Research Output per year
Research Output 2006 2019
2019
An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4 -/- Mice
McClements, M. E., Barnard, A. R., Singh, M., Charbel Issa, P., Jiang, Z., Radu, R. A. & MacLaren, R. E., May 1 2019, In : Human gene therapy. 30, 5, p. 590-600 11 p.Research output: Contribution to journal › Article
Viral Genes
Transgenes
Phenotype
Genetic Therapy
Genetic Recombination
Choroidal Neovascularization Associated with Pentosan Polysulfate Toxicity
Mishra, K., Patel, T. P. & Singh, M., Jan 1 2019, (Accepted/In press) In : Ophthalmology Retina.Research output: Contribution to journal › Article
Pentosan Sulfuric Polyester
Choroidal Neovascularization
Reproducibility of measurements of retinal structural parameters using optical coherence tomography in stargardt disease
Kong, X., Ho, A., Munoz, B., West, S., Strauss, R. W., Jha, A., Ervin, A., Buzas, J., Singh, M., Hu, Z., Cheetham, J., Ip, M. & Scholl, H. P. N., May 1 2019, In : Translational Vision Science and Technology. 8, 3, 46.Research output: Contribution to journal › Article
Open Access
Optical tomography
Optical Coherence Tomography
Retina
Diabetic Retinopathy
Reading
Retinal stem cell transplantation: Balancing safety and potential
Singh, M., Park, S. S., Albini, T. A., Canto-Soler, M. V., Klassen, H., MacLaren, R. E., Takahashi, M., Nagiel, A., Schwartz, S. D. & Bharti, K., Jan 1 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100779.Research output: Contribution to journal › Review article
Open Access
Stem Cell Transplantation
Safety
Retinal Diseases
Blindness
Stem Cell Research
2018
Inner retinal vasculopathy in Zika virus disease
Singh, M., Marquezan, M. C., Omiadze, R., Reddy, A., Belfort, R. & May, W., Jun 1 2018, In : American Journal of Ophthalmology Case Reports. 10, p. 6-7 2 p.Research output: Contribution to journal › Article
Retinal Vessels
Puerto Rico
Uveitis
Peripheral Nervous System Diseases
Neurologic Manifestations
Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges
Singh, M. & MacLaren, R. E., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD78-AMD82Research output: Contribution to journal › Review article
Induced Pluripotent Stem Cells
Retinal Degeneration
Retinal Pigment Epithelium
Macular Degeneration
Stem Cell Transplantation
2017
Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy
De Silva, S. R., Barnard, A. R., Hughes, S., Tam, S. K. E., Martin, C., Singh, M., Barnea-Cramer, A. O., McClements, M. E., During, M. J., Peirson, S. N., Hankins, M. W. & MacLaren, R. E., Oct 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11211-11216 6 p.Research output: Contribution to journal › Article
Retinal Degeneration
Genetic Therapy
Light
Optogenetics
Aptitude
PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT
Singh, M., Casswell, E. J., Boukouvala, S., Petrou, P. & Charteris, D. G., Feb 15 2017, (Accepted/In press) In : Retina.Research output: Contribution to journal › Article
Ectopia Lentis
Vitreous Detachment
Temazepam
Vitrectomy
Retinal Detachment
Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina
Hickey, D. G., Edwards, T. L., Barnard, A. R., Singh, M., De Silva, S. R., McClements, M. E., Flannery, J. G., Hankins, M. W. & MacLaren, R. E., Dec 1 2017, In : Gene Therapy. 24, 12, p. 787-800 14 p.Research output: Contribution to journal › Article
Dependovirus
Tropism
Primates
Retina
Green Fluorescent Proteins
2016
Characteristics and vitreoretinal management of retinal detachment in eyes with Boston keratoprosthesis
Petrou, P., Banerjee, P. J., Wilkins, M., Singh, M., Eastlake, K., Limb, G. A. & Charteris, D. G., Aug 26 2016, (Accepted/In press) In : British Journal of Ophthalmology.Research output: Contribution to journal › Article
Vitrectomy
Retinal Detachment
Proliferative Vitreoretinopathy
Temazepam
Visual Acuity
Emerging therapies for inherited retinal degeneration
Scholl, H. P. N., Strauss, R. W., Singh, M., Dalkara, D., Roska, B., Picaud, S. & Sahel, J. A., Dec 7 2016, In : Science Translational Medicine. 8, 368, 368rv6.Research output: Contribution to journal › Review article
Photoreceptor Cells
Retinal Degeneration
Molecular Biology
Visual Prosthesis
Optogenetics
Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients
Fischer, M. D., Hickey, D. G., Singh, M. & MacLaren, R. E., Aug 1 2016, In : Human gene therapy methods. 27, 4, p. 150-158 9 p.Research output: Contribution to journal › Article
Genetic Therapy
Injections
Poloxamer
Pressure
Polytetrafluoroethylene
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice
Barnea-Cramer, A. O., Wang, W., Lu, S. J., Singh, M., Luo, C., Huo, H., McClements, M. E., Barnard, A. R., MacLaren, R. E. & Lanza, R., Jul 13 2016, In : Scientific Reports. 6, 29784.Research output: Contribution to journal › Article
Pluripotent Stem Cells
Retinal Neurons
Induced Pluripotent Stem Cells
Retinal Diseases
Photoreceptor Cells
Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy
Singh, M., Broadgate, S., Mathur, R., Holt, R., Halford, S. & Maclaren, R. E., May 9 2016, In : Scientific Reports. 6, 23674.Research output: Contribution to journal › Article
Hypotrichosis
Retinal Diseases
Macular Degeneration
Genetic Therapy
Mutation
Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo
De Silva, S. R., Charbel Issa, P., Singh, M., Lipinski, D. M., Barnea-Cramer, A. O., Walker, N. J., Barnard, A. R., Hankins, M. W. & MacLaren, R. E., Nov 1 2016, In : Gene Therapy. 23, 11, p. 767-774 8 p.Research output: Contribution to journal › Article
Retinal Degeneration
Capsid
Retina
Mutation
Optogenetics
Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
Singh, M., Balmer, J., Barnard, A. R., Aslam, S. A., Moralli, D., Green, C. M., Barnea-Cramer, A., Duncan, I. & MacLaren, R. E., Nov 30 2016, In : Nature Communications. 7, 13537.Research output: Contribution to journal › Article
photoreceptors
Transplants
Protein Precursors
Chromosomes
transplantation
2015
CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa
Lipinski, D. M., Barnard, A. R., Singh, M., Martin, C., Lee, E. J., Davies, W. I. L. & MacLaren, R. E., Aug 1 2015, In : Molecular Therapy. 23, 8, p. 1308-1319 12 p.Research output: Contribution to journal › Article
Ciliary Neurotrophic Factor
Retinitis Pigmentosa
Genetic Therapy
Neurodegenerative Diseases
Retinal Cone Photoreceptor Cells
Subretinal Visual Implant Alpha IMS - Clinical trial interim report
Stingl, K., Bartz-Schmidt, K. U., Besch, D., Chee, C. K., Cottriall, C. L., Gekeler, F., Groppe, M., Jackson, T. L., MacLaren, R. E., Koitschev, A., Kusnyerik, A., Neffendorf, J., Nemeth, J., Naeem, M. A. N., Peters, T., Ramsden, J. D., Sachs, H., Simpson, A., Singh, M., Wilhelm, B. & 2 others, , Jun 1 2015, In : Vision Research. 111, p. 149-160 12 p.Research output: Contribution to journal › Article
Low Vision
Retinal Degeneration
Activities of Daily Living
Visual Acuity
Clinical Trials
2014
Application of ocular fundus photography and angiography
Lin Chee, C. K., Santiago, P. A., Lingam, G. & Singh, M., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 135-156 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Color photography
Angiography
Photography
Fluorescence
Ophthalmoscopes
Imaging of the eye after glaucoma surgery
Singh, M., Aquino, M. C. D. & Kuan Chew, P. T., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 179-194 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Glaucoma
Surgery
Imaging techniques
Eye Diseases
Quality of Life
Novel approaches to restore vision in end-stage age-related macular degeneration
Singh, M. & de Silva, S. R., Aug 1 2014, Current Issues in Age-Related Macular Degeneration. Future Medicine Ltd., p. 159-170 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Macular Degeneration
Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors
Lipinski, D. M., Barnard, A. R., Issa, P. C., Singh, M., De Silva, S. R., Trabalza, A., Eleftheriadou, I., Ellison, S. M., Mazarakis, N. D. & Maclaren, R. E., Jan 1 2014, In : Human Gene Therapy. 25, 1, p. 50-62 13 p.Research output: Contribution to journal › Article
Venezuelan Equine Encephalitis Viruses
Trabecular Meshwork
Corneal Endothelium
Lentivirus
Vesicular Stomatitis
2013
Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina
Charbel Issa, P., de Silva, S. R., Lipinski, D. M., Singh, M., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J. & MacLaren, R. E., Apr 9 2013, In : PLoS One. 8, 4, e60361.Research output: Contribution to journal › Article
tropisms
Tropism
retina
Primates
Retina
Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury
Aslam, S. A., Davies, W. I. L., Singh, M., Issa, P. C., Barnard, A. R., Scott, R. A. H. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5456-5465 10 p.Research output: Contribution to journal › Article
Ciliary Neurotrophic Factor
Retinal Cone Photoreceptor Cells
Lasers
In Situ Nick-End Labeling
Wounds and Injuries
Fundus autofluorescence in the Abca4-/- mouse model of stargardt disease-correlation with accumulation of A2E, retinal function, and histology
Charbel Issa, P., Barnard, A. R., Singh, M., Carter, E., Jiang, Z., Radu, R. A., Schraermeyer, U. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5602-5612 11 p.Research output: Contribution to journal › Article
Lipofuscin
Histology
Melanins
Retinal Pigment Epithelium
Electroretinography
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation
Singh, M., Issa, P. C., Butler, R., Martin, C., Lipinski, D. M., Sekaran, S., Barnard, A. R. & MacLaren, R. E., Jan 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1101-1106 6 p.Research output: Contribution to journal › Article
Retinal Degeneration
Transplantation
Vertebrate Photoreceptor Cells
Retinitis Pigmentosa
Light
Sleeping posture and intraocular pressure
Wong, M. H. Y., Lai, A. H. O., Singh, M. & Chew, P. T. K., Mar 2013, In : Singapore Medical Journal. 54, 3, p. 146-148 3 p.Research output: Contribution to journal › Article
Posture
Intraocular Pressure
Supine Position
Reading
Sleep
2012
Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration
Lee, E., Singh, M., Jones, H. E., Ahmed, B., Andolina, I. M., Clements, J. T. C., Luong, V., Munro, P. M., Lawton, M. P., Grieve, K. L., Aylward, G. W., Sillito, A. M. & Maclaren, R. E., May 2012, In : Investigative Ophthalmology and Visual Science. 53, 6, p. 2523-2532 10 p.Research output: Contribution to journal › Article
Choroid
Macular Degeneration
Bruch Membrane
Transplants
Retinal Pigment Epithelium
Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration
Issa, P. C., Singh, M., Lipinski, D. M., Chong, N. V., Delori, F. C., Barnard, A. R. & MacLaren, R. E., Feb 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 1066-1075 10 p.Research output: Contribution to journal › Article
Retinal Degeneration
Optical Imaging
Retinal Pigment Epithelium
Ophthalmoscopes
Phenotype
Quantitative assessment of changes in trabeculectomy blebs after laser suture lysis using anterior segment coherence tomography
Sng, C. C. A., Singh, M., Chew, P. T. K., Ngo, C. S., Zheng, C., Tun, T. A., See, J. L. S., Ang, M., Loon, S. C. & Aung, T., Jun 2012, In : Journal of Glaucoma. 21, 5, p. 313-317 5 p.Research output: Contribution to journal › Article
Trabeculectomy
Blister
Sutures
Lasers
Tomography
2011
Assessment of cone survival in response to CNTF, GDNF, and VEGF 165b in a novel ex vivo model of end-stage retinitis pigmentosa
Lipinski, D. M., Singh, M. & MacLaren, R. E., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7340-7346 7 p.Research output: Contribution to journal › Article
Ciliary Neurotrophic Factor
Retinitis Pigmentosa
Nerve Growth Factors
Neuroglia
Vascular Endothelial Growth Factor A
Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure
Sng, C. C. A., See, J. S. L., Ngo, C. S., Singh, M., Chan, Y. H., Aquino, M. C., Tan, A. M., Shabana, N. & Chew, P. T. K., May 2011, In : Eye. 25, 5, p. 619-625 7 p.Research output: Contribution to journal › Article
Optic Disk
Visual Fields
Nerve Fibers
Pallor
Visual Field Tests
Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of loci associated with human dominant retinal dystrophy
Lipinski, D. M., Yusuf, M., Barnard, A. R., Damant, C., Issa, P. C., Singh, M., Lee, E., Davies, W. L., Volpi, E. V. & McLaren, R. E., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6617-6623 7 p.Research output: Contribution to journal › Article
Retinal Dystrophies
Green Fluorescent Proteins
Retinal Degeneration
Transgenic Mice
Retinal Cone Photoreceptor Cells
Stem cells as a therapeutic tool for the blind: Biology and future prospects
Singh, M. & MacLaren, R. E., Oct 22 2011, In : Proceedings of the Royal Society B: Biological Sciences. 278, 1721, p. 3009-3016 8 p.Research output: Contribution to journal › Review article
blindness
future prospect
Blindness
Stem cells
photoreceptors
2010
Visual acuity outcomes with SA60D3, SN60D3, and ZM900 multifocal IOL implantation after phacoemulsification
Ngo, C., Singh, M., Sng, C., Loon, S. C., Chan, Y. H. & Thean, L., Mar 2010, In : Journal of Refractive Surgery. 26, 3, p. 177-182 6 p.Research output: Contribution to journal › Article
Intraocular Lens Implantation
Phacoemulsification
Cataract
Visual Acuity
Astigmatism
2009
High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment
Singh, M., See, J. L. S., Aquino, M. C., Thean, L. S. Y. & Chew, P. T. K., 2009, In : Clinical and Experimental Ophthalmology. 37, 4, p. 345-351 7 p.Research output: Contribution to journal › Article
Trabeculectomy
Optical Coherence Tomography
Blister
Spectral domain optical coherence tomography imaging of retinal diseases in Singapore
Singh, M. & Chee, C. K. L., May 2009, In : Ophthalmic Surgery Lasers and Imaging. 40, 3, p. 336-341 6 p.Research output: Contribution to journal › Article
Retinal Diseases
Singapore
Optical Coherence Tomography
Macular Edema
Chorioretinitis
Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy
Singh, M., Aung, T., Aquino, M. C. & Chew, P. T. K., Aug 2009, In : Journal of Glaucoma. 18, 6, p. 492-495 4 p.Research output: Contribution to journal › Article
Trabeculectomy
Optical Coherence Tomography
Blister
Sutures
Lasers
2008
Barotraumatic ocular haemorrhage sustained while scuba diving
Yeoh, R., Yeoh, R. & Singh, M., 2008, In : Clinical and Experimental Ophthalmology. 36, 6, p. 581-582 2 p.Research output: Contribution to journal › Letter
Eye Hemorrhage
Barotrauma
Eye Injuries
Diving
Recovery of Function
Conjunctival erosion after glaucoma drainage implant surgery
Singh, M. & Tan, D., Oct 2008, In : Asian Journal of Ophthalmology. 10, 5-6, p. 345-346 2 p.Research output: Contribution to journal › Editorial
Glaucoma Drainage Implants
Corneal patch graft repair of exposed glaucoma drainage implants
Singh, M., Chew, P. T. K. & Tan, D., Dec 2008, In : Cornea. 27, 10, p. 1171-1173 3 p.Research output: Contribution to journal › Article
Glaucoma Drainage Implants
Transplants
Eye Infections
Sclera
Pericardium
Spectral domain optical coherence tomography imaging of retinal diseases in Singapore
Singh, M. & Chee, C. K. L., Jul 2008, In : Ophthalmic Surgery Lasers and Imaging. 39, 4 SUPPL.Research output: Contribution to journal › Article
Retinal Diseases
Singapore
Optical Coherence Tomography
Macular Edema
Chorioretinitis
Time interval for the development of posterior capsular opacification in different intraocular lenses in Asian eyes
Ngo, C. S., Loon, S. C., Singh, M. & Thean, L. H., Oct 2008, In : Asian Journal of Ophthalmology. 10, 5-6, p. 354-359 6 p.Research output: Contribution to journal › Article
Intraocular Lenses
Silicones
Cataract
Solid-State Lasers
Intraocular Lens Implantation
2007
Anterior Segment Optical Coherence Tomography Imaging of Trabeculectomy Blebs Before and After Laser Suture Lysis
Singh, M., Aung, T., Friedman, D. S., Zheng, C., Foster, P. J., Nolan, W. P., See, J. L., Smith, S. D. & Chew, P. T. K., May 2007, In : American Journal of Ophthalmology. 143, 5, p. 873-875 3 p.Research output: Contribution to journal › Article
Trabeculectomy
Optical Coherence Tomography
Blister
Sutures
Lasers
Imaging of Trabeculectomy Blebs Using Anterior Segment Optical Coherence Tomography
Singh, M., Chew, P. T. K., Friedman, D. S., Nolan, W. P., See, J. L., Smith, S. D., Zheng, C., Foster, P. J. & Aung, T., Jan 2007, In : Ophthalmology. 114, 1, p. 47-53 7 p.Research output: Contribution to journal › Article
Trabeculectomy
Optical Coherence Tomography
Blister
Sclera
Conjunctiva
Sight-threatening orbital emphysema treated with needle decompression
Singh, M., Phua, V. M. & Sundar, G., May 2007, In : Clinical and Experimental Ophthalmology. 35, 4, p. 386-387 2 p.Research output: Contribution to journal › Article
Emphysema
Decompression
Intraocular Pressure
Needles
Subcutaneous Emphysema
2006
Ixodes tick infestation of the eyelid of a child [1]
Singh, M., Gopalakrishnakone, P. & Yeoh, R. L. S., 2006, In : Canadian Journal of Ophthalmology. 41, 6, p. 783-784 2 p.Research output: Contribution to journal › Letter
Tick Infestations
Ixodes
Eyelids