Research output per year
Research output per year
- 26 results
Search results
-
2022
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation
Sharrock, A. V., Mulligan, T. S., Hall, K. R., Williams, E. M., White, D. T., Zhang, L., Emmerich, K., Matthews, F., Nimmagadda, S., Washington, S., Le, K. D., Meir-Levi, D., Cox, O. L., Saxena, M. T., Calof, A. L., Lopez-Burks, M. E., Lander, A. D., Ding, D., Ji, H., Ackerley, D. F., & 1 others, Feb 2022, In: Nature Methods. 19, 2, p. 205-215 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa
Ganzen, L., Ko, M. J., Zhang, M., Xie, R., Chen, Y., Zhang, L., James, R., Mumm, J., van Rijn, R. M., Zhong, W., Pang, C. P., Zhang, M., Tsujikawa, M. & Leung, Y. F., Dec 2021, In: Scientific reports. 11, 1, 11432.Research output: Contribution to journal › Article › peer-review
Open Access -
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa
Zhang, L., Chen, C., Fu, J., Lilley, B., Berlinicke, C., Hansen, B., Ding, D., Wang, G., Wang, T., Shou, D., Ye, Y., Mulligan, T., Emmerich, K., Saxena, M. T., Hall, K. R., Sharrock, A. V., Brandon, C., Park, H., Kam, T. I., Dawson, V. L., & 10 others, Jun 2021, In: eLife. 10Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Multiplexed CRISPR/Cas9 targeting of genes implicated in retinal regeneration and degeneration
Eroglu, A. U., Mulligan, T. S., Zhang, L., White, D. T., Sengupta, S., Nie, C., Lu, N. Y., Qian, J., Xu, L., Pei, W., Burgess, S. M., Saxena, M. T. & Mumm, J. S., Aug 21 2018, In: Frontiers in Cell and Developmental Biology. 6, AUG, 88.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2017
Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration
Zhang, L., Zhang, X., Zhang, G., Pang, C. P., Leung, Y. F., Zhang, M. & Zhong, W., Dec 12 2017, In: Scientific Data. 4, 170182.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2016
A naturally-derived compound schisandrin B enhanced light sensation in the pde6c zebrafish model of retinal degeneration
Zhang, L., Xiang, L., Liu, Y., Venkatraman, P., Chong, L., Cho, J., Bonilla, S., Jin, Z. B., Pang, C. P., Ko, K. M., Ma, P., Zhang, M. & Leung, Y. F., Mar 2016, In: PloS one. 11, 3, e0149663.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates
White, D. T., Eroglu, A. U., Wang, G., Zhang, L., Sengupta, S., Ding, D., Rajpurohit, S. K., Walker, S. L., Ji, H., Qian, J. & Mumm, J. S., Dec 1 2016, In: Nature protocols. 11, 12, p. 2432-2453 22 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2015
Chemical genetics and regeneration
Sengupta, S., Zhang, L. & Mumm, J. S., Oct 2015, In: Future medicinal chemistry. 7, 16, p. 2263-2283 21 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Mesenchymal stem cells for treating ocular surface diseases
Zhang, L., Coulson-Thomas, V. J., Ferreira, T. G. & Kao, W. W. Y., Dec 17 2015, In: BMC Ophthalmology. 15, 1, 155.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma
Dong, F., Liu, C. Y., Yuan, Y., Zhang, Y., Li, W., Call, M., Zhang, L., Chen, Y., Liu, Z. & Kao, W. W. Y., Oct 15 2015, In: Developmental biology. 406, 2, p. 147-157 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2014
A high-throughput zebrafish screening method for visual mutants by light-induced locomotor response
Gao, Y., Chan, R. H. M., Chow, T. W. S., Zhang, L., Bonilla, S., Pang, C. P., Zhang, M. & Leung, Y. F., 2014, In: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 11, 4, p. 693-701 9 p., 6744583.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Expression profling of the RPE in zebrafsh smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation
Zhang, L., Ma, P., Collery, R., Trowbridge, S., Zhang, M., Zhong, W. & Leung, Y. F., Jan 6 2014, In: Molecular vision. 20, p. 56-72 17 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1
Zhang, L., Bonilla, S., Zhang, Y. & Leung, Y. F., Feb 2014, In: Developmental Dynamics. 243, 2, p. 315-323 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2013
The Role of egr1 in Early Zebrafish Retinogenesis
Zhang, L., Cho, J., Ptak, D. & Leung, Y. F., Feb 6 2013, In: PloS one. 8, 2, e56108.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Use of the zebrafish model to study refractive error
Li, Z., Zhang, L. & Leung, Y. F., Feb 2013, In: Expert Review of Ophthalmology. 8, 1, p. 1-3 3 p.Research output: Contribution to journal › Review article › peer-review
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2012
Phenylthiourea specifically reduces zebrafish eye size
Li, Z., Ptak, D., Zhang, L., Walls, E. K., Zhong, W. & Leung, Y. F., Jun 27 2012, In: PloS one. 7, 6, e40132.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
2011
Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas
Hensley, M., Emran, F., Bonilla, S., Zhang, L., Zhong, W., Grosu, P., Dowling, J. & Leung, Y., 2011, In: BMC Developmental Biology. 11, 45.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2010
Microdissection of zebrafish embryonic eye tissues
Zhang, L. & Leung, Y. F., Jun 2010, In: Journal of Visualized Experiments. 40, e2028.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Sodium 4-phenylbutyrate ameliorates the effects of cataractcausing mutant gammaD-crystallin in cultured cells
Gong, B., Zhang, L. Y., Lam, D. S. C., Pang, C. P. & Yam, G. H. F., 2010, In: Molecular vision. 16, p. 997-1003 7 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
2009
A novel mutation in CRYBB2 responsible for inherited coronary cataract
Lou, D., Tong, J. P., Zhang, L. Y., Chiang, S. W. Y., Lam, D. S. C. & Pang, C. P., May 2009, In: Eye. 23, 5, p. 1213-1220 8 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
A novel γD-crystallin mutation causes mild changes in protein properties but leads to congenital coralliform cataract
Zhang, L. Y., Gong, B., Tong, J. P., Fan, D. S. P., Chiang, S. W. Y., Lou, D., Lam, D. S. C., Yam, G. H. F. & Pang, C. P., Aug 6 2009, In: Molecular vision. 15, p. 1521-1529 9 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
An αA-crystallin gene mutation, Arg12Cys, causing inherited cataract-microcornea exhibits an altered heat-shock response
Zhang, L. Y., Yam, G. H. F., Tam, P. O. S., Lai, R. Y. K., Lam, D. S. C., Pang, C. P. & Fan, D. S. P., 2009, In: Molecular vision. 15, p. 1127-1138 12 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R alphaA-crystallin.
Gong, B., Zhang, L. Y., Pang, C. P., Lam, D. S. C. & Yam, G. H. F., 2009, In: Molecular vision. 15, p. 2829-2840 12 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
2007
A novel deletion variant of γD-crystallin responsible for congenital nuclear cataract
Zhang, L. Y., Yam, G. H. F., Fan, D. S. P., Tam, P. O. S., Lam, D. S. C. & Pang, C. P., Nov 7 2007, In: Molecular vision. 13, p. 2096-2104 9 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2006
The effect of recombinant human growth hormone on rabbit corneal ulcer rehabilitation
Dai, H. L., Zou, L. H., Zhao, M. & Zhang, L. Y., Jan 25 2006, In: Ophthalmology in China. 15, 1, p. 59-62 4 p.Research output: Contribution to journal › Article › peer-review
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2005
Study on enhanced leukocyte antigen-related tyrosine phosphatase in keratoconus
Zhang, L. Y. & Zou, L. H., Mar 2005, In: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 41, 3, p. 234-238 5 p.Research output: Contribution to journal › Article › peer-review