Mandeep Singh

Assistant Professor

20062020

Research output per year

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Research Output

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2020

Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors

Barnea-Cramer, A. O., Singh, M., Fischer, D., De Silva, S., McClements, M. E., Barnard, A. R. & MacLaren, R. E., Jan 1 2020, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

2019

An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4 -/- Mice

McClements, M. E., Barnard, A. R., Singh, M., Charbel Issa, P., Jiang, Z., Radu, R. A. & MacLaren, R. E., May 1 2019, In : Human gene therapy. 30, 5, p. 590-600 11 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization Associated with Pentosan Polysulfate Toxicity

Mishra, K., Patel, T. P. & Singh, M. S., Jan 1 2019, (Accepted/In press) In : Ophthalmology Retina.

Research output: Contribution to journalArticle

Reproducibility of measurements of retinal structural parameters using optical coherence tomography in stargardt disease

Kong, X., Ho, A., Munoz, B., West, S., Strauss, R. W., Jha, A., Ervin, A., Buzas, J., Singh, M., Hu, Z., Cheetham, J., Ip, M. & Scholl, H. P. N., May 1 2019, In : Translational Vision Science and Technology. 8, 3, 46.

Research output: Contribution to journalArticle

Open Access
2018

Inner retinal vasculopathy in Zika virus disease

Singh, M., Marquezan, M. C., Omiadze, R., Reddy, A., Belfort, R. & May, W., Jun 1 2018, In : American Journal of Ophthalmology Case Reports. 10, p. 6-7 2 p.

Research output: Contribution to journalArticle

2017

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

De Silva, S. R., Barnard, A. R., Hughes, S., Tam, S. K. E., Martin, C., Singh, M., Barnea-Cramer, A. O., McClements, M. E., During, M. J., Peirson, S. N., Hankins, M. W. & MacLaren, R. E., Oct 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11211-11216 6 p.

Research output: Contribution to journalArticle

PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT

Singh, M., Casswell, E. J., Boukouvala, S., Petrou, P. & Charteris, D. G., Feb 15 2017, (Accepted/In press) In : Retina.

Research output: Contribution to journalArticle

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

Hickey, D. G., Edwards, T. L., Barnard, A. R., Singh, M., De Silva, S. R., McClements, M. E., Flannery, J. G., Hankins, M. W. & MacLaren, R. E., Dec 1 2017, In : Gene Therapy. 24, 12, p. 787-800 14 p.

Research output: Contribution to journalArticle

2016

Characteristics and vitreoretinal management of retinal detachment in eyes with Boston keratoprosthesis

Petrou, P., Banerjee, P. J., Wilkins, M., Singh, M., Eastlake, K., Limb, G. A. & Charteris, D. G., Aug 26 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients

Fischer, M. D., Hickey, D. G., Singh, M. & MacLaren, R. E., Aug 1 2016, In : Human gene therapy methods. 27, 4, p. 150-158 9 p.

Research output: Contribution to journalArticle

Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice

Barnea-Cramer, A. O., Wang, W., Lu, S. J., Singh, M., Luo, C., Huo, H., McClements, M. E., Barnard, A. R., MacLaren, R. E. & Lanza, R., Jul 13 2016, In : Scientific Reports. 6, 29784.

Research output: Contribution to journalArticle

Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy

Singh, M., Broadgate, S., Mathur, R., Holt, R., Halford, S. & Maclaren, R. E., May 9 2016, In : Scientific Reports. 6, 23674.

Research output: Contribution to journalArticle

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo

De Silva, S. R., Charbel Issa, P., Singh, M., Lipinski, D. M., Barnea-Cramer, A. O., Walker, N. J., Barnard, A. R., Hankins, M. W. & MacLaren, R. E., Nov 1 2016, In : Gene Therapy. 23, 11, p. 767-774 8 p.

Research output: Contribution to journalArticle

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Singh, M., Balmer, J., Barnard, A. R., Aslam, S. A., Moralli, D., Green, C. M., Barnea-Cramer, A., Duncan, I. & MacLaren, R. E., Nov 30 2016, In : Nature Communications. 7, 13537.

Research output: Contribution to journalArticle

2015

CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

Lipinski, D. M., Barnard, A. R., Singh, M., Martin, C., Lee, E. J., Davies, W. I. L. & MacLaren, R. E., Aug 1 2015, In : Molecular Therapy. 23, 8, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

Subretinal Visual Implant Alpha IMS - Clinical trial interim report

Stingl, K., Bartz-Schmidt, K. U., Besch, D., Chee, C. K., Cottriall, C. L., Gekeler, F., Groppe, M., Jackson, T. L., MacLaren, R. E., Koitschev, A., Kusnyerik, A., Neffendorf, J., Nemeth, J., Naeem, M. A. N., Peters, T., Ramsden, J. D., Sachs, H., Simpson, A., Singh, M., Wilhelm, B. & 2 others, Wong, D. & Zrenner, E., Jun 1 2015, In : Vision Research. 111, p. 149-160 12 p.

Research output: Contribution to journalArticle

2014

Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors

Lipinski, D. M., Barnard, A. R., Issa, P. C., Singh, M., De Silva, S. R., Trabalza, A., Eleftheriadou, I., Ellison, S. M., Mazarakis, N. D. & Maclaren, R. E., Jan 1 2014, In : Human Gene Therapy. 25, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

2013

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Charbel Issa, P., de Silva, S. R., Lipinski, D. M., Singh, M., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J. & MacLaren, R. E., Apr 9 2013, In : PLoS One. 8, 4, e60361.

Research output: Contribution to journalArticle

Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury

Aslam, S. A., Davies, W. I. L., Singh, M., Issa, P. C., Barnard, A. R., Scott, R. A. H. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5456-5465 10 p.

Research output: Contribution to journalArticle

Fundus autofluorescence in the Abca4-/- mouse model of stargardt disease-correlation with accumulation of A2E, retinal function, and histology

Charbel Issa, P., Barnard, A. R., Singh, M., Carter, E., Jiang, Z., Radu, R. A., Schraermeyer, U. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5602-5612 11 p.

Research output: Contribution to journalArticle

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

Singh, M., Issa, P. C., Butler, R., Martin, C., Lipinski, D. M., Sekaran, S., Barnard, A. R. & MacLaren, R. E., Jan 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1101-1106 6 p.

Research output: Contribution to journalArticle

Sleeping posture and intraocular pressure

Wong, M. H. Y., Lai, A. H. O., Singh, M. & Chew, P. T. K., Mar 2013, In : Singapore Medical Journal. 54, 3, p. 146-148 3 p.

Research output: Contribution to journalArticle

2012

Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration

Lee, E., Singh, M., Jones, H. E., Ahmed, B., Andolina, I. M., Clements, J. T. C., Luong, V., Munro, P. M., Lawton, M. P., Grieve, K. L., Aylward, G. W., Sillito, A. M. & Maclaren, R. E., May 2012, In : Investigative Ophthalmology and Visual Science. 53, 6, p. 2523-2532 10 p.

Research output: Contribution to journalArticle

Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration

Issa, P. C., Singh, M., Lipinski, D. M., Chong, N. V., Delori, F. C., Barnard, A. R. & MacLaren, R. E., Feb 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 1066-1075 10 p.

Research output: Contribution to journalArticle

Quantitative assessment of changes in trabeculectomy blebs after laser suture lysis using anterior segment coherence tomography

Sng, C. C. A., Singh, M., Chew, P. T. K., Ngo, C. S., Zheng, C., Tun, T. A., See, J. L. S., Ang, M., Loon, S. C. & Aung, T., Jun 2012, In : Journal of Glaucoma. 21, 5, p. 313-317 5 p.

Research output: Contribution to journalArticle

2011

Assessment of cone survival in response to CNTF, GDNF, and VEGF 165b in a novel ex vivo model of end-stage retinitis pigmentosa

Lipinski, D. M., Singh, M. & MacLaren, R. E., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7340-7346 7 p.

Research output: Contribution to journalArticle

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Sng, C. C. A., See, J. S. L., Ngo, C. S., Singh, M., Chan, Y. H., Aquino, M. C., Tan, A. M., Shabana, N. & Chew, P. T. K., May 2011, In : Eye. 25, 5, p. 619-625 7 p.

Research output: Contribution to journalArticle

Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of loci associated with human dominant retinal dystrophy

Lipinski, D. M., Yusuf, M., Barnard, A. R., Damant, C., Issa, P. C., Singh, M., Lee, E., Davies, W. L., Volpi, E. V. & McLaren, R. E., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6617-6623 7 p.

Research output: Contribution to journalArticle

2010

Visual acuity outcomes with SA60D3, SN60D3, and ZM900 multifocal IOL implantation after phacoemulsification

Ngo, C., Singh, M., Sng, C., Loon, S. C., Chan, Y. H. & Thean, L., Mar 2010, In : Journal of Refractive Surgery. 26, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

2009

High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment

Singh, M., See, J. L. S., Aquino, M. C., Thean, L. S. Y. & Chew, P. T. K., 2009, In : Clinical and Experimental Ophthalmology. 37, 4, p. 345-351 7 p.

Research output: Contribution to journalArticle

Spectral domain optical coherence tomography imaging of retinal diseases in Singapore

Singh, M. & Chee, C. K. L., May 2009, In : Ophthalmic Surgery Lasers and Imaging. 40, 3, p. 336-341 6 p.

Research output: Contribution to journalArticle

Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy

Singh, M., Aung, T., Aquino, M. C. & Chew, P. T. K., Aug 2009, In : Journal of Glaucoma. 18, 6, p. 492-495 4 p.

Research output: Contribution to journalArticle

2008

Corneal patch graft repair of exposed glaucoma drainage implants

Singh, M., Chew, P. T. K. & Tan, D., Dec 2008, In : Cornea. 27, 10, p. 1171-1173 3 p.

Research output: Contribution to journalArticle

Spectral domain optical coherence tomography imaging of retinal diseases in Singapore

Singh, M. & Chee, C. K. L., Jul 2008, In : Ophthalmic Surgery Lasers and Imaging. 39, 4 SUPPL.

Research output: Contribution to journalArticle

Time interval for the development of posterior capsular opacification in different intraocular lenses in Asian eyes

Ngo, C. S., Loon, S. C., Singh, M. & Thean, L. H., Oct 2008, In : Asian Journal of Ophthalmology. 10, 5-6, p. 354-359 6 p.

Research output: Contribution to journalArticle

2007

Anterior Segment Optical Coherence Tomography Imaging of Trabeculectomy Blebs Before and After Laser Suture Lysis

Singh, M., Aung, T., Friedman, D. S., Zheng, C., Foster, P. J., Nolan, W. P., See, J. L., Smith, S. D. & Chew, P. T. K., May 2007, In : American Journal of Ophthalmology. 143, 5, p. 873-875 3 p.

Research output: Contribution to journalArticle

Imaging of Trabeculectomy Blebs Using Anterior Segment Optical Coherence Tomography

Singh, M., Chew, P. T. K., Friedman, D. S., Nolan, W. P., See, J. L., Smith, S. D., Zheng, C., Foster, P. J. & Aung, T., Jan 2007, In : Ophthalmology. 114, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

Sight-threatening orbital emphysema treated with needle decompression

Singh, M., Phua, V. M. & Sundar, G., May 2007, In : Clinical and Experimental Ophthalmology. 35, 4, p. 386-387 2 p.

Research output: Contribution to journalArticle