Linzhao Cheng

Professor

1989 …2019
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Induced Pluripotent Stem Cells Medicine & Life Sciences
Stem cells Chemical Compounds
Hematopoietic Stem Cells Medicine & Life Sciences
Pluripotent Stem Cells Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Genes Medicine & Life Sciences
Mutation Medicine & Life Sciences
Transgenes Medicine & Life Sciences

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Research Output 1989 2019

Open Access
Cell Aging
Stem Cells
Phenotype
Induced Pluripotent Stem Cells
Mesenchymal Stromal Cells

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior

Linville, R. M., DeStefano, J. G., Sklar, M. B., Xu, Z., Farrell, A. M., Bogorad, M. I., Chu, C., Walczak, P., Cheng, L., Machairaki, V., Whartenby, K., Calabresi, P. & Searson, P. C., Jan 1 2019, In : Biomaterials. 190-191, p. 24-37 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Microvessels
Blood-Brain Barrier
Brain
Endothelial Cells

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model

Katt, M. E., Mayo, L. N., Ellis, S. E., Machairaki, V., Rothstein, J. D., Cheng, L. & Searson, P. C., Jul 15 2019, In : Fluids and Barriers of the CNS. 16, 1, 20.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Blood-Brain Barrier
Neurodegenerative Diseases
Mutation
Poisons

Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system

Wu, M., Liu, S., Gao, Y., Bai, H., Machairaki, V., Li, G., Chen, T. & Cheng, L., May 1 2018, In : Stem Cell Research. 29, p. 6-14 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Gene Knockout Techniques
Guide RNA
Gene Order
Transgenes

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Wei, S., Wang, J., Oyinlade, O., Ma, D., Wang, S., Kratz, L., Lal, B., Xu, Q., Liu, S., Shah, S. R., Zhang, H., Li, Y., Quiñones-Hinojosa, A., Zhu, H., Huang, Z. Y., Cheng, L., Qian, J. & Xia, S., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Down-Regulation
Growth
Proteins
Mutation