Luigi M De Luca

Senior Associate

1968 …2015

Research output per year

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Research Output

2015
2011

Scurvy and cloudberries: A chapter in the history of nutritional sciences

De Luca, L. M. & Norum, K. R., Dec 1 2011, In : Journal of Nutrition. 141, 12, p. 2101-2105 5 p.

Research output: Contribution to journalArticle

2009

Therapeutic potential of "rexinoids" in cancer prevention and treatment

Tanaka, T. & De Luca, L. M., Jun 15 2009, In : Cancer Research. 69, 12, p. 4945-4947 3 p.

Research output: Contribution to journalArticle

2007
2006

Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: Translational implications and mechanism of action

Simmons, D. P., Peach, M. L., Friedman, J. R., Green, M. M. B., Nicklaus, M. C. & De Luca, L. M., Apr 1 2006, In : Carcinogenesis. 27, 4, p. 693-707 15 p.

Research output: Contribution to journalArticle

Retinoic acid is required early during adult neurogenesis in the dentate gyrus

Jacobs, S., Lie, D. C., DeCicco, K. L., Shi, Y., DeLuca, L. M., Gage, F. H. & Evans, R. M., Mar 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3902-3907 6 p.

Research output: Contribution to journalArticle

2004

Altered Localization of Retinoid X Receptor α Coincides with Loss of Retinoid Responsiveness in Human Breast Cancer MDA-MB-231 Cells

Tanaka, T., Dancheck, B. L., Trifiletti, L. C., Birnkrant, R. E., Taylor, B. J., Garfield, S. H., Thorgeirsson, U. & De Luca, L. M., May 1 2004, In : Molecular and cellular biology. 24, 9, p. 3972-3982 11 p.

Research output: Contribution to journalArticle

Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase: Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice

Andreola, F., Hayhurst, G. P., Luo, G., Ferguson, S. S., Gonzalez, F. J., Goldstein, J. A. & De Luca, L. M., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3434-3438 5 p.

Research output: Contribution to journalArticle

Reversal of Liver Fibrosis in Aryl Hydrocarbon Receptor null Mice by Dietary Vitamin A Depletion

Andreola, F., Calvisi, D. F., Elizondo, G., Jakowlew, S. B., Mariano, J., Gonzalez, F. J. & De Luca, L. M., Jan 1 2004, In : Hepatology. 39, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

The effect of thalidomide on non-small cell lung cancer (NSCLC) cell lines: Possible involvement in the PPARγ pathway

DeCicco, K. L., Tanaka, T., Andreola, F. & De Luca, L. M., Oct 1 2004, In : Carcinogenesis. 25, 10, p. 1805-1812 8 p.

Research output: Contribution to journalArticle

2003

A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis

Hansen, L. A., Brown, D., Virador, V., Tanaka, T., Andreola, F., Strain, K., Dancheck, B., Riley, R., Arbeit, J. M., De Luca, L. M., Kogan, S. & Yuspa, S. H., Sep 1 2003, In : Cancer Research. 63, 17, p. 5257-5265 9 p.

Research output: Contribution to journalArticle

2002

Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters

Simmons, D. P., Andreola, F. & De Luca, L. M., Nov 1 2002, In : Carcinogenesis. 23, 11, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

Open Access

Lung cancer evolution to preinvasive management

Mulshine, J. L., Cuttitta, F., Tockman, M. S. & De Luca, L. M., Jan 1 2002, In : Clinics in Chest Medicine. 23, 1, p. 37-48 12 p., 97.

Research output: Contribution to journalReview article

2001

Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras

Ogata, H., Sato, H., Takatsuka, J. & De Luca, L. M., Oct 30 2001, In : Cancer Letters. 172, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors α and γ through proteasomes in MCF-7 human breast cancer cells

Tanaka, T., Rodríguez De La Concepcón, M. L. & De Luca, L. M., Jun 1 2001, In : Biochemical Pharmacology. 61, 11, p. 1347-1355 9 p.

Research output: Contribution to journalArticle

Moving to the routine management of pre symptomatic lung cancer

Mulshine, J. L., Hong, S., Martínez, A., Tauler, J., Avis, I., Tockman, M. S., De Luca, L. M., Placke, M. E. & Cuttitta, F., Jan 1 2001, In : Lung Cancer. 34, SUPPL. 2, p. S1-S5

Research output: Contribution to journalArticle

Role of vitamin A deficiency in the pathogenesis of myeloproliferative disorders [6] (multiple letters)

Sivakumaran, M., De Luca, L. M. & Ozato, K., Sep 1 2001, In : Blood. 98, 5, p. 1636-1637 2 p.

Research output: Contribution to journalLetter

Vitamin A and gene expression

McCaffery, P., Andreola, F., Giandomenico, V. & De Luca, L. M., Jan 1 2001, Nutrient-Gene Interactions in Health and Disease. CRC Press, p. 283-319 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity

Misner, D. L., Jacobs, S., Shimizu, Y., De Urquiza, A. M., Solomin, L., Perlmann, T., De Luca, L. M., Stevens, C. F. & Evans, R. M., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11714-11719 6 p.

Research output: Contribution to journalArticle

2000
Open Access

Considerations in developing successful, population-based molecular screening and prevention of lung cancer

Mulshine, J. L., De Luca, L. M., Dedrick, R. L., Tockman, M. S., Webster, R. & Placke, M. E., Dec 1 2000, In : Cancer. 89, 11 SUPPL., p. 2465-2467 3 p.

Research output: Contribution to journalArticle

Differences in uptake and metabolism of retinoic acid between estrogen receptor-positive and -negative human breast cancer cells

Okamoto, K., Andreola, F., Chiantore, M. V., Dedrick, R. L. & De Luca, L. M., Jan 1 2000, In : Cancer Chemotherapy and Pharmacology. 46, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells

Andreola, F., Giandomenico, V., Spero, R. & De Luca, L. M., Dec 29 2000, In : Biochemical and Biophysical Research Communications. 279, 3, p. 920-924 5 p.

Research output: Contribution to journalArticle

Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: A pilot study

Dahl, A. R., Grossi, I. M., Houchens, D. P., Scovell, L. J., Placke, M. E., Imondi, A. R., Stoner, G. D., De Luca, L. M., Wang, D. & Mulshine, J. L., Aug 1 2000, In : Clinical Cancer Research. 6, 8, p. 3015-3024 10 p.

Research output: Contribution to journalArticle

Retinoids in chemoprevention and differentiation therapy

Hansen, L. A., Sigman, C. C., Andreola, F., Ross, S. A., Kelloff, G. J. & De Luca, L. M., Jan 1 2000, In : Carcinogenesis. 21, 7, p. 1271-1279 9 p.

Research output: Contribution to journalReview article

Open Access

Retinoids in embryonal development

Ross, S. A., McCaffery, P. J., Drager, U. C. & De Luca, L. M., Jul 2000, In : Physiological reviews. 80, 3, p. 1021-1054 34 p.

Research output: Contribution to journalReview article

Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors

Da Li Wang, L. W., Marko, M., Dahl, A. R., Engelke, K. S., Placke, M. E., Imondi, A. R., Mulshine, J. L. & De Luca, L. M., Sep 26 2000, In : Clinical Cancer Research. 6, 9, p. 3636-3645 10 p.

Research output: Contribution to journalArticle

Vitamin A deficiency in mice causes a systemic expansion of myeloid cells

Kuwata, T., Wang, I. M., Tamura, T., Ponnamperuma, R. M., Levine, R., Holmes, K. L., Morse, H. C., De Luca, L. M. & Ozato, K., Jun 1 2000, In : Blood. 95, 11, p. 3349-3356 8 p.

Research output: Contribution to journalArticle

β-Carotene fails to act as a tumor promoter, induces RAR expression, and prevents carcinoma formation in a two-stage model of skin carcinogenesis in male sencar mice

Ponnamperuma, R. M., Shimizu, Y., Kirchhof, S. M. & De Luca, L. M., Jan 1 2000, In : Nutrition and Cancer. 37, 1, p. 82-88 7 p.

Research output: Contribution to journalArticle

1999

Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet

Ponnamperuma, R. M., Kirchhof, S. M., Trifiletti, L. & De Luca, L. M., Oct 1999, In : American Journal of Clinical Nutrition. 70, 4, p. 502-508 7 p.

Research output: Contribution to journalArticle

Open Access

Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different signal transduction pathways in mouse fibroblasts (NIH 3T3 cells)

Giandomenico, V., Andreola, F., Rodriguez De La Concepcion, M. L., Collins, S. J. & De Luca, L. M., Jun 17 1999, In : Carcinogenesis. 20, 6, p. 1133-1135 3 p.

Research output: Contribution to journalArticle

Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells

Zhu, W. Y., Jones, C. S., Amin, S., Matsukuma, K., Haque, M., Vuligonda, V., Chandraratna, R. A. S. & De Luca, L. M., Jan 1 1999, In : Cancer Research. 59, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Reverse endocrinology as an approach to drug discovery

De Luca, L. M., Jan 1 1999, In : Drugs of the Future. 24, 11, p. 1213-1219 7 p.

Research output: Contribution to journalReview article

Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically

Trøen, G., Eskild, W., Fromm, S. H., De Luca, L. M., Ong, D. E., Wardlaw, S. A., Reppe, S. & Blomhoff, R., 1999, In : Journal of Nutrition. 129, 9, p. 1621-1627 7 p.

Research output: Contribution to journalArticle

Open Access
1998

Retinoids in differentiation and cancer research

De Luca, L. M., Apr 1 1998, In : Drugs of the Future. 23, 4, p. 415-421 7 p.

Research output: Contribution to journalReview article

The cloning and characterization of a novel cytochrome P450 family, CYP26, with specificity toward retinoic acid

Haque, M., Andreola, F. & DeLuca, L. M., Mar 1 1998, In : Nutrition reviews. 56, 3, p. 84-85 2 p.

Research output: Contribution to journalShort survey

Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion

Tennenbaum, T., Lowry, D., Darwiche, N., Morgan, D. L., Gartsbein, M., Hansen, L., De Luca, L. M., Hennings, H. & Yuspa, S. H., Apr 1 1998, In : Cancer Research. 58, 7, p. 1435-1443 9 p.

Research output: Contribution to journalArticle

1997

Aryl hydrocarbon receptor deficient mice (Ahr-/-) exhibit an accumulation of liver retinylpalmitate

Andreola, F., Fernandez-Salguero, P., Gonzalez, F. J. & De Luca, L. M., Dec 1 1997, In : FASEB Journal. 11, 3, p. A440

Research output: Contribution to journalArticle

Aryl hydrocarbon receptor knockout mice (AHR(-/-)) exhibit liver retinoid accumulation and reduced retinoic acid metabolism

Andreola, F., Fernandez-Salguero, P. M., Chiantore, M. V., Petkovich, M. P., Gonzalez, F. J. & De Luca, L. M., Jul 15 1997, In : Cancer Research. 57, 14, p. 2835-2838 4 p.

Research output: Contribution to journalArticle

Decreased retinoylation in NIH 3T3 cells transformed with activated Ha-ras

Takahashi, N., De Luca, L. M. & Breitman, T. R., Oct 9 1997, In : Biochemical and Biophysical Research Communications. 239, 1, p. 80-84 5 p.

Research output: Contribution to journalArticle

Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH- 3T3 cell growth

Isogai, M., Chiantore, M. V., Haque, M., Scita, G. & De Luca, L. M., Oct 15 1997, In : Cancer Research. 57, 20, p. 4460-4464 5 p.

Research output: Contribution to journalArticle

Liarozole potentiates retinoic acid effects on human prostate carcinoma cells

Islam C S Jones, M. N., Chiantore F Andreola, M. V. & De Luca, L. M., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1253

Research output: Contribution to journalArticle

Retinoic acid as a therapy for emphysema?

DeLuca, L. M. & Ross, S. A., Aug 1 1997, In : Nutrition reviews. 55, 8, p. 307-308 2 p.

Research output: Contribution to journalShort survey

Retinoic acid downregulates growth, fibronectin and RARα in 3T3 cells: Ha-ras blocks this response and RA metabolism

De Luca, L. M., Scita, G. & Takatsuka, J., Nov 1 1997, In : Journal of Cellular Physiology. 173, 2, p. 297-300 4 p.

Research output: Contribution to journalArticle

Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells

Zhu, W. Y., Jones, C. S., Kiss, A., Matsukuma, K., Amin, S. & De Luca, L. M., Aug 1 1997, In : Experimental cell research. 234, 2, p. 293-299 7 p.

Research output: Contribution to journalArticle

The role of vitamin A in differentiation and skin carcinogenesis

De Luca, L. M., Kosa, K. & Andreola, F., Aug 1 1997, In : Journal of Nutritional Biochemistry. 8, 8, p. 426-437 12 p.

Research output: Contribution to journalReview article

TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620

Kósa, K., Rosenberg, M. I., Chiantore, M. V. & De Luca, L. M., Mar 27 1997, In : Biochemical and Biophysical Research Communications. 232, 3, p. 737-741 5 p.

Research output: Contribution to journalArticle

1996

A new metabolite of retinol: All-trans-4-oxo-retinol as a receptor activator and differentiation agent

Ross, S. A. & De Luca, L. M., Nov 1996, In : Nutrition reviews. 54, 11 I, p. 355-356 2 p.

Research output: Contribution to journalReview article