Research Output 1990 2018

2018

Blood and Marrow Transplant Clinical Trials Network Report on the Development of Novel Endpoints and Selection of Promising Approaches for Graft-versus-Host Disease Prevention Trials

Pasquini, M. C. , Logan, B. , Jones, R. J. , Alousi, A. M. , Appelbaum, F. R. , Bolaños-Meade, J. , Flowers, M. E. D. , Giralt, S. , Horowitz, M. M. , Jacobsohn, D. , Koreth, J. , Levine, J. E. , Luznik, L. , Maziarz, R. , Mendizabal, A. , Pavletic, S. , Perales, M. A. , Porter, D. , Reshef, R. , Weisdorf, D. & 1 others Antin, J. H. Jan 1 2018 (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow
Clinical Trials
Transplants
Recurrence
Bone Marrow Transplantation
Cyclophosphamide
Tissue Donors
Confidence Intervals
Transplants

Have haploidentical transplants replaced umbilical cord transplants for acute leukemias?

Liu, J. H., Kanakry, C. G. & Luznik, L. Mar 1 2018 In : Current Opinion in Hematology. 25, 2, p. 103-111 9 p.

Research output: Contribution to journalReview article

Umbilical Cord
Stem Cell Transplantation
Leukemia
Cord Blood Stem Cell Transplantation
Transplants

NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: Dynamics and clinical implications

Russo, A., Oliveira, G., Berglund, S., Greco, R., Gambacorta, V., Cieri, N., Toffalori, C., Zito, L., Lorentino, F., Piemontese, S., Morelli, M., Giglio, F., Assanelli, A., Stanghellini, M. T. L., Bonini, C., Peccatori, J., Ciceri, F., Luznik, L. & Vago, L. Jan 11 2018 In : Blood. 131, 2, p. 247-262 16 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Stem cells
Natural Killer Cells
Cyclophosphamide
Grafts
Tacrolimus
Graft vs Host Disease
Bone Marrow Transplantation
Transplantation
Arm
Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow
Graft vs Host Disease
Bone Marrow Transplantation
Cyclophosphamide
Disease-Free Survival
Confidence Intervals

Immunomodulatory drugs: Immune checkpoint agents in acute leukemia

Knaus, H. A., Kanakry, C. G., Luznik, L. & Gojo, I. Mar 1 2017 In : Current Drug Targets. 18, 3, p. 315-331 17 p.

Research output: Contribution to journalReview article

Tumors
Leukemia
T-cells
Pharmaceutical Preparations
Immune system

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G. , Bolaños-Meade, J. , Kasamon, Y. L. , Zahurak, M. , Durakovic, N. , Furlong, T. , Mielcarek, M. , Medeot, M. , Gojo, I. , Smith, B. D. , Kanakry, J. A. , Borrello, I. M. , Brodsky, R. A. , Gladstone, D. E. , Huff, C. A. , Matsui, W. H. , Swinnen, L. J. , Cooke, K. R. , Ambinder, R. F. , Fuchs, E. J. & 6 others De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L. Mar 9 2017 In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Busulfan
Immunosuppressive Agents
Cyclophosphamide
Immunosuppression
Grafts
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Tissue Donors
Allografts
Hematologic Neoplasms
Bone Marrow Transplantation
Cyclophosphamide
Young Adult
Transplantation

Notching up B-cell pathology in chronic GVHD

Radojcic, V. & Luznik, L. Nov 9 2017 In : Blood. 130, 19, p. 2053-2054 2 p.

Research output: Contribution to journalComment/debate

Notch Receptors
Graft vs Host Disease
Pathology
Grafts
Blood

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J. , Paz, K. , Flynn, R. , Vulic, A. , Robinson, T. M. , Lineburg, K. E. , Alexander, K. A. , Meng, J. , Roy, S. , Panoskaltsis-Mortari, A. , Loschi, M. , Hill, G. R. , Serody, J. S. , Maillard, I. , Miklos, D. , Koreth, J. , Cutler, C. S. , Antin, J. H. , Ritz, J. , MacDonald, K. P. & 3 others Schacker, T. W., Luznik, L. & Blazar, B. R. May 4 2017 In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Macrophages
Graft vs Host Disease
Infiltration
Grafts
Transforming Growth Factor beta

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

Kanakry, C. G., Bakoyannis, G., Perkins, S. M., McCurdy, S. R., Vulic, A., Warren, E. H., Daguindau, E., Olmsted, T., Mumaw, C., Towlerton, A. M. H., Cooke, K. R., O’Donnell, P. V., Symons, H. J., Paczesny, S. & Luznik, L. Apr 30 2017 In : Haematologica. 102, 5, p. 932-940 9 p.

Research output: Contribution to journalArticle

HLA Antigens
Bone Marrow Transplantation
Proteomics
Cyclophosphamide
Transplantation

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R. & Blazar, B. R. Feb 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 2, p. 211-234 24 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Graft vs Host Disease
Advisory Committees
Consensus
Clinical Trials
2016

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment

Orozco, J. J., Kenoyer, A., Balkin, E. R., Gooley, T. A., Hamlin, D. K., Wilbur, D. S., Hylarides, M. D., Frost, S. H. L., Mawad, R., O'Donnell, P., Sandmaier, B. M., Fuchs, E. J., Luznik, L., Green, D. J., Gopal, A. K., Press, O. W. & Pagel, J. M. Jan 21 2016 In : Blood. 127, 3, p. 352-359 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Whole-Body Irradiation
Bone Marrow Transplantation
Bone
Transplantation
Medical Oncology
Transplantation
Bone Marrow

For Whom the Bell Tolls: Programmed Death 1 as a Marker of Post-Transplantation Mortality

Robinson, T. M. & Luznik, L. Dec 1 2016 In : Biology of Blood and Marrow Transplantation. 22, 12, p. 2115-2116 2 p.

Research output: Contribution to journalComment/debate

Transplantation
Mortality

Haploidentical bone marrow and stem cell transplantation: Experience with post-transplantation cyclophosphamide

Robinson, T. M., O'Donnell, P. V., Fuchs, E. J. & Luznik, L. Apr 1 2016 In : Seminars in Hematology. 53, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
HLA Antigens

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Chang, Y. J., Luznik, L., Fuchs, E. J. & Huang, X. J. 2016 In : Journal of Hematology and Oncology. 9, 1, 35

Research output: Contribution to journalReview article

Stem Cell Transplantation
HLA Antigens
Transplantation
Tissue Donors
T-Lymphocytes

Induction of MHC-mismatched Mouse Lung Allograft Acceptance with Combined Donor Bone Marrow: Lung Transplant using a 12-Hour Nonmyeloablative Conditioning Regimen

Dodd-o, J. M., Ganguly, S., Vulic, A., Panoskaltsis-Mortari, A., McDyer, J. F. & Luznik, L. Sep 21 2016 (Accepted/In press) In : Transplantation.

Research output: Contribution to journalArticle

Allografts
Bone Marrow
Tissue Donors
Transplants
Lung

Might haplo "be the (better) match"?

Kanakry, J. A. & Luznik, L. Feb 18 2016 In : Blood. 127, 7, p. 799-800 2 p.

Research output: Contribution to journalArticle

Transplantation Conditioning
Unrelated Donors
Antilymphocyte Serum
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease

Modern approaches to HLA-haploidentical blood or marrow transplantation

Kanakry, C. G., Fuchs, E. J. & Luznik, L. Jan 1 2016 In : Nature Reviews Clinical Oncology. 13, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

HLA Antigens
Bone Marrow Transplantation
Transplantation
Bone Marrow
Siblings

OCTET-CY: A phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation

Holtick, U., Chemnitz, J. M., Shimabukuro-Vornhagen, A., Theurich, S., Chakupurakal, G., Krause, A., Fiedler, A., Luznik, L., Hellmich, M., Wolf, D., Hallek, M., von Bergwelt-Baildon, M. & Scheid, C. Jan 1 2016 In : European Journal of Haematology. 96, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Cyclophosphamide
Immunosuppression
Transplants
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Tissue Donors
Neoplasms

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

Al Malki, M. M., Horowitz, M., Handgretinger, R., Leung, W., Roy, D. C., Huang, X. J., Fuchs, E., Locatelli, F., Blaise, D., Mineishi, S., Martelli, M., Miller, J., June, C., Ai, H. S., Luznik, L., Mavilio, D., Lugli, E., van den Brink, M. R. M., Champlin, R. E. & Ciurea, S. O. Apr 1 2016 In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22, 4, p. 594-604 11 p.

Research output: Contribution to journalArticle

San Francisco
Stem Cell Transplantation
Transplantation
Recurrence
Unrelated Donors

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R. , Paz, K. , Du, J. , Reichenbach, D. K. , Taylor, P. A. , Panoskaltsis-Mortari, A. , Vulic, A. , Luznik, L. , MacDonald, K. K. P. , Hill, G. R. , Nyuydzefe, M. S. , Weiss, J. M. , Chen, W. , Trzeciak, A. , Serody, J. S. , Aguilar, E. G. , Murphy, W. J. , Maillard, I. , Munn, D. , Koreth, J. & 6 others Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R. Apr 28 2016 In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Graft vs Host Disease
Grafts
STAT3 Transcription Factor
Interleukin-17
Busulfan
Drug Monitoring
Cyclophosphamide
Transplantation
Pharmacokinetics

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R. Aug 18 2016 In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

T-cells
Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Alternative donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Kanakry, C. G., de Lima, M. J. & Luznik, L. Jul 1 2015 In : Seminars in Hematology. 52, 3, p. 232-242 11 p.

Research output: Contribution to journalArticle

Cell Transplantation
HLA Antigens
Acute Myeloid Leukemia
Tissue Donors
Graft vs Host Disease

Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Ciurea, S. O. , Zhang, M. J. , Bacigalupo, A. A. , Bashey, A. , Appelbaum, F. R. , Aljitawi, O. S. , Armand, P. , Antin, J. H. , Chen, J. , Devine, S. M. , Fowler, D. H. , Luznik, L. , Nakamura, R. , O'Donnell, P. V. , Perales, M. A. , Pingali, S. R. , Porter, D. L. , Riches, M. R. , Ringdén, O. T. H. , Rocha, V. & 6 others Vij, R., Weisdorf, D. J., Champlin, R. E., Horowitz, M. M., Fuchs, E. J. & Eapen, M. Aug 20 2015 In : Blood. 126, 8, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

Unrelated Donors
Transplants
Acute Myeloid Leukemia
Cyclophosphamide
Graft vs Host Disease
Cyclophosphamide
Transplantation
Bone Marrow
Graft vs Host Disease
Disease-Free Survival

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R. , Kanakry, J. A. , Showel, M. M. , Tsai, H. L. , Bolaños-Meade, J. , Rosner, G. L. , Kanakry, C. G. , Perica, K. , Symons, H. J. , Brodsky, R. A. , Gladstone, D. E. , Huff, C. A. , Pratz, K. W. , Prince, G. T. , Dezern, A. E. , Gojo, I. , Matsui, W. H. , Borrello, I. , McDevitt, M. A. , Swinnen, L. J. & 7 others Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L. May 7 2015 In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Blood
Transplantation
Bone Marrow
Disease-Free Survival
Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
Anti-Inflammatory Agents

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, R. , Allen, J. L. , Luznik, L. , MacDonald, K. P. , Paz, K. , Alexander, K. A. , Vulic, A. , Du, J. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Poe, J. C. , Serody, J. S. , Murphy, W. J. , Hill, G. R. , Maillard, I. , Koreth, J. , Cutler, C. S. , Soiffer, R. J. , Antin, J. H. , Ritz, J. & 4 others Chao, N. J., Clynes, R. A., Sarantopoulos, S. & Blazar, B. R. Jun 25 2015 In : Blood. 125, 26, p. 4085-4094 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Protein-Tyrosine Kinases
B-Lymphocytes
Cells
2014
Histocompatibility Testing
Unrelated Donors
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Graft vs Host Disease

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L. Sep 25 2014 In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
Cyclophosphamide

Experts' considerations on HLA-haploidentical stem cell transplantation

Patriarca, F., Luznik, L., Medeot, M., Zecca, M., Bacigalupo, A., Di Bartolomeo, P., Arcese, W., Corradini, P., Ciceri, F., Vago, L., Kanakry, C. G., Fleischhauer, K., Martelli, M. F., Bosi, A., Rambaldi, A., Cesaro, S., Russo, D. & Fanin, R. 2014 In : European Journal of Haematology. 93, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
HLA Antigens
Transplants
Tissue Donors
T-Lymphocytes

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, J. A. , Flynn, R. , Du, J. , Harrington, B. K. , Zhong, Y. , Kaffenberger, B. , Yang, C. , Towns, W. H. , Lehman, A. , Johnson, A. J. , Muthusamy, N. , Devine, S. M. , Jaglowski, S. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Luznik, L. , Hill, G. R. , Wong, H. K. , MacDonald, K. K. P. & 10 others Maillard, I., Koreth, J., Elias, L., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Panoskaltsis-Mortari, A., Byrd, J. C. & Blazar, B. R. Nov 3 2014 In : Journal of Clinical Investigation. 124, 11, p. 4867-4876 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
B-Lymphocytes
Therapeutics
T-Lymphocytes
Isoantibodies

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R. , Du, J. , Veenstra, R. G. , Reichenbach, D. K. , Panoskaltsis-Mortari, A. , Taylor, P. A. , Freeman, G. J. , Serody, J. S. , Murphy, W. J. , Munn, D. H. , Sarantopoulos, S. , Luznik, L. , Maillard, I. , Koreth, J. , Cutler, C. , Soiffer, R. J. , Antin, J. H. , Ritz, J. , Dubovsky, J. A. , Byrd, J. C. & 3 others MacDonald, K. P., Hill, G. R. & Blazar, B. R. Jun 19 2014 In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Germinal Center
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Grafts

Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning

Kanakry, C. G., O'Donnell, P. V., Furlong, T., De Lima, M. J., Wei, W., Medeot, M., Mielcarek, M., Champlin, R. E., Jones, R. J., Thall, P. F., Andersson, B. S. & Luznik, L. Nov 1 2014 In : Journal of Clinical Oncology. 32, 31, p. 3497-3505 9 p.

Research output: Contribution to journalArticle

Busulfan
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Cyclophosphamide
Graft vs Host Disease
Grafts
Cyclophosphamide
Transplantation
Bone Marrow

Sustained CD4+ T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide

Ellsworth, S., Balmanoukian, A., Kos, F., Nirschl, C. J., Nirschl, T. R., Grossman, S. A., Luznik, L. & Drake, C. G. 2014 In : OncoImmunology. 3, 1, e27357

Research output: Contribution to journalArticle

temozolomide
Interleukin-15
Interleukin-7
Lymphopenia
Glioma