Mali Jiang

Research Associate

20022020

Research output per year

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Research Output

2020

Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease

Jiang, M., Zhang, X., Liu, H., LeBron, J., Alexandris, A., Peng, Q., Gu, H., Yang, F., Li, Y., Wang, R., Hou, Z., Arbez, N., Ren, Q., Dong, J. L., Whela, E., Wang, R., Ratovitski, T., Troncoso, J. C., Mori, S., Ross, C. A. & 2 others, Lim, J. & Duan, W., May 28 2020, In : Human molecular genetics. 29, 8, p. 1340-1352 13 p.

Research output: Contribution to journalArticle

2018

Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease

Zhou, X., Li, G., Kaplan, A., Gaschler, M. M., Zhang, X., Hou, Z., Jiang, M., Zott, R., Cremers, S., Stockwell, B. R. & Duan, W., May 1 2018, In : Human Molecular Genetics. 27, 9, p. 1545-1555 11 p.

Research output: Contribution to journalArticle

2017

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease

Wu, B., Jiang, M., Peng, Q., Li, G., Hou, Z., Milne, G. L., Mori, S., Alonso, R., Geisler, J. G. & Duan, W., Jul 1 2017, In : Experimental Neurology. 293, p. 83-90 8 p.

Research output: Contribution to journalArticle

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Ratovitski, T., O'Meally, R. N., Jiang, M., Chaerkady, R., Chighladze, E., Stewart, J. C., Wang, X., Arbez, N., Roby, E., Alexandris, A., Duan, W., Vijayvargia, R., Seong, I. S., Lavery, D. J., Cole, R. N. & Ross, C. A., Aug 4 2017, In : Journal of proteome research. 16, 8, p. 2692-2708 17 p.

Research output: Contribution to journalArticle

2016

Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 knock-in mouse model of huntington's disease

Peng, Q., Wu, B., Jiang, M., Jin, J., Hou, Z., Zheng, J., Zhang, J. & Duan, W., Feb 1 2016, In : PloS one. 11, 2, e0148839.

Research output: Contribution to journalArticle

Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

Jin, J., Gu, H., Anders, N. M., Ren, T., Jiang, M., Tao, M., Peng, Q., Rudek, M. A. & Duan, W., Dec 1 2016, In : Neuromolecular medicine. 18, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle

2015

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

Jin, J., Peng, Q., Hou, Z., Jiang, M., Wang, X., Langseth, A. J., Tao, M., Barker, P. B., Mori, S., Bergles, D. E., Ross, C. A., Detloff, P. J., Zhang, J. & Duan, W., Jan 1 2015, In : Human molecular genetics. 24, 9, p. 2508-2527 20 p.

Research output: Contribution to journalArticle

2014

Metabolism in HD: Still a relevant mechanism?

Duan, W., Jiang, M. & Jin, J., Sep 15 2014, In : Movement Disorders. 29, 11, p. 1366-1374 9 p.

Research output: Contribution to journalReview article

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Jiang, M., Zheng, J., Peng, Q., Hou, Z., Zhang, J., Mori, S., Ellis, J. L., Vlasuk, G. P., Fries, H., Suri, V. & Duan, W., Dec 2014, In : Annals of Clinical and Translational Neurology. 1, 12, p. 1047-1052 6 p.

Research output: Contribution to journalArticle

2013

Small-molecule TrKB receptor agonists improve motor function and extend survival in a mouse model of huntington's disease

Jiang, M., Peng, Q., Liu, X., Jin, J., Hou, Z., Zhang, J., Mori, S., Ross, C. A., Ye, K. & Duan, W., Jun 1 2013, In : Human molecular genetics. 22, 12, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

2012

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S. & 10 others, Moran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W., Jan 1 2012, In : Nature medicine. 18, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

Trans-(-)-ε-viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated Protein Kinase (AMPK), and protects cells in models of huntington disease

Fu, J., Jin, J., Cichewicz, R. H., Hageman, S. A., Ellis, T. K., Xiang, L., Peng, Q., Jiang, M., Arbez, N., Hotaling, K., Ross, C. A. & Duan, W., Jul 13 2012, In : Journal of Biological Chemistry. 287, 29, p. 24460-24472 13 p.

Research output: Contribution to journalArticle

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

Waldron-Roby, E., Ratovitski, T., Wang, X., Jiang, M., Watkin, E., Arbez, N., Graham, R. K., Hayden, M. R., Hou, Z., Mori, S., Swing, D., Pletnikov, M., Duan, W., Tessarollo, L. & Ross, C. A., Jan 4 2012, In : Journal of Neuroscience. 32, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

2010

Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism

Jiang, M., Porat-Shliom, Y., Pei, Z., Cheng, Y., Xiang, L., Sommers, K., Li, Q., Gillardon, F., Hengerer, B., Berlinicke, C., Smith, W. W., Zack, D. J., Poirier, M. A., Ross, C. A. & Duan, W., Jul 1 2010, In : Journal of Neurochemistry. 114, 2, p. 419-429 11 p.

Research output: Contribution to journalArticle

Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images

Zhang, J., Peng, Q., Li, Q., Jahanshad, N., Hou, Z., Jiang, M., Masuda, N., Langbehn, D. R., Miller, M. I., Mori, S., Ross, C. A. & Duan, W., Feb 1 2010, In : NeuroImage. 49, 3, p. 2340-2351 12 p.

Research output: Contribution to journalArticle

2009

Impairments of spatial learning and memory in rat offspring with fetal growth restriction

Huang, P., Gou, W., Jiang, M., Zhang, R. & Sun, Y., Jan 1 2009, In : Journal of Nanjing Medical University. 23, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons

Chen, H. X., Jiang, M., Akakin, D. & Roper, S. N., Dec 1 2009, In : Journal of neurophysiology. 102, 6, p. 3251-3259 9 p.

Research output: Contribution to journalArticle

2008

Impact of fetal growth restriction on spatial learning and memory abilities of the offspring of rats

Huang, P., Gou, W. L., Jiang, M. L., Zhang, R. & Sun, Y. P., Jul 1 2008, In : Journal of Sichuan University (Medical Science Edition). 39, 4, p. 627-630 4 p.

Research output: Contribution to journalArticle

Prolonged reversal of long-term potentiation that is N-methyl-D-aspartate receptor independent: Implications for memory formation

Shi, N. N., Jiang, M. L., Zhang, L. & Han, T. Z., Feb 1 2008, In : Current Neurovascular Research. 5, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model

Peng, Q., Masuda, N., Jiang, M., Li, Q., Zhao, M., Ross, C. A. & Duan, W., Mar 1 2008, In : Experimental Neurology. 210, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

Masuda, N., Peng, Q., Li, Q., Jiang, M., Liang, Y., Wang, X., Zhao, M., Wang, W., Ross, C. A. & Duan, W., Jun 1 2008, In : Neurobiology of Disease. 30, 3, p. 293-302 10 p.

Research output: Contribution to journalArticle

2006

The tetanus patterns for the induction of long-term depression in the adult rat hippocampus.

Chen, L., Jiang, M. L. & Han, T. Z., Jun 25 2006, In : Sheng li xue bao : [Acta physiologica Sinica]. 58, 3, p. 287-291 5 p.

Research output: Contribution to journalArticle

2004

Gender- and age-specific impairment of rat performance in the Morris water maze following prenatal exposure to an MRI magnetic field

Jiang, M. L., Han, T. Z., Pang, W. & Li, L., Jan 2 2004, In : Brain research. 995, 1, p. 140-144 5 p.

Research output: Contribution to journalArticle

2003

Morphological alteration of the hippocampal synapses in rats prenatally exposed to magnetic resonance imaging magnetic fields

Jiang, M. L., Han, T. Z., Yang, D. W. & Chen, M. X., Dec 25 2003, In : Acta Physiologica Sinica. 55, 6, p. 705-710 6 p.

Research output: Contribution to journalArticle

2002

Effect of Tanakan on hypoxic-ischemic brain damage and platelet activating factor level in neonatal rat

Jiang, M., Li, R. & Li, Z., Jan 1 2002, In : Journal of Xi'an Medical University, Chinese Edition. 23, 3, p. 299-301+313

Research output: Contribution to journalArticle