Lukasz Gondek

Assistant Professor

20052020

Research output per year

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Research Output

2020

Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS

Zeidner, J. F., Knaus, H. A., Zeidan, A. M., Blackford, A. L., Montiel-Esparza, R., Hackl, H., Prince, G. T., Gondek, L. P., Ghiaur, G., Showel, M., DeZern, A. E., Pratz, K., Smith, B. D., Levis, M. J., Gore, S. D., Coombs, C. C., Foster, M. C., Streicher, H., Karp, J. E., Luznik, L. & 1 others, Gojo, I., Jun 1 2020, In : Leukemia. 34, 6, p. 1563-1576 14 p.

Research output: Contribution to journalArticle

Stem cell donors should be screened for CHIP

DeZern, A. E. & Gondek, L. P., Feb 25 2020, In : Blood Advances. 4, 4, p. 784-788 5 p.

Research output: Contribution to journalReview article

Open Access

The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing

Brian Dalton, W., Helmenstine, E., Pieterse, L., Li, B., Gocke, C. D., Donaldson, J., Xiao, Z., Gondek, L. P., Ghiaur, G., Gojo, I., Douglas Smith, B., Levis, M. J. & DeZern, A. E., Apr 14 2020, In : Blood Advances. 4, 7, p. 1192-1196 5 p.

Research output: Contribution to journalReview article

Open Access

Genetic Alterations at Diagnosis Predict Outcome of AML Patients Age 60 or Older Undergoing Allogeneic Transplantation in First Remission

Murdock, H. M., Kim, H. T., Hambley, B., Vachhani, P., Denlinger, N., Gier, S. H., Cho, C., Perales, M. A., Koreth, J., Ho, V. T., Soiffer, R. J., McCurdy, S. R., Carroll, M., Vasu, S., Wang, E. S., Gondek, L. P., Devine, S., Alyea, E. P., Gibson, C. J. & Lindsley, R. C., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Hitting the bullseye with a nonlethal payload: Resistance in CD123-positive malignancies

Gondek, L. P., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4590-4592 3 p.

Research output: Contribution to journalReview article

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Brian Dalton, W., Helmenstine, E., Walsh, N., Gondek, L. P., Kelkar, D. S., Read, A., Natrajan, R., Christenson, E. S., Roman, B., Das, S., Zhao, L., Leone, R. D., Shinn, D., Groginski, T., Madugundu, A. K., Patil, A., Zabransky, D. J., Medford, A., Lee, J., Cole, A. J. & 12 others, Rosen, M., Thakar, M., Ambinder, A., Donaldson, J., DeZern, A. E., Cravero, K., Chu, D., Madero-Marroquin, R., Pandey, A., Hurley, P. J., Lauring, J. & Park, B. H., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4708-4723 16 p.

Research output: Contribution to journalArticle

The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Zheng, G., Chen, P., Pallavajjalla, A., Haley, L., Gondek, L., Dezern, A., Ling, H., De Marchi, F., Lin, M. T. & Gocke, C., Oct 1 2019, In : American journal of hematology. 94, 10, p. 1141-1148 8 p.

Research output: Contribution to journalArticle

2018

Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Lau, B., Huh, K., Madero-Marroquin, R., De Marchi, F., Lim, Y., Wang, Q., Lobo, F., Marchionni, L., Smith, B. D., Dezern, A., Levis, M. J., Aplan, P. D., Matsui, W. & Gondek, L., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2017

Anthracycline-induced acute myocarditis and ventricular fibrillation arrest

Pallazola, V. A., Murray, J. C., Al Harthy, M., Zimmerman, S., Webster, J. & Gondek, L., Jan 1 2017, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

2016

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

2015

Erratum for the research article: "Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia"

Lim, Y., Gondek, L., Li, L., Wang, Q., Ma, H., Chang, E., Huso, D. L., Foerster, S., Marchionni, L., McGovern, K., Watkins, D. N., Peacock, C., Levis, M., Smith, B. D., Merchant, A. A., Small, D. & Matsui, W., Jul 8 2015, In : Science translational medicine. 7, 295, 295er6.

Research output: Contribution to journalComment/debate

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia

Lim, Y., Gondek, L., Li, L., Wang, Q., Ma, H., Chang, E., Huso, D. L., Foerster, S., Marchionni, L., McGovern, K., Watkins, D. N., Peacock, C., Levis, M., Smith, B. D., Merchant, A. A., Small, D. & Matsui, W., Jun 10 2015, In : Science translational medicine. 7, 291, 96.

Research output: Contribution to journalArticle

2014

I Walk the Line: How to Tell MDS From Other Bone Marrow Failure Conditions

Gondek, L. P. & DeZern, A. E., Jan 1 2014, In : Current Hematologic Malignancy Reports. 9, 4, p. 389-399 11 p.

Research output: Contribution to journalReview article

2012

Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited

Jerez, A., Gondek, L. P., Jankowska, A. M., Makishima, H., Przychodzen, B., Tiu, R. V., O'Keefe, C. L., Mohamedali, A. M., Batista, D., Sekeres, M. A., McDevitt, M. A., Mufti, G. J. & Maciejewski, J. P., Apr 20 2012, In : Journal of Clinical Oncology. 30, 12, p. 1343-1349 7 p.

Research output: Contribution to journalArticle

2011

Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies

Tiu, R. V., Gondek, L. P., O'Keefe, C. L., Elson, P., Huh, J., Mohamedali, A., Kulasekararaj, A., Advani, A. S., Paquette, R., List, A. F., Sekeres, M. A., McDevitt, M. A., Mufti, G. J. & Maciejewski, J. P., Apr 28 2011, In : Blood. 117, 17, p. 4552-4560 9 p.

Research output: Contribution to journalArticle

2010

Characterization of chromosome arm 20q abnormalities in myeloid malignancies using genome-wide single nucleotide polymorphism array analysis

Huh, J., Tiu, R. V., Gondek, L. P., O'Keefe, C. L., Jasek, M., Makishima, H., Jankowska, A. M., Jiang, Y., Verma, A., Theil, K. S., McDevitt, M. A. & Maciejewski, J. P., Apr 1 2010, In : Genes Chromosomes and Cancer. 49, 4, p. 390-399 10 p.

Research output: Contribution to journalArticle

Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib

Paquette, R. L., Nicoll, J., Chalukya, M., Gondek, L., Jasek, M., Sawyers, C. L., Shah, N. P. & Maciejewski, J., Jun 1 2010, In : Leukemia Research. 34, 6, p. 708-713 6 p.

Research output: Contribution to journalArticle

FISH and SNP-A karyotyping in myelodysplastic syndromes: Improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q)

Makishima, H., Rataul, M., Gondek, L. P., Huh, J., Cook, J. R., Theil, K. S., Sekeres, M. A., Kuczkowski, E., O'Keefe, C. & Maciejewski, J. P., Apr 1 2010, In : Leukemia Research. 34, 4, p. 447-453 7 p.

Research output: Contribution to journalArticle

TP53 mutations in myeloid malignancies are either homozygous or hemizygous due to copy number-neutral loss of heterozygosity or deletion of 17p

Jasek, M., Gondek, L. P., Bejanyan, N., Tiu, R., Huh, J., Theil, K. S., O'Keefe, C., McDevitt, M. A. & MacIejewski, J. P., Jan 2010, In : Leukemia. 24, 1, p. 216-219 4 p.

Research output: Contribution to journalLetter

2009

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML

Jiang, Y., Dunbar, A., Gondek, L. P., Mohan, S., Rataul, M., O'Keefe, C., Sekeres, M., Saunthararajah, Y. & Maciejewski, J. P., Feb 5 2009, In : Blood. 113, 6, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

Clonotype analysis of cytomegalovirus-specific cytotoxic T lymphocytes

Babel, N., Brestrich, G., Gondek, L. P., Sattler, A., Wlodarski, M. W., Poliak, N., Bethke, N., Thiel, A., Hammer, M. H., Reinke, P. & Maciejewski, J. P., Feb 1 2009, In : Journal of the American Society of Nephrology. 20, 2, p. 344-352 9 p.

Research output: Contribution to journalArticle

New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia

Tiu, R. V., Gondek, L. P., O'Keefe, C. L., Huh, J., Sekeres, M. A., Elson, P., McDevitt, M. A., Wang, X. F., Levis, M. J., Karp, J. E., Advani, A. S. & Maciejewski, J. P., Nov 1 2009, In : Journal of Clinical Oncology. 27, 31, p. 5219-5226 8 p.

Research output: Contribution to journalArticle

P035 Improvement in cytogenetic diagnosis and clinical prognostication using SNP-A karyotyping in combination with metaphase cytogenetics in MDS, MDS/MPD and secondary AML

Tiu, R. V., Gondek, L. P., Huh, J., O'Keefe, C., Sekeres, M. A., Mufti, G. J., McDevitt, M. A., Advani, A. S. & Maciejewski, J., May 1 2009, In : Leukemia Research. 33, SUPPL. 1, p. S78-S79

Research output: Contribution to journalArticle

Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies

Ye, Y., McDevitt, M. A., Guo, M., Zhang, W., Galm, O., Gore, S. D., Karp, J. E., Maciejewski, J. P., Kowalski, J., Tsai, H. L., Gondek, L. P., Tsai, H. C., Wang, X., Hooker, C., Smith, B. D., Carraway, H. E. & Herman, J. G., Nov 1 2009, In : Cancer Research. 69, 21, p. 8482-8490 9 p.

Research output: Contribution to journalArticle

UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation

Szpurka, H., Gondek, L. P., Mohan, S. R., Hsi, E. D., Theil, K. S. & Maciejewski, J. P., Jan 1 2009, In : Leukemia. 23, 3, p. 610-614 5 p.

Research output: Contribution to journalArticle

2008

250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

Dunbar, A. J., Gondek, L. P., O'Keefe, C. L., Makishima, H., Rataul, M. S., Szpurka, H., Sekeres, M. A., Xiao, F. W., McDevitt, M. A. & Maciejewski, J. P., Dec 15 2008, In : Cancer Research. 68, 24, p. 10349-10357 9 p.

Research output: Contribution to journalArticle

Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome

Jankowska, A. M., Gondek, L. P., Szpurka, H., Nearman, Z. P., Tiu, R. V. & Maciejewski, J. P., Mar 2008, In : Leukemia. 22, 3, p. 551-558 8 p.

Research output: Contribution to journalArticle

Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

Gondek, L. P., Tiu, R., O'Keefe, C. L., Sekeres, M. A., Theil, K. S. & Maciejewski, J. P., Feb 12 2008, In : Blood. 111, 3, p. 1534-1542 9 p.

Research output: Contribution to journalArticle

2007

Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes

Tiu, R., Gondek, L., O'Keefe, C. & Maciejewski, J. P., Aug 2007, In : Leukemia. 21, 8, p. 1648-1657 10 p.

Research output: Contribution to journalReview article

Detection of cryptic chromosomal lesions including acquired segmental uniparental disomy in advanced and low-risk myelodysplastic syndromes

Gondek, L. P., Haddad, A. S., O'Keefe, C. L., Tiu, R., Wlodarski, M. W., Sekeres, M. A., Theil, K. S. & Maciejewski, J. P., Nov 1 2007, In : Experimental Hematology. 35, 11, p. 1728-1738 11 p.

Research output: Contribution to journalArticle

Evidence for genetic susceptibility towards development of posttransplant lymphoproliferative disorder in solid organ recipients

Babel, N., Vergopoulos, A., Trappe, R. U., Oertel, S., Hammer, M. H., Karaivanov, S., Schneider, N., Riess, H., Papp-Vary, M., Neuhaus, R., Gondek, L. P., Volk, H. D. & Reinke, P., Aug 1 2007, In : Transplantation. 84, 3, p. 387-391 5 p.

Research output: Contribution to journalArticle

High-Resolution Genomic Arrays Facilitate Detection of Novel Cryptic Chromosomal Lesions in Myelodysplastic Syndromes

O'Keefe, C. L., Tiu, R., Gondek, L. P., Powers, J., Theil, K. S., Kalaycio, M., Lichtin, A., Sekeres, M. A. & Maciejewski, J. P., Feb 1 2007, In : Experimental Hematology. 35, 2, p. 240-251 12 p.

Research output: Contribution to journalArticle

Immune-mediated bone marrow failure syndromes of progenitor and stem cells: Molecular analysis of cytotoxic T cell clones

Maciejewski, J. P., O'Keefe, C., Gondek, L. & Tiu, R., Jan 1 2007, In : Folia Histochemica et Cytobiologica. 45, 1, p. 5-14 10 p.

Research output: Contribution to journalReview article

Molecular analysis of alloreactive CTL post-hemopoietic stem cell transplantation

O'Keefe, C. L., Gondek, L., Davis, R., Kuczkowski, E., Sobecks, R. M., Rodriguez, A., Narvaez, Y., McIver, Z., Tuthill, R., Laughlin, M., Bolwell, B. & Maciejewski, J. P., Aug 1 2007, In : Journal of Immunology. 179, 3, p. 2013-2022 10 p.

Research output: Contribution to journalArticle

Open Access

Single nucleotide polymorphism arrays complement metaphase cytogenetics in detection of new chromosomal lesions in MDS [11]

Gondek, L. P., Tiu, R., Haddad, A. S., O'Keefe, C. L., Sekeres, M. A., Theil, K. S. & Maciejewski, J. P., Sep 2007, In : Leukemia. 21, 9, p. 2058-2061 4 p.

Research output: Contribution to journalLetter

SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD

Gondek, L. P., Dunbar, A. J., Szpurka, H., McDevitt, M. A. & Maciejewski, J. P., Nov 21 2007, In : PloS one. 2, 11, e1225.

Research output: Contribution to journalArticle

2006

Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome

Wlodarski, M. W., Gondek, L. P., Nearman, Z. P., Plasilova, M., Kalaycio, M., Hsi, E. D. & Maciejewski, J. P., Oct 15 2006, In : Blood. 108, 8, p. 2632-2641 10 p.

Research output: Contribution to journalArticle

2005

Efficient identification of T-cell clones associated with graft-versus-host disease in target tissue allows for subsequent detection in peripheral blood

Beck, R. C., Wlodarski, M., Gondek, L., Theil, K. S., Tuthill, R. J., Sobeck, R., Bolwell, B. & Maciejewski, J. P., May 1 2005, In : British journal of haematology. 129, 3, p. 411-419 9 p.

Research output: Contribution to journalArticle