Mandeep Singh

Assistant Professor

20062019
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Research Output 2006 2019

2019

An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4 -/- Mice

McClements, M. E., Barnard, A. R., Singh, M., Charbel Issa, P., Jiang, Z., Radu, R. A. & MacLaren, R. E., May 1 2019, In : Human gene therapy. 30, 5, p. 590-600 11 p.

Research output: Contribution to journalArticle

Viral Genes
Transgenes
Phenotype
Genetic Therapy
Genetic Recombination

Choroidal Neovascularization Associated with Pentosan Polysulfate Toxicity

Mishra, K., Patel, T. P. & Singh, M., Jan 1 2019, (Accepted/In press) In : Ophthalmology Retina.

Research output: Contribution to journalArticle

Pentosan Sulfuric Polyester
Choroidal Neovascularization

Reproducibility of measurements of retinal structural parameters using optical coherence tomography in stargardt disease

Kong, X., Ho, A., Munoz, B., West, S., Strauss, R. W., Jha, A., Ervin, A., Buzas, J., Singh, M., Hu, Z., Cheetham, J., Ip, M. & Scholl, H. P. N., May 1 2019, In : Translational Vision Science and Technology. 8, 3, 46.

Research output: Contribution to journalArticle

Open Access
Optical tomography
Optical Coherence Tomography
Retina
Diabetic Retinopathy
Reading

Retinal stem cell transplantation: Balancing safety and potential

Singh, M., Park, S. S., Albini, T. A., Canto-Soler, M. V., Klassen, H., MacLaren, R. E., Takahashi, M., Nagiel, A., Schwartz, S. D. & Bharti, K., Jan 1 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100779.

Research output: Contribution to journalReview article

Open Access
Stem Cell Transplantation
Safety
Retinal Diseases
Blindness
Stem Cell Research
2018

Inner retinal vasculopathy in Zika virus disease

Singh, M., Marquezan, M. C., Omiadze, R., Reddy, A., Belfort, R. & May, W., Jun 1 2018, In : American Journal of Ophthalmology Case Reports. 10, p. 6-7 2 p.

Research output: Contribution to journalArticle

Retinal Vessels
Puerto Rico
Uveitis
Peripheral Nervous System Diseases
Neurologic Manifestations

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

Singh, M. & MacLaren, R. E., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD78-AMD82

Research output: Contribution to journalReview article

Induced Pluripotent Stem Cells
Retinal Degeneration
Retinal Pigment Epithelium
Macular Degeneration
Stem Cell Transplantation
2017

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

De Silva, S. R., Barnard, A. R., Hughes, S., Tam, S. K. E., Martin, C., Singh, M., Barnea-Cramer, A. O., McClements, M. E., During, M. J., Peirson, S. N., Hankins, M. W. & MacLaren, R. E., Oct 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11211-11216 6 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Genetic Therapy
Light
Optogenetics
Aptitude

PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT

Singh, M., Casswell, E. J., Boukouvala, S., Petrou, P. & Charteris, D. G., Feb 15 2017, (Accepted/In press) In : Retina.

Research output: Contribution to journalArticle

Ectopia Lentis
Vitreous Detachment
Temazepam
Vitrectomy
Retinal Detachment

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

Hickey, D. G., Edwards, T. L., Barnard, A. R., Singh, M., De Silva, S. R., McClements, M. E., Flannery, J. G., Hankins, M. W. & MacLaren, R. E., Dec 1 2017, In : Gene Therapy. 24, 12, p. 787-800 14 p.

Research output: Contribution to journalArticle

Dependovirus
Tropism
Primates
Retina
Green Fluorescent Proteins
2016

Characteristics and vitreoretinal management of retinal detachment in eyes with Boston keratoprosthesis

Petrou, P., Banerjee, P. J., Wilkins, M., Singh, M., Eastlake, K., Limb, G. A. & Charteris, D. G., Aug 26 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Vitrectomy
Retinal Detachment
Proliferative Vitreoretinopathy
Temazepam
Visual Acuity

Emerging therapies for inherited retinal degeneration

Scholl, H. P. N., Strauss, R. W., Singh, M., Dalkara, D., Roska, B., Picaud, S. & Sahel, J. A., Dec 7 2016, In : Science Translational Medicine. 8, 368, 368rv6.

Research output: Contribution to journalReview article

Photoreceptor Cells
Retinal Degeneration
Molecular Biology
Visual Prosthesis
Optogenetics

Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients

Fischer, M. D., Hickey, D. G., Singh, M. & MacLaren, R. E., Aug 1 2016, In : Human gene therapy methods. 27, 4, p. 150-158 9 p.

Research output: Contribution to journalArticle

Genetic Therapy
Injections
Poloxamer
Pressure
Polytetrafluoroethylene

Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice

Barnea-Cramer, A. O., Wang, W., Lu, S. J., Singh, M., Luo, C., Huo, H., McClements, M. E., Barnard, A. R., MacLaren, R. E. & Lanza, R., Jul 13 2016, In : Scientific Reports. 6, 29784.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Neurons
Induced Pluripotent Stem Cells
Retinal Diseases
Photoreceptor Cells

Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy

Singh, M., Broadgate, S., Mathur, R., Holt, R., Halford, S. & Maclaren, R. E., May 9 2016, In : Scientific Reports. 6, 23674.

Research output: Contribution to journalArticle

Hypotrichosis
Retinal Diseases
Macular Degeneration
Genetic Therapy
Mutation

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo

De Silva, S. R., Charbel Issa, P., Singh, M., Lipinski, D. M., Barnea-Cramer, A. O., Walker, N. J., Barnard, A. R., Hankins, M. W. & MacLaren, R. E., Nov 1 2016, In : Gene Therapy. 23, 11, p. 767-774 8 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Capsid
Retina
Mutation
Optogenetics

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Singh, M., Balmer, J., Barnard, A. R., Aslam, S. A., Moralli, D., Green, C. M., Barnea-Cramer, A., Duncan, I. & MacLaren, R. E., Nov 30 2016, In : Nature Communications. 7, 13537.

Research output: Contribution to journalArticle

photoreceptors
Transplants
Protein Precursors
Chromosomes
transplantation
2015

CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

Lipinski, D. M., Barnard, A. R., Singh, M., Martin, C., Lee, E. J., Davies, W. I. L. & MacLaren, R. E., Aug 1 2015, In : Molecular Therapy. 23, 8, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Retinitis Pigmentosa
Genetic Therapy
Neurodegenerative Diseases
Retinal Cone Photoreceptor Cells

Subretinal Visual Implant Alpha IMS - Clinical trial interim report

Stingl, K., Bartz-Schmidt, K. U., Besch, D., Chee, C. K., Cottriall, C. L., Gekeler, F., Groppe, M., Jackson, T. L., MacLaren, R. E., Koitschev, A., Kusnyerik, A., Neffendorf, J., Nemeth, J., Naeem, M. A. N., Peters, T., Ramsden, J. D., Sachs, H., Simpson, A., Singh, M., Wilhelm, B. & 2 others, Wong, D. & Zrenner, E., Jun 1 2015, In : Vision Research. 111, p. 149-160 12 p.

Research output: Contribution to journalArticle

Low Vision
Retinal Degeneration
Activities of Daily Living
Visual Acuity
Clinical Trials
2014

Application of ocular fundus photography and angiography

Lin Chee, C. K., Santiago, P. A., Lingam, G. & Singh, M., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 135-156 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Color photography
Angiography
Photography
Fluorescence
Ophthalmoscopes

Imaging of the eye after glaucoma surgery

Singh, M., Aquino, M. C. D. & Kuan Chew, P. T., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 179-194 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glaucoma
Surgery
Imaging techniques
Eye Diseases
Quality of Life

Novel approaches to restore vision in end-stage age-related macular degeneration

Singh, M. & de Silva, S. R., Aug 1 2014, Current Issues in Age-Related Macular Degeneration. Future Medicine Ltd., p. 159-170 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Macular Degeneration

Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors

Lipinski, D. M., Barnard, A. R., Issa, P. C., Singh, M., De Silva, S. R., Trabalza, A., Eleftheriadou, I., Ellison, S. M., Mazarakis, N. D. & Maclaren, R. E., Jan 1 2014, In : Human Gene Therapy. 25, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Trabecular Meshwork
Corneal Endothelium
Lentivirus
Vesicular Stomatitis
2013

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Charbel Issa, P., de Silva, S. R., Lipinski, D. M., Singh, M., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J. & MacLaren, R. E., Apr 9 2013, In : PLoS One. 8, 4, e60361.

Research output: Contribution to journalArticle

tropisms
Tropism
retina
Primates
Retina

Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury

Aslam, S. A., Davies, W. I. L., Singh, M., Issa, P. C., Barnard, A. R., Scott, R. A. H. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5456-5465 10 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Retinal Cone Photoreceptor Cells
Lasers
In Situ Nick-End Labeling
Wounds and Injuries

Fundus autofluorescence in the Abca4-/- mouse model of stargardt disease-correlation with accumulation of A2E, retinal function, and histology

Charbel Issa, P., Barnard, A. R., Singh, M., Carter, E., Jiang, Z., Radu, R. A., Schraermeyer, U. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5602-5612 11 p.

Research output: Contribution to journalArticle

Lipofuscin
Histology
Melanins
Retinal Pigment Epithelium
Electroretinography

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

Singh, M., Issa, P. C., Butler, R., Martin, C., Lipinski, D. M., Sekaran, S., Barnard, A. R. & MacLaren, R. E., Jan 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1101-1106 6 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Transplantation
Vertebrate Photoreceptor Cells
Retinitis Pigmentosa
Light

Sleeping posture and intraocular pressure

Wong, M. H. Y., Lai, A. H. O., Singh, M. & Chew, P. T. K., Mar 2013, In : Singapore Medical Journal. 54, 3, p. 146-148 3 p.

Research output: Contribution to journalArticle

Posture
Intraocular Pressure
Supine Position
Reading
Sleep
2012

Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration

Lee, E., Singh, M., Jones, H. E., Ahmed, B., Andolina, I. M., Clements, J. T. C., Luong, V., Munro, P. M., Lawton, M. P., Grieve, K. L., Aylward, G. W., Sillito, A. M. & Maclaren, R. E., May 2012, In : Investigative Ophthalmology and Visual Science. 53, 6, p. 2523-2532 10 p.

Research output: Contribution to journalArticle

Choroid
Macular Degeneration
Bruch Membrane
Transplants
Retinal Pigment Epithelium

Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration

Issa, P. C., Singh, M., Lipinski, D. M., Chong, N. V., Delori, F. C., Barnard, A. R. & MacLaren, R. E., Feb 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 1066-1075 10 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Optical Imaging
Retinal Pigment Epithelium
Ophthalmoscopes
Phenotype

Quantitative assessment of changes in trabeculectomy blebs after laser suture lysis using anterior segment coherence tomography

Sng, C. C. A., Singh, M., Chew, P. T. K., Ngo, C. S., Zheng, C., Tun, T. A., See, J. L. S., Ang, M., Loon, S. C. & Aung, T., Jun 2012, In : Journal of Glaucoma. 21, 5, p. 313-317 5 p.

Research output: Contribution to journalArticle

Trabeculectomy
Blister
Sutures
Lasers
Tomography
2011

Assessment of cone survival in response to CNTF, GDNF, and VEGF 165b in a novel ex vivo model of end-stage retinitis pigmentosa

Lipinski, D. M., Singh, M. & MacLaren, R. E., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7340-7346 7 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Retinitis Pigmentosa
Nerve Growth Factors
Neuroglia
Vascular Endothelial Growth Factor A

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Sng, C. C. A., See, J. S. L., Ngo, C. S., Singh, M., Chan, Y. H., Aquino, M. C., Tan, A. M., Shabana, N. & Chew, P. T. K., May 2011, In : Eye. 25, 5, p. 619-625 7 p.

Research output: Contribution to journalArticle

Optic Disk
Visual Fields
Nerve Fibers
Pallor
Visual Field Tests

Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of loci associated with human dominant retinal dystrophy

Lipinski, D. M., Yusuf, M., Barnard, A. R., Damant, C., Issa, P. C., Singh, M., Lee, E., Davies, W. L., Volpi, E. V. & McLaren, R. E., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6617-6623 7 p.

Research output: Contribution to journalArticle

Retinal Dystrophies
Green Fluorescent Proteins
Retinal Degeneration
Transgenic Mice
Retinal Cone Photoreceptor Cells

Stem cells as a therapeutic tool for the blind: Biology and future prospects

Singh, M. & MacLaren, R. E., Oct 22 2011, In : Proceedings of the Royal Society B: Biological Sciences. 278, 1721, p. 3009-3016 8 p.

Research output: Contribution to journalReview article

blindness
future prospect
Blindness
Stem cells
photoreceptors
2010

Visual acuity outcomes with SA60D3, SN60D3, and ZM900 multifocal IOL implantation after phacoemulsification

Ngo, C., Singh, M., Sng, C., Loon, S. C., Chan, Y. H. & Thean, L., Mar 2010, In : Journal of Refractive Surgery. 26, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

Intraocular Lens Implantation
Phacoemulsification
Cataract
Visual Acuity
Astigmatism
2009

High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment

Singh, M., See, J. L. S., Aquino, M. C., Thean, L. S. Y. & Chew, P. T. K., 2009, In : Clinical and Experimental Ophthalmology. 37, 4, p. 345-351 7 p.

Research output: Contribution to journalArticle

Trabeculectomy
Optical Coherence Tomography
Blister

Spectral domain optical coherence tomography imaging of retinal diseases in Singapore

Singh, M. & Chee, C. K. L., May 2009, In : Ophthalmic Surgery Lasers and Imaging. 40, 3, p. 336-341 6 p.

Research output: Contribution to journalArticle

Retinal Diseases
Singapore
Optical Coherence Tomography
Macular Edema
Chorioretinitis

Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy

Singh, M., Aung, T., Aquino, M. C. & Chew, P. T. K., Aug 2009, In : Journal of Glaucoma. 18, 6, p. 492-495 4 p.

Research output: Contribution to journalArticle

Trabeculectomy
Optical Coherence Tomography
Blister
Sutures
Lasers
2008

Barotraumatic ocular haemorrhage sustained while scuba diving

Yeoh, R., Yeoh, R. & Singh, M., 2008, In : Clinical and Experimental Ophthalmology. 36, 6, p. 581-582 2 p.

Research output: Contribution to journalLetter

Eye Hemorrhage
Barotrauma
Eye Injuries
Diving
Recovery of Function

Conjunctival erosion after glaucoma drainage implant surgery

Singh, M. & Tan, D., Oct 2008, In : Asian Journal of Ophthalmology. 10, 5-6, p. 345-346 2 p.

Research output: Contribution to journalEditorial

Glaucoma Drainage Implants

Corneal patch graft repair of exposed glaucoma drainage implants

Singh, M., Chew, P. T. K. & Tan, D., Dec 2008, In : Cornea. 27, 10, p. 1171-1173 3 p.

Research output: Contribution to journalArticle

Glaucoma Drainage Implants
Transplants
Eye Infections
Sclera
Pericardium

Spectral domain optical coherence tomography imaging of retinal diseases in Singapore

Singh, M. & Chee, C. K. L., Jul 2008, In : Ophthalmic Surgery Lasers and Imaging. 39, 4 SUPPL.

Research output: Contribution to journalArticle

Retinal Diseases
Singapore
Optical Coherence Tomography
Macular Edema
Chorioretinitis

Time interval for the development of posterior capsular opacification in different intraocular lenses in Asian eyes

Ngo, C. S., Loon, S. C., Singh, M. & Thean, L. H., Oct 2008, In : Asian Journal of Ophthalmology. 10, 5-6, p. 354-359 6 p.

Research output: Contribution to journalArticle

Intraocular Lenses
Silicones
Cataract
Solid-State Lasers
Intraocular Lens Implantation
2007

Anterior Segment Optical Coherence Tomography Imaging of Trabeculectomy Blebs Before and After Laser Suture Lysis

Singh, M., Aung, T., Friedman, D. S., Zheng, C., Foster, P. J., Nolan, W. P., See, J. L., Smith, S. D. & Chew, P. T. K., May 2007, In : American Journal of Ophthalmology. 143, 5, p. 873-875 3 p.

Research output: Contribution to journalArticle

Trabeculectomy
Optical Coherence Tomography
Blister
Sutures
Lasers

Imaging of Trabeculectomy Blebs Using Anterior Segment Optical Coherence Tomography

Singh, M., Chew, P. T. K., Friedman, D. S., Nolan, W. P., See, J. L., Smith, S. D., Zheng, C., Foster, P. J. & Aung, T., Jan 2007, In : Ophthalmology. 114, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

Trabeculectomy
Optical Coherence Tomography
Blister
Sclera
Conjunctiva

Sight-threatening orbital emphysema treated with needle decompression

Singh, M., Phua, V. M. & Sundar, G., May 2007, In : Clinical and Experimental Ophthalmology. 35, 4, p. 386-387 2 p.

Research output: Contribution to journalArticle

Emphysema
Decompression
Intraocular Pressure
Needles
Subcutaneous Emphysema
2006

Ixodes tick infestation of the eyelid of a child [1]

Singh, M., Gopalakrishnakone, P. & Yeoh, R. L. S., 2006, In : Canadian Journal of Ophthalmology. 41, 6, p. 783-784 2 p.

Research output: Contribution to journalLetter

Tick Infestations
Ixodes
Eyelids