Research Output 1990 2017

Filter
Article
Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G. , Bolaños-Meade, J. , Kasamon, Y. L. , Zahurak, M. , Durakovic, N. , Furlong, T. , Mielcarek, M. , Medeot, M. , Gojo, I. , Smith, B. D. , Kanakry, J. A. , Borrello, I. M. , Brodsky, R. A. , Gladstone, D. E. , Huff, C. A. , Matsui, W. H. , Swinnen, L. J. , Cooke, K. R. , Ambinder, R. F. , Fuchs, E. J. & 6 others De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L. Mar 9 2017 In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Research - peer-reviewArticle

Immunosuppressive Agents
Cyclophosphamide
Busulfan
Immunosuppression
Grafts
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Tissue Donors
Confidence Intervals
Hematologic Neoplasms
Bone Marrow Transplantation
Cyclophosphamide
Young Adult
Transplantation

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J. , Paz, K. , Flynn, R. , Vulic, A. , Robinson, T. M. , Lineburg, K. E. , Alexander, K. A. , Meng, J. , Roy, S. , Panoskaltsis-Mortari, A. , Loschi, M. , Hill, G. R. , Serody, J. S. , Maillard, I. , Miklos, D. , Koreth, J. , Cutler, C. S. , Antin, J. H. , Ritz, J. , MacDonald, K. P. & 3 others Schacker, T. W., Luznik, L. & Blazar, B. R. May 4 2017 In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Transforming Growth Factor beta
Macrophages
Inhibition (Psychology)
pirfenidone

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

Kanakry, C. G., Bakoyannis, G., Perkins, S. M., McCurdy, S. R., Vulic, A., Warren, E. H., Daguindau, E., Olmsted, T., Mumaw, C., Towlerton, A. M. H., Cooke, K. R., O’Donnell, P. V., Symons, H. J., Paczesny, S. & Luznik, L. Apr 30 2017 In : Haematologica. 102, 5, p. 932-940 9 p.

Research output: Research - peer-reviewArticle

HLA Antigens
Bone Marrow Transplantation
Proteomics
Cyclophosphamide
Transplantation
2016

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment

Orozco, J. J., Kenoyer, A., Balkin, E. R., Gooley, T. A., Hamlin, D. K., Wilbur, D. S., Hylarides, M. D., Frost, S. H. L., Mawad, R., O'Donnell, P., Sandmaier, B. M., Fuchs, E. J., Luznik, L., Green, D. J., Gopal, A. K., Press, O. W. & Pagel, J. M. Jan 21 2016 In : Blood. 127, 3, p. 352-359 8 p.

Research output: Research - peer-reviewArticle

Radioimmunotherapy
Whole-Body Irradiation
Bone Marrow Transplantation
Transplantation
Tissue Donors

Haploidentical bone marrow and stem cell transplantation: Experience with post-transplantation cyclophosphamide

Robinson, T. M., O'Donnell, P. V., Fuchs, E. J. & Luznik, L. Apr 1 2016 In : Seminars in Hematology. 53, 2, p. 90-97 8 p.

Research output: Research - peer-reviewArticle

Stem Cell Transplantation
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Transplants

Induction of MHC-mismatched Mouse Lung Allograft Acceptance with Combined Donor Bone Marrow: Lung Transplant using a 12-Hour Nonmyeloablative Conditioning Regimen

Dodd-o, J. M., Ganguly, S., Vulic, A., Panoskaltsis-Mortari, A., McDyer, J. F. & Luznik, L. Sep 21 2016 (Accepted/In press) In : Transplantation.

Research output: Research - peer-reviewArticle

Allografts
Bone Marrow
Tissue Donors
Transplants
Lung

Might haplo "be the (better) match"?

Kanakry, J. A. & Luznik, L. Feb 18 2016 In : Blood. 127, 7, p. 799-800 2 p.

Research output: Research - peer-reviewArticle

Modern approaches to HLA-haploidentical blood or marrow transplantation

Kanakry, C. G., Fuchs, E. J. & Luznik, L. Jan 1 2016 In : Nature Reviews Clinical Oncology. 13, 1, p. 10-24 15 p.

Research output: Research - peer-reviewArticle

HLA Antigens
Bone Marrow Transplantation
Transplantation
Bone Marrow
Siblings

OCTET-CY: A phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation

Holtick, U., Chemnitz, J. M., Shimabukuro-Vornhagen, A., Theurich, S., Chakupurakal, G., Krause, A., Fiedler, A., Luznik, L., Hellmich, M., Wolf, D., Hallek, M., von Bergwelt-Baildon, M. & Scheid, C. Jan 1 2016 In : European Journal of Haematology. 96, 1, p. 27-35 9 p.

Research output: Research - peer-reviewArticle

Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Cyclophosphamide
Immunosuppression
Transplants
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Tissue Donors
Neoplasms

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

Al Malki, M. M., Horowitz, M., Handgretinger, R., Leung, W., Roy, D. C., Huang, X. J., Fuchs, E., Locatelli, F., Blaise, D., Mineishi, S., Martelli, M., Miller, J., June, C., Ai, H. S., Luznik, L., Mavilio, D., Lugli, E., van den Brink, M. R. M., Champlin, R. E. & Ciurea, S. O. Apr 1 2016 In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22, 4, p. 594-604 11 p.

Research output: Research - peer-reviewArticle

San Francisco
Stem Cell Transplantation
Transplantation
Recurrence
Therapeutics

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R. , Paz, K. , Du, J. , Reichenbach, D. K. , Taylor, P. A. , Panoskaltsis-Mortari, A. , Vulic, A. , Luznik, L. , MacDonald, K. K. P. , Hill, G. R. , Nyuydzefe, M. S. , Weiss, J. M. , Chen, W. , Trzeciak, A. , Serody, J. S. , Aguilar, E. G. , Murphy, W. J. , Maillard, I. , Munn, D. , Koreth, J. & 6 others Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R. Apr 28 2016 In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Research - peer-reviewArticle

rho-Associated Kinases
Graft vs Host Disease
Grafts
STAT3 Transcription Factor
Therapeutics
Busulfan
Drug Monitoring
Cyclophosphamide
Transplantation
Pharmacokinetics

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R. Aug 18 2016 In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Research - peer-reviewArticle

Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
Therapeutics
T-cells
2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Alternative donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Kanakry, C. G., de Lima, M. J. & Luznik, L. Jul 1 2015 In : Seminars in Hematology. 52, 3, p. 232-242 11 p.

Research output: Research - peer-reviewArticle

Cell Transplantation
HLA Antigens
Acute Myeloid Leukemia
Tissue Donors
Graft vs Host Disease

Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Ciurea, S. O. , Zhang, M. J. , Bacigalupo, A. A. , Bashey, A. , Appelbaum, F. R. , Aljitawi, O. S. , Armand, P. , Antin, J. H. , Chen, J. , Devine, S. M. , Fowler, D. H. , Luznik, L. , Nakamura, R. , O'Donnell, P. V. , Perales, M. A. , Pingali, S. R. , Porter, D. L. , Riches, M. R. , Ringdén, O. T. H. , Rocha, V. & 6 others Vij, R., Weisdorf, D. J., Champlin, R. E., Horowitz, M. M., Fuchs, E. J. & Eapen, M. Aug 20 2015 In : Blood. 126, 8, p. 1033-1040 8 p.

Research output: Research - peer-reviewArticle

Unrelated Donors
Acute Myeloid Leukemia
Cyclophosphamide
Transplants
Graft vs Host Disease
Cyclophosphamide
Transplantation
Bone Marrow
Blood
Survival
Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
Anti-Inflammatory Agents

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, R. , Allen, J. L. , Luznik, L. , MacDonald, K. P. , Paz, K. , Alexander, K. A. , Vulic, A. , Du, J. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Poe, J. C. , Serody, J. S. , Murphy, W. J. , Hill, G. R. , Maillard, I. , Koreth, J. , Cutler, C. S. , Soiffer, R. J. , Antin, J. H. , Ritz, J. & 4 others Chao, N. J., Clynes, R. A., Sarantopoulos, S. & Blazar, B. R. Jun 25 2015 In : Blood. 125, 26, p. 4085-4094 10 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
B-Lymphocytes
Syk Kinase
Grafts
Protein-Tyrosine Kinases
2014

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L. Sep 25 2014 In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Regulatory T-Lymphocytes
Cyclophosphamide
T-cells
Grafts

Experts' considerations on HLA-haploidentical stem cell transplantation

Patriarca, F., Luznik, L., Medeot, M., Zecca, M., Bacigalupo, A., Di Bartolomeo, P., Arcese, W., Corradini, P., Ciceri, F., Vago, L., Kanakry, C. G., Fleischhauer, K., Martelli, M. F., Bosi, A., Rambaldi, A., Cesaro, S., Russo, D. & Fanin, R. 2014 In : European Journal of Haematology. 93, 3, p. 187-197 11 p.

Research output: Research - peer-reviewArticle

Stem Cell Transplantation
HLA Antigens
Transplants
Tissue Donors
T-Lymphocytes

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, J. A. , Flynn, R. , Du, J. , Harrington, B. K. , Zhong, Y. , Kaffenberger, B. , Yang, C. , Towns, W. H. , Lehman, A. , Johnson, A. J. , Muthusamy, N. , Devine, S. M. , Jaglowski, S. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Luznik, L. , Hill, G. R. , Wong, H. K. , MacDonald, K. K. P. & 10 others Maillard, I., Koreth, J., Elias, L., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Panoskaltsis-Mortari, A., Byrd, J. C. & Blazar, B. R. Nov 3 2014 In : Journal of Clinical Investigation. 124, 11, p. 4867-4876 10 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Therapeutics
PCI 32765
B-Lymphocytes
T-Lymphocytes

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R. , Du, J. , Veenstra, R. G. , Reichenbach, D. K. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Freeman, G. J. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Sarantopoulos, S. , Luznik, L. , Maillard, I. , Koreth, J. , Cutler, C. , Soiffer, R. J. , Antin, J. H. , Ritz, J. , Dubovsky, J. A. , Byrd, J. C. & 3 others MacDonald, K. P., Hill, G. R. & Blazar, B. R. Jun 19 2014 In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Research - peer-reviewArticle

Bronchiolitis Obliterans
Germinal Center
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
B-Lymphocytes

Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning

Kanakry, C. G., O'Donnell, P. V., Furlong, T., De Lima, M. J., Wei, W., Medeot, M., Mielcarek, M., Champlin, R. E., Jones, R. J., Thall, P. F., Andersson, B. S. & Luznik, L. Nov 1 2014 In : Journal of Clinical Oncology. 32, 31, p. 3497-3505 9 p.

Research output: Research - peer-reviewArticle

Busulfan
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Cyclophosphamide
Graft vs Host Disease
Cyclophosphamide
Grafts
Transplantation
Bone Marrow

Sustained CD4+ T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide

Ellsworth, S., Balmanoukian, A., Kos, F., Nirschl, C. J., Nirschl, T. R., Grossman, S. A., Luznik, L. & Drake, C. G. 2014 In : OncoImmunology. 3, 1, e27357

Research output: Research - peer-reviewArticle

temozolomide
Interleukin-15
Interleukin-7
Lymphopenia
Glioma

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide

Kanakry, C. G., Ganguly, S., Zahurak, M., Bolaños-Meade, J., Thoburn, C., Perkins, B., Fuchs, E. J., Jones, R. J., Hess, A. D. & Luznik, L. Nov 13 2013 In : Science Translational Medicine. 5, 211, 211ra157

Research output: Research - peer-reviewArticle

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
T-Lymphocytes
Graft vs Host Disease

Lymphocyte Phenotype during Therapy for Acute Graft-versus-Host Disease: A Brief Report from BMT-CTN 0302

Bolaños-Meade, J., Wu, J., Logan, B. R., Levine, J. E., Ho, V. T., Alousi, A. M., Weisdorf, D. J. & Luznik, L. Mar 2013 In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19, 3, p. 481-485 5 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Lymphocytes
Phenotype
Therapeutics
trans-crotonin
HLA Antigens
Transplantation
Antibodies
Tissue Donors
Unrelated Donors

Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model

Fitzhugh, C. D., Weitzel, R. P., Hsieh, M. M., Phang, O. A., Madison, C., Luznik, L., Powell, J. D. & Tisdale, J. F. Oct 2013 In : Bone Marrow Transplantation. 48, 10, p. 1335-1341 7 p.

Research output: Research - peer-reviewArticle

Chimerism
Sirolimus
Transplants
Tissue Donors
Therapeutics
2012

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A. & Blazar, B. R. Feb 9 2012 In : Blood. 119, 6, p. 1570-1580 11 p.

Research output: Research - peer-reviewArticle

Bronchiolitis Obliterans
Isoantibodies
Germinal Center
B-Lymphocytes
Tissue Donors
Sickle Cell Anemia
Bone Marrow Transplantation
Cyclophosphamide
Tissue Donors
Bone

New treatment approaches in acute myeloid leukemia: Review of Recent Clinical Studies

Norsworthy, K., Luznik, L. & Gojo, I. 2012 In : Reviews on Recent Clinical Trials. 7, 3, p. 224-237 14 p.

Research output: Research - peer-reviewArticle

Acute Myeloid Leukemia
Therapeutics
Clinical Studies
Homologous Transplantation
Tissue Donors

Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation

Luznik, L., O'Donnell, P. V. & Fuchs, E. J. Dec 2012 In : Seminars in Oncology. 39, 6, p. 683-693 11 p.

Research output: Research - peer-reviewArticle

Transplantation Tolerance
HLA Antigens
Bone Marrow Transplantation
Cyclophosphamide
Hematopoietic Stem Cell Transplantation
2011
Azacitidine
Salvage Therapy
Homologous Transplantation
Bone Marrow Transplantation
Bone Marrow