Research Output 1989 2017

Filter
Article
2017

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

Yuan, X., Li, Z., Baines, A. C., Gavriilaki, E., Ye, Z., Wen, Z., Braunstein, E. M., Biesecker, L. G., Cheng, L., Dong, X. & Brodsky, R. A. Apr 1 2017 In : PLoS ONE. 12, 4, e0174074

Research output: Contribution to journalArticle

complement
mutation
Glycosylphosphatidylinositols
Neurons
Mutation

Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene

Liu, S., Ye, Z., Gao, Y., He, C., Williams, D. W., Moliterno, A., Spivak, J., Huang, H. & Cheng, L. Jan 1 2017 In : Stem Cell Research. 18, p. 57-59 3 p.

Research output: Contribution to journalArticle

Essential Thrombocythemia
Induced Pluripotent Stem Cells
Mutation
Genes
Thrombopoietin Receptors
megakaryocytes
Induced Pluripotent Stem Cells
Megakaryocytes
Status Epilepticus
induced pluripotent stem cells
2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E. M., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C. D., Valle, D., Brodsky, R. A. & Cheng, L. Jul 15 2016 In : Leukemia.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute

A method for genome editing in human pluripotent stem cells

Smith, C., Ye, Z. & Cheng, L. Apr 1 2016 In : Cold Spring Harbor Protocols. 2016, 4, p. 385-390 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Genome
Status Epilepticus
Cyclic AMP Receptor Protein
Regenerative Medicine

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z. May 1 2016 In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Hemangioblasts
Pluripotent Stem Cells
Hematopoietic Stem Cells
Clemastine
Status Epilepticus

Erratum to: Questions about NgAgo

Burgess, S., Cheng, L., Gu, F., Huang, J., Huang, Z., Lin, S., Li, J., Li, W., Qin, W., Sun, Y., Songyang, Z., Wei, W., Wu, Q., Wang, H., Wang, X., Xiong, J. W., Xi, J., Yang, H., Zhou, B. & Zhang, B. Dec 2 2016 In : Protein and Cell. p. 1 1 p.

Research output: Contribution to journalArticle

Genome editing in human pluripotent stem cells

Smith, C., Ye, Z. & Cheng, L. Apr 1 2016 In : Cold Spring Harbor Protocols. 2016, 4, p. 316-319 4 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Genome
Status Epilepticus
Cyclic AMP Receptor Protein
DNA

Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T)

Bhatt, N., Ghosh, R., Roy, S., Gao, Y., Armanios, M., Cheng, L. & Franco, S. Sep 1 2016 In : Stem Cell Research. 17, 2, p. 205-207 3 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Ataxia Telangiectasia
Erythroblasts
Mutation
In Vitro Techniques

Questions about NgAgo

Burgess, S., Cheng, L., Gu, F., Huang, J., Huang, Z., Lin, S., Li, J., Li, W., Qin, W., Sun, Y., Songyang, Z., Wei, W., Wu, Q., Wang, H., Wang, X., Xiong, J. W., Xi, J., Yang, H., Zhou, B. & Zhang, B. Nov 15 2016 In : Protein and Cell. p. 1-3 3 p.

Research output: Contribution to journalArticle

Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells

Bhatt, N., Ghosh, R., Roy, S., Gao, Y., Armanios, M., Cheng, L. & Franco, S. Sep 1 2016 In : Stem Cell Research. 17, 2, p. 296-305 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Ataxia Telangiectasia
Haploinsufficiency
Teratoma
Telomere
2015

A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: A clinically compliant approach

Chou, B. K. , Chou, B. K. , Gu, H. , Gu, H. , Gu, H. , Gao, Y. , Gao, Y. , Dowey, S. N. , Dowey, S. N. , Wang, Y. , Wang, Y. , Shi, J. , Shi, J. , Li, Y. , Li, Y. , Li, Y. , Ye, Z. , Ye, Z. , Cheng, T. , Cheng, T. & 3 others Cheng, L., Cheng, L. & Cheng, L. 2015 In : Stem cells translational medicine. 4, 4, p. 320-332 13 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Blood Cells
Paroxysmal Hemoglobinuria
Feeder Cells
Vitronectin

Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors

All, A. H., Gharibani, P., Gupta, S., Bazley, F. A., Pashai, N., Chou, B. K., Shah, S., Resar, L. M., Cheng, L., Gearhart, J. D. & Kerr, C. L. Jan 30 2015 In : PLoS One. 10, 1, e0116933

Research output: Contribution to journalArticle

spinal cord
stems
Induced Pluripotent Stem Cells
Oligodendroglia
Spinal Cord Injuries

Efficient and allele-specific genome editing of disease loci in human iPSCs

Smith, C., Abalde-Atristain, L., He, C., Brodsky, B. R., Braunstein, E. M., Chaudhari, P., Jang, Y. Y., Cheng, L. & Ye, Z. Mar 5 2015 In : Molecular Therapy. 23, 3, p. 570-577 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Alleles
Genome
Clustered Regularly Interspaced Short Palindromic Repeats
Point Mutation

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents

Liu, Y., Wang, Y., Wang, Y., Wang, Y., Gao, Y., Gao, Y., Forbes, J. A., Qayyum, R., Becker, L., Cheng, L., Cheng, L., Wang, Z. Z. & Wang, Z. Z. 2015 In : Stem cells translational medicine. 4, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Megakaryocytes
United States Food and Drug Administration
Pharmacology
Blood Platelets

Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient ipscs after genome editing of the sickle point mutation

Huang, X., Wang, Y., Yan, W., Smith, C., Ye, Z., Wang, J., Gao, Y., Mendelsohn, L. & Cheng, L. May 1 2015 In : Stem Cells. 33, 5, p. 1470-1479 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
beta-Globins
Point Mutation
Erythrocytes
Genome
2014

A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells

Huang, K., Shen, Y., Xue, Z., Bibikova, M., April, C., Liu, Z., Cheng, L., Nagy, A., Pellegrini, M., Fan, J. B. & Fan, G. Jan 14 2014 In : Stem Cell Reports. 2, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Embryonic Stem Cells
Methylation
Status Epilepticus
Aortic Arch Syndromes

Concise review: Stem cell-based approaches to red blood cell production for transfusion

Shah, S., Huang, X. & Cheng, L. 2014 In : Stem cells translational medicine. 3, 3, p. 346-355 10 p.

Research output: Contribution to journalArticle

Erythrocyte Transfusion
Stem Cells
Erythrocytes
Blood Platelets
Blood Component Transfusion

Differential sensitivity to jak inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells

Ye, Z., Liu, C. F., Lanikova, L., Dowey, S. N., He, C., Huang, X., Brodsky, R. A., Spivak, J. L., Prchal, J. T. & Cheng, L. Jan 2014 In : Stem Cells. 32, 1, p. 269-278 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Erythroblasts
Cell Line
Polycythemia Vera
Erythropoiesis

Early frameshift mutation in PIGA identified in a large XLID family without neonatal lethality

Belet, S., Fieremans, N., Yuan, X., Van Esch, H., Verbeeck, J., Ye, Z., Cheng, L., Brodsky, B. R., Hu, H., Kalscheuer, V. M., Brodsky, R. A. & Froyen, G. 2014 In : Human Mutation. 35, 3, p. 350-355 6 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Frameshift Mutation
Proteins
Muscle Hypotonia
Seizures

Efficient and scalable expansion of human pluripotent stem cells under clinically compliant settings: A view in 2013

Wang, Y., Cheng, L. & Gerecht, S. 2014 In : Annals of Biomedical Engineering. 42, 7, p. 1357-1372 16 p.

Research output: Contribution to journalArticle

Stem cells
Pluripotent Stem Cells
Cell culture
Substrates
Regenerative Medicine

Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors

Huang, X., Shah, S., Wang, J., Ye, Z., Dowey, S. N., Tsang, K. M., Mendelsohn, L. G., Kato, G. J., Kickler, T. S. & Cheng, L. Feb 2014 In : Molecular Therapy. 22, 2, p. 451-463 13 p.

Research output: Contribution to journalArticle

Erythroblasts
Fetal Blood
Blood Cells
Hemoglobins
Erythrocytes

Human induced pluripotent stem cell-derived mesenchymal stem cell seeding on calcium phosphate scaffold for bone regeneration

Tang, M., Chen, W., Liu, J., Weir, M. D., Cheng, L. & Xu, H. H. K. Apr 1 2014 In : Tissue Engineering - Part A. 20, 7-8, p. 1295-1305 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Bone Regeneration
Mesenchymal Stromal Cells
Phosphates
Calcium

Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis

Yu, Y., Liang, D., Tian, Q., Chen, X., Jiang, B., Chou, B. K., Hu, P., Cheng, L., Gao, P., Li, J. & Wang, G. Feb 2014 In : Stem Cells. 32, 2, p. 349-363 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cellular Reprogramming
Neoplasms
Forkhead Transcription Factors
1-Phosphatidylinositol 4-Kinase

Synaptic dysregulation in a human iPS cell model of mental disorders

Wen, Z. , Nguyen, H. N. , Guo, Z. , Lalli, M. A. , Wang, X. , Su, Y. , Kim, N. S. , Yoon, K. J. , Shin, J. , Zhang, C. , Makri, G. , Nauen, D. , Yu, H. , Guzman, E. , Chiang, C. H. , Yoritomo, N. , Kaibuchi, K. , Zou, J. , Christian, K. M. , Cheng, L. & 6 others Ross, C. A., Margolis, R. L., Chen, G., Kosik, K. S., Song, H. & Ming, G. L. Nov 20 2014 In : Nature. 515, 7527, p. 414-418 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Mental Disorders
Psychiatry
Schizophrenia
Neurons

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects

Connelly, J. P., Kwon, E. M., Gao, Y., Trivedi, N. S., Elkahloun, A. G., Horwitz, M. S., Cheng, L. & Liu, P. P. Sep 18 2014 In : Blood. 124, 12, p. 1926-1930 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Mutation
Status Epilepticus
Peptidyl Transferases
Acute Myeloid Leukemia

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

Smith, C., Gore, A., Yan, W., Abalde-Atristain, L., Li, Z., He, C., Wang, Y., Brodsky, R. A., Zhang, K., Cheng, L. & Ye, Z. Jul 3 2014 In : Cell Stem Cell. 15, 1, p. 12-13 2 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Genome

Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells

Cai, J., Miao, X., Li, Y., Smith, C., Tsang, K., Cheng, L. & Wang, Q. F. Aug 12 2014 In : Stem Cell Reports. 3, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Genome
Status Epilepticus
Nucleotides
Cyclic AMP Receptor Protein
2013

And then there were none: No need for pluripotency factors to induce reprogramming

Chou, B. K. & Cheng, L. Sep 5 2013 In : Cell Stem Cell. 13, 3, p. 261-262 2 p.

Research output: Contribution to journalArticle

Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing

Yan, W., Smith, C. & Cheng, L. 2013 In : Scientific Reports. 3, 2376

Research output: Contribution to journalArticle

Zinc Fingers
Genome
Gene Targeting
Plant Genome
Induced Pluripotent Stem Cells

Generation and homing of iPSC-derived hematopoietic cells in vivo

Chou, B. K., Ye, Z. & Cheng, L. Jul 2013 In : Molecular Therapy. 21, 7, p. 1292-1293 2 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Glycosylphosphatidylinositols
Blood Cells
Proteins
Mutation

Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells.

Ran, D., Lam, K., Shia, W. J., Lo, M. C., Fan, J. B., Knorr, D. A., Ferrell, P. I., Ye, Z., Yan, M., Cheng, L., Kaufman, D. S. & Zhang, D. E. Jun 27 2013 In : Blood. 121, 26, p. 5252-5253 2 p.

Research output: Contribution to journalArticle

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

Ran, D., Shia, W. J., Lo, M. C., Fan, J. B., Knorr, D. A., Ferrell, P. I., Ye, Z., Yan, M., Cheng, L., Kaufman, D. S. & Zhang, D. E. Apr 11 2013 In : Blood. 121, 15, p. 2882-2890 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Embryonic Stem Cells
Hematopoietic Stem Cells
Status Epilepticus
Embryoid Bodies

Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions

Wang, Y., Chou, B. K., Dowey, S., He, C., Gerecht, S. & Cheng, L. Nov 2013 In : Stem Cell Research. 11, 3, p. 1103-1116 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cryopreservation
Karyotype
Economics
Technology

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix

Kusuma, S., Shen, Y. I., Hanjaya-Putra, D., Mali, P., Cheng, L. & Gerecht, S. Jul 30 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. 12601-12606 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Blood Vessels
Pericytes
Microvessels
Endothelial Cells
2012

Concise review: Human cell engineering: Cellular reprogramming and genome editing

Mali, P. & Cheng, L. Jan 2012 In : Stem Cells. 30, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Cell Engineering
Human Engineering
Genome
Cellular Reprogramming
Induced Pluripotent Stem Cells

Efficient derivation and genetic modifications of human pluripotent stem cells on engineered human feeder cell lines

Zou, C., Chou, B. K., Dowey, S. N., Tsang, K., Huang, X., Liu, C. F., Smith, C., Yen, J., Mali, P., Zhang, Y. A., Cheng, L. & Ye, Z. Aug 10 2012 In : Stem Cells and Development. 21, 12, p. 2298-2311 14 p.

Research output: Contribution to journalArticle

Feeder Cells
Pluripotent Stem Cells
Medical Genetics
Cell Line
Embryonic Stem Cells

Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression

Dowey, S. N., Huang, X., Chou, B. K., Ye, Z. & Cheng, L. Nov 2012 In : Nature Protocols. 7, 11, p. 2013-2021 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Blood Cells
Plasmids
Blood
Status Epilepticus

Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression

Cheng, L., Hansen, N. F., Zhao, L., Du, Y., Zou, C., Donovan, F. X., Chou, B. K., Zhou, G., Li, S., Dowey, S. N., Ye, Z., Chandrasekharappa, S. C., Yang, H., Mullikin, J. C. & Liu, P. P. Mar 2 2012 In : Cell Stem Cell. 10, 3, p. 337-344 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Plasmids
Incidence
Cell Line
Genome

Promise and challenges of human iPSC-based hematologic disease modeling and treatment

Ye, Z., Chou, B. K. & Cheng, L. Jun 2012 In : International Journal of Hematology. 95, 6, p. 601-609 9 p.

Research output: Contribution to journalArticle

Hematologic Diseases
Hematopoietic Stem Cells
Bone Marrow
Pluripotent Stem Cells
Hematopoietic Stem Cell Transplantation

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells

Khatau, S. B., Kusuma, S., Hanjaya-Putra, D., Mali, P., Cheng, L., Lee, J. S. H., Gerecht, S. & Wirtz, D. May 4 2012 In : PLoS One. 7, 5, e36689

Research output: Contribution to journalArticle

Cytoskeleton
Actins
actin
Status Epilepticus
Embryonic Stem Cells

The phenotype of a germline mutation in PIGA: The gene somatically mutated in paroxysmal nocturnal hemoglobinuria

Johnston, J. J., Gropman, A. L., Sapp, J. C., Teer, J. K., Martin, J. M., Liu, C. F., Yuan, X., Ye, Z., Cheng, L., Brodsky, R. A. & Biesecker, L. G. Feb 10 2012 In : American Journal of Human Genetics. 90, 2, p. 295-300 6 p.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Glycosylphosphatidylinositols
Germ-Line Mutation
Phenotype
Genes
2011

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

Chou, B. K., Mali, P., Huang, X., Ye, Z., Dowey, S. N., Resar, L. M. S., Zou, C., Zhang, Y. A., Tong, J. & Cheng, L. Mar 2011 In : Cell Research. 21, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

Transcriptome
Epigenomics
Blood Cells
Plasmids
Induced Pluripotent Stem Cells

Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood

Broxmeyer, H. E., Lee, M. R., Hangoc, G., Cooper, S., Prasain, N., Kim, Y. J., Mallett, C., Ye, Z., Witting, S., Cornetta, K., Cheng, L. & Yoder, M. C. May 5 2011 In : Blood. 117, 18, p. 4773-4777 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cell Separation
Hematopoietic Stem Cells
Fetal Blood
Status Epilepticus

Molecular imaging and stem cell research

Jang, Y. Y., Ye, Z. & Cheng, L. Mar 2011 In : Molecular Imaging. 10, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Stem Cell Research
Molecular Imaging
Stem Cells
Stem cells
stem cells

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: Functional correction by zinc finger nuclease-mediated safe harbor targeting

Zou, J., Sweeney, C. L., Chou, B. K., Choi, U., Pan, J., Wang, H., Dowey, S. N., Cheng, L. & Malech, H. L. May 26 2011 In : Blood. 117, 21, p. 5561-5572 12 p.

Research output: Contribution to journalArticle

Chronic Granulomatous Disease
Induced Pluripotent Stem Cells
Zinc Fingers
Oxidoreductases
Neutrophils

Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent Stem cells

Choi, S. M., Liu, H., Chaudhari, P., Kim, Y., Cheng, L., Feng, J., Sharkis, S., Ye, Z. & Jang, Y. Y. Aug 18 2011 In : Blood. 118, 7, p. 1801-1805 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Human Herpesvirus 4
B-Lymphocytes
Cell Line
Castration

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

Zou, J., Mali, P., Huang, X., Dowey, S. N. & Cheng, L. Oct 27 2011 In : Blood. 118, 17, p. 4599-4608 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Sickle Cell Anemia
Point Mutation
Genes
Supravalvular Aortic Stenosis

Zinc fingers hit off target

Cheng, L. 2011 In : Nature Medicine. 17, 10, p. 1193 1 p.

Research output: Contribution to journalArticle

Zinc Fingers