Lirong Shao

Research output

Research output per year 2004 2004 2005 2018 2019 2020 2021 2022 2023 2023

• 20 Article
• 4 Review article
• 1 Chapter
• 1 Letter

Research output per year

Research output per year

Search results

• 2023

  Antiseizure effect of 2-deoxyglucose is not dependent on the presynaptic vacuole ATP pump or the somatic ATP-sensitive K1 channel

  Shao, L. R., Janicot, R. & Stafstrom, C. E., Jun 2023, In: Journal of neurophysiology. 129, 6, p. 1423-1433 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Deoxyglucose 100%
  • Vacuoles 91%
  • Adenosine Triphosphate 67%
  • Glycolysis 45%
  • Adenosine Triphosphatases 34%

• Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21

  Shao, L. R., Gao, F., Chinnasamy, V., Kazuki, Y., Oshimura, M., Reeves, R. H. & Stafstrom, C. E., Aug 2023, In: Neurobiology of Disease. 184, 106198.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infantile Spasms 100%
  • Chromosomes, Human, Pair 21 97%
  • Human Chromosomes 84%
  • Down Syndrome 77%
  • Inhibitory Postsynaptic Potentials 9%
• 2022

  2-deoxyglucose and β-hydroxybutyrate fail to attenuate seizures in the betamethasone-NMDA model of infantile spasms

  Janicot, R., Shao, L. R. & Stafstrom, C. E., Mar 2022, In: Epilepsia Open. 7, 1, p. 181-186 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydroxybutyrates 100%
  • Betamethasone 85%
  • Infantile Spasms 84%
  • Deoxyglucose 73%
  • N-Methylaspartate 68%

• Enhanced burst discharges in the CA1 area of the immature versus adult hippocampus: patterns and cellular mechanisms

  Shao, L. R. & Dudek, F. E., Dec 2022, In: Journal of neurophysiology. 128, 6, p. 1566-1577 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hippocampus 100%
  • AMPA Receptors 74%
  • Excitatory Postsynaptic Potentials 72%
  • Pyramidal Cells 65%
  • Brain 46%
• 2021

  Na⁺-K⁺-ATPase functions in the developing hippocampus: Regional differences in CA1 and CA3 neuronal excitability and role in epileptiform network bursting

  Shao, L. R., Janicot, R. & Stafstrom, C. E., Jan 2021, In: Journal of neurophysiology. 125, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Strophanthidin 100%
  • sodium-translocating ATPase 91%
  • Hippocampus 66%
  • Neurons 51%
  • Excitatory Postsynaptic Potentials 27%

• Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model

  Sullivan, B. J., Kipnis, P. A., Carter, B. M., Shao, L. R. & Kadam, S. D., Nov 9 2021, In: Science signaling. 14, 708, eabg2648.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • potassium-chloride symporters 100%
  • Phenobarbital 78%
  • Refractory 64%
  • Seizures 48%
  • Ischemia 46%
• 2020

  2-Deoxyglucose terminates pilocarpine-induced status epilepticus in neonatal rats

  Janicot, R., Stafstrom, C. E. & Shao, L. R., Jul 1 2020, In: Epilepsia. 61, 7, p. 1528-1537 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pilocarpine 100%
  • Deoxyglucose 93%
  • Levetiracetam 23%
  • Electroencephalography 22%
  • Seizures 20%
  2 Scopus citations

• Infantile spasms: An update on pre-clinical models and eeg mechanisms

  Janicot, R., Shao, L. R. & Stafstrom, C. E., Jan 2020, In: Children. 7, 1, 5.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Infantile Spasms 100%
  • Brain Diseases 11%
  • Electroencephalography 10%
  • Epilepsy 10%
  • Animal Models 8%

• The efficacy of fructose-1,6-bisphosphate in suppressing status epilepticus in developing rats

  Janicot, R., Stafstrom, C. E. & Shao, L. R., Dec 2020, In: Epilepsy Research. 168, 106500.

  Research output: Contribution to journal › Article › peer-review

  • fructose-1,6-diphosphate 100%
  • Seizures 37%
  • Pilocarpine 24%
  • Anticonvulsants 18%
  • Electroencephalography 16%
• 2019

  2-deoxyglucose and beta-hydroxybutyrate: Metabolic agents for seizure control

  Rho, J. M., Shao, L. R. & Stafstrom, C. E., Apr 12 2019, In: Frontiers in Cellular Neuroscience. 13, 172.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • 3-Hydroxybutyric Acid 100%
  • Deoxyglucose 88%
  • Seizures 59%
  • Ketogenic Diet 53%
  • Glycemic Index 51%
  12 Scopus citations

• Pediatric epilepsy mechanisms: Expanding the paradigm of excitation/inhibition imbalance

  Shao, L. R., Habela, C. W. & Stafstrom, C. E., Feb 2019, In: Children. 6, 2, 23.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Epilepsy 100%
  • Seizures 92%
  • Pediatrics 76%
  • Ion Channels 29%
  • Neurotransmitter Agents 25%
• 2018

  Glycolytic inhibition: A novel approach toward controlling neuronal excitability and seizures

  Shao, L. R., Rho, J. M. & Stafstrom, C. E., Dec 2018, In: Epilepsia Open. 3, S2, p. 191-197 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Seizures 100%
  • Glucose 65%
  • Glycolysis 54%
  • High-Protein Low-Carbohydrate Diets 42%
  • Ketogenic Diet 36%
  7 Scopus citations

• The glycolytic metabolite, fructose-1,6-bisphosphate, blocks epileptiform bursts by attenuating voltage-activated calcium currents in hippocampal slices

  Shao, L. R., Wang, G. & Stafstrom, C. E., Jun 15 2018, In: Frontiers in Cellular Neuroscience. 12, 168.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fructose-1,6-diphosphate 100%
  • Calcium 46%
  • Pentose Phosphate Pathway 25%
  • Seizures 22%
  • Glycolysis 20%
  7 Scopus citations
• 2017

  Glycolytic inhibition by 2-deoxy-D-glucose abolishes both neuronal and network bursts in an in vitro seizure model

  Shao, L. R. & Stafstrom, C. E., 2017, In: Journal of neurophysiology. 118, 1, p. 103-113 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deoxyglucose 100%
  • Seizures 67%
  • In Vitro Techniques 37%
  • Neurons 31%
  • Baths 17%
  15 Scopus citations
• 2016

  Pediatric Epileptic Encephalopathies: Pathophysiology and Animal Models

  Shao, L. R. & Stafstrom, C. E., May 1 2016, In: Seminars in Pediatric Neurology. 23, 2, p. 98-107 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Brain Diseases 100%
  • Epileptic Syndromes 89%
  • Animal Models 75%
  • Pediatrics 67%
  • Lennox Gastaut Syndrome 52%
  11 Scopus citations
• 2013

  Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition

  He, S., Shao, L. R., Wang, Y. & Bausch, S. B., 2013, In: Journal of neurophysiology. 109, 6, p. 1535-1547 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ro 25-6981 100%
  • N-Methyl-D-Aspartate Receptors 65%
  • Neuronal Plasticity 62%
  • Acids 43%
  • 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione 31%
  9 Scopus citations
• 2012

  Increased Kv1 channel expression may contribute to decreased sipsc frequency following chronic inhibition of NR2B-containing NMDAR

  He, S., Shao, L. R., Rittase, W. B. & Bausch, S. B., May 2012, In: Neuropsychopharmacology. 37, 6, p. 1338-1356 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • NR2B NMDA receptor 100%
  • Inhibitory Postsynaptic Potentials 83%
  • Ro 25-6981 76%
  • Interneurons 46%
  • 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione 42%
  5 Scopus citations
• 2011

  Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy

  Shao, L. R. & Dudek, F. E., Feb 2011, In: Journal of neurophysiology. 105, 2, p. 522-527 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Perforant Pathway 100%
  • Kainic Acid 83%
  • Dentate Gyrus 78%
  • Epilepsy 60%
  • Excitatory Postsynaptic Potentials 41%
  12 Scopus citations
• 2010

  Possible roles of nonsynaptic mechanisms in synchronization of epileptic seizures: Potential antiepileptic targets?

  Edward Dudek, F., Shao, L. R. & Rash, J. E., Jan 1 2010, Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC Press, p. 209-228 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Anticonvulsants 100%
  • Seizures 82%
  • Gap Junctions 48%
  • Extracellular Space 47%
  • Aminobutyrates 31%
  3 Scopus citations
• 2009

  Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats

  Shao, L. R. & Dudek, F. E., Dec 2009, In: Journal of Physiology. 587, 24, p. 5907-5923 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyramidal Cells 100%
  • Population 44%
  • FG 9041 30%
  • GABA-A Receptor Antagonists 25%
  • AMPA Receptors 22%
  14 Scopus citations
• 2006

  Changes in mIPSCs and sIPSCs after kainate treatment: Status epilepticus-induced neuronal loss or direct activation of kainate receptors? [3]

  Shao, L. R. & Dudek, F. E., 2006, In: Journal of neurophysiology. 96, 2, p. 961-962 2 p.

  Research output: Contribution to journal › Letter › peer-review
  2 Scopus citations
• 2005

  Changes in mIPSCs and sIPSCs after kainate treatment: Evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses

  Shao, L. R. & Dudek, F. E., Aug 2005, In: Journal of neurophysiology. 94, 2, p. 952-960 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Kainic Acid 100%
  • Interneurons 39%
  • FG 9041 19%
  • 2-Amino-5-phosphonovalerate 17%
  • Inhibitory Postsynaptic Potentials 15%
  66 Scopus citations

• Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate

  Shao, L. R. & Dudek, F. E., Jul 2005, In: Epilepsia. 46, SUPPL. 5, p. 100-106 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Photolysis 100%
  • Kainic Acid 65%
  • Glutamic Acid 61%
  • Hippocampus 56%
  • Epilepsy 47%
  12 Scopus citations

• Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum

  Shao, L. R. & Dudek, F. E., May 2005, In: Journal of neurophysiology. 93, 5, p. 3007-3011 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Photolysis 100%
  • Pyramidal Cells 74%
  • Glutamic Acid 61%
  • Hippocampus 56%
  • Neurons 21%
  17 Scopus citations
• 2004

  Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy

  Shao, L. R. & Dudek, F. E., Sep 2004, In: Journal of neurophysiology. 92, 3, p. 1366-1373 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kainic Acid 100%
  • Pyramidal Cells 90%
  • Epilepsy 72%
  • Photolysis 30%
  • Glutamic Acid 28%
  43 Scopus citations

• Riluzole-Sensitive Slowly Inactivating Sodium Current in Rat Suprachiasmatic Nucleus Neurons

  Kononenko, N. I., Shao, L. R. & Dudek, F. E., Feb 2004, In: Journal of neurophysiology. 91, 2, p. 710-718 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Suprachiasmatic Nucleus Neurons 100%
  • Riluzole 98%
  • Sodium 55%
  • Neurons 40%
  • Architectural Accessibility 13%
  56 Scopus citations