Mahendra Damarla

Assistant Professor

20062019
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Research Output 2006 2019

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2019

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Caspase 3
Thrombin
Caspases
Electric Impedance
Endothelial Cells

Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension

Suresh, K., Servinsky, L., Jiang, H., Bigham, Z., Zaldumbide, J., Huetsch, J. C., Kliment, C., Acoba, M. G., Kirsch, B. J., Claypool, S. M., Le, A., Damarla, M. & Shimoda, L. A., Nov 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 5, p. L639-L652

Research output: Contribution to journalArticle

Open Access
Pulmonary Hypertension
Endothelial Cells
TRPV Cation Channels
Semaxinib
Hypoxia

SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

Peloquin, G. L., Johnston, L., Damarla, M., Damico, R. L., Hassoun, P. M. & Kolb, T. M., Jun 17 2019, In : Respiratory research. 20, 1, 123.

Research output: Contribution to journalArticle

Open Access
Pulmonary Hypertension
Endothelial Cells
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-2
Cell Proliferation
2018

Altered expression of TIAM1 in endotoxin-challenged airway epithelial cells and rodent septic models

Ma, J., Chen, C., Liu, Y., Damarla, M., Vonakis, B. M., Guan, X. & Gao, L., Jun 1 2018, In : Journal of Thoracic Disease. 10, 6, p. 3187-3195 9 p.

Research output: Contribution to journalArticle

Endotoxins
Rodentia
Lymphoma
Epithelial Cells
Neoplasm Metastasis

Imatinib Is Protective Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Lung Injury

Magruder, J. T., Grimm, J. C., Crawford, T. C., Johnston, L., Santhanam, L., Stephens, R., Berkowitz, D. E., Shah, A. S., Bush, E., Damarla, M., Damico, R. L., Hassoun, P. M. & Kim, B. S., Mar 1 2018, In : Annals of Thoracic Surgery. 105, 3, p. 950-956 7 p.

Research output: Contribution to journalArticle

Lung Injury
Reperfusion Injury
Rabbits
Lung
Bronchoalveolar Lavage
TRPV Cation Channels
Pulmonary Hypertension
Reactive Oxygen Species
Endothelial Cells
Lung
2017
Xanthine Dehydrogenase
Lipopolysaccharides
Sepsis
Lung
Survival
2016

Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells

Singer, B. D., Mock, J. R., D'Alessio, F., Aggarwal, N. R., Mandke, P., Johnston, L. & Damarla, M., Mar 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L796-L801

Research output: Contribution to journalArticle

Lung
Flow Cytometry
Cell Death
Staining and Labeling
Pulmonary Circulation
MAP Kinase Kinase Kinase 5
Xanthine Dehydrogenase
Macrophage Migration-Inhibitory Factors
Smoke
Tobacco Products

Trials and tribulations of therapies for the acute respiratory distress syndrome

Damarla, M. & Hassoun, P. M., Jun 1 2016, In : Critical Care Medicine. 44, 6, p. e453-e454

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Artificial Respiration
Therapeutics
2015

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia

Kim, B. S., Serebreni, L., Fallica, J., Hamdan, O., Wang, L., Johnston, L., Kolb, T. M., Damarla, M., Damico, R. L. & Hassoun, P. M., Apr 1 2015, In : PLoS One. 10, 4, e0124189.

Research output: Contribution to journalArticle

Xanthine Dehydrogenase
Cyclin-Dependent Kinase 5
xanthine
cyclin-dependent kinase
Cyclin-Dependent Kinases

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension

Kolb, T. M., Peabody, J., Baddoura, P., Fallica, J., Mock, J. R., Singer, B. D., D'Alessio, F., Damarla, M., Damico, R. L. & Hassoun, P. M., Nov 1 2015, In : Microcirculation. 22, 8, p. 724-736 13 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Hypertrophy
Gene Expression
Muscle Cells
Flow Cytometry

The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice

Stephens, R., Johnston, L., Servinsky, L., Kim, B. S. & Damarla, M., Nov 1 2015, In : Physiological Reports. 3, 11, e12589.

Research output: Contribution to journalArticle

Lung Injury
Protein-Tyrosine Kinases
Lipopolysaccharides
Sepsis
Lung
2014

A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome

Hikmat, F., Pearse, D. B. & Damarla, M., Nov 1 2014, In : Canadian Respiratory Journal. 21, 6, p. 337-340 4 p.

Research output: Contribution to journalArticle

Churg-Strauss Syndrome
Hemoptysis
Vasculitis
Bronchial Arteries
Tomography

Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage

Fallica, J., Boyer, L., Kim, B. S., Serebreni, L., Varela, L., Hamdan, O., Wang, L., Simms, T., Damarla, M., Kolb, T. M., Bucala, R., Mitzner, W. A., Hassoun, P. M. & Damico, R. L., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Smoke
Tobacco Products
Lung
Endothelial cells

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

Damarla, M., Parniani, A. R., Johnston, L., Maredia, H., Serebreni, L., Hamdan, O., Sidhaye, V., Shimoda, L., Myers, A. C., Crow, M. T., Schmidt, E. P., Machamer, C. E., Gaestel, M., Rane, M. J., Kolb, T. M., Kim, B. S., Damico, R. L. & Hassoun, P. M., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Capillary Permeability
Mitogen-Activated Protein Kinases
Caspase 3
Protein Kinases
Apoptosis
2013

Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis

Kim, B. S., Serebreni, L., Hamdan, O., Wang, L., Parniani, A., Sussan, T., Stephens, R., Boyer, L., Damarla, M., Hassoun, P. M. & Damico, R. L., Jul 2013, In : Free Radical Biology and Medicine. 60, p. 336-343 8 p.

Research output: Contribution to journalArticle

Xanthine Dehydrogenase
Endothelial cells
Smoke
Tobacco Products
DNA Damage
2012

Febrile-range hyperthermia augments reversible TNF - Induced hyperpermeability in human microvascular lung endothelial cells

Shah, N. G., Tulapurkar, M. E., Damarla, M., Singh, I. S., Goldblum, S. E., Shapiro, P. & Hasday, J. D., Nov 2012, In : International Journal of Hyperthermia. 28, 7, p. 627-635 9 p.

Research output: Contribution to journalArticle

Fever
Endothelial Cells
Permeability
Lung
Tumor Necrosis Factor-alpha
2011
Type 2 Cyclic Nucleotide Phosphodiesterases
Acute Lung Injury
Inflammation
Lung
Ventilator-Induced Lung Injury
Macrophages
Endothelial cells
Smoke
Tobacco Products
Endothelial Cells
2010

Moderate oxygen augments lipopolysaccharide-induced lung injury in mice

Aggarwal, N. R., D'Alessio, F., Tsushima, K., Files, D. C., Damarla, M., Sidhaye, V., Fraig, M. M., Polotsky, V. & King, L. S., Mar 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 3

Research output: Contribution to journalArticle

Lung Injury
Lipopolysaccharides
Oxygen
Acute Lung Injury
Neutrophils

Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung

Peng, X. Q., Damarla, M., Skirball, J., Nonas, S., Wang, X. Y., Han, E. J., Hasan, E. J., Cao, X., Boueiz, A., Damico, R. L., Tuder, R. M., Sciuto, A. M., Anderson, D. R., Garcia, J. G., Kass, D. A., Hassoun, P. M. & Zhang, J. T., Feb 2010, In : Acta Pharmacologica Sinica. 31, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

Mechanical Stress
p38 Mitogen-Activated Protein Kinases
Phosphatidylinositol 3-Kinases
Lung Injury
Lung
2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R. L., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6

Research output: Contribution to journalArticle

Mechanical Ventilators
Protein C
Artificial Respiration
rho-Associated Kinases
Lung

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

Damarla, M., Hasan, E., Boueiz, A., Le Thi, Q. H., Pae, H. H., Montouchet, C., Kolb, T. M., Simms, T., Myers, A., Kayyali, U. S., Gaestel, M., Peng, X., Reddy, S. P., Damico, R. L. & Hassoun, P. M., Feb 25 2009, In : PLoS One. 4, 2, e4600.

Research output: Contribution to journalArticle

ventilators
Lung Injury
Mechanical Ventilators
Mitogen-Activated Protein Kinases
Phosphorylation
2008

Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury

Le Thi, Q. H., Damico, R. L., Damarla, M., Boueiz, A., Hyun, H. P., Skirball, J., Hasan, E., Peng, X., Chesley, A., Crow, M. T., Reddy, S. P., Tuder, R. M. & Hassoun, P. M., Oct 2008, In : Journal of Applied Physiology. 105, 4, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Ventilator-Induced Lung Injury
Xanthine Dehydrogenase
Alveolar Epithelial Cells
p38 Mitogen-Activated Protein Kinases
Caspases

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Schmidt, E. P., Damarla, M., Rentsendorj, O., Servinsky, L. E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P. M. & Pearse, D. B., Dec 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 6

Research output: Contribution to journalArticle

Ventilator-Induced Lung Injury
Lung
Ventilation
Nitric Oxide
Soluble Guanylyl Cyclase
Xanthine Dehydrogenase
Acute Lung Injury
Enzymes
Reperfusion Injury
Atherosclerosis
2006

Discrepancy in the use of confirmatory tests in patients hospitalized with the diagnosis of chronic obstructive pulmonary disease or congestive heart failure

Damarla, M., Celli, B. R., Mullerova, H. X. & Pinto-Plata, V. M., Oct 2006, In : Respiratory Care. 51, 10, p. 1120-1124 5 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Heart Failure
Spirometry
Echocardiography
Respiratory Insufficiency