Lyle Ostrow

Assistant Professor

20002019
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Research Output 2000 2019

2019

Diseases of the nERVous system: Retrotransposon activity in neurodegenerative disease

Tam, O. H., Ostrow, L. & Gale Hammell, M., Jul 26 2019, In : Mobile DNA. 10, 1, 32.

Research output: Contribution to journalReview article

Open Access
Retroelements
DNA Transposable Elements
Nervous System Diseases
Neurodegenerative Diseases
Endogenous Retroviruses

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Genome-Wide Association Study
Linkage Disequilibrium
Random Allocation
Smoking

Teaching NeuroImages: Neurolymphomatosis

DeBoer, S. R., Lesche, S., Rodriguez, F. J. & Ostrow, L., Sep 17 2019, In : Neurology. 93, 12, p. e1229-e1230

Research output: Contribution to journalArticle

Open Access
Marek Disease
Teaching
2018

ALSUntangled 41: “Eric Is Winning”

THE ALSUNTANGLED GROUP, Jan 2 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 1-2, p. 157-160 4 p.

Research output: Contribution to journalArticle

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Pereira, G. C., Sanchez, L., Schaughency, P. M., Rubio-Roldán, A., Choi, J. A., Planet, E., Batra, R., Turelli, P., Trono, D., Ostrow, L., Ravits, J., Kazazian, H., Wheelan, S., Heras, S. R., Mayer, J., García-Pérez, J. L. & Goodier, J. L., Dec 15 2018, In : Mobile DNA. 9, 1, 35.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Retroelements
Proteins
RNA-Binding Proteins
Nuclear Proteins

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Mayer, J., Harz, C., Sanchez, L., Pereira, G. C., Maldener, E., Heras, S. R., Ostrow, L., Ravits, J., Batra, R., Meese, E., García-Pérez, J. L. & Goodier, J. L., Aug 2 2018, In : Molecular Neurodegeneration. 13, 1, 39.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Amyotrophic Lateral Sclerosis
Proteins
Complementary DNA
env Genes

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

The New York Genome Center ALS Consortium, Jul 13 2018, In : eLife. 7, e37754.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
Brain
RNA-Binding Proteins
Genes
2017

ALSUntangled 38: L-serine

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 148-151 4 p.

Research output: Contribution to journalArticle

ALSUntangled No. 36: Accilion

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 142-147 6 p.

Research output: Contribution to journalArticle

ALSUntangled No. 37: Inosine*

THE ALSUNTANGLED GROUP, Apr 3 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 3-4, p. 309-312 4 p.

Research output: Contribution to journalArticle

S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects

Antinone, S. E., Ghadge, G. D., Ostrow, L., Roos, R. P. & Green, W. N., Jan 25 2017, In : Scientific Reports. 7, 41141.

Research output: Contribution to journalArticle

Motor Neuron Disease
Acylation
Amyotrophic Lateral Sclerosis
Copper
Spinal Cord
2016

ALSUntangled No. 34: GM604

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 617-621 5 p.

Research output: Contribution to journalArticle

ALSUntangled No. 35: Hyperbaric Oxygen Therapy*

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 622-624 3 p.

Research output: Contribution to journalArticle

Herpes Zoster
Paresis
Multiple Sclerosis
Dimethyl Fumarate

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Ayers, J. I., Diamond, J., Sari, A., Fromholt, S., Galaleldeen, A., Ostrow, L., Glass, J. D., Hart, P. J. & Borchelt, D. R., Oct 4 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-14 14 p.

Research output: Contribution to journalArticle

Superoxide Dismutase-1
Pathology
Spinal Cord
Permissiveness
Mutation

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine

Burns, T. M., Smith, G. A., Allen, J. A., Amato, A. A., Arnold, W. D., Barohn, R., Benatar, M., Bird, S. J., Bromberg, M., Chahin, N., Ciafaloni, E., Cohen, J. A., Corse, A. M., Crum, B. A., David, W. S., Dimberg, E., De Sousa, E. A., Donofrio, P. D., Dyck, P. J. B., Engel, A. G. & 86 others, Ensrud, E. R., Ferrante, M., Freimer, M., Gable, K. L., Gibson, S., Gilchrist, J. M., Goldstein, J. M., Gooch, C. L., Goodman, B. P., Gorelov, D., Gospe, S. M., Goyal, N. A., Guidon, A. C., Guptill, J. T., Gutmann, L., Gutmann, L., Gwathmey, K., Harati, Y., Harper, C. M., Hehir, M. K., Hobson-Webb, L. D., Howard, J. F., Jackson, C. E., Johnson, N., Jones, S. M., Juel, V. C., Kaminski, H. J., Karam, C., Kennelly, K. D., Khella, S., Khoury, J., Kincaid, J. C., Kissel, J. T., Kolb, N., Lacomis, D., Ladha, S., Larriviere, D., Lewis, R. A., Li, Y., Litchy, W. J., Logigian, E., Lou, J. S., Macgowen, D. J. L., Maselli, R., Massey, J. M., Mauermann, M. L., Mathews, K. D., Meriggioli, M. N., Miller, R. G., Moon, J. S., Mozaffar, T., Nations, S. P., Nowak, R. J., Ostrow, L., Pascuzzi, R. M., Peltier, A., Ruzhansky, K., Richman, D. P., Ross, M. A., Rubin, D. I., Russell, J. A., Sachs, G. M., Salajegheh, M. K., Saperstein, D. S., Scelsa, S., Selcen, D., Shaibani, A., Shieh, P. B., Silvestri, N. J., Singleton, J. R., Smith, B. E., So, Y. T., Solorzano, G., Sorenson, E. J., Srinivasen, J., Tavee, J., Tawil, R., Thaisetthawatkul, P., Thornton, C., Trivedi, J., Vernino, S., Wang, A. K., Webb, T. A., Weiss, M. D., Windebank, A. J. & Wolfe, G. I., Feb 1 2016, In : Muscle and Nerve. 53, 2, p. 165-168 4 p.

Research output: Contribution to journalArticle

2015

ALSUntangled: Introducing the table of evidence

ALSUntangled Group, Mar 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 142-145 4 p.

Research output: Contribution to journalArticle

ALSUntangled No. 29: MitoQ

The Alsuntangled Lsuntangled Grouproup, Aug 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 5-6, p. 427-429 3 p.

Research output: Contribution to journalArticle

Hickam's dictum and the rare convergence of antisynthetase syndrome and hemoglobin SC disease

Wilkinson, S. T., Grunwald, M. R., Paik, J., Ostrow, L. & Gelber, A., Sep 1 2015, In : QJM. 108, 9, p. 735-737 3 p., hcu242.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Acute Chest Syndrome
Myositis
X Ray Computed Tomography
Myalgia

Human endogenous retrovirus-K contributes to motor neuron disease

Li, W., Lee, M. H., Henderson, L., Tyagi, R., Bachani, M., Steiner, J., Campanac, E., Hoffman, D. A., Geldern, G. V., Johnson, K., Maric, D., Morris, H. D., Lentz, M., Pak, K., Mammen, A., Ostrow, L., Rothstein, J. D. & Nath, A., Sep 30 2015, In : Science Translational Medicine. 7, 307

Research output: Contribution to journalArticle

Endogenous Retroviruses
Motor Neuron Disease
Neurons
Amyotrophic Lateral Sclerosis
Anterior Horn Cells

Loss of rad-23 protects against models of motor neuron disease by enhancing mutant protein clearance

Jablonski, A. M., Lamitina, T., Liachko, N. F., Sabatella, M., Lu, J., Zhang, L., Ostrow, L., Gupta, P., Wu, C. Y., Doshi, S., Mojsilovic-Petrovic, J., Lans, H., Wang, J., Kraemer, B. & Kalb, R. G., Oct 21 2015, In : Journal of Neuroscience. 35, 42, p. 14286-14306 21 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Mutant Proteins
Amyotrophic Lateral Sclerosis
Proteins
Ubiquitination

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Zhang, K., Donnelly, C. J., Haeusler, A. R., Grima, J. C., Machamer, J. B., Steinwald, P., Daley, E. L., Miller, S. J., Cunningham, K. M., Vidensky, S., Gupta, S., Thomas, M. A., Hong, I., Chiu, S-L., Huganir, R. L., Ostrow, L., Matunis, M. J., Wang, J., Sattler, R., Lloyd, T. & 1 others, Rothstein, J. D., Sep 3 2015, In : Nature. 525, 7567, p. 56-61 6 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Amyotrophic Lateral Sclerosis
RNA
Neurons
Diptera
2014

ALSUntangled no. 26: Lunasin

ALSUntangled Group, Dec 1 2014, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15, 7-8, p. 622-626 5 p.

Research output: Contribution to journalArticle

2013

ALS untangled no. 20: The Deanna protocol

Fournier, C., Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S., Rowland, L. P. & 69 others, Pioro, E., Kinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Maragakis, N. J., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J. D., Pastula, D., Levitsky, G., Ogino, M., Rosenfeld, J., Carmi, E., Oster, C., Barkhaus, P. & Valor, E., May 2013, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, 4, p. 319-323 5 p.

Research output: Contribution to journalArticle

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

Miller, T. M., Pestronk, A., David, W., Rothstein, J. D., Simpson, E., Appel, S. H., Andres, P. L., Mahoney, K., Allred, P., Alexander, K., Ostrow, L., Schoenfeld, D., Macklin, E. A., Norris, D. A., Manousakis, G., Crisp, M., Smith, R., Bennett, C. F., Bishop, K. M. & Cudkowicz, M. E., May 2013, In : The Lancet Neurology. 12, 5, p. 435-442 8 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Placebos
Amyotrophic Lateral Sclerosis
Safety
Infusion Pumps

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Kang, S. H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D. W., Ostrow, L., Rothstein, J. D. & Bergles, D. E., May 2013, In : Nature Neuroscience. 16, 5, p. 571-579 9 p.

Research output: Contribution to journalArticle

Oligodendroglia
Amyotrophic Lateral Sclerosis
Regeneration
Spinal Cord
Demyelinating Diseases

Iatrogenic Exserohilum infection of the central nervous system: Mycological identification and histopathological findings

Robert Bell, W., Dalton, J. B., McCall, C. M., Karram, S., Pearce, D. T., Memon, W., Lee, R., Carroll, K. C., Lyons, J. L., Gireesh, E. D., Trivedi, J. B., Saylor, D., Smith, B. R., Chang, T., Tochen, L., Ratchford, J. N., Harrison, D. M., Ostrow, L., Stevens, R. D., Chen, L. & 1 others, Zhang, S. X., Feb 2013, In : Modern Pathology. 26, 2, p. 166-170 5 p.

Research output: Contribution to journalArticle

Central Nervous System Infections
Fungi
Meningitis
Epidural Injections
Disease Outbreaks

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

Zu, T., Liu, Y., Bañez-Coronel, M., Reid, T., Pletnikova, O., Lewis, J., Miller, T. M., Harms, M. B., Falchook, A. E., Subramony, S. H., Ostrow, L., Rothstein, J. D., Troncoso, J. C. & Ranum, L. P. W., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51

Research output: Contribution to journalArticle

Antisense RNA
Chromosomes, Human, Pair 9
Open Reading Frames
Microsatellite Repeats
Proteins
2012

ALS untangled no. 17: "When ALS Is Lyme"

Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S., Rowland, L. P., Pioro, E. & 61 others, Kinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Marigakis, N., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J. D. & Pastula, D., Sep 2012, In : Amyotrophic Lateral Sclerosis. 13, 5, p. 487-491 5 p.

Research output: Contribution to journalArticle

Lyme Disease
Amyotrophic Lateral Sclerosis
Differential Diagnosis
Cohort Studies

Expanding the spectrum of monoclonal light chain deposition disease in muscle

Ostrow, L., Corse, A. M., Morrison, B., Huff, C. A., Carrino, J. A., Hoke, A. & Mammen, A. L., May 2012, In : Muscle and Nerve. 45, 5, p. 755-761 7 p.

Research output: Contribution to journalArticle

Paraproteinemias
Biopsy
Light
Muscles
Amyloid

Fatal exserohilum meningitis and central nervous system vasculitis after cervical epidural methylprednisolone injection

Lyons, J. L., Gireesh, E. D., Trivedi, J. B., Robert Bell, W., Saylor, D., Smith, B. R., Karram, S., Chang, T., Tochen, L., Zhang, S. X., McCall, C. M., Pearce, D. T., Carroll, K. C., Chen, L., Ratchford, J. N., Harrison, D. M., Ostrow, L. & Stevens, R. D., 2012, In : Annals of Internal Medicine. 157, 11, p. 835-836 2 p.

Research output: Contribution to journalArticle

Central Nervous System Vasculitis
Epidural Injections
Methylprednisolone
Meningitis
Abnormal Reflexes

Immunohistochemistry of affected tissue may guide cGVHD treatment decisions

Williams, K. M., Ostrow, L., Loeb, D. M., Tse, C. M., Cohn, R. D., Corse, A. M., Mammen, A. L. & Chen, A. R., May 2012, In : Bone Marrow Transplantation. 47, 5, p. 731-733 3 p.

Research output: Contribution to journalArticle

Myositis
Graft vs Host Disease
Immunohistochemistry
Dermatomyositis
Therapeutics
2011
Endothelin-1
Ion Channels
Astrocytes
Rats
Calcium

Tonic status and electrodecremental paroxysms in an adult without epilepsy

Ostrow, L. & Kaplan, P. W., Mar 2011, In : Epileptic Disorders. 13, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

Status Epilepticus
Epilepsy
Meningoencephalitis
Intellectual Disability
Hospital Emergency Service
2009

Eastchester clapping sign: A novel test of parietal neglect

Ostrow, L. & Llinas, R. H., Jul 2009, In : Annals of Neurology. 66, 1, p. 114-117 4 p.

Research output: Contribution to journalArticle

Hand
Perceptual Disorders
Psychology

PML-IRIS in patients with HIV infection: Clinical manifestations and treatment with steroids

Tan, K., Roda, R., Ostrow, L., McArthur, J. C. & Nath, A., Apr 28 2009, In : Neurology. 72, 17, p. 1458-1464 7 p.

Research output: Contribution to journalArticle

Immune Reconstitution Inflammatory Syndrome
Progressive Multifocal Leukoencephalopathy
HIV Infections
Steroids
Therapeutics
2008

The varicella zoster virus vasculopathies: Clinical, CSF, imaging, and virologic features

Nagel, M. A., Cohrs, R. J., Mahalingam, R., Wellish, M. C., Forghani, B., Schiller, A., Safdieh, J. E., Kamenkovich, E., Ostrow, L., Levy, M., Greenberg, B., Russman, A. N., Katzan, I., Gardner, C. J., Häusler, M., Nau, R., Saraya, T., Wada, H., Goto, H., De Martino, M. & 4 others, Ueno, M., Brown, W. D., Terborg, C. & Gilden, D. H., Mar 2008, In : Neurology. 70, 11, p. 853-860 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 3
Exanthema
Arteries
Immunoglobulin G
Leukocytosis
2005

Mechanosensation and endothelin in astrocytes - Hypothetical roles in CNS pathophysiology

Ostrow, L. & Sachs, F., Jun 2005, In : Brain Research Reviews. 48, 3, p. 488-508 21 p.

Research output: Contribution to journalArticle

Endothelins
Astrocytes
Mechanical Stress
Pathology
Brain
2004

Mechanosensitive ion channels as drug targets

Gottlieb, P. A., Suchyna, T. M., Ostrow, L. & Sachs, F., Aug 2004, In : Current Drug Targets: CNS and Neurological Disorders. 3, 4, p. 287-295 9 p.

Research output: Contribution to journalArticle

Ion Channels
Pharmaceutical Preparations
Scleroproteins
Spider Venoms
L Forms
2000

Stretch-induced endothelin-1 production by astrocytes

Ostrow, L., Langan, T. J. & Sachs, F., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

Endothelin-1
Astrocytes
Gliosis
Endothelins
Central Nervous System