K. & Bhujwalla, Z. M. Jul 2011 In : NMR in Biomedicine. 24, 6, p. 636-647 12 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Tumors
Imaging techniques
Neoplasms
Therapeutics

Metabolic signatures imaged in cancer-induced cachexia

Penet, M. F., Gadiya, M. M., Krishnamachary, B., Nimmagadda, S., Pomper, M. G., Artemov, D. & Bhujwalla, Z. M. Nov 15 2011 In : Cancer Research. 71, 22, p. 6948-6956 9 p.

Research output: Contribution to journalArticle

Cachexia
Neoplasms
Choline
Weight Loss
Lipids

MRI of metastasis-permissive microenvironments

Penet, M. F., Chen, Z. & Bhujwalla, Z. M. Nov 2011 In : Future Oncology. 7, 11, p. 1269-1284 16 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Neoplasms
Tumor Microenvironment
Molecular Imaging
Molecular Biology
Cachexia
Neoplasms
Molecular Imaging
Lipid Metabolism
Fatigue
2010

Applications of molecular MRI and optical imaging in cancer

Penet, M. F., Mikhaylova, M., Li, C., Krishnamachary, B., Glunde, K., Pathak, A. P. & Bhujwalla, Z. M. Jun 2010 In : Future Medicinal Chemistry. 2, 6, p. 975-988 14 p.

Research output: Contribution to journalArticle

Molecular Imaging
Optical Imaging
Neoplasms
Pharmaceutical Preparations
Nanoparticles

Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells

Shah, T., Wildes, F., Penet, M. F., Winnard, P. T., Glunde, K., Artemov, D., Ackerstaff, E., Gimi, B., Kakkad, S., Raman, V. & Bhujwalla, Z. M. 2010 In : NMR in Biomedicine. 23, 6, p. 633-642 10 p.

Research output: Contribution to journalArticle

Choline Kinase
Drug Resistance
Cells
Breast Neoplasms
MCF-7 Cells
Magnetic resonance spectroscopy
Molecular imaging
Magic angle spinning
Molecular biology
Biopsy

Molecular and functional imaging of invasion and metastasis: Windows into the metastatic cascade

Stasinopoulos, I., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M. 2010 In : Cancer Biomarkers. 7, 4-5, p. 173-188 16 p.

Research output: Contribution to journalArticle

Molecular Imaging
Neoplasm Metastasis
Neoplasms
Cellular Microenvironment
Tumor Microenvironment

Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy

Li, C., Penet, M. F., Wildes, F., Takagi, T., Chen, Z., Winnard, P. T., Artemov, D. & Bhujwalla, Z. M. Nov 23 2010 In : ACS Nano. 4, 11, p. 6707-6716 10 p.

Research output: Contribution to journalArticle

Prodrugs
RNA
Small Interfering RNA
enzymes
therapy
2009
Heterografts
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Microenvironment
Capillary Permeability
2008
Cytosine Deaminase
Prodrugs
Lysine
Enzymes
Neoplasms

Image-guided enzyme/prodrug cancer therapy

Li, C., Penet, M. F., Winnard, P., Artemov, D. & Bhujwalla, Z. M. Jan 15 2008 In : Clinical Cancer Research. 14, 2, p. 515-522 8 p.

Research output: Contribution to journalArticle

Prodrugs
Enzymes
Neoplasms
Therapeutics
Optical Imaging

Molecular and functional MRI of the tumor microenvironment

Penet, M. F., Glunde, K., Jacobs, M. A., Pathak, A. P. & Bhujwalla, Z. M. May 1 2008 In : Journal of Nuclear Medicine. 49, 5, p. 687-690 4 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Extracellular Matrix
Magnetic Resonance Imaging
Neoplasms
Hypoxia

Protection against cerebral malaria by the low-molecular-weight thiol pantethine

Penet, M. F., Abou-Hamdan, M., Coltel, N., Cornille, E., Grau, G. E., De Reggi, M. & Gharib, B. Jan 29 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1321-1326 6 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Sulfhydryl Compounds
Molecular Weight
ATP-Binding Cassette Transporters
Malaria
2007

Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA

Penet, M. F., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J. M., Grau, G. E., Cozzone, P. J. & Viola, A. May 11 2007 In : Journal of Biological Chemistry. 282, 19, p. 14505-14514 10 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Cerebral Malaria
Plasmodium berghei
Metabolome
Brain
2006

In vivo characterization of brain morphometric and metabolic endophenotypes in three inbred strains of mice using magnetic resonance techniques

Penet, M. F., Laigle, C., Fur, Y. L., Confort-Gouny, S., Heurteaux, C., Cozzone, P. J. & Viola, A. Sep 2006 In : Behavior Genetics. 36, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

129 Strain Mouse
Endophenotypes
Neuroanatomy
Inbred Strains Mice
Psychiatry
2005

Imaging experimental cerebral malaria in vivo: Significant role of ischemic brain edema

Penet, M. F., Viola, A., Confort-Gouny, S., Le Fur, Y., Duhamel, G., Kober, F., Ibarrola, D., Izquierdo, M., Coltel, N., Gharib, B., Grau, G. E. & Cozzone, P. J. Aug 10 2005 In : Journal of Neuroscience. 25, 32, p. 7352-7358 7 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Brain Edema
Edema
Blood-Brain Barrier
Angiography
2004

Vanin-1-/- mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher gluthathione stores

Martin, F., Penet, M. F., Malergue, F., Lepidi, H., Dessein, A., Galland, F., De Reggi, M., Naquet, P. & Gharib, B. Feb 2004 In : Journal of Clinical Investigation. 113, 4, p. 591-597 7 p.

Research output: Contribution to journalArticle

Schistosoma
Cysteamine
Non-Steroidal Anti-Inflammatory Agents
Cystamine
Pantothenic Acid