Maire E. Doyle

Assistant Professor

19982019

Research output per year

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Research Output

2019

Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics

Liu, Q. R., Huang, N. S., Qu, H., O’Connell, J. F., Gonzalez-Mariscal, I., Santa-Cruz-Calvo, S., Doyle, M. E., Xi, Z. X., Wang, Y., Onaivi, E. S. & Egan, J. M., Mar 1 2019, In : Acta Pharmacologica Sinica. 40, 3, p. 387-397 11 p.

Research output: Contribution to journalArticle

IGFBP-2 and aging: A 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population

Van Den Beld, A. W., Carlson, O. D., Doyle, M. E., Rizopoulos, D., Ferrucci, L., Van Der Lely, A. J. & Egan, J. M., Feb 1 2019, In : European Journal of Endocrinology. 180, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

2018

Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets

González-Mariscal, I., Montoro, R. A., Doyle, M. E., Liu, Q. R., Rouse, M., O’Connell, J. F., Santa-Cruz Calvo, S., Krzysik-Walker, S. M., Ghosh, S., Carlson, O. D., Lehrmann, E., Zhang, Y., Becker, K. G., Chia, C. W., Ghosh, P. & Egan, J. M., Jun 1 2018, In : Diabetologia. 61, 6, p. 1470-1483 14 p.

Research output: Contribution to journalArticle

Diabetic serum from older women increases adipogenic differentiation in mesenchymal stem cells

Moseley, K., Doyle, M. E. & Jan De Beur, S. M., Mar 9 2018, (Accepted/In press) In : Endocrine Research. p. 1-11 11 p.

Research output: Contribution to journalArticle

Insulin is transcribed and translated in mammalian taste bud cells

Doyle, M. E., Fiori, J. L., Mariscal, I. G., Liu, Q. R., Goodstein, E., Yang, H., Shin, Y. K., Calvo, S. S. C., Indig, F. E. & Egan, J. M., Jan 1 2018, In : Endocrinology. 159, 9, p. 3331-3339 9 p.

Research output: Contribution to journalArticle

2017

The identification of a SIRT6 activator from brown algae fucus distichus

Rahnasto-Rilla, M. K., McLoughlin, P., Kulikowicz, T., Doyle, M., Bohr, V. A., Lahtela-Kakkonen, M., Ferrucci, L., Hayes, M. & Moaddel, R., Jun 2017, In : Marine Drugs. 15, 6, 190.

Research output: Contribution to journalArticle

2016

Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism

González-Mariscal, I., Krzysik-Walker, S. M., Doyle, M. E., Liu, Q. R., Cimbro, R., Santa-Cruz Calvo, S., Ghosh, S., Cieala, A., Moaddel, R., Carlson, O. D., Witek, R. P., O'Connell, J. F. & Egan, J. M., Sep 19 2016, In : Scientific reports. 6, 33302.

Research output: Contribution to journalArticle

2013

Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet

Fiori, J. L., Shin, Y. K., Kim, W., Krzysik-Walker, S. M., González-Mariscal, I., Carlson, O. D., Sanghvi, M., Moaddel, R., Farhang, K., Gadkaree, S. K., Doyle, M. E., Pearson, K. J., Mattison, J. A., De Cabo, R. & Egan, J. M., Oct 1 2013, In : Diabetes. 62, 10, p. 3500-3513 14 p.

Research output: Contribution to journalArticle

2012

Blockade of β-cell KATP channels by the endocannabinoid, 2-arachidonoylglycerol

Spivak, C. E., Kim, W., Liu, Q. R., Lupica, C. R. & Doyle, M. E., Jun 22 2012, In : Biochemical and Biophysical Research Communications. 423, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

2011

Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells

Kim, W., Doyle, M. E., Liu, Z., Lao, Q., Shin, Y. K., Carlson, O. D., Kim, H. S., Thomas, S., Napora, J. K., Lee, E. K., Moaddel, R., Wang, Y., Maudsley, S., Martin, B., Kulkarni, R. N. & Egan, J. M., Apr 1 2011, In : Diabetes. 60, 4, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

Detailed protocol for evaluation of dynamic perifusion of human islets to assess β-cell function

Bentsi-Barnes, K., Doyle, M. E., Abad, D., Kandeel, F. & Al-Abdullah, I. H., Sep 1 2011, In : Islets. 3, 5, p. 284-290 7 p.

Research output: Contribution to journalArticle

Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease

Airavaara, M., Pletnikova, O., Doyle, M. E., Zhang, Y. E., Troncoso, J. C. & Liu, Q. R., Dec 30 2011, In : Journal of Biological Chemistry. 286, 52, p. 45093-45102 10 p.

Research output: Contribution to journalArticle

The role of the endocannabinoid system in islet biology

Doyle, M. E., Apr 1 2011, In : Current Opinion in Endocrinology, Diabetes and Obesity. 18, 2, p. 153-158 6 p.

Research output: Contribution to journalArticle

2008

The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens

Saban, D. R., Cornelius, J., Masli, S., Schwartzkopff, J., Doyle, M., Chauhan, S. K., Peck, A. B. & Grant, M. B., Dec 19 2008, In : Molecular vision. 14, p. 2435-2442 8 p.

Research output: Contribution to journalArticle

The skeleton: Endocrine regulator of phosphate homeostasis

Doyle, M. E. & Jan de Beur, S. M., Dec 1 2008, In : Current Osteoporosis Reports. 6, 4, p. 134-141 8 p.

Research output: Contribution to journalReview article

2007

Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition

Doyle, M. E., Boggs, L., Attia, R., Cooper, L. R., Saban, D. R., Nguyen, C. Q. & Peck, A. B., Oct 2007, In : American Journal of Pathology. 171, 4, p. 1224-1236 13 p.

Research output: Contribution to journalArticle

Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, M. E. & Egan, J. M., Mar 1 2007, In : Pharmacology and Therapeutics. 113, 3, p. 546-593 48 p.

Research output: Contribution to journalReview article

2006

Human duodenal enteroendocrine cells: Source of both incretin peptides, GLP-1 and GIP

Theodorakis, M. J., Carlson, O., Michopoulos, S., Doyle, M. E., Juhaszova, M., Petraki, K. & Egan, J. M., Mar 1 2006, In : American Journal of Physiology - Endocrinology and Metabolism. 290, 3, p. E550-E559

Research output: Contribution to journalArticle

Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: Gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus

Nguyen, C., Nguyen, C., Singson, E., Kim, J. Y., Cornelius, J. G., Attia, R., Doyle, M. E., Bulosan, M., Cha, S. & Peck, A. B., Sep 1 2006, In : Scandinavian Journal of Immunology. 64, 3, p. 295-307 13 p.

Research output: Contribution to journalArticle

2005

In vivo biological activity of exendin (1-30)

Doyle, M. E., McConville, P., Theodorakis, M. J., Goetschkes, M. M., Bernier, M., Spencer, R. G. S., Holloway, H. W., Greig, N. H. & Egan, J. M., Jun 1 2005, In : Endocrine. 27, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2003

Pharmacological agents that directly modulate insulin secretion

Doyle, M. E. & Egan, J. M., Mar 1 2003, In : Pharmacological reviews. 55, 1, p. 105-131 27 p.

Research output: Contribution to journalReview article

The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity

Doyle, M. E., Theodorakis, M. J., Holloway, H. W., Bernier, M., Greig, N. H. & Egan, J. M., Jul 15 2003, In : Regulatory Peptides. 114, 2-3, p. 153-158 6 p.

Research output: Contribution to journalArticle

2002

Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3β transcription factors

Zhou, J., Pineyro, M. A., Wang, X., Doyle, M. E. & Egan, J. M., Aug 10 2002, In : Journal of Cellular Physiology. 192, 3, p. 304-314 11 p.

Research output: Contribution to journalArticle

2001

Glucagon-like peptide-1

Doyle, M. E. & Egan, J. M., Jan 1 2001, In : Recent progress in hormone research. 56, p. 377-399 23 p.

Research output: Contribution to journalReview article

Open Access

Insertion of an n-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent

Doyle, M. E., Greig, N. H., Holloway, H. W., Betkey, J. A., Bernier, M. & Egan, J. M., Jan 1 2001, In : Endocrinology. 142, 10, p. 4462-4468 7 p.

Research output: Contribution to journalArticle

Open Access

PUVA downregulates whn expression in primary mouse keratinocytes

Alge, C., Baxter, R. M., Doyle, M. E., Moor, A. C. E., Brissette, J. L. & Ortel, B., Nov 1 2001, In : Journal of Photochemistry and Photobiology B: Biology. 64, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

2000

Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats

Szayna, M., Doyle, M. E., Betkey, J. A., Holloway, H. W., Spencer, R. G. S., Greig, N. H. & Egan, J. M., Jan 1 2000, In : Endocrinology. 141, 6, p. 1936-1941 6 p.

Research output: Contribution to journalArticle

Open Access

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats

Perfetti, R., Zhou, J. I. E., Doyle, M. E. & Egan, J. M., Jan 1 2000, In : Endocrinology. 141, 12, p. 4600-4605 6 p.

Research output: Contribution to journalArticle

Open Access
1999

Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells

Wang, X., Cahill, C. M., Pineyro, M. A., Zhou, J., Doyle, M. E. & Egan, J. M., Jan 1 1999, In : Endocrinology. 140, 10, p. 4904-4907 4 p.

Research output: Contribution to journalArticle

Open Access
1998

Photochemistry of substituted cyclic enones. Part 11. Synthesis and photophysics of 5-arylalkyl-3-phenylcyclopentenones

Kelly, J. F. D., Doyle, M. E., Guha, M., Kavanagh, P. V., Kelly, J. M. & McMurry, T. B. H., Jul 1 1998, In : Journal of the Chemical Society. Perkin Transactions 2. 7, p. 1635-1641 7 p.

Research output: Contribution to journalArticle