Lisa Kratz

Director.Asst Professor

1986 …2018
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Research Output 1986 2018

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2018

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Wei, S., Wang, J., Oyinlade, O., Ma, D., Wang, S., Kratz, L., Lal, B., Xu, Q., Liu, S., Shah, S. R., Zhang, H., Li, Y., Quiñones-Hinojosa, A., Zhu, H., Huang, Z. Y., Cheng, L., Qian, J. & Xia, S. May 30 2018 (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Down-Regulation
Growth
Proteins
Mutation
2017

A placebo-controlled trial of simvastatin therapy in Smith-Lemli-Opitz syndrome

Wassif, C. A., Kratz, L., Sparks, S. E., Wheeler, C., Bianconi, S., Gropman, A., Calis, K. A., Kelley, R. I., Tierney, E. & Porter, F. D. Mar 1 2017 In : Genetics in Medicine. 19, 3, p. 297-305 9 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Simvastatin
Placebos
Dehydrocholesterols
Sterols

Randomized open-label trial of dextromethorphan in Rett syndrome

Smith-Hicks, C. L., Gupta, S., Ewen, J. B., Hong, M., Kratz, L., Kelley, R., Tierney, E., Vaurio, R., Bibat, G., Sanyal, A., Yenokyan, G., Brereton, N., Johnston, M. V. & Naidu, S. Oct 17 2017 In : Neurology. 89, 16, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Dextromethorphan
Rett Syndrome
Seizures
Checklist
Electroencephalography
2016

Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes

Edmunds, L. R. , Otero, P. A. , Sharma, L. , D'Souza, S. , Dolezal, J. M. , David, S. , Lu, J. , Lamm, L. , Basantani, M. , Zhang, P. , Sipula, I. J. , Li, L. , Zeng, X. , Ding, Y. , Ding, F. , Beck, M. E. , Vockley, J. , Monga, S. P. S. , Kershaw, E. E. , O'Doherty, R. M. & 6 others Kratz, L. E., Yates, N. A., Goetzman, E. P., Scott, D., Duncan, A. W. & Prochownik, E. V. May 24 2016 In : Oncotarget. 7, 21, p. 30379-30395 17 p.

Research output: Contribution to journalArticle

Hepatocytes
Lipids
Cytochrome P-450 Enzyme System
Liver
Tyrosinemias

Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain

Driver, A. M., Kratz, L. E., Kelley, R. I. & Stottmann, R. W. Jul 1 2016 In : Neurobiology of Disease. 91, p. 69-82 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Prosencephalon
Cholesterol
17-Hydroxysteroid Dehydrogenases
Embryonic Structures
2015

Adult presentation of X-linked Conradi-Hünermann-Happle syndrome

Posey, J. E., Burrage, L. C., Campeau, P. M., Lu, J. T., Eble, T. N., Kratz, L., Schlesinger, A. E., Gibbs, R. A., Lee, B. H. & Nagamani, S. C. S. Jun 1 2015 In : American Journal of Medical Genetics, Part A. 167, 6, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

Chondrodysplasia Punctata
Cataract
Exome
Congenital Ichthyosiform Erythroderma
Extremities

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

Gabitova, L., Restifo, D., Gorin, A., Manocha, K., Handorf, E., Yang, D. H., Cai, K. Q., Klein-Szanto, A. J., Cunningham, D., Kratz, L. E., Herman, G. E., Golemis, E. A. & Astsaturov, I. Sep 22 2015 In : Cell Reports. 12, 11, p. 1927-1938 12 p.

Research output: Contribution to journalArticle

Sterols
Metabolites
Epidermal Growth Factor Receptor
Liver
Tumors
2014

Decreased cerebral spinal fluid neurotransmitter levels in Smith-Lemli-Opitz syndrome

Sparks, S. E., Wassif, C. A., Goodwin, H., Conley, S. K., Lanham, D. C., Kratz, L. E., Hyland, K., Gropman, A., Tierney, E. & Porter, F. D. 2014 In : Journal of Inherited Metabolic Disease. 37, 3, p. 415-420 6 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Neurotransmitter Agents
Homovanillic Acid
Hydroxyindoleacetic Acid
Sterols

Desmosterolosis: An illustration of diagnostic ambiguity of cholesterol synthesis disorders

Dias, C., Rupps, R., Millar, B., Choi, K., Marra, M., Demos, M., Kratz, L. E. & Boerkoel, C. F. Jun 25 2014 In : Orphanet Journal of Rare Diseases. 9, 1, 94

Research output: Contribution to journalArticle

Cholesterol
Agenesis of Corpus Callosum
Failure to Thrive
Mutation
Atrophy
2013

A Liver-Specific Defect of Acyl-CoA Degradation Produces Hyperammonemia, Hypoglycemia and a Distinct Hepatic Acyl-CoA Pattern

Gauthier, N., Wu, J. W., Wang, S. P., Allard, P., Mamer, O. A., Sweetman, L., Moser, A. B., Kratz, L., Alvarez, F., Robitaille, Y., Lépine, F. & Mitchell, G. A. Jul 5 2013 In : PLoS One. 8, 7, e60581

Research output: Contribution to journalArticle

acyl coenzyme A
Hyperammonemia
Acyl Coenzyme A
hypoglycemia
Hypoglycemia

Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation

Sukhanova, A. , Gorin, A. , Serebriiskii, I. G. , Gabitova, L. , Zheng, H. , Restifo, D. , Egleston, B. L. , Cunningham, D. , Bagnyukova, T. , Liu, H. , Nikonova, A. , Adams, G. P. , Zhou, Y. , Yang, D. H. , Mehra, R. , Burtness, B. , Cai, K. Q. , Klein-Szanto, A. , Kratz, L. E. , Kelley, R. I. & 4 others Weiner, L. M., Herman, G. E., Golemis, E. A. & Astsaturov, I. Jan 2013 In : Cancer Discovery. 3, 1, p. 96-112 17 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Cholesterol
Genes
NADP
Neoplasms
2012
Adrenoleukodystrophy
Lysophosphatidylcholines
Carnitine
Choline
Screening

Disorders of sterol synthesis: Beyond Smith-Lemli-Opitz syndrome

Herman, G. E. & Kratz, L. Nov 15 2012 In : American Journal of Medical Genetics, Part A. 160 C, 4, p. 301-321 21 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Sterols
Cholesterol
Lanosterol
Enzymes

Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner

Clark, P. J., Thompson, A. J., Vock, D. M., Kratz, L. E., Tolun, A. A., Muir, A. J., Mchutchison, J. G., Subramanian, M., Millington, D. M., Kelley, R. I. & Patel, K. Jul 2012 In : Hepatology. 56, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Hepacivirus
Cholesterol
Genotype
Lanosterol
Sterols
2011

Cholesterol metabolism is required for intracellular Hedgehog signal transduction in vivo

Stottmann, R. W., Turbe-Doan, A., Tran, P., Kratz, L. E., Moran, J. L., Kelley, R. I. & Beier, D. R. Sep 2011 In : PLoS Genetics. 7, 9, e1002224

Research output: Contribution to journalArticle

cholesterol metabolism
Hedgehogs
Erinaceidae
signal transduction
Signal Transduction

Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature

Schaaf, C. P., Koster, J., Katsonis, P., Kratz, L., Shchelochkov, O. A., Scaglia, F., Kelley, R. I., Lichtarge, O., Waterham, H. R. & Shinawi, M. Jul 2011 In : American Journal of Medical Genetics, Part A. 155, 7, p. 1597-1604 8 p.

Research output: Contribution to journalArticle

Desmosterol
Megalencephaly
Arthrogryposis
Mutation
Flavin-Adenine Dinucleotide

Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay

He, M., Kratz, L. E., Michel, J. J., Vallejo, A. N., Ferris, L., Kelley, R. I., Hoover, J. J., Jukic, D., Gibson, K. M., Wolfe, L. A., Ramachandran, D., Zwick, M. E. & Vockley, J. Mar 1 2011 In : Journal of Clinical Investigation. 121, 3, p. 976-984 9 p.

Research output: Contribution to journalArticle

Microcephaly
Meiosis
Dermatitis
Sterols
Mutation
2010

A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

Pei, W., Kratz, L. E., Bernardini, I., Sood, R., Yokogawa, T., Dorward, H., Ciccone, C., Kelley, R. I., Anikster, Y., Burgess, H. A., Huizing, M. & Feldman, B. Aug 1 2010 In : Development. 137, 15, p. 2587-2596 10 p.

Research output: Contribution to journalArticle

Zebrafish
Acids
Movement Disorders
Ataxia
Optic Nerve

Clinical observations, molecular genetic analysis, and treatment of sitosterolemia in infants and children

Niu, D. M., Chong, K. W., Hsu, J. H., Wu, T. J. T., Yu, H. C., Huang, C. H., Lo, M. Y., Kwok, C. F., Kratz, L. E. & Ho, L. T. Aug 2010 In : Journal of Inherited Metabolic Disease. 33, 4, p. 437-443 7 p.

Research output: Contribution to journalArticle

Molecular Biology
Phytosterols
Therapeutics
Cholesterol
Cholestyramine Resin

Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome

McLarren, K. W. , Severson, T. M. , Du Souich, C. , Stockton, D. W. , Kratz, L. E. , Cunningham, D. , Hendson, G. , Morin, R. D. , Wu, D. , Paul, J. E. , An, J. , Nelson, T. N. , Chou, A. , Debarber, A. E. , Merkens, L. S. , Michaud, J. L. , Waters, P. J. , Yin, J. , McGillivray, B. , Demos, M. & 20 others Rouleau, G. A., Grzeschik, K. H., Smith, R., Tarpey, P. S., Shears, D., Schwartz, C. E., Gecz, J., Stratton, M. R., Arbour, L., Hurlburt, J., Van Allen, M. I., Herman, G. E., Zhao, Y., Moore, R., Kelley, R. I., Jones, S. J. M., Steiner, R. D., Raymond, F. L., Marra, M. A. & Boerkoel, C. F. Dec 10 2010 In : American Journal of Human Genetics. 87, 6, p. 905-914 10 p.

Research output: Contribution to journalArticle

Alleles
Cholesterol
Temperature
Sterols
Intellectual Disability
2007

Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of Smith-Lemli-Opitz Syndrome (SLOS)

Shackleton, C. H. L., Marcos, J., Palomaki, G. E., Craig, W. Y., Kelley, R. I., Kratz, L. E. & Haddow, J. E. Sep 15 2007 In : American Journal of Medical Genetics, Part A. 143, 18, p. 2129-2136 8 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Prenatal Diagnosis
Mothers
Urine
Pregnanetriol
2006

Abnormalities of cholesterol metabolism in autism spectrum disorders

Tierney, E., Bukelis, I., Thompson, R. E., Ahmed, K., Aneja, A., Kratz, L. & Kelley, R. I. Sep 5 2006 In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 141, 6, p. 666-668 3 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Sterols
Cholesterol
Autistic Disorder
Incidence

Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy

Correa-Cerro, L. S., Wassif, C. A., Kratz, L., Miller, G. F., Munasinghe, J. P., Grinberg, A., Fliesler, S. J. & Porter, F. D. Mar 2006 In : Human Molecular Genetics. 15, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Simvastatin
Central Nervous System
Dietary Cholesterol
Sterols

Identifying Smith-Lemli-Opitz syndrome in conjunction with prenatal screening for Down syndrome

Craig, W. Y., Haddow, J. E., Palomaki, G. E., Kelley, R. I., Kratz, L. E., Shackleton, C. H. L., Marcos, J., Stephen Tint, G., MacRae, A. R., Nowaczyk, M. J., Kloza, E. M., Irons, M. B. & Roberson, M. Sep 2006 In : Prenatal Diagnosis. 26, 9, p. 842-849 8 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Down Syndrome
Prenatal Diagnosis
Pregnancy
Mothers

Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy

Barreiro, C. J., Williams, J. A., Fitton, T. P., Lange, M. S., Blue, M. E., Kratz, L., Barker, P. B., Degaonkar, M., Gott, V. L., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. May 2006 In : Annals of Thoracic Surgery. 81, 5, p. 1593-1598 6 p.

Research output: Contribution to journalArticle

Diazoxide
Nervous System Trauma
Choline
Brain Injuries
Canidae

Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery

Williams, J. A., Barreiro, C. J., Nwakanma, L. U., Lange, M. S., Kratz, L. E., Blue, M. E., Berrong, J., Patel, N. D., Gott, V. L., Troncoso, J. C., Johnston, M. V. & Baumgartner, W. A. Jun 2006 In : Annals of Thoracic Surgery. 81, 6, p. 2235-2242 8 p.

Research output: Contribution to journalArticle

Valproic Acid
Brain Injuries
Thoracic Surgery
Canidae
Dogs
2003

Clinical variability in Rett syndrome

Naidu, S., Bibat, G., Kratz, L., Kelley, R. I., Pevsner, J., Hoffman, E., Cuffari, C., Rohde, C., Blue, M. E. & Johnston, M. V. Oct 2003 In : Journal of Child Neurology. 18, 10, p. 662-668 7 p.

Research output: Contribution to journalArticle

Rett Syndrome
Mutation
Neurons
X Chromosome Inactivation
Missense Mutation

Lathosterolosis: An inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency

Krakowiak, P. A., Wassif, C. A., Kratz, L., Cozma, D., Kovářová, M., Harris, G., Grinberg, A., Yang, Y., Hunter, A. G. W., Tsokos, M., Kelley, R. I. & Porter, F. D. Jul 1 2003 In : Human Molecular Genetics. 12, 13, p. 1631-1641 11 p.

Research output: Contribution to journalArticle

Cholesterol
Micrognathism
Smith-Lemli-Opitz Syndrome
Mucolipidoses
Hedgehogs

Response of obligate heterozygotes for phytosterolemia to a low-fat diet and to a plant sterol ester dietary challenge

Kwiterovich, P. O., Chen, S. C., Virgil, D. G., Schweitzer, A., Arnold, D. R. & Kratz, L. E. Jun 2003 In : Journal of Lipid Research. 44, 6, p. 1143-1155 13 p.

Research output: Contribution to journalArticle

Phytosterols
Fat-Restricted Diet
Heterozygote
Nutrition
Esters
2002

Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia

Kelley, R. I., Kratz, L. E., Glaser, R. L., Netzloff, M. L., Wolf, L. M. & Jabs, E. W. Jun 15 2002 In : American Journal of Medical Genetics. 110, 2, p. 95-102 8 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Disorders of Sex Development
Sterols
14-alpha Demethylase Inhibitors
Sterol 14-Demethylase

Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay

Andersson, H. C., Kratz, L. & Kelley, R. Dec 15 2002 In : American Journal of Medical Genetics. 113, 4, p. 315-319 5 p.

Research output: Contribution to journalArticle

Desmosterol
Cholesterol
Sterols
Micrognathism
Oxidoreductases
2001

Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith-Lemli-Opitz syndrome

Wassif, C. A., Zhu, P., Kratz, L., Krakowiak, P. A., Battaile, K. P., Weight, F. F., Grinberg, A., Steiner, R. D., Nwokoro, N. A., Kelley, R. I., Stewart, R. R. & Porter, F. D. Mar 15 2001 In : Human Molecular Genetics. 10, 6, p. 555-564 10 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Genetic Models
Intellectual Disability
Oxidoreductases
Cholesterol

Dehydro-oestriol and dehydropregnanetriol are candidate analytes for prenatal diagnosis of Smith-Lemli-Opitz syndrome

Shackleton, C. H. L., Roitman, E., Kratz, L. & Kelley, R. 2001 In : Prenatal Diagnosis. 21, 3, p. 207-212 6 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Prenatal Diagnosis
Urine
Mothers
Serum

Lethal form of chondrodysplasia punctata with normal plasmalogen and cholesterol biosynthesis

Kumada, S., Hayashi, M., Kenmochi, J., Kurosawa, S., Shimozawa, N., Kratz, L. E., Kelley, R. I., Taki, K. & Okaniwa, M. Jan 22 2001 In : American Journal of Medical Genetics. 98, 3, p. 250-255 6 p.

Research output: Contribution to journalArticle

Rhizomelic Chondrodysplasia Punctata
Chondrodysplasia Punctata
Plasmalogens
Enchondromatosis
Fibroblasts
2000

CHILD syndrome caused by deficiency of 3β-hydroxysteroid-Δ8, Δ7- isomerase

Grange, D. K., Kratz, L. E., Braverman, N. E. & Kelley, R. I. 2000 In : American Journal of Medical Genetics. 90, 4, p. 328-335 8 p.

Research output: Contribution to journalArticle

Hydroxysteroids
Isomerases
Chondrodysplasia Punctata
Extremities
Ichthyosis

Difficult prenatal diagnosis in mild Smith-Lemli-Opitz syndrome

Nowaczyk, M. J. M., Heshka, T., Kratz, L. E. & Kelley, R. E. Dec 11 2000 In : American Journal of Medical Genetics. 95, 4, p. 396-398 3 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Prenatal Diagnosis
Fetus
Chorionic Villi
Sterols
1999

Abnormal sterol metabolism in patients with Conradi-Hunermann-Happle syndrome and sporadic lethal chondrodysplasia punctata

Kelley, R. I., Wilcox, W. G., Smith, M., Kratz, L. E., Moser, A. & Rimoin, D. S. Mar 19 1999 In : American Journal of Medical Genetics. 83, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

Chondrodysplasia Punctata
Sterols
Hydroxysteroids
Isomerases
Inborn Genetic Diseases

Equine type estrogens produced by a pregnant woman carrying a Smith- Lemli-Opitz syndrome fetus

Shackleton, C. H. L., Roitman, E., Kratz, L. E. & Kelley, R. I. 1999 In : Journal of Clinical Endocrinology and Metabolism. 84, 3, p. 1157-1159 3 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Estriol
Horses
Pregnant Women
Estrogens
Chondrodysplasia Punctata
Medical Genetics
Sterols

Midgestational maternal urine steroid markers of fetal Smith-Lemli- Opitz (SLO) syndrome (7-dehydrocholesterol 7-reductase deficiency)

Shackleton, C. H. L., Roitman, E., Kratz, L. E. & Kelley, R. I. Jul 1999 In : Steroids. 64, 7, p. 446-452 7 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Oxidoreductases
Steroids
Mothers
Urine

Mutations in the gene encoding 3β-hydroxysteroid-Δ8,Δ7-isomerase cause X-linked dominant Conradi-Hunermann syndrome

Braverman, N., Lin, P., Moebius, F. F., Obie, C., Moser, A., Glossmann, H., Wilcox, W. R., Rimoin, D. L., Smith, M., Kratz, L., Kelley, R. I. & Valle, D. Jul 1999 In : Nature Genetics. 22, 3, p. 291-294 4 p.

Research output: Contribution to journalArticle

Chondrodysplasia Punctata
Hydroxysteroids
Isomerases
Sterols
Mutation

Prenatal diagnosis of the RSH/Smith-Lemli-Opitz syndrome

Kratz, L. E. & Kelley, R. I. Feb 19 1999 In : American Journal of Medical Genetics. 82, 5, p. 376-381 6 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Prenatal Diagnosis
Mothers
Amniotic Fluid
Chorionic Villi
1997

Clinical and biochemical spectrum of patients with RSH/Smith-Lemli- Opitz syndrome and abnormal cholesterol metabolism

Cunniff, C., Kratz, L. E., Moser, A., Natowicz, M. R. & Kelley, R. I. 1997 In : American Journal of Medical Genetics. 68, 3, p. 263-269 7 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Cholesterol
Syndactyly
Toes
Holoprosencephaly
1995

3-methylglutaconic acidemia in smith-lemli-opitz syndrome

Kelley, R. I. & Kratz, L. 1995 In : Pediatric Research. 37, 5, p. 671-674 4 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Terpenes
Sterols
Mevalonic Acid
Leucine

Cloning of glutaryl-coa dehydrogenase cDNA, and expression of wild type and mutant enzymes in Escherichia coli

I.goodman, S., Kratz, L. E., Digiulio, K. A., Biery, B. J., Goodman, K. E., Isaya, G. & Frerman, F. E. Sep 1995 In : Human Molecular Genetics. 4, 9, p. 1493-1498 6 p.

Research output: Contribution to journalArticle

Glutaryl-CoA Dehydrogenase
Cloning
CDNA
Mutant
Escherichia coli
1993

Short-term response to dietary therapy in molybdenum cofactor deficiency

Boles, R. G., Ment, L. R., Meyn, M. S., Horwich, A. L., Kratz, L. E. & Rinaldo, P. Nov 1993 In : Annals of Neurology. 34, 5, p. 742-744 3 p.

Research output: Contribution to journalArticle

Sulfites
Microcephaly
Lactic Acidosis
Methionine
Cysteine
1992

Pork and human cDNAs encoding glutaryl-CoA dehydrogenase.

Goodman, S. I., Kratz, L. E. & Frerman, F. E. 1992 In : Progress in Clinical and Biological Research. 375, p. 169-173 5 p.

Research output: Contribution to journalArticle

Glutaryl-CoA Dehydrogenase
Molecular Sequence Data
Genetic Code
Amino Acid Sequence Homology
Structure-Activity Relationship
1991

1,3-Dialkyltriazenes: Reactive intermediates and DNA alkylation

Kroeger-Koepke, M. B., Smith, R. H., Goodnow, E. A., Brashears, J., Kratz, L., Andrews, A. W., Alvord, W. G. & Michejda, C. J. 1991 In : Chemical Research in Toxicology. 4, 3, p. 334-340 7 p.

Research output: Contribution to journalArticle

Alkylation
Ionic strength
Osmolar Concentration
Triazenes
DNA
1990

Association of scleroderma with a T cell antigen receptor γ gene restriction fragment length polymorphism

Kratz, L. E., Boughman, J. A., Pincus, T., Cohen, D. I. & Needleman, B. W. Apr 1990 In : Arthritis and Rheumatism. 33, 4, p. 569-573 5 p.

Research output: Contribution to journalArticle

T-Cell Receptor gamma Genes
T-Cell Receptor alpha Genes
T-Cell Antigen Receptor
T-Cell Receptor beta Genes
Restriction Fragment Length Polymorphisms