Research Output 1997 2017

2017

An investigation of doubt in obsessive–compulsive disorder

Samuels, J. , Bienvenu, O. J. , Krasnow, J. , Wang, Y. , Grados, M. A. , Cullen, B. , Goes, F. S. , Maher, B. , Greenberg, B. D. , McLaughlin, N. C. , Rasmussen, S. A. , Fyer, A. J. , Knowles, J. A. , Nestadt, P. , McCracken, J. T. , Piacentini, J. , Geller, D. , Pauls, D. L. , Stewart, S. E. , Murphy, D. L. & 5 others Shugart, Y. Y., Kamath, V., Bakker, A., Riddle, M. A. & Nestadt, G. May 1 2017 In : Comprehensive Psychiatry. 75, p. 117-124 8 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Compulsive Personality Disorder
Personality Disorders
Anxiety Disorders
Age of Onset

Autism Spectrum Symptoms in a Tourette's Disorder Sample

Darrow, S. M., Grados, M., Sandor, P., Hirschtritt, M. E., Illmann, C., Osiecki, L., Dion, Y., King, R., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Jul 1 2017 In : Journal of the American Academy of Child and Adolescent Psychiatry. 56, 7, p. 610-617.e1

Research output: Research - peer-reviewArticle

Tourette Syndrome
Autistic Disorder
Autism Spectrum Disorder
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity

Behavioral and psychiatric manifestations in Cornelia de Lange syndrome

Grados, M. A., Alvi, M. H. & Srivastava, S. 2017 In : Current Opinion in Psychiatry. 30, 2, p. 92-96 5 p.

Research output: Research - peer-reviewReview article

De Lange Syndrome
Psychiatry
Self-Injurious Behavior
Quality of Life
Phenotype

C9orf72 hexanucleotide repeat expansions are not a common cause of obsessive-compulsive disorder

Arthur, K. C., Rivera, A. M., Samuels, J., Wang, Y., Grados, M., Goes, F. S., Maher, B., Nestadt, G. & Traynor, B. J. Apr 15 2017 In : Journal of the Neurological Sciences. 375, p. 71-72 2 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Frontotemporal Dementia With Motor Neuron Disease
Obsessive Behavior
Genetic Testing
Psychotic Disorders

Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts from the 7th biennial scientific and educational symposium 2016

Kline, A. D. , Krantz, I. D. , Deardorff, M. A. , Shirahige, K. , Dorsett, D. , Gerton, J. L. , Wu, M. , Mehta, D. , Mills, J. A. , Carrico, C. S. , Noon, S. , Herrera, P. S. , Horsfield, J. A. , Bettale, C. , Morgan, J. , Huisman, S. A. , Moss, J. , McCleery, J. , Grados, M. , Hansen, B. D. & 8 others Srivastava, S., Taylor-Snell, E., Kerr, L. M., Katz, O., Calof, A. L., Musio, A., Egense, A. & Haaland, R. E. May 1 2017 In : American Journal of Medical Genetics, Part A. 173, 5, p. 1172-1185 14 p.

Research output: Research - peer-reviewArticle

De Lange Syndrome
cohesins
Baltimore
Developmental Biology
Regulator Genes

De Novo Coding Variants Are Strongly Associated with Tourette Disorder

Willsey, A. J. , Fernandez, T. V. , Yu, D. , King, R. A. , Dietrich, A. , Xing, J. , Sanders, S. J. , Mandell, J. D. , Huang, A. Y. , Richer, P. , Smith, L. , Dong, S. , Samocha, K. E. , Abdulkadir, M. , Bohnenpoll, J. , Bromberg, Y. , Brown, L. W. , Cheon, K. A. , Coffey, B. J. , Deng, L. & 108 others Dietrich, A., Dong, S., Elzerman, L., Fernandez, T. V., Fründt, O., Garcia-Delgar, B., Gedvilaite, E., Gilbert, D. L., Grice, D. E., Hagstrøm, J., Hedderly, T., Heiman, G. A., Heyman, I., Hoekstra, P. J., Hong, H. J., Huyser, C., Ibanez-Gomez, L., Kim, Y. K., Kim, Y. S., King, R. A., Koh, Y. J., Kook, S., Kuperman, S., Lamerz, A., Leventhal, B., Ludolph, A. G., Lühr da Silva, C., Madruga-Garrido, M., Mandell, J. D., Maras, A., Mir, P., Morer, A., Münchau, A., Murphy, T. L., Nasello, C., Openneer, T. J. C., Plessen, K. J., Richer, P., Roessner, V., Sanders, S., Shin, E. Y., Sival, D. A., Smith, L., Song, D. H., Song, J., State, M. W., Stolte, A. M., Sun, N., Tischfield, J. A., Tübing, J., Visscher, F., Walker, M. F., Wanderer, S., Wang, S., Willsey, A. J., Woods, M., Xing, J., Zhang, Y., Zhou, A., Zinner, S. H., Barr, C. L., Batterson, J. R., Berlin, C., Bruun, R. D., Budman, C. L., Cath, D. C., Chouinard, S., Coppola, G., Cox, N. J., Darrow, S., Davis, L. K., Dion, Y., Freimer, N. B., Grados, M. A., Hirschtritt, M. E., Huang, A. Y., Illmann, C., King, R. A., Kurlan, R., Leckman, J. F., Lyon, G. J., Malaty, I. A., Mathews, C. A., MaMahon, W. M., Neale, B. M., Okun, M. S., Osiecki, L., Pauls, D. L., Posthuma, D., Ramensky, V., Robertson, M. M., Rouleau, G. A., Sandor, P., Scharf, J. M., Singer, H. S., Smit, J., Sul, J. H., Yu, D., Neale, B. M., Coppola, G., Mathews, C. A., Tischfield, J. A., Scharf, J. M., State, M. W., Heiman, G. A., Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG) & Tourette Syndrome Association International Consortium for Genetics (TSAICG) May 3 2017 In : Neuron. 94, 3, p. 486-499.e9

Research output: Research - peer-reviewArticle

Tourette Syndrome
Genes
Exome
Genetic Association Studies
Cadherins

Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Jun 27 2017 (Accepted/In press) In : Psychological Medicine. p. 1-15 15 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Attention Deficit Disorder with Hyperactivity
Hoarding
Statistical Factor Analysis
Fear

Identification of two heritable cross-disorder endophenotypes for tourette syndrome

Darrow, S. M. , Hirschtritt, M. E. , Davis, L. K. , Illmann, C. , Osiecki, L. , Grados, M. , Sandor, P. , Dion, Y. , King, R. , Pauls, D. , Budman, C. L. , Cath, D. C. , Greenberg, E. , Lyon, G. J. , Yu, D. , McGrath, L. M. , McMahon, W. M. , Lee, P. C. , Delucchi, K. L. , Scharf, J. M. & 2 others Mathews, C. A. & Tourette Syndrome Association International Consortium for Genetics Apr 1 2017 In : American Journal of Psychiatry. 174, 4, p. 387-396 10 p.

Research output: Research - peer-reviewArticle

Endophenotypes
Tourette Syndrome
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Phenotype

Parental bonding and hoarding in obsessive–compulsive disorder

Chen, D. , Bienvenu, O. J. , Krasnow, J. , Wang, Y. , Grados, M. A. , Cullen, B. , Goes, F. S. , Maher, B. , Greenberg, B. D. , McLaughlin, N. C. , Rasmussen, S. A. , Fyer, A. J. , Knowles, J. A. , McCracken, J. T. , Piacentini, J. , Geller, D. , Pauls, D. L. , Stewart, S. E. , Murphy, D. L. , Shugart, Y. Y. & 3 others Riddle, M. A., Nestadt, G. & Samuels, J. Feb 1 2017 In : Comprehensive Psychiatry. 73, p. 43-52 10 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Object Attachment
Hoarding
Mothers
Parenting

Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD

Guo, W. , Samuels, J. F. , Wang, Y. , Cao, H. , Ritter, M. , Nestadt, P. S. , Krasnow, J. , Greenberg, B. D. , Fyer, A. J. , McCracken, J. T. , Geller, D. A. , Murphy, D. L. , Knowles, J. A. , Grados, M. A. , Riddle, M. A. , Rasmussen, S. A. , McLaughlin, N. C. , Nurmi, E. L. , Askland, K. D. , Cullen, B. A. & 12 others Piacentini, J., Pauls, D. L., Bienvenu, O. J., Stewart, S. E., Goes, F. S., Maher, B., Pulver, A. E., Valle, D., Mattheisen, M., Qian, J., Nestadt, G. & Shugart, Y. Y. Jul 1 2017 In : European Neuropsychopharmacology. 27, 7, p. 657-666 10 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Autism Spectrum Disorder
Datasets
Genome-Wide Association Study
Genome

Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome

Greenberg, E. , Tung, E. S. , Gauvin, C. , Osiecki, L. , Yang, K. G. , Curley, E. , Essa, A. , Illmann, C. , Sandor, P. , Dion, Y. , Lyon, G. J. , King, R. A. , Darrow, S. , Hirschtritt, M. E. , Budman, C. L. , Grados, M. , Pauls, D. L. , Keuthen, N. J. , Mathews, C. A. , Scharf, J. M. & 1 others The Tourette Association of America International Consortium for Genetics Nov 2 2017 (Accepted/In press) In : European Child and Adolescent Psychiatry. p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Hair
Skin
Obsessive-Compulsive Disorder
Tics
2016

ADHD and executive functioning deficits in OCD youths who hoard

Park, J. M. , Samuels, J. F. , Grados, M. A. , Riddle, M. A. , Bienvenu, O. J. , Goes, F. S. , Cullen, B. , Wang, Y. , Krasnow, J. , Murphy, D. L. , Rasmussen, S. A. , McLaughlin, N. C. , Piacentini, J. , Pauls, D. L. , Stewart, S. E. , Shugart, Y. Y. , Maher, B. , Pulver, A. E. , Knowles, J. A. , Greenberg, B. D. & 4 others Fyer, A. J., McCracken, J. T., Nestadt, G. & Geller, D. A. Nov 1 2016 In : Journal of Psychiatric Research. 82, p. 141-148 8 p.

Research output: Research - peer-reviewArticle

Attention Deficit Hyperactivity Disorder
Obsessive-compulsive Disorder
Hoard
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity

A review of animal models of obsessive-compulsive disorder: A focus on developmental, immune, endocrine and behavioral models

Grados, M., Prazak, M., Saif, A. & Halls, A. Jan 2 2016 In : Expert Opinion on Drug Discovery. 11, 1, p. 27-43 17 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Animal Models
Grooming
Drug Discovery
Phenotype

Cornelia de Lange syndrome: Correlation of brain MRI findings with behavioral assessment

Roshan Lal, T. R., Kliewer, M. A., Lopes, T., Rebsamen, S. L., O'Connor, J., Grados, M. A., Kimball, A., Clemens, J. & Kline, A. D. 2016 (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Research - peer-reviewArticle

De Lange Syndrome
Brain
Checklist
White Matter
Gliosis

Dependent personality, separation anxiety disorder and other anxiety disorders in OCD

Mroczkowski, M. M., Goes, F. S., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Greenberg, B. D., Fyer, A. J., Mccracken, J. T., Rauch, S. L., Murphy, D. L., Knowles, J. A., Piacentini, J., Cullen, B., Rasmussen, S. A., Pauls, D. L., Nestadt, G. & Samuels, J. Feb 1 2016 In : Personality and Mental Health. 10, 1, p. 22-28 7 p.

Research output: Research - peer-reviewArticle

Separation Anxiety
Obsessive-Compulsive Disorder
Anxiety Disorders
Personality
Dependent Personality Disorder

OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE for TWO DIMENSIONS

Riddle, M. A., Maher, B. S., Wang, Y., Grados, M., Bienvenu, O. J., Goes, F. S., Cullen, B., Murphy, D. L., Rauch, S. L., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Pinto, A., Piacentini, J., Pauls, D. L., Rasmussen, S. A., Shugart, Y. Y., Nestadt, G. & Samuels, J. Feb 1 2016 In : Depression and Anxiety. 33, 2, p. 128-135 8 p.

Research output: Research - peer-reviewArticle

Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Genetic Linkage
Quantitative Trait Loci

Patterned changes in urge ratings with tic suppression in youth with chronic tic disorders

Brabson, L. A., Brown, J. L., Capriotti, M. R., Ramanujam, K., Himle, M. B., Nicotra, C. M., Ostrander, R., Kelly, L. M., Grados, M. A., Walkup, J. T., Perry-Parrish, C., Reynolds, E. K., Hankinson, J. C. & Specht, M. W. Aug 11 2016 In : Journal of Behavior Therapy and Experimental Psychiatry. 50, p. 162-170 9 p., 1155

Research output: Research - peer-reviewArticle

Rating
Suppression
Tic Disorders
Tics
Individual Differences

Social disinhibition is a heritable subphenotype of tics in Tourette syndrome

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D. L., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M. & Mathews, C. A. Aug 2 2016 In : Neurology. 87, 5, p. 497-504 8 p.

Research output: Research - peer-reviewArticle

Tics
Tourette Syndrome
Phenotype
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity

Structure and clinical correlates of obsessive–compulsive symptoms in a large sample of children and adolescents: a factor analytic study across five nations

Højgaard, D. R. M. A., Mortensen, E. L., Ivarsson, T., Hybel, K., Skarphedinsson, G., Nissen, J. B., Valderhaug, R., Dahl, K., Weidle, B., Torp, N. C., Grados, M., Lewin, A. B., Melin, K. H., Storch, E. A., Wolters, L. H., Murphy, T. K., Sonuga-Barke, E. J. S. & Thomsen, P. H. Jul 7 2016 (Accepted/In press) In : European Child and Adolescent Psychiatry. p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Obsessive-compulsive Disorder
Obsessive-Compulsive Disorder
Anxiety
Hoarding
Cleaning

Use of modified positive behavioral interventions and supports in a psychiatric inpatient unit for high-risk youths

Reynolds, E. K., Grados, M. A., Praglowski, N., Hankinson, J. C., Deboard-Lucas, R., Goldstein, L., Perry-Parrish, C. K., Specht, M. W. & Ostrander, R. May 1 2016 In : Psychiatric Services. 67, 5, p. 570-573 4 p.

Research output: Research - peer-reviewArticle

Psychiatry
Inpatients
Prospective Studies
Research

Whole-genome association analysis of treatment response in obsessive-compulsive disorder

Qin, H. , Samuels, J. F. , Wang, Y. , Zhu, Y. , Grados, M. A. , Riddle, M. A. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , McCracken, J. T. , Murphy, D. L. , Rasmussen, S. A. , Cullen, B. A. , Piacentini, J. , Geller, D. , Stewart, S. E. , Pauls, D. , Bienvenu, O. J. , Goes, F. S. , Maher, B. & 10 others Pulver, A. E., Valle, D., Lange, C., Mattheisen, M., McLaughlin, N. C., Liang, K. Y., Nurmi, E. L., Askland, K. D., Nestadt, G. & Shugart, Y. Y. Feb 1 2016 In : Molecular Psychiatry. 21, 2, p. 270-276 7 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Therapeutics
Single Nucleotide Polymorphism
2015

A selective review of glutamate pharmacological therapy in obsessive–compulsive and related disorders

Grados, M. A., Atkins, E. B., Kovacikova, G. I. & McVicar, E. Apr 28 2015 In : Psychology Research and Behavior Management. 8, p. 115-131 17 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Glutamic Acid
Pharmacology
Therapeutics
Trichotillomania

Cross-disorder genome-wide analyses suggest a complex genetic relationship between tourette's syndrome and OCD

Yu, D. , Mathews, C. A. , Scharf, J. M. , Neale, B. M. , Davis, L. K. , Gamazon, E. R. , Derks, E. M. , Evans, P. , Edlund, C. K. , Crane, J. , Fagerness, J. A. , Osiecki, L. , Gerber, G. , Haddad, S. , Illmann, C. , McGrath, L. M. , Mayerfeld, C. , Arepalli, S. , Barlassina, C. , Barr, C. L. & 79 others Bellodi, L., Benarroch, F., Bedoya Berrió, G., Bienvenu, J., Black, D. W., Bloch, M. H., Brentani, H., Bruun, R. D., Budman, C. L., Camarena, B., Campbell, D. D., Cappi, C., Cardona Silgado, J. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Cook, E. H., Cookson, M. R., Coric, V., Cullen, B., Cusi, D., Delorme, R., Denys, D., Dion, Y., Eapen, V., Egberts, K., Falkai, P., Fernandez, T., Fournier, E., Garrido, H., Geller, D., Gilbert, D. L., Girard, S. L., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Grünblatt, E., Hardy, J., Heiman, G. A., Hemmings, S. M. J., Herrera, L. D., Hezel, D. M., Hoekstra, P. J., Jankovic, J., Kennedy, J. L., King, R. A., Konkashbaev, A. I., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Lupoli, S., Macciardi, F., Maier, W., Manunta, P., Marconi, M., McCracken, J. T., Mesa Restrepo, S. C., Moessner, R., Moorjani, P., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Nurmi, E., Cornejo Ochoa, W., Ophoff, R. A., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C. & Pollak, Y. Jan 1 2015 In : American Journal of Psychiatry. 172, 1, p. 82-93 12 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Obsessive-Compulsive Disorder
Genome
Obsessive-compulsive Disorder
Syndrome

Efficacy of glutamate modulators in tic suppression: A double-blind, randomized control trial of D-serine and riluzole in tourette syndrome

Lemmon, M. E., Grados, M., Kline, T., Thompson, C. B., Ali, S. F. & Singer, H. S. Jun 1 2015 In : Pediatric Neurology. 52, 6, p. 629-634 6 p.

Research output: Research - peer-reviewArticle

Riluzole
Tics
Tourette Syndrome
Serine
Glutamic Acid

Genome-wide association study in obsessive-compulsive disorder: Results from the OCGAS

Mattheisen, M. , Samuels, J. F. , Wang, Y. , Greenberg, B. D. , Fyer, A. J. , Mccracken, J. T. , Geller, D. A. , Murphy, D. L. , Knowles, J. A. , Grados, M. A. , Riddle, M. A. , Rasmussen, S. A. , Mclaughlin, N. C. , Nurmi, E. L. , Askland, K. D. , Qin, H. D. , Cullen, B. A. , Piacentini, J. , Pauls, D. L. , Bienvenu, O. J. & 9 others Stewart, S. E., Liang, K. Y., Goes, F. S., Maher, B., Pulver, A. E., Shugart, Y. Y., Valle, D., Lange, C. & Nestadt, G. Mar 12 2015 In : Molecular Psychiatry. 20, 3, p. 337-344 8 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Genetic Association Studies
Genes
Synapses

Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in tourette syndrome

Hirschtritt, M. E. , Lee, P. C. , Pauls, D. L. , Dion, Y. , Grados, M. A. , Illmann, C. , King, R. A. , Sandor, P. , McMahon, W. M. , Lyon, G. J. , Cath, D. C. , Kurlan, R. , Robertson, M. M. , Osiecki, L. , Scharf, J. M. , Mathews, C. A. , Posthuma, D. , Singer, H. S. , Yu, D. , Cox, N. J. & 5 others Freimer, N. B., Budman, C. L., Chouinard, S., Rouleau, G. A. & Barr, C. L. Apr 1 2015 In : JAMA Psychiatry. 72, 4, p. 325-333 9 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Psychiatry
Syndrome
Attention Deficit Disorder with Hyperactivity
Obsessive-Compulsive Disorder

Prevalence and predictors of affective lability after paediatric traumatic brain injury

Vasa, R. A., Suskauer, S. J., Thorn, J. M., Kalb, L., Grados, M. A., Slomine, B. S., Salorio, C. F. & Gerring, J. P. Jul 1 2015 In : Brain Injury. 29, 7-8, p. 921-928 8 p.

Research output: Research - peer-reviewArticle

Pediatrics
Predictors
Traumatic Brain Injury
Affective
Wounds and Injuries

Risk Factors for Seclusion and Restraint in a Pediatric Psychiatry Day Hospital

Timbo, W., Sriram, A., Reynolds, E. K., DeBoard-Lucas, R., Specht, M., Howell, C., McSweeney, C. & Grados, M. A. Dec 7 2015 (Accepted/In press) In : Child Psychiatry and Human Development. p. 1-9 9 p.

Research output: Research - peer-reviewArticle

Psychiatry
Pediatrics
Pediatric Hospitals
Psychiatric Hospitals
Post-Traumatic Stress Disorders

Tolerability, safety, and benefits of risperidone in children and adolescents with autism: 21-month follow-up after 8-week placebo-controlled trial

Aman, M., Rettiganti, M., Nagaraja, H. N., Hollway, J. A., Mccracken, J., Mcdougle, C. J., Tierney, E., Scahill, L., Arnold, L. E., Hellings, J., Posey, D. J., Swiezy, N. B., Ghuman, J., Grados, M., Shah, B. & Vitiello, B. Aug 1 2015 In : Journal of Child and Adolescent Psychopharmacology. 25, 6, p. 482-493 12 p.

Research output: Research - peer-reviewArticle

Risperidone
Autistic Disorder
Placebos
Safety
Therapeutics
2014

A Comparison of Urge Intensity and the Probability of Tic Completion During Tic Freely and Tic Suppression Conditions

Specht, M. W., Nicotra, C. M., Kelly, L. M., Woods, D. W., Ricketts, E. J., Perry-Parrish, C., Reynolds, E., Hankinson, J., Grados, M. A., Ostrander, R. S. & Walkup, J. T. 2014 In : Behavior Modification. 38, 2, p. 297-318 22 p.

Research output: Research - peer-reviewArticle

Completion
Suppression
Tics
Aptitude
Therapeutics

Autism traits in children and adolescents with Cornelia de Lange syndrome

Srivastava, S., Landy-Schmitt, C., Clark, B., Kline, A. D., Specht, M. & Grados, M. A. 2014 In : American Journal of Medical Genetics, Part A. 164, 6, p. 1400-1410 11 p.

Research output: Research - peer-reviewArticle

De Lange Syndrome
Autistic Disorder
Socialization
Psychological Adaptation
Communication

Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD collaborative genetics study

Samuels, J. , Shugart, Y. Y. , Wang, Y. , Grados, M. A. , Bienvenu, O. J. , Pinto, A. , Rauch, S. L. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , Piacentini, J. , Pauls, D. L. , Cullen, B. , Rasmussen, S. A. , Stewart, S. E. , Geller, D. A. , Maher, B. S. , Goes, F. S. , Murphy, D. L. , Mccracken, J. T. & 2 others Riddle, M. A. & Nestadt, G. 2014 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 165, 4, p. 326-336 11 p.

Research output: Research - peer-reviewArticle

Genetic Linkage
Obsessive-Compulsive Disorder
Communication
Separation Anxiety
Chromosomes, Human, Pair 12

Continuous performance test in pediatric obsessive-compulsive disorder and tic disorders: The role of sustained attention

Lucke, I. M., Lin, C., Conteh, F., Federline, A., Sung, H., Specht, M. & Grados, M. A. Jun 26 2014 In : CNS Spectrums. 20, 5, p. 479-489 11 p.

Research output: Research - peer-reviewArticle

Tic Disorders
Obsessive-Compulsive Disorder
Pediatrics
Attention Deficit Disorder with Hyperactivity
Diagnostic and Statistical Manual of Mental Disorders

Copy number variation in obsessive-compulsive disorder and tourette syndrome: A cross-disorder study

McGrath, L. M. , Yu, D. , Marshall, C. , Davis, L. K. , Thiruvahindrapuram, B. , Li, B. , Cappi, C. , Gerber, G. , Wolf, A. , Schroeder, F. A. , Osiecki, L. , O'Dushlaine, C. , Kirby, A. , Illmann, C. , Haddad, S. , Gallagher, P. , Fagerness, J. A. , Barr, C. L. , Bellodi, L. , Benarroch, F. & 101 others Bienvenu, O. J., Black, D. W., Bloch, M. H., Bruun, R. D., Budman, C. L., Camarena, B., Cath, D. C., Cavallini, M. C., Chouinard, S., Coric, V., Cullen, B., Delorme, R., Denys, D., Derks, E. M., Dion, Y., Rosário, M. C., Eapen, V., Evans, P., Falkai, P., Fernandez, T. V., Garrido, H., Geller, D., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Grünblatt, E., Heiman, G. A., Hemmings, S. M. J., Herrera, L. D., Hounie, A. G., Jankovic, J., Kennedy, J. L., King, R. A., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Lochner, C., Lowe, T. L., Lyon, G. J., MacCiardi, F., Maier, W., McCracken, J. T., McMahon, W., Murphy, D. L., Naarden, A. L., Neale, B. M., Nurmi, E., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Reus, V. I., Richter, M. A., Riddle, M., Robertson, M. M., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Tischfield, J. A., Vallada, H., Veenstra-Vanderweele, J., Walitza, S., Wang, Y., Wendland, J. R., Shugart, Y. Y., Miguel, E. C., Nicolini, H., Oostra, B. A., Moessner, R., Wagner, M., Ruiz-Linares, A., Heutink, P., Nestadt, G., Freimer, N., Petryshen, T., Posthuma, D., Jenike, M. A., Cox, N. J., Hanna, G. L., Brentani, H., Scherer, S. W., Arnold, P. D., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cook, E. H., Pauls, D. L., Wang, K. & Scharf, J. M. 2014 In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 8, p. 910-919 10 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Obsessive-Compulsive Disorder
Genome
Neurodevelopmental Disorders

Genetic association signal near NTN4 in Tourette syndrome

Paschou, P. , Yu, D. , Gerber, G. , Evans, P. , Tsetsos, F. , Davis, L. K. , Karagiannidis, I. , Chaponis, J. , Gamazon, E. , Mueller-Vahl, K. , Stuhrmann, M. , Schloegelhofer, M. , Stamenkovic, M. , Hebebrand, J. , Noethen, M. , Nagy, P. , Barta, C. , Tarnok, Z. , Rizzo, R. , Depienne, C. & 18 others Worbe, Y., Hartmann, A., Cath, D. C., Budman, C. L., Sandor, P., Barr, C., Wolanczyk, T., Singer, H., Chou, I. C., Grados, M., Posthuma, D., Rouleau, G. A., Aschauer, H., Freimer, N. B., Pauls, D. L., Cox, N. J., Mathews, C. A. & Scharf, J. M. 2014 In : Annals of Neurology. 76, 2, p. 310-315 6 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Single Nucleotide Polymorphism
Meta-Analysis
Chromosomes
Alleles
Obsessive-Compulsive Disorder
Sirolimus
Brain
Pharmaceutical Preparations
Brain-Derived Neurotrophic Factor

Hoarding in children and adolescents with obsessive-compulsive disorder

Samuels, J. , Grados, M. A. , Riddle, M. A. , Bienvenu, O. J. , Goes, F. S. , Cullen, B. , Wang, Y. , Greenberg, B. D. , Fyer, A. J. , McCracken, J. T. , Geller, D. , Murphy, D. L. , Knowles, J. A. , Rasmussen, S. A. , McLaughlin, N. C. , Piacentini, J. , Pauls, D. L. , Stewart, S. E. , Shugart, Y. Y. , Maher, B. & 2 others Pulver, A. E. & Nestadt, G. Oct 1 2014 In : Journal of Obsessive-Compulsive and Related Disorders. 3, 4, p. 325-331 7 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Hoarding
Age of Onset
Obsessive Behavior
Tics
2013

Effects of tic suppression: Ability to suppress, rebound, negative reinforcement, and habituation to the premonitory urge

Specht, M. W., Woods, D. W., Nicotra, C. M., Kelly, L. M., Ricketts, E. J., Conelea, C. A., Grados, M. A., Ostrander, R. S. & Walkup, J. T. Jan 2013 In : Behaviour Research and Therapy. 51, 1, p. 24-30 7 p.

Research output: Research - peer-reviewArticle

Tics
Aptitude
Reinforcement (Psychology)
Suppression
Reinforcement

Genome-wide association study of obsessive-compulsive disorder

Stewart, S. E. , Yu, D. , Scharf, J. M. , Neale, B. M. , Fagerness, J. A. , Mathews, C. A. , Arnold, P. D. , Evans, P. D. , Gamazon, E. R. , Osiecki, L. , McGrath, L. , Haddad, S. , Crane, J. , Hezel, D. , Illman, C. , Mayerfeld, C. , Konkashbaev, A. , Liu, C. , Pluzhnikov, A. , Tikhomirov, A. & 111 others Edlund, C. K., Rauch, S. L., Moessner, R., Falkai, P., Maier, W., Ruhrmann, S., Grabe, H. J., Lennertz, L., Wagner, M., Bellodi, L., Cavallini, M. C., Richter, M. A., Cook, E. H., Kennedy, J. L., Rosenberg, D., Stein, D. J., Hemmings, S. M. J., Lochner, C., Azzam, A., Chavira, D. A., Fournier, E., Garrido, H., Sheppard, B., Umaña, P., Murphy, D. L., Wendland, J. R., Veenstra-Vanderweele, J., Denys, D., Blom, R., Deforce, D., Van Nieuwerburgh, F., Westenberg, H. G. M., Walitza, S., Egberts, K., Renner, T., Miguel, E. C., Cappi, C., Hounie, A. G., Conceição Do Rosário, M., Sampaio, A. S., Vallada, H., Nicolini, H., Lanzagorta, N., Camarena, B., Delorme, R., Leboyer, M., Pato, C. N., Pato, M. T., Voyiaziakis, E., Heutink, P., Cath, D. C., Posthuma, D., Smit, J. H., Samuels, J., Bienvenu, O. J., Cullen, B., Fyer, A. J., Grados, M. A., Greenberg, B. D., McCracken, J. T., Riddle, M. A., Wang, Y., Coric, V., Leckman, J. F., Bloch, M., Pittenger, C., Eapen, V., Black, D. W., Ophoff, R. A., Strengman, E., Cusi, D., Turiel, M., Frau, F., MacCiardi, F., Gibbs, J. R., Cookson, M. R., Singleton, A., Arepalli, S., Cookson, M. R., Dillman, A., Ferrucci, L., Gibbs, J. R., Hernandez, D. G., Johnson, R., Longo, D. L., Nalls, M. A., O'Brien, R., Singleton, A., Traynor, B., Troncoso, J., Van Der Brug, M., Zielke, H. R., Zonderman, A., Hardy, J., Crenshaw, A. T., Parkin, M. A., Mirel, D. B., Conti, D. V., Purcell, S., Nestadt, G., Hanna, G. L., Jenike, M. A., Knowles, J. A., Cox, N., Pauls, D. L., Hardy, J. A., Ryten, M., Smith, C., Trabzuni, D., Walker, R. & Weale, M. Jul 2013 In : Molecular Psychiatry. 18, 7, p. 788-798 11 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Genome
Post-Synaptic Density

Genome-wide association study of Tourette's syndrome

Scharf, J. M. , Yu, D. , Mathews, C. A. , Neale, B. M. , Stewart, S. E. , Fagerness, J. A. , Evans, P. , Gamazon, E. , Edlund, C. K. , Service, S. K. , Tikhomirov, A. , Osiecki, L. , Illmann, C. , Pluzhnikov, A. , Konkashbaev, A. , Davis, L. K. , Han, B. , Crane, J. , Moorjani, P. , Crenshaw, A. T. & 78 others Parkin, M. A., Reus, V. I., Lowe, T. L., Rangel-Lugo, M., Chouinard, S., Dion, Y., Girard, S., Cath, D. C., Smit, J. H., King, R. A., Fernandez, T. V., Leckman, J. F., Kidd, K. K., Kidd, J. R., Pakstis, A. J., State, M. W., Herrera, L. D., Romero, R., Fournier, E., Sandor, P., Barr, C. L., Phan, N., Gross-Tsur, V., Benarroch, F., Pollak, Y., Budman, C. L., Bruun, R. D., Erenberg, G., Naarden, A. L., Lee, P. C., Weiss, N., Kremeyer, B., Berrío, G. B., Campbell, D. D., Cardona Silgado, J. C., Ochoa, W. C., Mesa Restrepo, S. C., Muller, H., Valencia Duarte, A. V., Lyon, G. J., Leppert, M., Morgan, J., Weiss, R., Grados, M. A., Anderson, K., Davarya, S., Singer, H., Walkup, J., Jankovic, J., Tischfield, J. A., Heiman, G. A., Gilbert, D. L., Hoekstra, P. J., Robertson, M. M., Kurlan, R., Liu, C., Gibbs, J. R., Singleton, A., Hardy, J., Strengman, E., Ophoff, R. A., Wagner, M., Moessner, R., Mirel, D. B., Posthuma, D., Sabatti, C., Eskin, E., Conti, D. V., Knowles, J. A., Ruiz-Linares, A., Rouleau, G. A., Purcell, S., Heutink, P., Oostra, B. A., McMahon, W. M., Freimer, N. B., Cox, N. J. & Pauls, D. L. Jun 2013 In : Molecular Psychiatry. 18, 6, p. 721-728 8 p.

Research output: Research - peer-reviewArticle

Tourette Syndrome
Genome-Wide Association Study
Jews
Quebec
Israel

Glutamate drugs and pharmacogenetics of OCD: A pathway-based exploratory approach

Grados, M. A., Specht, M. W., Sung, H. M. & Fortune, D. Dec 2013 In : Expert Opinion on Drug Discovery. 8, 12, p. 1515-1527 13 p.

Research output: Research - peer-reviewArticle

Pharmacogenetics
Obsessive-Compulsive Disorder
Glutamic Acid
Pharmaceutical Preparations
Pharmacology

Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

Stewart, S. E. , Mayerfeld, C. , Arnold, P. D. , Crane, J. R. , O'Dushlaine, C. , Fagerness, J. A. , Yu, D. , Scharf, J. M. , Chan, E. , Kassam, F. , Moya, P. R. , Wendland, J. R. , Delorme, R. , Richter, M. A. , Kennedy, J. L. , Veenstra-Vanderweele, J. , Samuels, J. , Greenberg, B. D. , Mccracken, J. T. , Knowles, J. A. & 17 others Fyer, A. J., Rauch, S. L., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Cullen, B., Wang, Y., Shugart, Y. Y., Piacentini, J., Rasmussen, S., Nestadt, G., Murphy, D. L., Jenike, M. A., Cook, E. H., Pauls, D. L., Hanna, G. L. & Mathews, C. A. Jun 2013 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 162, 4, p. 367-379 13 p.

Research output: Research - peer-reviewArticle

Amino Acid Transport System X-AG
Obsessive-Compulsive Disorder
Meta-Analysis
Genes
Single Nucleotide Polymorphism

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Davis, L. K. , Yu, D. , Keenan, C. L. , Gamazon, E. R. , Konkashbaev, A. I. , Derks, E. M. , Neale, B. M. , Yang, J. , Lee, S. H. , Evans, P. , Barr, C. L. , Bellodi, L. , Benarroch, F. , Berrio, G. B. , Bienvenu, O. J. , Bloch, M. H. , Blom, R. M. , Bruun, R. D. , Budman, C. L. , Camarena, B. & 111 others Campbell, D., Cappi, C., Cardona Silgado, J. C., Cath, D. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Conti, D. V., Cook, E. H., Coric, V., Cullen, B. A., Deforce, D., Delorme, R., Dion, Y., Edlund, C. K., Egberts, K., Falkai, P., Fernandez, T. V., Gallagher, P. J., Garrido, H., Geller, D., Girard, S. L., Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Haddad, S., Heiman, G. A., Hemmings, S. M. J., Hounie, A. G., Illmann, C., Jankovic, J., Jenike, M. A., Kennedy, J. L., King, R. A., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Macciardi, F., McCracken, J. T., McGrath, L. M., Mesa Restrepo, S. C., Moessner, R., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Ochoa, W. C., Ophoff, R. A., Osiecki, L., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Rauch, S. L., Renner, T. J., Reus, V. I., Richter, M. A., Riddle, M. A., Robertson, M. M., Romero, R., Rosàrio, M. C., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Ruiz-Linares, A., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Strengman, E., Tischfield, J. A., Valencia Duarte, A. V., Vallada, H., Van Nieuwerburgh, F., Veenstra-VanderWeele, J., Walitza, S., Wang, Y., Wendland, J. R., Westenberg, H. G. M., Shugart, Y. Y., Miguel, E. C., McMahon, W., Wagner, M., Nicolini, H., Posthuma, D., Hanna, G. L., Heutink, P., Denys, D., Arnold, P. D., Oostra, B. A., Nestadt, G., Freimer, N. B., Pauls, D. L., Wray, N. R., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cox, N. J. & Scharf, J. M. Oct 2013 In : PLoS Genetics. 9, 10, e1003864

Research output: Research - peer-reviewArticle

obsessive-compulsive disorder
heritability
partitioning
Tourette Syndrome
Obsessive-Compulsive Disorder
2012

Genetic Understanding of OCD and Spectrum Disorders

Samuels, J. F., Grados, M. A., Planalp, E. & Bienvenu, O. J. Sep 18 2012 The Oxford Handbook of Obsessive Compulsive and Spectrum Disorders. Oxford University Press

Research output: ResearchChapter

Genes
Genetic Polymorphisms
Molecular Biology
Phenotype

Homeobox genes in obsessive-compulsive disorder

Nestadt, G. , Wang, Y. , Grados, M. A. , Riddle, M. A. , Greenberg, B. D. , Knowles, J. A. , Fyer, A. J. , Mccracken, J. T. , Rauch, S. L. , Murphy, D. L. , Rasmussen, S. A. , Cullen, B. , Piacentini, J. , Geller, D. , Pauls, D. , Bienvenu, O. J. , Chen, Y. , Liang, K. Y. , Goes, F. S. , Maher, B. & 5 others Pulver, A. E., Shugart, Y. Y., Valle, D., Samuels, J. F. & Chang, Y. C. Jan 2012 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 159 B, 1, p. 53-60 8 p.

Research output: Research - peer-reviewArticle

Homeobox Genes
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Social Adjustment
Genes

Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective

Bienvenu, O. J., Samuels, J. F., Wuyek, L. A., Liang, K. Y., Wang, Y., Grados, M. A., Cullen, B. A., Riddle, M. A., Greenberg, B. D., Rasmussen, S. A., Fyer, A. J., Pinto, A., Rauch, S. L., Pauls, D. L., McCracken, J. T., Piacentini, J., Murphy, D. L., Knowles, J. A. & Nestadt, G. Jan 2012 In : Psychological Medicine. 42, 1, p. 1-13 13 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Anxiety Disorders
Disruptive, Impulse Control, and Conduct Disorders
Morbidity
Firesetting Behavior
2011
Compulsive Personality Disorder
Serotonin Plasma Membrane Transport Proteins
Personality Disorders
Alleles
Obsessive-Compulsive Disorder

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

Voyiaziakis, E. , Evgrafov, O. , Li, D. , Yoon, H. J. , Tabares, P. , Samuels, J. , Wang, Y. , Riddle, M. A. , Grados, M. A. , Bienvenu, O. J. , Shugart, Y. Y. , Liang, K. Y. , Greenberg, B. D. , Rasmussen, S. A. , Murphy, D. L. , Wendland, J. R. , McCracken, J. T. , Piacentini, J. , Rauch, S. L. , Pauls, D. L. & 3 others Nestadt, G., Fyer, A. J. & Knowles, J. A. Jan 2011 In : Molecular Psychiatry. 16, 1, p. 108-120 13 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Haplotypes
HapMap Project
Linkage Disequilibrium
Genetic Association Studies

Cognitive functioning in compulsive hoarding

Blom, R. M., Samuels, J. F., Grados, M. A., Chen, Y., Bienvenu, O. J., Riddle, M. A., Liang, K. Y., Brandt, J. & Nestadt, G. Dec 2011 In : Journal of Anxiety Disorders. 25, 8, p. 1139-1144 6 p.

Research output: Research - peer-reviewArticle

Obsessive-Compulsive Disorder
Hoarding
Reaction Time
Decision Making
Gambling

Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder

Samuels, J., Wang, Y., Riddle, M. A., Greenberg, B. D., Fyer, A. J., Mccracken, J. T., Rauch, S. L., Murphy, D. L., Grados, M. A., Knowles, J. A., Piacentini, J., Cullen, B., Bienvenu, O. J., Rasmussen, S. A., Geller, D., Pauls, D. L., Liang, K. Y., Shugart, Y. Y. & Nestadt, G. Jun 2011 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 156, 4, p. 472-477 6 p.

Research output: Research - peer-reviewArticle

Amino Acid Transport System X-AG
Obsessive-Compulsive Disorder
Single Nucleotide Polymorphism
Genes
Viverridae