Loyal Goff

Assistant Professor

20042019
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Long Noncoding RNA Medicine & Life Sciences
RNA Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Genes Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Gene Expression Medicine & Life Sciences
Untranslated RNA Medicine & Life Sciences
Genome Medicine & Life Sciences

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Research Output 2004 2019

A screen of 1,049 schizophrenia and 30 Alzheimer's-associated variants for regulatory potential

Myint, L., Wang, R., Boukas, L., Hansen, K. D., Goff, L. & Avramopoulos, D., Jan 1 2019, (Accepted/In press) In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Research output: Contribution to journalReview article

Single Nucleotide Polymorphism
Schizophrenia
Genome-Wide Association Study
Alleles
Alzheimer Disease

Decomposing Cell Identity for Transfer Learning across Cellular Measurements, Platforms, Tissues, and Species

Stein-O'Brien, G. L., Clark, B. S., Sherman, T., Zibetti, C., Hu, Q., Sealfon, R., Liu, S., Qian, J., Colantuoni, C., Blackshaw, S., Goff, L. & Fertig, E., May 22 2019, In : Cell Systems. 8, 5, p. 395-411.e8

Research output: Contribution to journalArticle

Open Access
Small Cytoplasmic RNA
Space Flight
Workflow
Transfer (Psychology)
Datasets

Differential variation analysis enables detection of tumor heterogeneity using single-cell RNA-sequencing data

Davis-Marcisak, E. F., Sherman, T. D., Orugunta, P., Stein-O'Brien, G. L., Puram, S. V., Roussos Torres, E., Hopkins, A. C., Jaffee, E., Favorov, A., Afsari, B., Goff, L. & Fertig, E., Oct 1 2019, In : Cancer Research. 79, 19, p. 5102-5112 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Neoplasms
Neoplasm Metastasis
Gene Expression
Tumor Microenvironment

Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

Heng, J. S., Rattner, A., Stein-O’Brien, G. L., Winer, B. L., Jones, B. W., Vernon, H. J., Goff, L. & Nathans, J., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 9103-9114 12 p.

Research output: Contribution to journalArticle

Retina
Neuroglia
Brain
RNA Sequence Analysis
Transcriptome

Linear models enable powerful differential activity analysis in massively parallel reporter assays

Myint, L., Avramopoulos, D., Goff, L. & Hansen, K. D., Mar 12 2019, In : BMC genomics. 20, 1, 209.

Research output: Contribution to journalArticle

Open Access
Linear Models
Statistical Data Interpretation
Datasets