Malia Edwards

Assistant Professor

20062019
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Research Output 2006 2019

2019

Ultrastructural analysis of submacular choriocapillaris and its transport systems in AMD and aged control eyes

Grebe, R., Mughal, I., Bryden, W., McLeod, S., Edwards, M., Hageman, G. S. & Lutty, G. A., Apr 1 2019, In : Experimental eye research. 181, p. 252-262 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Endothelial Cells
Bruch Membrane
Caveolae
Alleles
2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Bhutto, I. A., Ogura, S., Baldeosingh, R., McLeod, D. S., Lutty, G. A. & Edwards, M. M., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD143-AMD151

Research output: Contribution to journalArticle

Geographic Atrophy
Optical Tomography
Wounds and Injuries
Injections
Neuroglia

Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy

Goldberg, M. F., McLeod, S., Tso, M., Packo, K., Edwards, M., Bhutto, I. A., Baldeosingh, R., Eberhart, C., Weber, B. H. F. & Lutty, G. A., Apr 1 2018, In : Ophthalmology Retina. 2, 4, p. 360-378 19 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Bruch Membrane
Choroid
Retina
Islands
2017

Mast cell-derived tryptase in geographic atrophy

McLeod, D. S., Bhutto, I., Edwards, M., Gedam, M., Baldeosingh, R. & Lutty, G. A., Nov 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 13, p. 5887-5896 10 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Tryptases
Bruch Membrane
Mast Cells
Atrophy

Subretinal glial membranes in eyes with geographic atrophy

Edwards, M., McLeod, D. S., Bhutto, I. A., Grebe, R., Duffy, M. & Lutty, G. A., Mar 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1352-1367 16 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Neuroglia
Vimentin
Membranes
Retina
2016

Albumen transport to bruch’s membrane and RPE by choriocapillaris caveolae

Nakanishi, M., Grebe, R., Bhutto, I. A., Edwards, M., Scott Mcleod, D. & Lutty, G. A., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2213-2224 12 p.

Research output: Contribution to journalArticle

Bruch Membrane
Caveolae
Tight Junctions
Bovine Serum Albumin
Gold

Defective angiogenesis and intraretinal bleeding in mouse models with disrupted inner retinal lamination

Simmons, A. B., Merrill, M. M., Reed, J. C., Deans, M. R., Edwards, M. & Fuerst, P. G., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1563-1577 15 p.

Research output: Contribution to journalArticle

Hemorrhage
Neurons
Retina
Cell Adhesion Molecules
Down Syndrome

Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration

McLeod, D. S., Bhutto, I., Edwards, M., Silver, R. E., Seddon, J. M. & Lutty, G. A., Nov 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 14, p. 5843-5855 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Macrophages
HLA-DR Antigens
Choroid
Macrophage Activation

Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration

Seddon, J. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Silver, R. E., Wenick, A., Edwards, M. & Lutty, G. A., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Blood Vessels
Retinal Pigments
Geographic Atrophy
Atrophy
2015

Idiopathic preretinal glia in aging and age-related macular degeneration

Edwards, M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Seddon, J. M. & Lutty, G. A., Mar 19 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Macular Degeneration
Neuroglia
Retina
Membranes
Glial Fibrillary Acidic Protein
Dendrimers
Microglia
Reperfusion
Retina
Ischemia

βa3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes

Valapala, M., Edwards, M., Hose, S., Hu, J., Wawrousek, E., Lutty, G. A., Zigler, J. S., Qian, J. & Sinha, D., 2015, In : Scientific Reports. 5, 8755.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Crystallins
Optic Nerve
Astrocytes
Glial Fibrillary Acidic Protein
2014

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In : Aging Cell. 13, 6, p. 1091-1094 4 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Knockout Mice
Retinal Pigments
Inflammation

Retinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease

Edwards, M., Rodríguez, J. J., Gutierrez-Lanza, R., Yates, J., Verkhratsky, A. & Lutty, G. A., 2014, In : Experimental Eye Research. 127, p. 252-260 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Alzheimer Disease
Retina
Neuroglia
Astrocytes
2013

Laminins and retinal vascular development

Edwards, M. & Lefebvre, O., Jan 2013, In : Cell Adhesion and Migration. 7, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Retinal Vessels
Laminin
Blood Vessels
Retina
Diabetic Retinopathy
2012

From blood islands to blood vessels: Morphologic observations and expression of key molecules during hyaloid vascular system development

Scott Mcleod, D., Hasegawa, T., Baba, T., Grebe, R., d'Auriac, I. G., Merges, C., Edwards, M. & Lutty, G. A., Dec 2012, In : Investigative Ophthalmology and Visual Science. 53, 13, p. 7912-7927 16 p.

Research output: Contribution to journalArticle

Blood Vessels
Hemangioblasts
Erythroblasts
Pregnancy
Weibel-Palade Bodies

The deletion of Math5 disrupts retinal blood vessel and glial development in mice

Edwards, M., McLeod, D. S., Li, R., Grebe, R., Bhutto, I., Mu, X. & Lutty, G. A., Mar 2012, In : Experimental Eye Research. 96, 1, p. 147-156 10 p.

Research output: Contribution to journalArticle

Retinal Vessels
Neuroglia
Retina
Ganglia
Blood Vessels

VEGF 165b in the developing vasculatures of the fetal human eye

Baba, T., Mcleod, D. S., Edwards, M., Merges, C., Sen, T., Sinha, D. & Lutty, G. A., Mar 2012, In : Developmental Dynamics. 241, 3, p. 595-607 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Retinal Pigment Epithelium
Nerve Fibers
Blood Vessels
Ependymoglial Cells
2011

Functional role of laminin α1 chain during cerebellum development

Heng, C., Lefebvre, O., Klein, A., Edwards, M., Simon-Assmann, P., Orend, G. & Bagnard, D., Nov 2011, In : Cell Adhesion and Migration. 5, 6, p. 480-489 10 p.

Research output: Contribution to journalArticle

Cerebellum
Organogenesis
Neocortex
Laminin
Basement Membrane

Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice

Edwards, M., McLeod, D. S., Grebe, R., Heng, C., Lefebvre, O. & Lutty, G. A., 2011, In : BMC Developmental Biology. 11, 60.

Research output: Contribution to journalArticle

Epiretinal Membrane
Extraembryonic Membranes
Retinal Vessels
Blood Vessels
Mutation

NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development

Won, J., de Evsikova, C. M., Smith, R. S., Hicks, W. L., Edwards, M., Longo-Guess, C., Li, T., Naggert, J. K. & Nishina, P. M., Feb 2011, In : Human Molecular Genetics. 20, 3, p. 482-496 15 p., ddq494.

Research output: Contribution to journalArticle

Cilia
Synapses
Spermatozoa
Maintenance
Retina
2010

Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation

Edwards, M., Mammadova-Bach, E., Alpy, F., Klein, A., Hicks, W. L., Roux, M., Simon-Assmann, P., Smith, R. S., Orend, G., Wu, J., Peachey, N. S., Naggert, J. K., Lefebvre, O. & Nishina, P. M., Mar 5 2010, In : Journal of Biological Chemistry. 285, 10, p. 7697-7711 15 p.

Research output: Contribution to journalArticle

Retinal Vessels
Homozygote
Laminin
Membranes
Mutation

Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice

Budzynski, E., Gross, A. K., McAlear, S. D., Peachey, N. S., Shukla, M., He, F., Edwards, M., Won, J., Hicks, W. L., Wensel, T. G., Naggert, J. K. & Nishina, P. M., May 7 2010, In : Journal of Biological Chemistry. 285, 19, p. 14521-14533 13 p.

Research output: Contribution to journalArticle

Light Signal Transduction
Opsins
Rhodopsin
Genes
Chemical activation

Photoreceptor Degeneration, Azoospermia, Leukoencephalopathy, And Abnormal RPE Cell Function In Mice Expressing An Early Stop Mutation In CLCN2

Edwards, M., de Evsikova, C. M., Collin, G. B., Gifford, E., Wu, J., Hicks, W. L., Whiting, C., Varvel, N. H., Lamb, B. T., Maphis, N., Naggert, J. K., Nishina, P. M. & Peachey, N. S., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3264-3272 9 p.

Research output: Contribution to journalArticle

Leukoencephalopathies
Azoospermia
Retinal Pigment Epithelium
Retina
Mutation
2006

TNF alpha affects the expression of GFAP and S100B: Implications for Alzheimer's disease

Edwards, M. & Robinson, S. R., Nov 2006, In : Journal of Neural Transmission. 113, 11, p. 1709-1715 7 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
Alzheimer Disease
Tumor Necrosis Factor-alpha
Neurodegenerative Diseases