Mandeep Singh

2020

Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors

Barnea-Cramer, A. O., Singh, M., Fischer, D., De Silva, S., McClements, M. E., Barnard, A. R. & MacLaren, R. E., Jan 1 2020, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journal › Article

2019

An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4 ^-/- Mice

McClements, M. E., Barnard, A. R., Singh, M., Charbel Issa, P., Jiang, Z., Radu, R. A. & MacLaren, R. E., May 1 2019, In : Human gene therapy. 30, 5, p. 590-600 11 p.

Research output: Contribution to journal › Article

Choroidal Neovascularization Associated with Pentosan Polysulfate Toxicity

Mishra, K., Patel, T. P. & Singh, M. S., Jan 1 2019, (Accepted/In press) In : Ophthalmology Retina.

Research output: Contribution to journal › Article

Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema

Iftikhar, M., Mir, T. A., Hafiz, G., Zimmer-Galler, I., Scott, A. W., Solomon, S. D., Sodhi, A., Wenick, A. S., Meyerle, C., Jiramongkolchai, K., Liu, T. Y. A., Arevalo, J. F., Singh, M., Kherani, S., Handa, J. T. & Campochiaro, P. A., Sep 1 2019, In : American journal of ophthalmology. 205, p. 17-26 10 p.

Research output: Contribution to journal › Article

Reproducibility of measurements of retinal structural parameters using optical coherence tomography in stargardt disease

Kong, X., Ho, A., Munoz, B., West, S., Strauss, R. W., Jha, A., Ervin, A., Buzas, J., Singh, M., Hu, Z., Cheetham, J., Ip, M. & Scholl, H. P. N., May 1 2019, In : Translational Vision Science and Technology. 8, 3, 46.

Research output: Contribution to journal › Article

Open Access

Retinal stem cell transplantation: Balancing safety and potential

Singh, M., Park, S. S., Albini, T. A., Canto-Soler, M. V., Klassen, H., MacLaren, R. E., Takahashi, M., Nagiel, A., Schwartz, S. D. & Bharti, K., Jan 1 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100779.

Research output: Contribution to journal › Review article

Open Access

2018

Inner retinal vasculopathy in Zika virus disease

Singh, M., Marquezan, M. C., Omiadze, R., Reddy, A., Belfort, R. & May, W., Jun 1 2018, In : American Journal of Ophthalmology Case Reports. 10, p. 6-7 2 p.

Research output: Contribution to journal › Article

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

Singh, M. & MacLaren, R. E., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD78-AMD82

Research output: Contribution to journal › Review article

2017

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

De Silva, S. R., Barnard, A. R., Hughes, S., Tam, S. K. E., Martin, C., Singh, M., Barnea-Cramer, A. O., McClements, M. E., During, M. J., Peirson, S. N., Hankins, M. W. & MacLaren, R. E., Oct 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11211-11216 6 p.

Research output: Contribution to journal › Article

PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT

Singh, M., Casswell, E. J., Boukouvala, S., Petrou, P. & Charteris, D. G., Feb 15 2017, (Accepted/In press) In : Retina.

Research output: Contribution to journal › Article

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

Hickey, D. G., Edwards, T. L., Barnard, A. R., Singh, M., De Silva, S. R., McClements, M. E., Flannery, J. G., Hankins, M. W. & MacLaren, R. E., Dec 1 2017, In : Gene Therapy. 24, 12, p. 787-800 14 p.

Research output: Contribution to journal › Article

2016

Characteristics and vitreoretinal management of retinal detachment in eyes with Boston keratoprosthesis

Petrou, P., Banerjee, P. J., Wilkins, M., Singh, M., Eastlake, K., Limb, G. A. & Charteris, D. G., Aug 26 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journal › Article

Emerging therapies for inherited retinal degeneration

Scholl, H. P. N., Strauss, R. W., Singh, M., Dalkara, D., Roska, B., Picaud, S. & Sahel, J. A., Dec 7 2016, In : Science Translational Medicine. 8, 368, 368rv6.

Research output: Contribution to journal › Review article

Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients

Fischer, M. D., Hickey, D. G., Singh, M. & MacLaren, R. E., Aug 1 2016, In : Human gene therapy methods. 27, 4, p. 150-158 9 p.

Research output: Contribution to journal › Article

Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice

Barnea-Cramer, A. O., Wang, W., Lu, S. J., Singh, M., Luo, C., Huo, H., McClements, M. E., Barnard, A. R., MacLaren, R. E. & Lanza, R., Jul 13 2016, In : Scientific Reports. 6, 29784.

Research output: Contribution to journal › Article

Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy

Singh, M., Broadgate, S., Mathur, R., Holt, R., Halford, S. & Maclaren, R. E., May 9 2016, In : Scientific Reports. 6, 23674.

Research output: Contribution to journal › Article

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4^-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo

De Silva, S. R., Charbel Issa, P., Singh, M., Lipinski, D. M., Barnea-Cramer, A. O., Walker, N. J., Barnard, A. R., Hankins, M. W. & MacLaren, R. E., Nov 1 2016, In : Gene Therapy. 23, 11, p. 767-774 8 p.

Research output: Contribution to journal › Article

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Singh, M., Balmer, J., Barnard, A. R., Aslam, S. A., Moralli, D., Green, C. M., Barnea-Cramer, A., Duncan, I. & MacLaren, R. E., Nov 30 2016, In : Nature Communications. 7, 13537.

Research output: Contribution to journal › Article

2015

CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

Lipinski, D. M., Barnard, A. R., Singh, M., Martin, C., Lee, E. J., Davies, W. I. L. & MacLaren, R. E., Aug 1 2015, In : Molecular Therapy. 23, 8, p. 1308-1319 12 p.

Research output: Contribution to journal › Article

Subretinal Visual Implant Alpha IMS - Clinical trial interim report

Stingl, K., Bartz-Schmidt, K. U., Besch, D., Chee, C. K., Cottriall, C. L., Gekeler, F., Groppe, M., Jackson, T. L., MacLaren, R. E., Koitschev, A., Kusnyerik, A., Neffendorf, J., Nemeth, J., Naeem, M. A. N., Peters, T., Ramsden, J. D., Sachs, H., Simpson, A., Singh, M., Wilhelm, B. & 2 others, Wong, D. & Zrenner, E., Jun 1 2015, In : Vision Research. 111, p. 149-160 12 p.

Research output: Contribution to journal › Article

2014

Application of ocular fundus photography and angiography

Lin Chee, C. K., Santiago, P. A., Lingam, G. & Singh, M., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 135-156 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Imaging of the eye after glaucoma surgery

Singh, M., Aquino, M. C. D. & Kuan Chew, P. T., Jan 1 2014, Ophthalmological Imaging and Applications. CRC Press, p. 179-194 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Novel approaches to restore vision in end-stage age-related macular degeneration

Singh, M. & de Silva, S. R., Aug 1 2014, Current Issues in Age-Related Macular Degeneration. Future Medicine Ltd., p. 159-170 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors

Lipinski, D. M., Barnard, A. R., Issa, P. C., Singh, M., De Silva, S. R., Trabalza, A., Eleftheriadou, I., Ellison, S. M., Mazarakis, N. D. & Maclaren, R. E., Jan 1 2014, In : Human Gene Therapy. 25, 1, p. 50-62 13 p.

Research output: Contribution to journal › Article

2013

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Charbel Issa, P., de Silva, S. R., Lipinski, D. M., Singh, M., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J. & MacLaren, R. E., Apr 9 2013, In : PLoS One. 8, 4, e60361.

Research output: Contribution to journal › Article

Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury

Aslam, S. A., Davies, W. I. L., Singh, M., Issa, P. C., Barnard, A. R., Scott, R. A. H. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5456-5465 10 p.

Research output: Contribution to journal › Article

Fundus autofluorescence in the Abca4^-/- mouse model of stargardt disease-correlation with accumulation of A2E, retinal function, and histology

Charbel Issa, P., Barnard, A. R., Singh, M., Carter, E., Jiang, Z., Radu, R. A., Schraermeyer, U. & MacLaren, R. E., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5602-5612 11 p.

Research output: Contribution to journal › Article

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

Singh, M., Issa, P. C., Butler, R., Martin, C., Lipinski, D. M., Sekaran, S., Barnard, A. R. & MacLaren, R. E., Jan 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1101-1106 6 p.

Research output: Contribution to journal › Article

Sleeping posture and intraocular pressure

Wong, M. H. Y., Lai, A. H. O., Singh, M. & Chew, P. T. K., Mar 2013, In : Singapore Medical Journal. 54, 3, p. 146-148 3 p.

Research output: Contribution to journal › Article

2012

Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration

Lee, E., Singh, M., Jones, H. E., Ahmed, B., Andolina, I. M., Clements, J. T. C., Luong, V., Munro, P. M., Lawton, M. P., Grieve, K. L., Aylward, G. W., Sillito, A. M. & Maclaren, R. E., May 2012, In : Investigative Ophthalmology and Visual Science. 53, 6, p. 2523-2532 10 p.

Research output: Contribution to journal › Article

Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration

Issa, P. C., Singh, M., Lipinski, D. M., Chong, N. V., Delori, F. C., Barnard, A. R. & MacLaren, R. E., Feb 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 1066-1075 10 p.

Research output: Contribution to journal › Article

Quantitative assessment of changes in trabeculectomy blebs after laser suture lysis using anterior segment coherence tomography

Sng, C. C. A., Singh, M., Chew, P. T. K., Ngo, C. S., Zheng, C., Tun, T. A., See, J. L. S., Ang, M., Loon, S. C. & Aung, T., Jun 2012, In : Journal of Glaucoma. 21, 5, p. 313-317 5 p.

Research output: Contribution to journal › Article

2011

Assessment of cone survival in response to CNTF, GDNF, and VEGF _165b in a novel ex vivo model of end-stage retinitis pigmentosa

Lipinski, D. M., Singh, M. & MacLaren, R. E., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7340-7346 7 p.

Research output: Contribution to journal › Article

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Sng, C. C. A., See, J. S. L., Ngo, C. S., Singh, M., Chan, Y. H., Aquino, M. C., Tan, A. M., Shabana, N. & Chew, P. T. K., May 2011, In : Eye. 25, 5, p. 619-625 7 p.

Research output: Contribution to journal › Article

Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of loci associated with human dominant retinal dystrophy

Lipinski, D. M., Yusuf, M., Barnard, A. R., Damant, C., Issa, P. C., Singh, M., Lee, E., Davies, W. L., Volpi, E. V. & McLaren, R. E., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6617-6623 7 p.

Research output: Contribution to journal › Article

Stem cells as a therapeutic tool for the blind: Biology and future prospects

Singh, M. & MacLaren, R. E., Oct 22 2011, In : Proceedings of the Royal Society B: Biological Sciences. 278, 1721, p. 3009-3016 8 p.

Research output: Contribution to journal › Review article

2010

Visual acuity outcomes with SA60D3, SN60D3, and ZM900 multifocal IOL implantation after phacoemulsification

Ngo, C., Singh, M., Sng, C., Loon, S. C., Chan, Y. H. & Thean, L., Mar 2010, In : Journal of Refractive Surgery. 26, 3, p. 177-182 6 p.

Research output: Contribution to journal › Article

2009

High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment

Singh, M., See, J. L. S., Aquino, M. C., Thean, L. S. Y. & Chew, P. T. K., 2009, In : Clinical and Experimental Ophthalmology. 37, 4, p. 345-351 7 p.

Research output: Contribution to journal › Article

Spectral domain optical coherence tomography imaging of retinal diseases in Singapore

Singh, M. & Chee, C. K. L., May 2009, In : Ophthalmic Surgery Lasers and Imaging. 40, 3, p. 336-341 6 p.

Research output: Contribution to journal › Article

Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy

Singh, M., Aung, T., Aquino, M. C. & Chew, P. T. K., Aug 2009, In : Journal of Glaucoma. 18, 6, p. 492-495 4 p.

Research output: Contribution to journal › Article

2008

2007

2006

Ixodes tick infestation of the eyelid of a child [1]

Singh, M., Gopalakrishnakone, P. & Yeoh, R. L. S., 2006, In : Canadian Journal of Ophthalmology. 41, 6, p. 783-784 2 p.

Research output: Contribution to journal › Letter