Lyle Ostrow

Assistant Professor

20002019

Research output per year

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Research Output

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2019

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

The NYGC ALS Consortium, Oct 29 2019, In : Cell Reports. 29, 5, p. 1164-1177.e5

Research output: Contribution to journalArticle

Open Access

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

2018

ALSUntangled 41: “Eric Is Winning”

THE ALSUNTANGLED GROUP, Jan 2 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 1-2, p. 157-160 4 p.

Research output: Contribution to journalArticle

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Pereira, G. C., Sanchez, L., Schaughency, P. M., Rubio-Roldán, A., Choi, J. A., Planet, E., Batra, R., Turelli, P., Trono, D., Ostrow, L. W., Ravits, J., Kazazian, H. H., Wheelan, S. J., Heras, S. R., Mayer, J., García-Pérez, J. L. & Goodier, J. L., Dec 15 2018, In : Mobile DNA. 9, 1, 35.

Research output: Contribution to journalArticle

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Mayer, J., Harz, C., Sanchez, L., Pereira, G. C., Maldener, E., Heras, S. R., Ostrow, L. W., Ravits, J., Batra, R., Meese, E., García-Pérez, J. L. & Goodier, J. L., Aug 2 2018, In : Molecular neurodegeneration. 13, 1, 39.

Research output: Contribution to journalArticle

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

The New York Genome Center ALS Consortium, Jul 13 2018, In : eLife. 7, e37754.

Research output: Contribution to journalArticle

2017

ALSUntangled 38: L-serine

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 148-151 4 p.

Research output: Contribution to journalArticle

ALSUntangled No. 36: Accilion

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 142-147 6 p.

Research output: Contribution to journalArticle

ALSUntangled No. 37: Inosine*

THE ALSUNTANGLED GROUP, Apr 3 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 3-4, p. 309-312 4 p.

Research output: Contribution to journalArticle

S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects

Antinone, S. E., Ghadge, G. D., Ostrow, L., Roos, R. P. & Green, W. N., Jan 25 2017, In : Scientific Reports. 7, 41141.

Research output: Contribution to journalArticle

2016

ALSUntangled No. 34: GM604

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 617-621 5 p.

Research output: Contribution to journalArticle

ALSUntangled No. 35: Hyperbaric Oxygen Therapy*

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 622-624 3 p.

Research output: Contribution to journalArticle

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Ayers, J. I., Diamond, J., Sari, A., Fromholt, S., Galaleldeen, A., Ostrow, L., Glass, J. D., Hart, P. J. & Borchelt, D. R., Oct 4 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-14 14 p.

Research output: Contribution to journalArticle

2015

ALSUntangled No. 29: MitoQ

The Alsuntangled Lsuntangled Grouproup, Aug 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 5-6, p. 427-429 3 p.

Research output: Contribution to journalArticle

Hickam's dictum and the rare convergence of antisynthetase syndrome and hemoglobin SC disease

Wilkinson, S. T., Grunwald, M. R., Paik, J. J., Ostrow, L. W. & Gelber, A. C., Sep 1 2015, In : QJM. 108, 9, p. 735-737 3 p., hcu242.

Research output: Contribution to journalArticle

Human endogenous retrovirus-K contributes to motor neuron disease

Li, W., Lee, M. H., Henderson, L., Tyagi, R., Bachani, M., Steiner, J. P., Campanac, E., Hoffman, D. A., Geldern, G. V., Johnson, K., Maric, D., Morris, H. D., Lentz, M., Pak, K., Mammen, A., Ostrow, L., Rothstein, J. & Nath, A., Sep 30 2015, In : Science translational medicine. 7, 307

Research output: Contribution to journalArticle

Loss of rad-23 protects against models of motor neuron disease by enhancing mutant protein clearance

Jablonski, A. M., Lamitina, T., Liachko, N. F., Sabatella, M., Lu, J., Zhang, L., Ostrow, L. W., Gupta, P., Wu, C. Y., Doshi, S., Mojsilovic-Petrovic, J., Lans, H., Wang, J., Kraemer, B. & Kalb, R. G., Oct 21 2015, In : Journal of Neuroscience. 35, 42, p. 14286-14306 21 p.

Research output: Contribution to journalArticle

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Zhang, K., Donnelly, C. J., Haeusler, A. R., Grima, J. C., Machamer, J. B., Steinwald, P., Daley, E. L., Miller, S. J., Cunningham, K. M., Vidensky, S., Gupta, S., Thomas, M. A., Hong, I., Chiu, S. L., Huganir, R. L., Ostrow, L. W., Matunis, M. J., Wang, J., Sattler, R., Lloyd, T. E. & 1 others, Rothstein, J. D., Sep 3 2015, In : Nature. 525, 7567, p. 56-61 6 p.

Research output: Contribution to journalArticle

2013

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

Miller, T. M., Pestronk, A., David, W., Rothstein, J., Simpson, E., Appel, S. H., Andres, P. L., Mahoney, K., Allred, P., Alexander, K., Ostrow, L. W., Schoenfeld, D., Macklin, E. A., Norris, D. A., Manousakis, G., Crisp, M., Smith, R., Bennett, C. F., Bishop, K. M. & Cudkowicz, M. E., May 1 2013, In : The Lancet Neurology. 12, 5, p. 435-442 8 p.

Research output: Contribution to journalArticle

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Kang, S. H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D. W., Ostrow, L. W., Rothstein, J. D. & Bergles, D. E., May 1 2013, In : Nature neuroscience. 16, 5, p. 571-579 9 p.

Research output: Contribution to journalArticle

Iatrogenic Exserohilum infection of the central nervous system: Mycological identification and histopathological findings

Robert Bell, W., Dalton, J. B., McCall, C. M., Karram, S., Pearce, D. T., Memon, W., Lee, R., Carroll, K. C., Lyons, J. L., Gireesh, E. D., Trivedi, J. B., Cettomai, D., Smith, B. R., Chang, T., Tochen, L., Ratchford, J. N., Harrison, D. M., Ostrow, L. W., Stevens, R. D., Chen, L. & 1 others, Zhang, S. X., Feb 1 2013, In : Modern Pathology. 26, 2, p. 166-170 5 p.

Research output: Contribution to journalArticle

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

Zu, T., Liu, Y., Bañez-Coronel, M., Reid, T., Pletnikova, O., Lewis, J., Miller, T. M., Harms, M. B., Falchook, A. E., Subramony, S. H., Ostrow, L. W., Rothstein, J. D., Troncoso, J. C. & Ranum, L. P. W., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. E4968-E4977

Research output: Contribution to journalArticle

2012

Expanding the spectrum of monoclonal light chain deposition disease in muscle

Ostrow, L. W., Corse, A. M., Morrison, B. M., Huff, C. A., Carrino, J. A., Hoke, A. & Mammen, A. L., May 1 2012, In : Muscle and Nerve. 45, 5, p. 755-761 7 p.

Research output: Contribution to journalArticle

Immunohistochemistry of affected tissue may guide cGVHD treatment decisions

Williams, K. M., Ostrow, L. W., Loeb, D. M., Chung, T., Cohn, R. D., Corse, A. M., Mammen, A. L. & Chen, A. R., May 1 2012, In : Bone marrow transplantation. 47, 5, p. 731-733 3 p.

Research output: Contribution to journalArticle

2011

Tonic status and electrodecremental paroxysms in an adult without epilepsy

Ostrow, L. W. & Kaplan, P. W., Mar 1 2011, In : Epileptic Disorders. 13, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

2009

Eastchester clapping sign: A novel test of parietal neglect

Ostrow, L. W. & Llinás, R. H., Jul 1 2009, In : Annals of neurology. 66, 1, p. 114-117 4 p.

Research output: Contribution to journalArticle

PML-IRIS in patients with HIV infection: Clinical manifestations and treatment with steroids

Tan, K., Roda, R., Ostrow, L., McArthur, J. & Nath, A., Apr 28 2009, In : Neurology. 72, 17, p. 1458-1464 7 p.

Research output: Contribution to journalArticle

2008

The varicella zoster virus vasculopathies: Clinical, CSF, imaging, and virologic features

Nagel, M. A., Cohrs, R. J., Mahalingam, R., Wellish, M. C., Forghani, B., Schiller, A., Safdieh, J. E., Kamenkovich, E., Ostrow, L. W., Levy, M., Greenberg, B., Russman, A. N., Katzan, I., Gardner, C. J., Häusler, M., Nau, R., Saraya, T., Wada, H., Goto, H., De Martino, M. & 4 others, Ueno, M., Brown, W. D., Terborg, C. & Gilden, D. H., Mar 2008, In : Neurology. 70, 11, p. 853-860 8 p.

Research output: Contribution to journalArticle

2000

Stretch-induced endothelin-1 production by astrocytes

Ostrow, L. W., Langan, T. J. & Sachs, F., Jan 1 2000, In : Journal of cardiovascular pharmacology. 36, 5 SUPPL. 1, p. S274-S277

Research output: Contribution to journalArticle