Research Output 1990 2017

Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow

Immunomodulatory drugs: Immune checkpoint agents in acute leukemia

Knaus, H. A., Kanakry, C. G., Luznik, L. & Gojo, I. Mar 1 2017 In : Current Drug Targets. 18, 3, p. 315-331 17 p.

Research output: Contribution to journalReview article

Contraception Behavior
Leukemia
T-cells
Neoplasms
Inborn Errors Amino Acid Metabolism

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G. , Bolaños-Meade, J. , Kasamon, Y. L. , Zahurak, M. , Durakovic, N. , Furlong, T. , Mielcarek, M. , Medeot, M. , Gojo, I. , Smith, B. D. , Kanakry, J. A. , Borrello, I. M. , Brodsky, R. A. , Gladstone, D. E. , Huff, C. A. , Matsui, W. H. , Swinnen, L. J. , Cooke, K. R. , Ambinder, R. F. , Fuchs, E. J. & 6 others De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L. Mar 9 2017 In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Cyclophosphamide
Busulfan
Immunosuppression
Supravalvular Aortic Stenosis
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Confidence Intervals
Allografts
Hematologic Neoplasms
Bone Marrow Transplantation
Cyclophosphamide
Young Adult
Transplantation

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J. , Paz, K. , Flynn, R. , Vulic, A. , Robinson, T. M. , Lineburg, K. E. , Alexander, K. A. , Meng, J. , Roy, S. , Panoskaltsis-Mortari, A. , Loschi, M. , Hill, G. R. , Serody, J. S. , Maillard, I. , Miklos, D. , Koreth, J. , Cutler, C. S. , Antin, J. H. , Ritz, J. , MacDonald, K. P. & 3 others Schacker, T. W., Luznik, L. & Blazar, B. R. May 4 2017 In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Transforming Growth Factor beta
Macrophages
Supravalvular Aortic Stenosis
Grafts

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

Kanakry, C. G., Bakoyannis, G., Perkins, S. M., McCurdy, S. R., Vulic, A., Warren, E. H., Daguindau, E., Olmsted, T., Mumaw, C., Towlerton, A. M. H., Cooke, K. R., O’Donnell, P. V., Symons, H. J., Paczesny, S. & Luznik, L. Apr 30 2017 In : Haematologica. 102, 5, p. 932-940 9 p.

Research output: Contribution to journalArticle

HLA Antigens
Bone Marrow Transplantation
Proteomics
Cyclophosphamide
Transplantation

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R. & Blazar, B. R. Feb 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 2, p. 211-234 24 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Graft vs Host Disease
Advisory Committees
Clinical Trials
Cell Transplantation
2016

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment

Orozco, J. J., Kenoyer, A., Balkin, E. R., Gooley, T. A., Hamlin, D. K., Wilbur, D. S., Hylarides, M. D., Frost, S. H. L., Mawad, R., O'Donnell, P., Sandmaier, B. M., Fuchs, E. J., Luznik, L., Green, D. J., Gopal, A. K., Press, O. W. & Pagel, J. M. Jan 21 2016 In : Blood. 127, 3, p. 352-359 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Whole-Body Irradiation
Bone Marrow Transplantation
Transplantation
Bone

For Whom the Bell Tolls: Programmed Death 1 as a Marker of Post-Transplantation Mortality

Robinson, T. M. & Luznik, L. Dec 1 2016 In : Biology of Blood and Marrow Transplantation. 22, 12, p. 2115-2116 2 p.

Research output: Contribution to journalComment/debate

Haploidentical bone marrow and stem cell transplantation: Experience with post-transplantation cyclophosphamide

Robinson, T. M., O'Donnell, P. V., Fuchs, E. J. & Luznik, L. Apr 1 2016 In : Seminars in Hematology. 53, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Transplants

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Chang, Y. J., Luznik, L., Fuchs, E. J. & Huang, X. J. 2016 In : Journal of Hematology and Oncology. 9, 1, 35

Research output: Contribution to journalReview article

Stem Cell Transplantation
HLA Antigens
Transplantation
T-Lymphocytes
Antilymphocyte Serum
Allografts
Bone Marrow
Transplants
Lung
Transplantation Tolerance
HLA Antigens
Bone Marrow Transplantation
Acute Myeloid Leukemia
Cyclophosphamide
Haplotypes

Might haplo "be the (better) match"?

Kanakry, J. A. & Luznik, L. Feb 18 2016 In : Blood. 127, 7, p. 799-800 2 p.

Research output: Contribution to journalArticle

Modern approaches to HLA-haploidentical blood or marrow transplantation

Kanakry, C. G., Fuchs, E. J. & Luznik, L. Jan 1 2016 In : Nature Reviews Clinical Oncology. 13, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

HLA Antigens
Bone Marrow Transplantation
Transplantation
Bone Marrow
Siblings

OCTET-CY: A phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation

Holtick, U., Chemnitz, J. M., Shimabukuro-Vornhagen, A., Theurich, S., Chakupurakal, G., Krause, A., Fiedler, A., Luznik, L., Hellmich, M., Wolf, D., Hallek, M., von Bergwelt-Baildon, M. & Scheid, C. Jan 1 2016 In : European Journal of Haematology. 96, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Cyclophosphamide
Immunosuppression
Transplants
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Graft vs Host Disease
Homologous Transplantation

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

Al Malki, M. M., Horowitz, M., Handgretinger, R., Leung, W., Roy, D. C., Huang, X. J., Fuchs, E., Locatelli, F., Blaise, D., Mineishi, S., Martelli, M., Miller, J., June, C., Ai, H. S., Luznik, L., Mavilio, D., Lugli, E., van den Brink, M. R. M., Champlin, R. E. & Ciurea, S. O. Apr 1 2016 In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22, 4, p. 594-604 11 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Transplantation
Recurrence
Unrelated Donors
Treatment Failure

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R. , Paz, K. , Du, J. , Reichenbach, D. K. , Taylor, P. A. , Panoskaltsis-Mortari, A. , Vulic, A. , Luznik, L. , MacDonald, K. K. P. , Hill, G. R. , Nyuydzefe, M. S. , Weiss, J. M. , Chen, W. , Trzeciak, A. , Serody, J. S. , Aguilar, E. G. , Murphy, W. J. , Maillard, I. , Munn, D. , Koreth, J. & 6 others Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R. Apr 28 2016 In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Graft vs Host Disease
Grafts
Supravalvular Aortic Stenosis
Anthralin
Busulfan
Drug Monitoring
Cyclophosphamide
Transplantation
Pharmacokinetics

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R. Aug 18 2016 In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
Supravalvular Aortic Stenosis
Grafts
2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Alternative donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Kanakry, C. G., de Lima, M. J. & Luznik, L. Jul 1 2015 In : Seminars in Hematology. 52, 3, p. 232-242 11 p.

Research output: Contribution to journalArticle

Cell Transplantation
HLA Antigens
Acute Myeloid Leukemia
Graft vs Host Disease
Siblings

Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Ciurea, S. O. , Zhang, M. J. , Bacigalupo, A. A. , Bashey, A. , Appelbaum, F. R. , Aljitawi, O. S. , Armand, P. , Antin, J. H. , Chen, J. , Devine, S. M. , Fowler, D. H. , Luznik, L. , Nakamura, R. , O'Donnell, P. V. , Perales, M. A. , Pingali, S. R. , Porter, D. L. , Riches, M. R. , Ringdén, O. T. H. , Rocha, V. & 6 others Vij, R., Weisdorf, D. J., Champlin, R. E., Horowitz, M. M., Fuchs, E. J. & Eapen, M. Aug 20 2015 In : Blood. 126, 8, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

Unrelated Donors
Acute Myeloid Leukemia
Cyclophosphamide
Transplants
Iodamide
Cyclophosphamide
Transplantation
Bone Marrow
Graft vs Host Disease
Mortality
Cyclophosphamide
Transplantation
Bone Marrow
Hypopharyngeal Neoplasms
Supravalvular Aortic Stenosis
Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
Anti-Inflammatory Agents

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, R. , Allen, J. L. , Luznik, L. , MacDonald, K. P. , Paz, K. , Alexander, K. A. , Vulic, A. , Du, J. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Poe, J. C. , Serody, J. S. , Murphy, W. J. , Hill, G. R. , Maillard, I. , Koreth, J. , Cutler, C. S. , Soiffer, R. J. , Antin, J. H. , Ritz, J. & 4 others Chao, N. J., Clynes, R. A., Sarantopoulos, S. & Blazar, B. R. Jun 25 2015 In : Blood. 125, 26, p. 4085-4094 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Protein-Tyrosine Kinases
B-Lymphocytes
Spleen
Supravalvular Aortic Stenosis
2014

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L. Sep 25 2014 In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Regulatory T-Lymphocytes
Cyclophosphamide
Supravalvular Aortic Stenosis
Grafts

Experts' considerations on HLA-haploidentical stem cell transplantation

Patriarca, F., Luznik, L., Medeot, M., Zecca, M., Bacigalupo, A., Di Bartolomeo, P., Arcese, W., Corradini, P., Ciceri, F., Vago, L., Kanakry, C. G., Fleischhauer, K., Martelli, M. F., Bosi, A., Rambaldi, A., Cesaro, S., Russo, D. & Fanin, R. 2014 In : European Journal of Haematology. 93, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
HLA Antigens
Transplants
T-Lymphocytes
Hematopoietic Stem Cell Transplantation

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, J. A. , Flynn, R. , Du, J. , Harrington, B. K. , Zhong, Y. , Kaffenberger, B. , Yang, C. , Towns, W. H. , Lehman, A. , Johnson, A. J. , Muthusamy, N. , Devine, S. M. , Jaglowski, S. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Luznik, L. , Hill, G. R. , Wong, H. K. , MacDonald, K. K. P. & 10 others Maillard, I., Koreth, J., Elias, L., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Panoskaltsis-Mortari, A., Byrd, J. C. & Blazar, B. R. Nov 3 2014 In : Journal of Clinical Investigation. 124, 11, p. 4867-4876 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Lymphocytes
B-Lymphocytes
Isoantibodies
Protein-Tyrosine Kinases

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R. , Du, J. , Veenstra, R. G. , Reichenbach, D. K. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Freeman, G. J. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Sarantopoulos, S. , Luznik, L. , Maillard, I. , Koreth, J. , Cutler, C. , Soiffer, R. J. , Antin, J. H. , Ritz, J. , Dubovsky, J. A. , Byrd, J. C. & 3 others MacDonald, K. P., Hill, G. R. & Blazar, B. R. Jun 19 2014 In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Germinal Center
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
B-Lymphocytes

Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning

Kanakry, C. G., O'Donnell, P. V., Furlong, T., De Lima, M. J., Wei, W., Medeot, M., Mielcarek, M., Champlin, R. E., Jones, R. J., Thall, P. F., Andersson, B. S. & Luznik, L. Nov 1 2014 In : Journal of Clinical Oncology. 32, 31, p. 3497-3505 9 p.

Research output: Contribution to journalArticle

Busulfan
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Cyclophosphamide
Graft vs Host Disease
Cyclophosphamide
Supravalvular Aortic Stenosis
Transplantation
Bone Marrow

Sustained CD4+ T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide

Ellsworth, S., Balmanoukian, A., Kos, F., Nirschl, C. J., Nirschl, T. R., Grossman, S. A., Luznik, L. & Drake, C. G. 2014 In : OncoImmunology. 3, 1, e27357

Research output: Contribution to journalArticle

Interleukin-15
Interleukin-7
Lymphopenia
Glioma
Radiation

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide

Kanakry, C. G., Ganguly, S., Zahurak, M., Bolaños-Meade, J., Thoburn, C., Perkins, B., Fuchs, E. J., Jones, R. J., Hess, A. D. & Luznik, L. Nov 13 2013 In : Science Translational Medicine. 5, 211, 211ra157

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
T-Lymphocytes
Graft vs Host Disease
Histiocytic Sarcoma
HLA Antigens
Hematopoietic Stem Cells
Transplants

Lymphocyte Phenotype during Therapy for Acute Graft-versus-Host Disease: A Brief Report from BMT-CTN 0302

Bolaños-Meade, J., Wu, J., Logan, B. R., Levine, J. E., Ho, V. T., Alousi, A. M., Weisdorf, D. J. & Luznik, L. Mar 2013 In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19, 3, p. 481-485 5 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Lymphocytes
Phenotype
Lymphocyte Count
B-Lymphocytes
Peripheral T-Cell Lymphoma
Transplantation
Bone Marrow
Confidence Intervals
Disease-Free Survival
HLA Antigens
Transplantation
Antibodies
Unrelated Donors
Bone Marrow

Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model

Fitzhugh, C. D., Weitzel, R. P., Hsieh, M. M., Phang, O. A., Madison, C., Luznik, L., Powell, J. D. & Tisdale, J. F. Oct 2013 In : Bone Marrow Transplantation. 48, 10, p. 1335-1341 7 p.

Research output: Contribution to journalArticle

Sirolimus
Transplants
Hematologic Diseases
Sickle Cell Anemia
Vulnerable Populations
2012

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A. & Blazar, B. R. Feb 9 2012 In : Blood. 119, 6, p. 1570-1580 11 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Isoantibodies
Germinal Center
B-Lymphocytes
Lung