Lei Wang

Research Associate

20052018
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Research Output 2005 2018

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Article
2018

Oxidative stress induces an interactive decline in Wnt and Nrf2 signaling in degenerating retinal pigment epithelium

Ebrahimi, K. B., Cano, M., Rhee, J., Datta, S., Wang, L. & Handa, J., Aug 1 2018, In : Antioxidants and Redox Signaling. 29, 4, p. 389-407 19 p.

Research output: Contribution to journalArticle

Oxidative stress
Retinal Pigments
Retinal Pigment Epithelium
Oxidative Stress
Macular Degeneration
MicroRNAs
Lipid Metabolism
Inflammation
Lipids
Oxidative Stress
2017

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice

Huang, H., Liu, Y., Wang, L. & Li, W., Mar 1 2017, In : PLoS One. 12, 3, e0173716.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Knockout Mice
Tumors

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

Datta, S., Cano, M., Ebrahimi, K., Wang, L. & Handa, J., 2017, (Accepted/In press) In : Progress in Retinal and Eye Research.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Oxidative Stress
Inflammation
Bruch Membrane
2016
Macular Degeneration
Epitopes
Lipids
Innate Immunity
Micronutrients

Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation

Wang, L., Cano, M., Datta, S., Wei, H., Ebrahimi, K. B., Gorashi, Y., Garlanda, C. & Handa, J., Dec 1 2016, In : Journal of Pathology. 240, 4, p. 495-506 12 p.

Research output: Contribution to journalArticle

Inflammasomes
Complement Factor H
Oxidative Stress
Macular Degeneration
Interleukin-1
2014

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J., 2014, In : Free Radical Biology and Medicine. 70, p. 155-166 12 p.

Research output: Contribution to journalArticle

Complement Activation
Smoke
Tobacco Products
Epithelial Cells
Chemical activation

Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells

Cano, M., Wang, L., Wan, J., Barnett, B. P., Ebrahimi, K., Qian, J. & Handa, J., Apr 2014, In : Free Radical Biology and Medicine. 69, p. 1-14 14 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Mitochondria
Oxidative stress
Oxidative Stress
Epithelial Cells
Cytoprotection
Retinal Pigment Epithelium
Smoke
Tobacco Products
Oxidative Stress
2010
LH Receptors
Ovary
Carrier Proteins
Messenger RNA
Proteins
2007

Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary

Menon, K. M. J., Nair, A. K., Wang, L. & Peegel, H., Jan 2 2007, In : Molecular and Cellular Endocrinology. 260-262, p. 109-116 8 p.

Research output: Contribution to journalArticle

LH Receptors
RNA-Binding Proteins
Ovary
Messenger RNA
RNA Stability

Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: Relationship to sterol metabolism

Wang, L., Nair, A. K. & Menon, K. M. J., Sep 2007, In : Molecular Endocrinology. 21, 9, p. 2233-2241 9 p.

Research output: Contribution to journalArticle

mevalonate kinase
LH Receptors
Granulosa Cells
Sterols
Carrier Proteins
2005
mevalonate kinase
LH Receptors
Luteinizing Hormone
Chorionic Gonadotropin
Ovary