Research Output 1997 2017

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2017

An investigation of doubt in obsessive–compulsive disorder

Samuels, J. , Bienvenu, O. J. , Krasnow, J. , Wang, Y. , Grados, M. A. , Cullen, B. , Goes, F. S. , Maher, B. , Greenberg, B. D. , McLaughlin, N. C. , Rasmussen, S. A. , Fyer, A. J. , Knowles, J. A. , Nestadt, P. , McCracken, J. T. , Piacentini, J. , Geller, D. , Pauls, D. L. , Stewart, S. E. , Murphy, D. L. & 5 others Shugart, Y. Y., Kamath, V., Bakker, A., Riddle, M. A. & Nestadt, G. May 1 2017 In : Comprehensive Psychiatry. 75, p. 117-124 8 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Compulsive Personality Disorder
Personality Disorders
Obsessive Hoarding
Anxiety Disorders

Autism Spectrum Symptoms in a Tourette's Disorder Sample

Darrow, S. M., Grados, M., Sandor, P., Hirschtritt, M. E., Illmann, C., Osiecki, L., Dion, Y., King, R., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Jul 1 2017 In : Journal of the American Academy of Child and Adolescent Psychiatry. 56, 7, p. 610-617.e1

Research output: Contribution to journalArticle

Tourette Syndrome
Autistic Disorder
Pervasive Child Development Disorders
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity

C9orf72 hexanucleotide repeat expansions are not a common cause of obsessive-compulsive disorder

Arthur, K. C., Rivera, A. M., Samuels, J., Wang, Y., Grados, M., Goes, F. S., Maher, B., Nestadt, G. & Traynor, B. J. Apr 15 2017 In : Journal of the Neurological Sciences. 375, p. 71-72 2 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Frontotemporal Dementia
Amyotrophic Lateral Sclerosis
Obsessive Behavior
Genetic Testing

Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts from the 7th biennial scientific and educational symposium 2016

Kline, A. D. , Krantz, I. D. , Deardorff, M. A. , Shirahige, K. , Dorsett, D. , Gerton, J. L. , Wu, M. , Mehta, D. , Mills, J. A. , Carrico, C. S. , Noon, S. , Herrera, P. S. , Horsfield, J. A. , Bettale, C. , Morgan, J. , Huisman, S. A. , Moss, J. , McCleery, J. , Grados, M. , Hansen, B. D. & 8 others Srivastava, S., Taylor-Snell, E., Kerr, L. M., Katz, O., Calof, A. L., Musio, A., Egense, A. & Haaland, R. E. May 1 2017 In : American Journal of Medical Genetics, Part A. 173, 5, p. 1172-1185 14 p.

Research output: Contribution to journalArticle

De Lange Syndrome
Baltimore
Developmental Biology
Regulator Genes
Autistic Disorder

De Novo Coding Variants Are Strongly Associated with Tourette Disorder

Willsey, A. J. , Fernandez, T. V. , Yu, D. , King, R. A. , Dietrich, A. , Xing, J. , Sanders, S. J. , Mandell, J. D. , Huang, A. Y. , Richer, P. , Smith, L. , Dong, S. , Samocha, K. E. , Abdulkadir, M. , Bohnenpoll, J. , Bromberg, Y. , Brown, L. W. , Cheon, K. A. , Coffey, B. J. , Deng, L. & 108 others Dietrich, A., Dong, S., Elzerman, L., Fernandez, T. V., Fründt, O., Garcia-Delgar, B., Gedvilaite, E., Gilbert, D. L., Grice, D. E., Hagstrøm, J., Hedderly, T., Heiman, G. A., Heyman, I., Hoekstra, P. J., Hong, H. J., Huyser, C., Ibanez-Gomez, L., Kim, Y. K., Kim, Y. S., King, R. A., Koh, Y. J., Kook, S., Kuperman, S., Lamerz, A., Leventhal, B., Ludolph, A. G., Lühr da Silva, C., Madruga-Garrido, M., Mandell, J. D., Maras, A., Mir, P., Morer, A., Münchau, A., Murphy, T. L., Nasello, C., Openneer, T. J. C., Plessen, K. J., Richer, P., Roessner, V., Sanders, S., Shin, E. Y., Sival, D. A., Smith, L., Song, D. H., Song, J., State, M. W., Stolte, A. M., Sun, N., Tischfield, J. A., Tübing, J., Visscher, F., Walker, M. F., Wanderer, S., Wang, S., Willsey, A. J., Woods, M., Xing, J., Zhang, Y., Zhou, A., Zinner, S. H., Barr, C. L., Batterson, J. R., Berlin, C., Bruun, R. D., Budman, C. L., Cath, D. C., Chouinard, S., Coppola, G., Cox, N. J., Darrow, S., Davis, L. K., Dion, Y., Freimer, N. B., Grados, M. A., Hirschtritt, M. E., Huang, A. Y., Illmann, C., King, R. A., Kurlan, R., Leckman, J. F., Lyon, G. J., Malaty, I. A., Mathews, C. A., MaMahon, W. M., Neale, B. M., Okun, M. S., Osiecki, L., Pauls, D. L., Posthuma, D., Ramensky, V., Robertson, M. M., Rouleau, G. A., Sandor, P., Scharf, J. M., Singer, H. S., Smit, J., Sul, J. H., Yu, D., Neale, B. M., Coppola, G., Mathews, C. A., Tischfield, J. A., Scharf, J. M., State, M. W., Heiman, G. A., Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG) & Tourette Syndrome Association International Consortium for Genetics (TSAICG) May 3 2017 In : Neuron. 94, 3, p. 486-499.e9

Research output: Contribution to journalArticle

Tourette Syndrome
Genes
Exome
Genetic Association Studies
Cadherins

Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Jun 27 2017 In : Psychological Medicine. p. 1-15 15 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Attention Deficit Disorder with Hyperactivity
Obsessive Hoarding
Statistical Factor Analysis
Fear

Identification of two heritable cross-disorder endophenotypes for tourette syndrome

Darrow, S. M. , Hirschtritt, M. E. , Davis, L. K. , Illmann, C. , Osiecki, L. , Grados, M. , Sandor, P. , Dion, Y. , King, R. , Pauls, D. , Budman, C. L. , Cath, D. C. , Greenberg, E. , Lyon, G. J. , Yu, D. , McGrath, L. M. , McMahon, W. M. , Lee, P. C. , Delucchi, K. L. , Scharf, J. M. & 2 others Mathews, C. A. & Tourette Syndrome Association International Consortium for Genetics Apr 1 2017 In : American Journal of Psychiatry. 174, 4, p. 387-396 10 p.

Research output: Contribution to journalArticle

Endophenotypes
Tourette Syndrome
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Phenotype

Parental bonding and hoarding in obsessive–compulsive disorder

Chen, D. , Bienvenu, O. J. , Krasnow, J. , Wang, Y. , Grados, M. A. , Cullen, B. , Goes, F. S. , Maher, B. , Greenberg, B. D. , McLaughlin, N. C. , Rasmussen, S. A. , Fyer, A. J. , Knowles, J. A. , McCracken, J. T. , Piacentini, J. , Geller, D. , Pauls, D. L. , Stewart, S. E. , Murphy, D. L. , Shugart, Y. Y. & 3 others Riddle, M. A., Nestadt, G. & Samuels, J. Feb 1 2017 In : Comprehensive Psychiatry. 73, p. 43-52 10 p.

Research output: Contribution to journalArticle

Obsessive Hoarding
Obsessive-Compulsive Disorder
Object Attachment
Parenting
Personality Disorders

Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD

Guo, W. , Samuels, J. F. , Wang, Y. , Cao, H. , Ritter, M. , Nestadt, P. S. , Krasnow, J. , Greenberg, B. D. , Fyer, A. J. , McCracken, J. T. , Geller, D. A. , Murphy, D. L. , Knowles, J. A. , Grados, M. A. , Riddle, M. A. , Rasmussen, S. A. , McLaughlin, N. C. , Nurmi, E. L. , Askland, K. D. , Cullen, B. A. & 12 others Piacentini, J., Pauls, D. L., Bienvenu, O. J., Stewart, S. E., Goes, F. S., Maher, B., Pulver, A. E., Valle, D., Mattheisen, M., Qian, J., Nestadt, G. & Shugart, Y. Y. Jul 1 2017 In : European Neuropsychopharmacology. 27, 7, p. 657-666 10 p.

Research output: Contribution to journalArticle

Pervasive Child Development Disorders
Obsessive-Compulsive Disorder
Datasets
Genome-Wide Association Study
Genome
2016

ADHD and executive functioning deficits in OCD youths who hoard

Park, J. M. , Samuels, J. F. , Grados, M. A. , Riddle, M. A. , Bienvenu, O. J. , Goes, F. S. , Cullen, B. , Wang, Y. , Krasnow, J. , Murphy, D. L. , Rasmussen, S. A. , McLaughlin, N. C. , Piacentini, J. , Pauls, D. L. , Stewart, S. E. , Shugart, Y. Y. , Maher, B. , Pulver, A. E. , Knowles, J. A. , Greenberg, B. D. & 4 others Fyer, A. J., McCracken, J. T., Nestadt, G. & Geller, D. A. Nov 1 2016 In : Journal of Psychiatric Research. 82, p. 141-148 8 p.

Research output: Contribution to journalArticle

Obsessive Hoarding
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Obsessive-compulsive disorder
Attention deficit hyperactivity disorder

A review of animal models of obsessive-compulsive disorder: A focus on developmental, immune, endocrine and behavioral models

Grados, M., Prazak, M., Saif, A. & Halls, A. Jan 2 2016 In : Expert Opinion on Drug Discovery. 11, 1, p. 27-43 17 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Grooming
Drug Discovery
Phenotype
Obsessive Hoarding

Cornelia de Lange syndrome: Correlation of brain MRI findings with behavioral assessment

Roshan Lal, T. R., Kliewer, M. A., Lopes, T., Rebsamen, S. L., O'Connor, J., Grados, M. A., Kimball, A., Clemens, J. & Kline, A. D. 2016 In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

De Lange Syndrome
Brain
Checklist
White Matter
Gliosis

Dependent personality, separation anxiety disorder and other anxiety disorders in OCD

Mroczkowski, M. M., Goes, F. S., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Greenberg, B. D., Fyer, A. J., Mccracken, J. T., Rauch, S. L., Murphy, D. L., Knowles, J. A., Piacentini, J., Cullen, B., Rasmussen, S. A., Pauls, D. L., Nestadt, G. & Samuels, J. Feb 1 2016 In : Personality and Mental Health. 10, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

Separation Anxiety
Obsessive-Compulsive Disorder
Anxiety Disorders
Personality
Dependent Personality Disorder

OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE for TWO DIMENSIONS

Riddle, M. A., Maher, B. S., Wang, Y., Grados, M., Bienvenu, O. J., Goes, F. S., Cullen, B., Murphy, D. L., Rauch, S. L., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Pinto, A., Piacentini, J., Pauls, D. L., Rasmussen, S. A., Shugart, Y. Y., Nestadt, G. & Samuels, J. Feb 1 2016 In : Depression and Anxiety. 33, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Obsessive Hoarding
Genetic Linkage

Patterned changes in urge ratings with tic suppression in youth with chronic tic disorders

Brabson, L. A., Brown, J. L., Capriotti, M. R., Ramanujam, K., Himle, M. B., Nicotra, C. M., Ostrander, R., Kelly, L. M., Grados, M. A., Walkup, J. T., Perry-Parrish, C., Reynolds, E. K., Hankinson, J. C. & Specht, M. W. Aug 11 2016 In : Journal of Behavior Therapy and Experimental Psychiatry. 50, p. 162-170 9 p., 1155

Research output: Contribution to journalArticle

Rating
Tic Disorders
Tics
Suppression
Uniformity

Social disinhibition is a heritable subphenotype of tics in Tourette syndrome

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D. L., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Aug 2 2016 In : Neurology. 87, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

Tics
Tourette Syndrome
Phenotype
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity

Structure and clinical correlates of obsessive–compulsive symptoms in a large sample of children and adolescents: a factor analytic study across five nations

Højgaard, D. R. M. A., Mortensen, E. L., Ivarsson, T., Hybel, K., Skarphedinsson, G., Nissen, J. B., Valderhaug, R., Dahl, K., Weidle, B., Torp, N. C., Grados, M., Lewin, A. B., Melin, K. H., Storch, E. A., Wolters, L. H., Murphy, T. K., Sonuga-Barke, E. J. S. & Thomsen, P. H. Jul 7 2016 In : European Child and Adolescent Psychiatry. p. 1-11 11 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Obsessive-compulsive disorder
Obsessive Hoarding
Anxiety
Tic Disorders

Use of modified positive behavioral interventions and supports in a psychiatric inpatient unit for high-risk youths

Reynolds, E. K., Grados, M. A., Praglowski, N., Hankinson, J. C., Deboard-Lucas, R., Goldstein, L., Perry-Parrish, C. K., Specht, M. W. & Ostrander, R. May 1 2016 In : Psychiatric Services. 67, 5, p. 570-573 4 p.

Research output: Contribution to journalArticle

Psychiatry
Inpatients
Prospective Studies

Whole-genome association analysis of treatment response in obsessive-compulsive disorder

Qin, H. , Samuels, J. F. , Wang, Y. , Zhu, Y. , Grados, M. A. , Riddle, M. A. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , McCracken, J. T. , Murphy, D. L. , Rasmussen, S. A. , Cullen, B. A. , Piacentini, J. , Geller, D. , Stewart, S. E. , Pauls, D. , Bienvenu, O. J. , Goes, F. S. , Maher, B. & 10 others Pulver, A. E., Valle, D., Lange, C., Mattheisen, M., McLaughlin, N. C., Liang, K. Y., Nurmi, E. L., Askland, K. D., Nestadt, G. & Shugart, Y. Y. Feb 1 2016 In : Molecular Psychiatry. 21, 2, p. 270-276 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Single Nucleotide Polymorphism
Self Report
2015

A selective review of glutamate pharmacological therapy in obsessive–compulsive and related disorders

Grados, M. A., Atkins, E. B., Kovacikova, G. I. & McVicar, E. Apr 28 2015 In : Psychology Research and Behavior Management. 8, p. 115-131 17 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Glutamic Acid
Pharmacology
Trichotillomania
Tourette Syndrome

Cross-disorder genome-wide analyses suggest a complex genetic relationship between tourette's syndrome and OCD

Yu, D. , Mathews, C. A. , Scharf, J. M. , Neale, B. M. , Davis, L. K. , Gamazon, E. R. , Derks, E. M. , Evans, P. , Edlund, C. K. , Crane, J. , Fagerness, J. A. , Osiecki, L. , Gerber, G. , Haddad, S. , Illmann, C. , McGrath, L. M. , Mayerfeld, C. , Arepalli, S. , Barlassina, C. , Barr, C. L. & 79 others Bellodi, L., Benarroch, F., Bedoya Berrió, G., Bienvenu, J., Black, D. W., Bloch, M. H., Brentani, H., Bruun, R. D., Budman, C. L., Camarena, B., Campbell, D. D., Cappi, C., Cardona Silgado, J. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Cook, E. H., Cookson, M. R., Coric, V., Cullen, B., Cusi, D., Delorme, R., Denys, D., Dion, Y., Eapen, V., Egberts, K., Falkai, P., Fernandez, T., Fournier, E., Garrido, H., Geller, D., Gilbert, D. L., Girard, S. L., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Grünblatt, E., Hardy, J., Heiman, G. A., Hemmings, S. M. J., Herrera, L. D., Hezel, D. M., Hoekstra, P. J., Jankovic, J., Kennedy, J. L., King, R. A., Konkashbaev, A. I., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Lupoli, S., Macciardi, F., Maier, W., Manunta, P., Marconi, M., McCracken, J. T., Mesa Restrepo, S. C., Moessner, R., Moorjani, P., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Nurmi, E., Cornejo Ochoa, W., Ophoff, R. A., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C. & Pollak, Y. Jan 1 2015 In : American Journal of Psychiatry. 172, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Obsessive-Compulsive Disorder
Genome
Obsessive-compulsive disorder
Syndrome

Efficacy of glutamate modulators in tic suppression: A double-blind, randomized control trial of D-serine and riluzole in tourette syndrome

Lemmon, M. E., Grados, M., Kline, T., Thompson, C. B., Ali, S. F. & Singer, H. S. Jun 1 2015 In : Pediatric Neurology. 52, 6, p. 629-634 6 p.

Research output: Contribution to journalArticle

Riluzole
Tics
Tourette Syndrome
Serine
Glutamic Acid

Genome-wide association study in obsessive-compulsive disorder: Results from the OCGAS

Mattheisen, M. , Samuels, J. F. , Wang, Y. , Greenberg, B. D. , Fyer, A. J. , Mccracken, J. T. , Geller, D. A. , Murphy, D. L. , Knowles, J. A. , Grados, M. A. , Riddle, M. A. , Rasmussen, S. A. , Mclaughlin, N. C. , Nurmi, E. L. , Askland, K. D. , Qin, H. D. , Cullen, B. A. , Piacentini, J. , Pauls, D. L. , Bienvenu, O. J. & 9 others Stewart, S. E., Liang, K. Y., Goes, F. S., Maher, B., Pulver, A. E., Shugart, Y. Y., Valle, D., Lange, C. & Nestadt, G. Mar 12 2015 In : Molecular Psychiatry. 20, 3, p. 337-344 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Genetic Association Studies
Genes
Synapses

Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in tourette syndrome

Hirschtritt, M. E. , Lee, P. C. , Pauls, D. L. , Dion, Y. , Grados, M. A. , Illmann, C. , King, R. A. , Sandor, P. , McMahon, W. M. , Lyon, G. J. , Cath, D. C. , Kurlan, R. , Robertson, M. M. , Osiecki, L. , Scharf, J. M. , Mathews, C. A. , Posthuma, D. , Singer, H. S. , Yu, D. , Cox, N. J. & 5 others Freimer, N. B., Budman, C. L., Chouinard, S., Rouleau, G. A. & Barr, C. L. Apr 1 2015 In : JAMA Psychiatry. 72, 4, p. 325-333 9 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Psychiatry
Syndrome
Attention Deficit Disorder with Hyperactivity
Obsessive-Compulsive Disorder

Prevalence and predictors of affective lability after paediatric traumatic brain injury

Vasa, R. A., Suskauer, S. J., Thorn, J. M., Kalb, L., Grados, M. A., Slomine, B. S., Salorio, C. F. & Gerring, J. P. Jul 1 2015 In : Brain Injury. 29, 7-8, p. 921-928 8 p.

Research output: Contribution to journalArticle

Brain Injuries
Pediatrics
Wounds and Injuries
Affective
Traumatic brain injury

Risk Factors for Seclusion and Restraint in a Pediatric Psychiatry Day Hospital

Timbo, W., Sriram, A., Reynolds, E. K., DeBoard-Lucas, R., Specht, M., Howell, C., McSweeney, C. & Grados, M. A. Dec 7 2015 In : Child Psychiatry and Human Development. p. 1-9 9 p.

Research output: Contribution to journalArticle

Psychiatry
Pediatrics
Pediatric Hospitals
Psychiatric Hospitals
Post-Traumatic Stress Disorders

Tolerability, safety, and benefits of risperidone in children and adolescents with autism: 21-month follow-up after 8-week placebo-controlled trial

Aman, M., Rettiganti, M., Nagaraja, H. N., Hollway, J. A., Mccracken, J., Mcdougle, C. J., Tierney, E., Scahill, L., Arnold, L. E., Hellings, J., Posey, D. J., Swiezy, N. B., Ghuman, J., Grados, M., Shah, B. & Vitiello, B. Aug 1 2015 In : Journal of Child and Adolescent Psychopharmacology. 25, 6, p. 482-493 12 p.

Research output: Contribution to journalArticle

Risperidone
Autistic Disorder
Placebos
Safety
Weight Gain
2014

A Comparison of Urge Intensity and the Probability of Tic Completion During Tic Freely and Tic Suppression Conditions

Specht, M. W., Nicotra, C. M., Kelly, L. M., Woods, D. W., Ricketts, E. J., Perry-Parrish, C., Reynolds, E., Hankinson, J., Grados, M. A., Ostrander, R. S. & Walkup, J. T. 2014 In : Behavior Modification. 38, 2, p. 297-318 22 p.

Research output: Contribution to journalArticle

Tics
Suppression
Tic Disorders
Completion
Intelligence

Autism traits in children and adolescents with Cornelia de Lange syndrome

Srivastava, S., Landy-Schmitt, C., Clark, B., Kline, A. D., Specht, M. & Grados, M. A. 2014 In : American Journal of Medical Genetics, Part A. 164, 6, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

De Lange Syndrome
Autistic Disorder
Socialization
Psychological Adaptation
Communication

Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD collaborative genetics study

Samuels, J. , Shugart, Y. Y. , Wang, Y. , Grados, M. A. , Bienvenu, O. J. , Pinto, A. , Rauch, S. L. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , Piacentini, J. , Pauls, D. L. , Cullen, B. , Rasmussen, S. A. , Stewart, S. E. , Geller, D. A. , Maher, B. S. , Goes, F. S. , Murphy, D. L. , Mccracken, J. T. & 2 others Riddle, M. A. & Nestadt, G. 2014 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 165, 4, p. 326-336 11 p.

Research output: Contribution to journalArticle

Genetic Linkage
Obsessive-Compulsive Disorder
Communication
Separation Anxiety
Chromosomes, Human, Pair 12

Continuous performance test in pediatric obsessive-compulsive disorder and tic disorders: The role of sustained attention

Lucke, I. M., Lin, C., Conteh, F., Federline, A., Sung, H., Specht, M. & Grados, M. A. Jun 26 2014 In : CNS Spectrums. 20, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Tic Disorders
Obsessive-Compulsive Disorder
Pediatrics
Attention Deficit Disorder with Hyperactivity
Diagnostic and Statistical Manual of Mental Disorders

Copy number variation in obsessive-compulsive disorder and tourette syndrome: A cross-disorder study

McGrath, L. M. , Yu, D. , Marshall, C. , Davis, L. K. , Thiruvahindrapuram, B. , Li, B. , Cappi, C. , Gerber, G. , Wolf, A. , Schroeder, F. A. , Osiecki, L. , O'Dushlaine, C. , Kirby, A. , Illmann, C. , Haddad, S. , Gallagher, P. , Fagerness, J. A. , Barr, C. L. , Bellodi, L. , Benarroch, F. & 101 others Bienvenu, O. J., Black, D. W., Bloch, M. H., Bruun, R. D., Budman, C. L., Camarena, B., Cath, D. C., Cavallini, M. C., Chouinard, S., Coric, V., Cullen, B., Delorme, R., Denys, D., Derks, E. M., Dion, Y., Rosário, M. C., Eapen, V., Evans, P., Falkai, P., Fernandez, T. V., Garrido, H., Geller, D., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Grünblatt, E., Heiman, G. A., Hemmings, S. M. J., Herrera, L. D., Hounie, A. G., Jankovic, J., Kennedy, J. L., King, R. A., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Lochner, C., Lowe, T. L., Lyon, G. J., MacCiardi, F., Maier, W., McCracken, J. T., McMahon, W., Murphy, D. L., Naarden, A. L., Neale, B. M., Nurmi, E., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Reus, V. I., Richter, M. A., Riddle, M., Robertson, M. M., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Tischfield, J. A., Vallada, H., Veenstra-Vanderweele, J., Walitza, S., Wang, Y., Wendland, J. R., Shugart, Y. Y., Miguel, E. C., Nicolini, H., Oostra, B. A., Moessner, R., Wagner, M., Ruiz-Linares, A., Heutink, P., Nestadt, G., Freimer, N., Petryshen, T., Posthuma, D., Jenike, M. A., Cox, N. J., Hanna, G. L., Brentani, H., Scherer, S. W., Arnold, P. D., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cook, E. H., Pauls, D. L., Wang, K. & Scharf, J. M. 2014 In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 8, p. 910-919 10 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Obsessive-Compulsive Disorder
Genome

Genetic association signal near NTN4 in Tourette syndrome

Paschou, P. , Yu, D. , Gerber, G. , Evans, P. , Tsetsos, F. , Davis, L. K. , Karagiannidis, I. , Chaponis, J. , Gamazon, E. , Mueller-Vahl, K. , Stuhrmann, M. , Schloegelhofer, M. , Stamenkovic, M. , Hebebrand, J. , Noethen, M. , Nagy, P. , Barta, C. , Tarnok, Z. , Rizzo, R. , Depienne, C. & 18 others Worbe, Y., Hartmann, A., Cath, D. C., Budman, C. L., Sandor, P., Barr, C., Wolanczyk, T., Singer, H., Chou, I. C., Grados, M., Posthuma, D., Rouleau, G. A., Aschauer, H., Freimer, N. B., Pauls, D. L., Cox, N. J., Mathews, C. A. & Scharf, J. M. 2014 In : Annals of Neurology. 76, 2, p. 310-315 6 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Single Nucleotide Polymorphism
Axons
Meta-Analysis
Chromosomes
Obsessive-Compulsive Disorder
Sirolimus
Brain
Brain-Derived Neurotrophic Factor
Genes

Hoarding in children and adolescents with obsessive-compulsive disorder

Samuels, J. , Grados, M. A. , Riddle, M. A. , Bienvenu, O. J. , Goes, F. S. , Cullen, B. , Wang, Y. , Greenberg, B. D. , Fyer, A. J. , McCracken, J. T. , Geller, D. , Murphy, D. L. , Knowles, J. A. , Rasmussen, S. A. , McLaughlin, N. C. , Piacentini, J. , Pauls, D. L. , Stewart, S. E. , Shugart, Y. Y. , Maher, B. & 2 others Pulver, A. E. & Nestadt, G. Oct 1 2014 In : Journal of Obsessive-Compulsive and Related Disorders. 3, 4, p. 325-331 7 p.

Research output: Contribution to journalArticle

Obsessive Hoarding
Obsessive-Compulsive Disorder
Age of Onset
Obsessive Behavior
Tics
2013

Effects of tic suppression: Ability to suppress, rebound, negative reinforcement, and habituation to the premonitory urge

Specht, M. W., Woods, D. W., Nicotra, C. M., Kelly, L. M., Ricketts, E. J., Conelea, C. A., Grados, M. A., Ostrander, R. S. & Walkup, J. T. Jan 2013 In : Behaviour Research and Therapy. 51, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

Tics
Reinforcement (Psychology)
Suppression
Rating
Tic Disorders

Genome-wide association study of obsessive-compulsive disorder

Stewart, S. E. , Yu, D. , Scharf, J. M. , Neale, B. M. , Fagerness, J. A. , Mathews, C. A. , Arnold, P. D. , Evans, P. D. , Gamazon, E. R. , Osiecki, L. , McGrath, L. , Haddad, S. , Crane, J. , Hezel, D. , Illman, C. , Mayerfeld, C. , Konkashbaev, A. , Liu, C. , Pluzhnikov, A. , Tikhomirov, A. & 111 others Edlund, C. K., Rauch, S. L., Moessner, R., Falkai, P., Maier, W., Ruhrmann, S., Grabe, H. J., Lennertz, L., Wagner, M., Bellodi, L., Cavallini, M. C., Richter, M. A., Cook, E. H., Kennedy, J. L., Rosenberg, D., Stein, D. J., Hemmings, S. M. J., Lochner, C., Azzam, A., Chavira, D. A., Fournier, E., Garrido, H., Sheppard, B., Umaña, P., Murphy, D. L., Wendland, J. R., Veenstra-Vanderweele, J., Denys, D., Blom, R., Deforce, D., Van Nieuwerburgh, F., Westenberg, H. G. M., Walitza, S., Egberts, K., Renner, T., Miguel, E. C., Cappi, C., Hounie, A. G., Conceição Do Rosário, M., Sampaio, A. S., Vallada, H., Nicolini, H., Lanzagorta, N., Camarena, B., Delorme, R., Leboyer, M., Pato, C. N., Pato, M. T., Voyiaziakis, E., Heutink, P., Cath, D. C., Posthuma, D., Smit, J. H., Samuels, J., Bienvenu, O. J., Cullen, B., Fyer, A. J., Grados, M. A., Greenberg, B. D., McCracken, J. T., Riddle, M. A., Wang, Y., Coric, V., Leckman, J. F., Bloch, M., Pittenger, C., Eapen, V., Black, D. W., Ophoff, R. A., Strengman, E., Cusi, D., Turiel, M., Frau, F., MacCiardi, F., Gibbs, J. R., Cookson, M. R., Singleton, A., Arepalli, S., Cookson, M. R., Dillman, A., Ferrucci, L., Gibbs, J. R., Hernandez, D. G., Johnson, R., Longo, D. L., Nalls, M. A., O'Brien, R., Singleton, A., Traynor, B., Troncoso, J., Van Der Brug, M., Zielke, H. R., Zonderman, A., Hardy, J., Crenshaw, A. T., Parkin, M. A., Mirel, D. B., Conti, D. V., Purcell, S., Nestadt, G., Hanna, G. L., Jenike, M. A., Knowles, J. A., Cox, N., Pauls, D. L., Hardy, J. A., Ryten, M., Smith, C., Trabzuni, D., Walker, R. & Weale, M. Jul 2013 In : Molecular Psychiatry. 18, 7, p. 788-798 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Genome
Post-Synaptic Density

Genome-wide association study of Tourette's syndrome

Scharf, J. M. , Yu, D. , Mathews, C. A. , Neale, B. M. , Stewart, S. E. , Fagerness, J. A. , Evans, P. , Gamazon, E. , Edlund, C. K. , Service, S. K. , Tikhomirov, A. , Osiecki, L. , Illmann, C. , Pluzhnikov, A. , Konkashbaev, A. , Davis, L. K. , Han, B. , Crane, J. , Moorjani, P. , Crenshaw, A. T. & 78 others Parkin, M. A., Reus, V. I., Lowe, T. L., Rangel-Lugo, M., Chouinard, S., Dion, Y., Girard, S., Cath, D. C., Smit, J. H., King, R. A., Fernandez, T. V., Leckman, J. F., Kidd, K. K., Kidd, J. R., Pakstis, A. J., State, M. W., Herrera, L. D., Romero, R., Fournier, E., Sandor, P., Barr, C. L., Phan, N., Gross-Tsur, V., Benarroch, F., Pollak, Y., Budman, C. L., Bruun, R. D., Erenberg, G., Naarden, A. L., Lee, P. C., Weiss, N., Kremeyer, B., Berrío, G. B., Campbell, D. D., Cardona Silgado, J. C., Ochoa, W. C., Mesa Restrepo, S. C., Muller, H., Valencia Duarte, A. V., Lyon, G. J., Leppert, M., Morgan, J., Weiss, R., Grados, M. A., Anderson, K., Davarya, S., Singer, H., Walkup, J., Jankovic, J., Tischfield, J. A., Heiman, G. A., Gilbert, D. L., Hoekstra, P. J., Robertson, M. M., Kurlan, R., Liu, C., Gibbs, J. R., Singleton, A., Hardy, J., Strengman, E., Ophoff, R. A., Wagner, M., Moessner, R., Mirel, D. B., Posthuma, D., Sabatti, C., Eskin, E., Conti, D. V., Knowles, J. A., Ruiz-Linares, A., Rouleau, G. A., Purcell, S., Heutink, P., Oostra, B. A., McMahon, W. M., Freimer, N. B., Cox, N. J. & Pauls, D. L. Jun 2013 In : Molecular Psychiatry. 18, 6, p. 721-728 8 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Genome-Wide Association Study
Jews
Quebec
Israel

Glutamate drugs and pharmacogenetics of OCD: A pathway-based exploratory approach

Grados, M. A., Specht, M. W., Sung, H. M. & Fortune, D. Dec 2013 In : Expert Opinion on Drug Discovery. 8, 12, p. 1515-1527 13 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Obsessive-Compulsive Disorder
Glutamic Acid
Pharmacology
Genes

Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

Stewart, S. E. , Mayerfeld, C. , Arnold, P. D. , Crane, J. R. , O'Dushlaine, C. , Fagerness, J. A. , Yu, D. , Scharf, J. M. , Chan, E. , Kassam, F. , Moya, P. R. , Wendland, J. R. , Delorme, R. , Richter, M. A. , Kennedy, J. L. , Veenstra-Vanderweele, J. , Samuels, J. , Greenberg, B. D. , Mccracken, J. T. , Knowles, J. A. & 17 others Fyer, A. J., Rauch, S. L., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Cullen, B., Wang, Y., Shugart, Y. Y., Piacentini, J., Rasmussen, S., Nestadt, G., Murphy, D. L., Jenike, M. A., Cook, E. H., Pauls, D. L., Hanna, G. L. & Mathews, C. A. Jun 2013 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 162, 4, p. 367-379 13 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Obsessive-Compulsive Disorder
Meta-Analysis
Genes
Single Nucleotide Polymorphism

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Davis, L. K. , Yu, D. , Keenan, C. L. , Gamazon, E. R. , Konkashbaev, A. I. , Derks, E. M. , Neale, B. M. , Yang, J. , Lee, S. H. , Evans, P. , Barr, C. L. , Bellodi, L. , Benarroch, F. , Berrio, G. B. , Bienvenu, O. J. , Bloch, M. H. , Blom, R. M. , Bruun, R. D. , Budman, C. L. , Camarena, B. & 111 others Campbell, D., Cappi, C., Cardona Silgado, J. C., Cath, D. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Conti, D. V., Cook, E. H., Coric, V., Cullen, B. A., Deforce, D., Delorme, R., Dion, Y., Edlund, C. K., Egberts, K., Falkai, P., Fernandez, T. V., Gallagher, P. J., Garrido, H., Geller, D., Girard, S. L., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Haddad, S., Heiman, G. A., Hemmings, S. M. J., Hounie, A. G., Illmann, C., Jankovic, J., Jenike, M. A., Kennedy, J. L., King, R. A., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Macciardi, F., McCracken, J. T., McGrath, L. M., Mesa Restrepo, S. C., Moessner, R., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Ochoa, W. C., Ophoff, R. A., Osiecki, L., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Rauch, S. L., Renner, T. J., Reus, V. I., Richter, M. A., Riddle, M. A., Robertson, M. M., Romero, R., Rosàrio, M. C., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Ruiz-Linares, A., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Strengman, E., Tischfield, J. A., Valencia Duarte, A. V., Vallada, H., Van Nieuwerburgh, F., Veenstra-VanderWeele, J., Walitza, S., Wang, Y., Wendland, J. R., Westenberg, H. G. M., Shugart, Y. Y., Miguel, E. C., McMahon, W., Wagner, M., Nicolini, H., Posthuma, D., Hanna, G. L., Heutink, P., Denys, D., Arnold, P. D., Oostra, B. A., Nestadt, G., Freimer, N. B., Pauls, D. L., Wray, N. R., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cox, N. J. & Scharf, J. M. Oct 2013 In : PLoS Genetics. 9, 10, e1003864

Research output: Contribution to journalArticle

Tourette Syndrome
Obsessive-Compulsive Disorder
heritability
obsessive-compulsive disorder
Genome
2012

Homeobox genes in obsessive-compulsive disorder

Nestadt, G. , Wang, Y. , Grados, M. A. , Riddle, M. A. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , Mccracken, J. T. , Rauch, S. L. , Murphy, D. L. , Rasmussen, S. A. , Cullen, B. , Piacentini, J. , Geller, D. , Pauls, D. , Bienvenu, O. J. , Chen, Y. , Liang, K. Y. , Goes, F. S. , Maher, B. & 5 others Pulver, A. E., Shugart, Y. Y., Valle, D., Samuels, J. F. & Chang, Y. C. Jan 2012 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 159 B, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

Homeobox Genes
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Social Adjustment
Genes

Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective

Bienvenu, O. J., Samuels, J. F., Wuyek, L. A., Liang, K. Y., Wang, Y., Grados, M. A., Cullen, B. A., Riddle, M. A., Greenberg, B. D., Rasmussen, S. A., Fyer, A. J., Pinto, A., Rauch, S. L., Pauls, D. L., McCracken, J. T., Piacentini, J., Murphy, D. L., Knowles, J. A. & Nestadt, G. Jan 2012 In : Psychological Medicine. 42, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Anxiety Disorders
Impulse Control Disorders
Morbidity
Firesetting Behavior
2011
Compulsive Personality Disorder
Serotonin Plasma Membrane Transport Proteins
Personality Disorders
Alleles
Obsessive-Compulsive Disorder

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

Voyiaziakis, E. , Evgrafov, O. , Li, D. , Yoon, H. J. , Tabares, P. , Samuels, J. , Wang, Y. , Riddle, M. A. , Grados, M. A. , Bienvenu, O. J. , Shugart, Y. Y. , Liang, K. Y. , Greenberg, B. D. , Rasmussen, S. A. , Murphy, D. L. , Wendland, J. R. , McCracken, J. T. , Piacentini, J. , Rauch, S. L. , Pauls, D. L. & 3 others Nestadt, G., Fyer, A. J. & Knowles, J. A. Jan 2011 In : Molecular Psychiatry. 16, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Haplotypes
HapMap Project
Linkage Disequilibrium
Genetic Association Studies

Cognitive functioning in compulsive hoarding

Blom, R. M., Samuels, J. F., Grados, M. A., Chen, Y., Bienvenu, O. J., Riddle, M. A., Liang, K. Y., Brandt, J. & Nestadt, G. Dec 2011 In : Journal of Anxiety Disorders. 25, 8, p. 1139-1144 6 p.

Research output: Contribution to journalArticle

Obsessive Hoarding
Obsessive-Compulsive Disorder
Reaction Time
Decision Making
Gambling

Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder

Samuels, J., Wang, Y., Riddle, M. A., Greenberg, B. D., Fyer, A. J., Mccracken, J. T., Rauch, S. L., Murphy, D. L., Grados, M. A., Knowles, J. A., Piacentini, J., Cullen, B., Bienvenu, O. J., Rasmussen, S. A., Geller, D., Pauls, D. L., Liang, K. Y., Shugart, Y. Y. & Nestadt, G. Jun 2011 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 156, 4, p. 472-477 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Genes
Viverridae
Tourette Syndrome
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Logistic Models

Family-based genetic association study of DLGAP3 in Tourette Syndrome

Crane, J. , Fagerness, J. , Osiecki, L. , Gunnell, B. , Stewart, S. E. , Pauls, D. L. , Scharf, J. M. , Cath, D. , Heutink, P. , Grados, M. , Singer, H. S. , Walkup, J. T. , J.M. Scharf, S. , Illmann, C. , Yu, D. , Platko, J. , Santangelo, S. , Stewart, S. E. , Pauls, D. L. , Cox, N. J. & 27 others Service, S., Keen-Kim, D., Sabatti, C., Freimer, N., Robertson, M. M., Rouleau, G. A., Riviere, J. B., Chouinard, S., Richer, F., Lesperance, P., Dion, Y., King, R. A., Kidd, J. R., Pakstis, A. J., Leckman, J. F., Kidd, K. K., Kurlan, R., Como, P., Palumbo, D., Verkerk, A., Oostra, B. A., McMahon, W., Leppert, M., Coon, H., Mathews, C., Sandor, P. & Barr, C. L. Jan 2011 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 156, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

Tourette Syndrome
Genetic Association Studies
Obsessive-Compulsive Disorder
Genes
Trichotillomania

Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD

Ross, J., Badner, J., Garrido, H., Sheppard, B., Chavira, D. A., Grados, M., Woo, J. M., Doo, P., Umaña, P., Fournier, E., Murray, S. S. & Mathews, C. A. Dec 2011 In : Human Genetics. 130, 6, p. 795-805 11 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Chromosomes
Costa Rica
Genes
Ryanodine Receptor Calcium Release Channel