Lee J Martin

Professor

1984 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1984 2020

Filter
Article
1997

Excitotoxic neuronal death in the immature brain is an apoptosis- necrosis morphological continuum

Portera-Cailliau, C., Price, D. L. & Martin, L. J., Feb 3 1997, In : Journal of Comparative Neurology. 378, 1, p. 70-87 18 p.

Research output: Contribution to journalArticle

Necrosis
Apoptosis
Cell Death
Brain
Neurons

Glutamate transporter protein subtypes are expressed differentially during rat cns development

Furuta, A., Rothstein, J. D. & Martin, L. J., 1997, In : Journal of Neuroscience. 17, 21, p. 8363-8375 13 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Prosencephalon
Brain
Neuroglia
Cerebellum

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

Lee, M. K., Borchelt, D. R., Kim, G., Thinakaran, G., Slunt, H. H., Ratovitski, T., Martin, L. J., Kittur, A., Gandy, S., Levey, A. I., Jenkins, N., Copeland, N., Price, D. L. & Sisodia, S. S., Jul 1997, In : Nature Medicine. 3, 7, p. 756-760 5 p.

Research output: Contribution to journalArticle

Presenilin-1
Alzheimer Disease
Derivatives
Codon
Transgenic Mice

Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

Martin, L. J., Brambrink, A. M., Lehmann, C., Portera-Cailliau, C., Koehler, R. C., Rothstein, J. D. & Traystman, R. J., Sep 1997, In : Annals of Neurology. 42, 3, p. 335-348 14 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Astrocytes
Ischemia
Neurons
Excitatory Amino Acids
Electroencephalography

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease

Sze, C. I., Troncoso, J. C., Kawas, C., Mouton, P., Price, D. L. & Martin, L. J., Aug 1997, In : Journal of Neuropathology and Experimental Neurology. 56, 8, p. 933-944 12 p.

Research output: Contribution to journalArticle

Synaptophysin
Hippocampus
Alzheimer Disease
Proteins
Occipital Lobe

Neither L-arginine nor L-NAME affects neurological outcome after global ischemia in cats

Kirsch, J. R., Bhardwaj, A., Martin, L. J., Hanley, D. F. & Traystman, R. J., Nov 1997, In : Stroke. 28, 11, p. 2259-2265 7 p.

Research output: Contribution to journalArticle

NG-Nitroarginine Methyl Ester
Arginine
Cats
Ischemia
Subclavian Artery
D-Aspartic Acid
N-Methylaspartate
Necrosis
Apoptosis
Brain

Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors

Blue, M. E., Martin, L. J., Brennan, E. M. & Johnston, M. V., Sep 15 1997, In : Journal of Comparative Neurology. 386, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

Quisqualic Acid
Vibrissae
Neuropil
Glutamate Receptors
Dendrites

Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: II. α-AMPA and kainate receptors

Brennan, E. M., Martin, L. J., Johnston, M. V. & Blue, M. E., Sep 15 1997, In : Journal of Comparative Neurology. 386, 1, p. 29-45 17 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
AMPA Receptors
Glutamate Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Kainic Acid

Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia

Martin, L. J., Brambrink, A., Koehler, R. C. & Traystman, R. J., Jan 13 1997, In : Journal of Comparative Neurology. 377, 2, p. 262-285 24 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Prosencephalon
Ischemia
Silver Staining
Somatosensory Cortex
1996

Comparative evaluation of synaptophysin-based methods for quantification of synapses

Calhoun, M. E., Jucker, M., Martin, L. J., Thinakaran, G., Price, D. L. & Mouton, P. R., 1996, In : Journal of Neurocytology. 25, 12, p. 821-828 8 p.

Research output: Contribution to journalArticle

Synaptophysin
Synapses
Dentate Gyrus
Densitometry
Western Blotting

Diabetic chronic hyperglycemia and neurologic outcome following global ischemia in dogs

Sieber, F., Martin, L. J., Randall Brown, P., Palmon, S. C. & Traystman, R. J., 1996, In : Journal of Cerebral Blood Flow and Metabolism. 16, 6, p. 1230-1235 6 p.

Research output: Contribution to journalArticle

Hyperglycemia
Nervous System
Ischemia
Dogs
Blood Glucose

Effect of AMPA receptor antagonist nbqx on neuronal survival in basal ganglia after asphymc cardiac arrest in neonatal pigs

Bramhrink, A. M., Martin, L. J., Hanley, D. F., Becker, K., Shaffher, H. D., Koehler, R. C. & Trayitman, R. J., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

cardiac arrest
AMPA Receptors
Rain
Status Epilepticus
Putamen

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

Lee, M. K., Slunt, H. H., Martin, L. J., Thinakaran, G., Kim, G., Gandy, S. E., Seeger, M., Koo, E., Price, D. L. & Sisodia, S. S., Dec 1 1996, In : Journal of Neuroscience. 16, 23, p. 7513-7525 13 p.

Research output: Contribution to journalArticle

Presenilin-2
Presenilin-1
Messenger RNA
Presenilins
Brain
Brain Fornix
Amino Acid Transport System X-AG
Glutamate Receptors
Hippocampus
Down-Regulation

Neuropathology in controls and demented subjects from the Baltimore longitudinal study of aging

Troncoso, J. C., Martin, L. J., Dal Forno, G. & Kawas, C. H., May 1996, In : Neurobiology of Aging. 17, 3, p. 365-371 7 p.

Research output: Contribution to journalArticle

Baltimore
Amyloid Plaques
Longitudinal Studies
Neocortex
Alzheimer Disease
Nitric Oxide Synthase
Protein Isoforms
Brain
Antibodies
Proteins
Rhombencephalon
Neurology
Prosencephalon
N-Methyl-D-Aspartate Receptors
Rats

Ontogeny of glutamate transporters in the sheep brain

Northington, F., Trayslman, R. J., Koehler, R. C., Rpthstein, J. D. & Martin, L. J., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
glutamates
transporters
ontogeny
Brain

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

Ohshima, T., Ward, J. M., Huh, C. G., Longenecker, G., Veeranna, Pant, H. C., Brady, R. O., Martin, L. J. & Kulkarni, A. B., Oct 1 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 20, p. 11173-11178 6 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Pathology
Genes
Brain
Phosphotransferases
1995

Cellular and molecular biology of Alzheimer's disease and animal models

Sisodia, S. S., Martin, L. J., Walker, L. C., Borchelt, D. R. & Price, D. L., 1995, In : Neuroimaging Clinics of North America. 5, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Cell Biology
Molecular Biology
Alzheimer Disease
Animal Models

Global incomplete cerebral ischemia produces predominantly cortical neuronal injury

Sieber, F., Palmon, S. C., Traystman, R. J. & Martin, L. J., 1995, In : Stroke. 26, 11, p. 2091-2095 5 p.

Research output: Contribution to journalArticle

Brain Ischemia
Canidae
Ischemia
Wounds and Injuries

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus

Furuta, A., Price, D. L., Pardo-Villamizar, C. A., Troncoso, J. C., Xu, Z. S., Taniguchi, N. & Martin, L. J., 1995, In : American Journal of Pathology. 146, 2, p. 357-367 11 p.

Research output: Contribution to journalArticle

Neocortex
Down Syndrome
Superoxide Dismutase
Hippocampus
Alzheimer Disease

Microtubule-associated protein 2 (MAP-2): a sensitive marker of seizure-related brain damage

Ballough, G. P. H., Martin, L. J., Cann, F. J., Graham, J. S., Smith, C. D., Kling, C. E., Forster, J. S., Phann, S. & Filbert, M. G., 1995, In : Journal of Neuroscience Methods. 61, 1-2, p. 23-32 10 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Seizures
Brain
Staining and Labeling
Soman

Non-NMDA glutamate receptors are present throughout the primate hypothalamus

Ginsberg, S. D., Price, D. L., Blackstone, C. D., Huganir, R. L. & Martin, L. J., 1995, In : Journal of Comparative Neurology. 353, 4, p. 539-552 14 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Primates
Hypothalamus
Neurons
Isoxazoles

Quantitative and qualitative changes in AMPA receptor expression during spinal cord development

Jakowec, M. W., Fox, A. J., Martin, L. J. & Kalb, R. G., 1995, In : Neuroscience. 67, 4, p. 893-907 15 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Motor Neurons
Spinal Cord
Acids

Regional deafferentation down-regulates subtypes of glutamate transporter proteins

Ginsberg, S. D., Martin, L. J. & Rothstein, J. D., 1995, In : Journal of Neurochemistry. 65, 6, p. 2800-2803 4 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
D-Aspartic Acid
Hippocampus
Down-Regulation
Aspartic Acid

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J. & Kuncl, R. W., Jul 1995, In : Annals of Neurology. 38, 1, p. 73-84 12 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Amyotrophic Lateral Sclerosis
Neuroglia
Motor Cortex
Astrocytes

The ampa glutamate receptor GluR3 is enriched in oxytocinergic magnocellular neurons and is localized at synapses

Ginsberg, S. D., Price, D. L., Blackstone, C. D., Huganir, R. L. & Martin, L. J., 1995, In : Neuroscience. 65, 2, p. 563-575 13 p.

Research output: Contribution to journalArticle

Isoxazoles
Propionates
Glutamate Receptors
Synapses
Haplorhini
1994

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Chandrasekaran, K., Giordano, T., Brady, D. R., Stoll, J., Martin, L. J. & Rapoport, S. I., 1994, In : Molecular Brain Research. 24, 1-4, p. 336-340 5 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Alzheimer Disease
Gene Expression
Brain
Messenger RNA

Localization of neuronal and glial glutamate transporters

Rothstein, J. D., Martin, L., Levey, A. I., Dykes-Hoberg, M., Jin, L., Wu, D., Nash, N. & Kuncl, R. W., 1994, In : Neuron. 13, 3, p. 713-725 13 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Neuroglia
Astrocytes
Neurons
Hippocampus
Amyloidogenic Proteins
Amyloid Plaques
Amyloid beta-Protein Precursor
Neuroglia
Cerebral Cortex
1993

AMPA glutamate receptor subunits are differentially distributed in rat brain

Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L. & Price, D. L., 1993, In : Neuroscience. 53, 2, p. 327-358 32 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Brain
Neurons
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Amyloid Plaques
Macaca
Amyloid
Cerebral Cortex
Primates

Cellular localizations of AMPA glutamate receptors within the basal forebrain magnocellular complex of rat and monkey

Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L. & Price, D. L., 1993, In : Journal of Neuroscience. 13, 5, p. 2249-2263 15 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Haplorhini
Neurons
Cholinergic Neurons
Inositol 1,4,5-Trisphosphate Receptors
Type C Phospholipases
Second Messenger Systems
Basal Ganglia
Primates

The striatal mosaic in primates: Striosomes and matrix are differentially enriched in lonotropic glutamate receptor subunits

Martin, L. J., Blackstone, C. D., Huganir, R. L. & Price, D. L., 1993, In : Journal of Neuroscience. 13, 2, p. 782-792 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Glutamate Receptors
Primates
Caudate Nucleus
Nucleus Accumbens
1992

Age-associated inclusions in normal and transgenic mouse brain

Jucker, M., Walker, L. C., Martin, L. J., Kitt, C. A., Kleinman, H. K., Ingram, D. K., Price, D. L., Wirak, D., Bayney, R., Ramabhadran, T. V., Fracasso, R. P., Hart, J. T., Hauer, P. E., Hsiau, P., Pekar, S. K., Scangos, G. A., Trapp, B. D. & Unterbeck, A. J., 1992, In : Science. 255, 5050, p. 1443-1445 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Inbred C57BL Mouse
Transgenic Mice
Brain

Alzheimer's disease-type brain abnormalities in animal models.

Price, D. L., Martin, L. J., Sisodia, S. S., Walker, L. C. & Cork, L. C., 1992, In : Progress in Clinical and Biological Research. 379, p. 271-287 17 p.

Research output: Contribution to journalArticle

Animal Disease Models
Amyloid beta-Peptides
Macaca mulatta
Transgenic Mice
Alzheimer Disease

Amyloidosis in aging and Alzheimer's disease

Price, D. L., Walker, L. C., Martin, L. J. & Sisodia, S. S., 1992, In : American Journal of Pathology. 141, 4, p. 767-772 6 p.

Research output: Contribution to journalArticle

Animal Disease Models
Genetically Modified Animals
Amyloid beta-Protein Precursor
Amyloidosis
Macaca mulatta

Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain

Blackstone, C. D., Moss, S. J., Martin, L. J., Levey, A. I., Price, D. L. & Huganir, R. L., Mar 1992, In : Journal of Neurochemistry. 58, 3, p. 1118-1126 9 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
Synaptic Membranes
Propionates
Glutamate Receptors
Cell membranes

Cellular localization of a metabotropic glutamate receptor in rat brain

Martin, L. J., Blackstone, C. D., Huganir, R. L. & Price, D. L., 1992, In : Neuron. 9, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Brain
AMPA Receptors
Isoxazoles
Parahippocampal Gyrus

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

Rothstein, J. D., Martin, L. J. & Kuncl, R. W., May 28 1992, In : New England Journal of Medicine. 326, 22, p. 1464-1468 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Glutamic Acid
Spinal Cord
Brain
Synaptosomes

Immunological detection of glutamate receptor subtypes in human central nervous system

Blackstone, C. D., Levey, A. I., Martin, L. J., Price, D. L. & Huganir, R. L., Jun 1992, In : Annals of Neurology. 31, 6, p. 680-683 4 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Central Nervous System
Nerve Tissue
Proteins
Neurotransmitter Receptor

Mesenteric mast cell degranulation in acute T-2 toxin poisoning

Doebler, J. A., Martin, L. J., Morse, J. D., Ballough, G. P., Strauss, J. A. & Anthony, A., 1992, In : Toxicology Letters. 62, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

T-2 Toxin
Cell Degranulation
Mast Cells
Poisoning
Granulation

Neuronal degeneration in human diseases and animal models

Price, D. L., Martin, L. J., Clatterbuck, R. E., Koliatsos, V. E., Sisodia, S. S., Walker, L. C. & Cork, L. C., 1992, In : Journal of Neurobiology. 23, 9, p. 1277-1294 18 p.

Research output: Contribution to journalArticle

Animal Disease Models
Nerve Growth Factor Receptor
Nerve Degeneration
Motor Neuron Disease
Nervous System Diseases

The G-protein-coupled receptor kinases βARK1 and βARK2 are widely distributed at synapses in rat brain

Arriza, J. L., Dawson, T. M., Simerly, R. B., Martin, L. J., Caron, M. G., Snyder, S. H. & Lefkowitz, R. J., 1992, In : Journal of Neuroscience. 12, 10, p. 4045-4055 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Synapses
Adrenergic Receptors
Phosphotransferases
Neurotransmitter Receptor
1991

Aged non-human primates: An animal model of age-associated neurodegenerative disease

Price, D. L., Martin, L. J., Sisodia, S. S., Wagster, M. V., Koo, E. H., Walker, L. C., Koliatsos, V. E. & Cork, L. C., 1991, In : Brain Pathology. 1, 4, p. 287-296 10 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Primates
Animal Models
Amyloid Plaques
Nerve Growth Factor

Amyloid precursor protein in aged nonhuman primates

Martin, L. J., Sisodia, S. S., Koo, E. H., Cork, L. C., Dellovade, T. L., Weidemann, A., Beyreuther, K., Masters, C. & Price, D. L., 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 4, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Primates
Amyloid Plaques
Axons
Neurites